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Mending the broken in amyotrophic lateral sclerosis: DNA damage and repair in motor neuron degeneration

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Neural Regeneration Research 2021年第1期16卷 104-105页

作者： Byung Woo kim Lee j.Martin Department of Pathology Division of Neuropathologythe Pathobiology Graduate Training ProgramJohns Hopkins University School of MedicineBaltimoreMDUSA Department of Neuroscience Johns Hopkins University School of MedicineBaltimoreMDUSA

Amyotrophic lateral sclerosis(ALS)is a fatal neurodegenerative disease that causes paralysis and respiratory failure(Petrov et al.,2017).The driving mechanisms are unknown,and there are no effective treatments(Petrov et al.,2017).Aging and a few gene mutations,a common one being missense mutations in superoxide dismutase-1(SOD1),are risk factors for ALS(Figure 1).The recent Food and Drug Administration approval of edaravone for the treatment of ALS putatively supports a role for oxidative and nitrative stresses in the disease processes(Figure 1A).DNA damage,abnormalities in DNA repair,and other nuclear abnormalities are implicated also in the pathogenesis of human ALS(Bradley and Krasin,1982;kim et al.,2020).

关键词： al. damage degeneration

Magnetic force improvement and parameter optimization for magnetic abrasive polishing of AZ31 magnesium alloy

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中国有色金属学会会刊：英文版 2008年第A1期18卷 369-373页

作者： S.O.kim j.S.KWAK Graduate School of Mechanical Engineering Pukyong National UniversitySouth Korea School of Mechanical Engineering Pukyong National UniversitySouth Korea

The magnetic force acting on workpiece to be machined plays a significantly important role in magnetic abrasive polishing *** in a case of polishing nonferrous materials,the strength of magnetic force is very low and it leads lower polishing *** magnesium alloy that has superior mechanical properties for industrial application such as a lightweight and high specific strength is one of the most famous nonferrous *** improving strategy of the magnetic force for the AZ31 magnesium alloy installed with a permanent magnet was proposed and experimental verification was carried *** the proposed strategy,the effect of process parameters on the surface roughness of the AZ31 magnesium alloy was evaluated by a design of experimental method.

关键词：镁合金物理性能磁力最优化设计磁性

Benefits of Stochastic Optimization for Scheduling Energy Storage in Wholesale Electricity Markets

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journal of Modern Power Systems and Clean Energy 2021年第1期9卷 181-189页

作者： Hyeong jun kim Ramteen Sioshansi Antonio j.Conejo the Department of Integrated Systems Engineering The Ohio State UniversityColumbusOhioUSA the Department of Electrical and Computer Engineering The Ohio State UniversityColumbus.OhioUSA

We propose a two-stage stochastic model for optimizing the operation of energy storage. The model captures two important features: uncertain real-time prices when day-ahead operational commitments are made;and the price impact of charging and discharging energy storage. We demonstrate that if energy storage has full flexibility to make real-time adjustments to its day-ahead commitment and market prices do not respond to charging and discharging decisions, there is no value in using a stochastic modeling framework, i.e., the value of stochastic solution is always zero. This is because in such a case the energy storage behaves purely as a financial arbitrageur day ahead, which can be captured using a deterministic *** show also that prices responding to its operation can make it profitable for energy storage to "waste" energy, for instance by charging and discharging simultaneously, which is normally sub-optimal. We demonstrate our model and how to calibrate the price-response functions from historical data with a practical case study.

关键词： Energy storage stochastic optimization value of stochastic solution electricity market

Development of mathematical model with a genetic algorithm for automatic arc welding process

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Acta Metallurgica Sinica(English Letters) 2010年第3期23卷 230-240页

作者： D.T.Thao I.S.kim j.W.jeong j.H.Lee j.Y.Shim H.H.kim Department of Mechanical Engineering Mokpo National University

This paper is to represent new algorithms to predict process parameters on top-bead width in robotic gas metal arc（GMA） welding *** models have been developed：linear, curvilinear and intelligent model based on full factorial design with two *** analysis was employed for optimization of the coefficients of linear and curvilinear models, while genetic algorithm（GA） was utilized to estimate the coefficients of an intelligent *** only the fitting of these models were checked and compared by using a variance test（ANOVA）, but also the prediction on top-bead width using the developed models were carried out based on the additional *** developed models were employed to investigate the characteristic between process parameters and top-bead *** solutions and graphical representation showed that the intelligent model developed can be employed for prediction of bead geometry in GMA welding process.

