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Plasma Proteome Profiling with Monoclonal Antibody Libraries: A Pilot Biomarker Analysis for Nanomedicine-Induced Complement Activation

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Advances in Nanoparticles 2013年第2期2卷 133-144页

作者： jános Szebeni zsóka Weiszhár zoltán Rozsnyay Todd Martinsky jános Kádas józsef Lázár László Takács István Kurucz Arrayit Corporation Sunnyvale USA Biosystems International Kft. Debrecen Hungary Nanomedicine Research and Education Center Semmelweis University Budapest Hungary Seroscience Ltd. Budapest Hungary

Complement (C) activation-related hypersensitivity reactions (HSRs) represent an unsolved adverse immune effect of many i.v. administered “nanomedicines”, such as liposomal doxorubicin (Doxil/Caelyx). Because these pseudoallergic reactions can be severe or even lethal, it is an important clinical objective to find biomarkers for proneness for C activation by reactogenic nanoparticles that will allow the prediction of in vivo reactions by in vitro assays. With this goal in mind we identified a normal human blood donor who consistently showed high sensitivity to Caelyx-induced C activation in vitro, whose plasma (Caelyx sensitive plasma, CSP) was subjected to proteome profiling with a library of human plasma proteome specific mAbs. The chip (PlasmaScan-380TM) contained 380 non redundant (with respect to epitopes) mAbs. The analysis revealed 8 proteins that were differentially represented in CSP in comparison with Caelyx-insensitive control plasma. These proteins were identified by mass spectrometry and Western blot analyses to represent factor H (decreased in CSP), factor H related protein, serum amyloid P component, fibronectin, complement component C4, Apo B100, prothrombin and alpha-2-HS glycoprotein (all increased in CSP). Some of these protein changes are consistent with proneness for increased C activation, suggesting the potential use of this method in the search for biomarkers for liposome-induced or other types of nanomedicine-induced HSRs.

关键词： Hypersensitivity Reactions Complement Factor H Serum Amyloid P Proteome Profiling Biomarkers

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Magnetic Multilayers

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journal of Materials Science & Technology 1993年第1期9卷 1-8页

作者： j.P.Renard Institut

Magnetic multilayers are artificially structured materials made of ultrathin films of two different mate- rials,alternately ferromagnetic and *** exhibit new magnetic properties differ- ent from those of bulk *** review the magnetic properties of metallic magnetic multilayers and focus on interface magnetic anisotropy,giant magnetoresistance and interlayer couplings,which are of great promise for applications to high density magnetic storage.

关键词： magnetic multilayer interface magnetic storage

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氯化度对饮用水中消毒副产物安全标准的影响

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给水排水 2000年第1期26卷 22-25页

作者：杨宏伟蒋展鹏管运涛 W.z.Tang A.j.Pierotti 清华大学环境科学与工程系美国佛罗里达国际大学土木与环境工程学系

研究了７种消毒副产物的单变量毒性ＱＳＡＲ模型。毒性指标采用了３种毒性安全标准，包括ＬＴＥＣ，ＬＴＥＡ和ＲｆＤ；分子描述符采用了３个物理化学常数，包括ｌｏｇＰ，ＨＯＭＯ，ＬＵＭＯ。分别研究了３个分子描述符与３个... 详细信息

研究了７种消毒副产物的单变量毒性ＱＳＡＲ模型。毒性指标采用了３种毒性安全标准，包括ＬＴＥＣ，ＬＴＥＡ和ＲｆＤ；分子描述符采用了３个物理化学常数，包括ｌｏｇＰ，ＨＯＭＯ，ＬＵＭＯ。分别研究了３个分子描述符与３个毒性安全标准之间的相关性，并得出了各自的ＱＳＡＲ方程。

关键词：消毒副产物 QSAR模型毒性安全标准

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Cardiovascular risk factors and hearing loss among adults in a tertiary center of Northwestern Nigeria

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World journal of Otorhinolaryngology-Head and Neck Surgery 2018年第4期4卷 253-257页

作者： Stephen Semen Yikawe Kufre Robert Iseh Anas Ahmad Sabir Mfon ime Inoh joseph Hassan Solomon Nasiru Aliyu Department of Otolaryngology Usmanu Danfodiyo University Teaching HospitalSokotoNigeria Department of Internal Medicine Usmanu Danfodiyo University Teaching HospitalSokotoNigeria

Objective:To assess the effect of cardiovascular risk factors on hearing ***:This was a cross sectional study conducted in Usmanu Danfodiyo University Teaching Hospital,Sokoto.A pretested questionnaire was used to obtain information about the biodata and medical history of participants after which,they were examined and had their hearing thresholds ***:In this study,total of 220 participants were *** these participants,112(55.5%)were females,while 98(44.5%)were *** average age of the participants was(45.2412.21)*** mean of pure tone average among the participants was(19.159.28)dB ***-six(16.4%)of the participants had some degree of hearing ***,30 of them(13.6%)had hypertension,while 23(10.5%)presented with diabetes *** addition,43 participants(19.5%)had BMI(body mass index)that was25 kg/***,9 out of the 220 participants(4.1%)had a history of cigarette *** studies indicated that hypertension,diabetes mellitus,BMI of25 kg/m2,and aging were significantly associated with the risk of hearing loss.

