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Degradation of indomethacin in river water under stress and non-stress laboratory conditions:degradation products,long-term evolution and adsorption to sediment

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journal of Environmental Sciences 2017年第1期29卷 13-20页

作者： juan j.jimenez Maria I.Sanchez Rafael Pardo Beatriz E.Munoz Department of Analytical Chemistry Faculty of SciencesCampus Miguel DelibesUniversity of ValladolidPaseo de Belen 747012 ValladolidSpain I.U.CINQUIMA Campus Miguel DelibesUniversity of ValladolidPaseo de Belen 547011 ValladolidSpain Department of Analytical Chemistry School of Industrial EngineersUniversity of ValladoliclFrancisco Mendizdbal 147014 ValladolidSpain

The pharmaceutical compound indomethacin is not totally removed in wastewater treatment plants,whose effluents flow into aquatic environments;concentrations in the 0.1-100 ng/L range are commonly found in surface waters,and its fate is ***,biological,photochemical and thermal degradation assays were conducted under stress and non-stress conditions to estimate its degradation rate in river water and establish its degradation products over *** results revealed that direct sunlight irradiation promoted the complete degradation of indomethacin（2 μg/L） in less than 6 hr,but indomethacin was detected over a period of 4 months when water was kept under the natural day-night cycle and the exposure to sunlight was partially limited,as occurs inside a body of *** biological degradation in water was negligible,while the hydrolysis at pH 7.8 was *** were monitored by ultra-pressure liquid chromatography/quadrupole time-of-flight/mass spectrometry after solid-phase extraction,and six degradation products were found;their structures were proposed based on the molecular formulae and fragmentation observed in high-resolution tandem mass spectra.4-Chlorobenzoic and 2-acetamido-5-methoxybenzoic acids were the long-term transformation products,persisting for at least 30 weeks in water kept under non-stress ***,the degradation in the presence of sediment was also monitored over time,with some differences being *** adsorption coefficients of indomethacin and degradation products on river sediment were calculated;long-term degradation products did not have significant adsorption to sediment.

关键词： Indomethacin Degradation products River water Adsorption coefficients High-resolution mass spectrometry

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher j.O’Connell Matthew j.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA james L.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon j.Brown Rafael j.Yáñez-Muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

Women in visual neural regeneration research

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Neural Regeneration Research 2025年第2期20卷 489-490页

作者： Tonia S.Rex David j.Calkins Vanderbilt Eye Institute Vanderbilt University Medical CenterNashvilleTNUSA

The year 2024 marks the 60^(th)anniversary of Title IX and 25 years since the New York Times revealed bias against female faculty members at the Massachusetts Institute of *** take an opportunity here to examine the state of gender bias in a relatively new yet already prominent field,neural regeneration in the visual system,for which there is a well-defined context useful for this *** National Eye Institute(NEI)provided the first round of research funding for its Audacious Goals Initiative(AGI)on visual neural regeneration in 2013 and the last round in ***,we focus on this *** sources included PubMed,the National Science Foundation(NSF),the NEI,the Blue Ridge Institute for Medical Research and data from the major professional organization for eye and vision research,the Association for Research in Vision and Ophthalmology(ARVO).

关键词： neural visual Times

Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael j.Lee Ryota L.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

What can a heavy U(1)B-L Z'boson do to the muon(g-2)u anomaly and to a new Higgs boson mass?

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Chinese Physics C 2021年第1期45卷 32-46页

作者： Antonio P.Morais roman Pasechnik j.Pedro Rodrigues Departamenlo de Fisica da Universidade de Aveiro and CIDMA Campus de Santiago 3810-183 AveiroPortugal Department of Astronomy and Theoretical Physics Lund UniversitySE 223-62 LundSweden Nuclear Physics Institute ASCR 25068 RezCzech Republic Departamento de Fisica CFMUniversidade Federal de Santa CatarinaC.P.476CEP 88.040-900FlorianopolisSCBrazil

The minimal U(1)B_L extension of the Standard Model(B-L-SM)offers an explanation for neutrino mass generatio n via a seesaw mechanism;it also offers two new physics states,namely an extra Higgs bos on and a new Z'gauge *** emerge nee of a second Higgs particle as well as a new Z'gauge boson,both lin ked to the breaking of a local U(1)B_L symmetry,makes the B-L-SM rather constrained by direct searches in Large Hadron Collider(LHC)*** investigate the phenomenological status of the B-L-SM by confr on ting the new physics predictions with the LHC and electroweak precision *** into account the current bounds from direct LHC searches,we demonstrate that the prediction for the muon(g-2)u anomaly in the B-L-SM yields at most a contribution of approximately 8.9×10^-12,which represents a tension of 3.28 standard deviations,with the current 1σuncertainty,by means of a Z'boson if its mass is in the range of 6.3 to 6.5 TeV,within the reach of future LHC *** means that the B-L-SM,with heavy yet allowed Z‘bos on mass range,in practice,does not resolve the tension between the observed anomaly in the muon(g-2)u and the theoretical prediction in the Standard *** a heavy Z'boson also implies that the minimal value for the new Higgs mass is of the order of 400 GeV.