关键词： Top-bead width Genetic algorithm Multiple regression Robotic arc welding GMA welding

A Characteristic Non-Reflecting Boundary Treatment in Lattice Boltzmann Method

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Chinese Physics Letters 2008年第6期25卷 1964-1967页

作者： kim Dehee kim Hyung Min jHON Myung S VINAY Ⅲ Stephen j. BUCHANAN john Department of Chemical Engineering Carnegie Mellon University 5000 Forbes Ave Pittsburgh PA 15213 USA Division of Mechanical System Design Engineering Kyonggi University Suwon Kyonggi-do Korea Bechtel Bettis Inc West Mifflin PA 15122 USA

In lattice Boltzmann methods, disturbances develop at the initial stages of the simulation, the decay characteristics depend mainly on boundary treatment methods; open boundary conditions such as equilibrium and bounce-back schemes potentially generate uncontrollable disturbances. Excessive disturbances originate from non-physical reflecting waves at boundaries. Characteristic boundary conditions utilizing the signs of waves at boundaries which suppress these reflecting waves, as well as their implementation in the lattice Boltzmann method, are introduced herein. The performance of our novel boundary treatment method to effectively suppress excessive disturbances is verified by three different numerical experiments.

关键词： HYPERBOLIC SYSTEMS EQUATION FLOWS

壮通饮通过Nrf2-SCL7A11/xCT-Gpx4通路调控铁死亡改善脑缺血再灌注损伤

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中山大学学报（医学科学版） 2024年第4期45卷 539-548页

作者：王成毅蔡粤芳宁振求邓敏贞孙景波 Sookja kim CHUNG 李岩程骁广州中医药大学第二临床医学院广东广州510006 深圳市人民医院、南方科技大学第一附属医院、暨南大学第二临床医学院广东深圳518020 省部共建中医湿证国家重点实验室广东广州510120 广东省中医急症研究重点实验室广东广州510120 澳门科技大学医学院中国澳门999078 广西国际壮医医院广西南宁530201

【目的】探究壮通饮通过Nrf2-SCL7A11/xCT-Gpx4通路调控铁死亡对大脑中动脉栓塞模型小鼠脑缺血再灌注损伤的保护作用及其机制。【方法】将C57BL/6j小鼠随机分为假手术组(Sham)、模型组(MCAO)、低剂量壮通饮组(ZTY-L+MCAO),高剂量壮通饮... 详细信息

【目的】探究壮通饮通过Nrf2-SCL7A11/xCT-Gpx4通路调控铁死亡对大脑中动脉栓塞模型小鼠脑缺血再灌注损伤的保护作用及其机制。【方法】将C57BL/6j小鼠随机分为假手术组(Sham)、模型组(MCAO)、低剂量壮通饮组(ZTY-L+MCAO),高剂量壮通饮组(ZTY-H+MCAO),每组5只。其中MCAO组采用硅胶线栓法进行造模,小鼠大脑中动脉栓塞1h,拔出线栓再灌注72h后进行心脏灌注取脑,Sham组除了不插入线栓其余操作同MCAO组。采用Zea-Longa法对小鼠神经功能进行评分;采用TTC染色评估小鼠脑梗死体积;采用HE染色、尼氏染色评估脑损伤程度;采用普鲁士蓝染色评价三价铁离子蓄积水平;qPCR检测铁离子转运相关载体受体TfR1和DMT1、脂质过氧化相关基因ACSL4以及铁死亡标志物PTGS2 mRNA表达;ELISA试剂盒检测4-HNE的含量评估小鼠大脑脂质过氧化水平;Western-blot、免疫荧光检测小鼠脑组织中Nrf2、SCL7A11/xCT、Gpx4蛋白水平。【结果】①壮通饮改善了MCAO/R后小鼠神经功能(P<0.05)和大脑梗死体积(P<0.05)及缓解MCAO/R后大脑皮层细胞病理损伤。②壮通饮减弱了MCAO/R后小鼠大脑组织的三价铁离子蓄积状态;减少MCAO/R后小鼠大脑中与铁离子转运入细胞内相关载体TfR1和DMT1 mRNA的表达(P<0.001);下调MCAO/R后小鼠大脑脂质过氧化物4-HNE含量和组织脂质过氧化物酶ACSL4 mRNA表达(P<0.001);降低MCAO/R后小鼠大脑铁死亡标志物PTGS2 mRNA表达(P<0.001)。③壮通饮增加MCAO/R后Nrf2入核表达(P<0.001),以及增加xCT和Gpx4在神经元中的表达(P<0.001)。【结论】壮通饮能够改善MCAO/R小鼠神经功能和脑梗死体积,缓解大脑皮层细胞病理损伤,影响Nrf2-SCL7A11/xCT-Gpx4通路关键信号分子表达,所以壮通饮改善小鼠MCAO/R损伤的作用机制可能是通过Nrf2-SCL7A11/xCT-Gpx4通路调节铁死亡水平达到的。

关键词：缺血性脑卒中铁死亡壮通饮 Nrf2-SCL7A11/xCT-Gpx4通路机制研究

Luminescence and low temperature trap centers in mixed rare earth borate crystal

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journal of Rare Earths 2018年第10期36卷 1024-1029页

作者： D.joseph Danie Indra Raj Panday H.j.kim Sunghwan kim U.Fawad Department of Physics Kyungpook National University Department of Radiological Science Cheongju University Department of Physics Kohat University of Science and Technology

The single crystal of this compound has been grown from melt by using a conventional Czochralski technique. The temperature dependent luminescence spectra were measured using a 265 nm laser as an exciting source in the range of 10-300 K. The scintillation decay time profile was measured and found to have three components. The influence of the trap centers on the luminescence properties was studied by means of thermoluminescence（TL） glow peak analysis. Low temperature TL glow peaks were measured in the temperature range of 10-300 K at the heating rate of 0.1 K/s for X-ray irradiated sample. The TL glow peak consists of two dominant peaks at 88 and 109 K. Several glow peaks with a complex nature causes the decrease in the light yield at temperatures below 250 K, and along with long scintillation decay components were observed. The trap parameters such as activation energy（E）, frequency factor（s）and order of kinetics（b） were calculated using various standard methods such as peak shape（PS）,variable heating rate（VHR）, initial rise（IR） and computerized glow curve deconvolution（CGCD）.

关键词： Rare earth Decay time Thermoluminescence Kinetic parameters

Azoospermia:vasal agenesis

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Asian journal of Andrology 2022年第1期24卷 1-4页

作者： j Sam Fisher Edward D kim Department of Urology University of TennesseeKnoxvilleTN 37920USA

SPECIFIC GENETIC TESTS(CFTR AND INTRON 8 SPLICE VARIANT TESTING)AND THEIR SIGNIFICANCE Congenital bilateral absence of the vas deferens(CBAVD)and cystic fibrosis(CF)began as separate entities with an apparent clinical *** occurs in 1%–2%of men presenting with infertility at urological departments and has an incidence of 1:1000–1:2000 in Caucasian *** example of this anatomic variant is shown in Figure 1.

关键词： correlation. clinical Figure

非增强MR淋巴管（结）成像在术后乳糜胸或颈部乳糜漏的诊断和术前计划中的实用价值

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国际医学放射学杂志 2022年第3期 367-368页

作者： D.Hyun H.Y.Lee j.H.Cho H.K.kim Y.S.Choi j.kim 孙素晔

摘要目的明确非增强MR淋巴管(结)成像(MRL)在治疗术后乳糜胸或颈部乳糜漏中的作用。方法 2016年5月—2020年4月间共有50例病人先后接受了非增强MRL和胸

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