关键词： beyond Standard Model Higgs physics gauge extensions of the Standard Model Z'boson

Conic hyperspectral dispersion mapping applied to semiconductor plasmonics

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Light(Science & Applications) 2012年第1期1卷 48-55页

作者： Dominic Lepage Alvaro jimenez jacques Beauvais jan j Dubowski Department of Electrical and Computer Engineering Interdisciplinary Institute for Technological Innovation(3IT)Universite´de SherbrookeSherbrookeQue´.Canada

The surface plasmon resonance tracking over metal surfaces is a well-established,commercially available,biochemical quantification tool primarily applied in *** utilization of such a tool is,however,constrained to highly specialized industries,capable of justifying the human and instrumental resource investments required by the characterization *** have proposed to expand the field of application of this biosensing approach by redesigning this method through the integration and miniaturization within a semiconductor *** and broadband emission from a light-emitting semiconductor is employed to couple a continuum of surface plasmon modes over a metal–dielectric architecture interfaced with a GaAs–AlGaAs substrate.A tensor version of rigorous coupled wave theory is employed to optimize the various fabrication specifications and to predict the light scatterings over a wide range of *** then present a hyperspectral characterization microscope capable of directly mapping the dispersion relation of scattered light,including diffracted surface plasmons,as an intensity distribution versus photon energy and surface *** carried out in a buffered solution demonstrate the accurate description of the uncollimated and broadband surface plasmon ***,we introduce a simplified method of dispersion mapping,in which quasi-conic cross-sections of the light’s scattering can be acquired directly,thus monitoring surficial responses in as fast as 1.2 *** is over 300 times faster than required by implementing full dispersion *** compromising on the volume of collected information,this method,combined with the solid-state integration of the platform,shows great promise for the fast detection of biochemical agents.

关键词： biosensors light scattering optical devices semiconductors surface plasmon resonance

Neuroprotection by resveratrol-glucuronide and quercetin-glucuronide via binding to polyphenol-and glycosaminoglycan-binding sites in the laminin receptor

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Neural Regeneration Research 2025年第3期20卷 819-820页

作者： Rayudu Gopalakrishna jennifer Aguilar Emily Lee William j.Mack Department of Integrative Anatomical Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of Neurological Surgery Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA

The dietary polyphenolic compounds resveratrol and quercetin prevent neurodegenerative diseases in experimental models;however, they reach the brain only in nanomolar concentrations in the glucuronidated and sulfated ... 详细信息

关键词： resveratrol molar dated

Real-time detection of influenza A virus using semiconductor nanophotonics

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Light(Science & Applications) 2013年第1期2卷 184-191页

作者： Dominic Lepage Alvaro jimenez jacques Beauvais jan j Dubowski Laboratory for Quantum Semiconductors and Photon-based BioNanotechnology Interdisciplinary Institute for Technological Innovation(3IT)Department of Electrical and Computer EngineeringUniversite´de SherbrookeSherbrookeQC J1K 2R1Canada

Modern miniaturization and the digitalization of characterization instruments greatly facilitate the diffusion of technological advances in new fields and generate innovative *** concept of a portable,inexpensive and semi-automated biosensing platform,or lab-on-a-chip,is a vision shared by many researchers and venture *** this scope,we present a semiconductor monolithic integration approach to conduct surface plasmon resonance *** technology is already commonly used for biochemical characterization in pharmaceutical industries,but we have reduced the technological platform to a few nanometers in scale on a semiconductor *** evaluate the signal quality of this nanophotonic device using hyperspectral-imaging technology,and we compare its performance with that of a standard prism-based commercial *** standard biochemical agents are employed for this characterization study:bovine serum albumin and inactivated influenza A *** resolutions of data acquisition varying between 360 and 2.2 s are presented,yielding 2.731025–1.531026 RIU resolutions,respectively.

关键词： GaAs/AlGaAs quantum well device hyperspectral imaging technology influenza A virus integrated surface plasmon resonance biosensor