关键词： Hearing loss Hypertension Diabetes mellitus Cigarette smoking

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EFFECTS OF 6-OHDA CEL AND BSTLP LESION,WATER AND FOOD DEPRIVATION ON ETHANOL CONSUMPTION IN C57BL/6j MICE USING 3-BOTTLE CHOICE

EFFECTS OF 6-OHDA CEL AND BSTLP LESION,WATER AND FOOD DEPRIV...

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第七届全国药物依赖性学术会议

作者： Robert j.Hitzemann Department of Behavioral Neuroscience Oregon Health and Science University3181 SW Sam Jackson Park RoadPortlandOR 97201

Several lines of evidence point to the importance of the extended amygdala in the mechanisms of sub- stance *** further explore the dopaminergic circuits of the extended amygdala in mediating ethanol response,we investigated the role of 6-hydroxydopamine(6-OHDA)lesions of the central nucleus of the amygdala,lateral division(CeL)and the bed nucleus of the stria terminalis,lateral division,posterior part(BSTLP)in mouse ethanol consumption with three-bottle choice and food-water deprivation para- *** C57BL/6j mice were divided into naive,sham,and lesion groups.6-OHDA(8mg·kg, 0.1 or 0.25μl/side)was injected bilaterally into mouse CeL and/or BSTLP with pargyline and desipra- mine(15mg·kg,ip respectively)pretreatment.1 week after surgery,all mice were given with three bottles of water for 3 days,followed by one bottle of water with two bottles of ethanol(3%-20%)for 15 *** groups had limited food and water *** transportor(DAT)or tyrosine hydroxy-

关键词： 6-OHDA dopamine BSTLP

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Monsoon Subdiyisional Rainfall Dimensionality and Predictability

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Advances in Atmospheric Sciences 1991年第3期8卷 351-356页

作者： j.R.Kulkarni Indian Institute of Tropical meteorology Pune-411008 India

For summer monsoon rainfall purpose India is divided into 35 *** daily rainfall series of one such subdivision(Konkan)has been analysed using the phase space *** years(1959-1973)of daily rainfall data have been utilised in this *** shows that the variability is due to the existing of strange attractor of dimension about *** predictability is estimated by computing the Lyapunov characteristic *** computations show that the predictability is about 8 days.

关键词： Monsoon Subdiyisional Rainfall Dimensionality and Predictability

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Gene SGL,encoding a kinesin-like protein,is involved in grain length and plant height in rice

Gene SGL,encoding a kinesin-like protein,is involved in grai...

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2013全国植物生物学大会

作者： WU T SHEN Y Y zHENG M YANG C Y CHEN Y L FENG z M LIU X LIU S j CHENG z j LEI C L WANG j L jIANG L WAN j M State Key Laboratory for Crop Genetics and Germplasm Enhancement Jiangsu Plant Gene Engineering Research CenterNanjing Agricultural University National Key Facility for Crop Gene Resources and Genetic Improvement Institute of Crop ScienceChinese Academy of Agricultural Sciences

Grain shape,a complex agronomic trait,plays an important role in determining yield and quality in *** the present study,a mutant named short grain length(sgl) was identified among explants of tiss

关键词： Oryza sativa short grain length kinesin-like protein GA

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Purification of the Drosophila melanogaster Proteins Inscuteable and Staufen Expressed in Escherichia coli

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Advances in Bioscience and Biotechnology 2015年第7期6卷 485-493页

作者： Xristo zárate Megan M.McEvoy Teresa Vargas-Cortez jéssica j.Gómez-Lugo Claudia j.Barahona Elena Cantú-Cárdenas Alberto Gómez-Trevino Universidad Autónoma de Nuevo León Facultad de Ciencias QuímicasCd.UniversitariaSan Nicolás de los GarzaMéxico Department of Chemistry and Biochemistry University of ArizonaTucsonUSA

The proteins Inscuteable and Staufen are key components during asymmetric cell division of neuroblasts for the development of Drosophila melanogaster. Expression and purification of both proteins has been a difficult task for structure-function studies. Based on codon optimization for protein expression in Escherichia coli, we have been able to produce, in soluble form, the C-terminal domains of Inscuteable and Staufen as chimeras with N-terminal maltose binding protein tag that contains a rigid linker between them for feasible crystallization. In addition, using an optimized synthetic gene, corresponding to the amino acid region 250 - 623 of Inscuteable fused to glutathione-S-transferase, low-scale expression experiments showed production of soluble protein. Finally, eukaryotic expression of Inscuteable in the methylothropic yeast Pichia pastoris failed to produce the Drosophila protein at detectable amounts, reinforcing the fact that E. coli still was the microorganism of choice for high-yield protein expression.

关键词： Inscuteable Staufen Protein Expression and Purification Maltose-Binding Protein Escherichia coli

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Dy^(3+):ThO_2的选择激发光谱和能级结构

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光谱学与光谱分析 2001年第4期21卷 417-419页

作者：尹民 j C KRUPA 中国科学技术大学物理系合肥230026 法国国家科学研究中心Orsay核物理研究所

本文首次用熔融法生长了Dy3 + :ThO2 晶体 ,详细研究了其光谱特性。通过 12K下格位选择激发下的发射光谱测量 ,利用晶场理论 ,确定了Dy3 + 在ThO2 中的格位对称性为C3v。列表给出了Dy3 + :ThO2 的晶场能级结构。测量和讨论了 4 F9/ 2 ... 详细信息

本文首次用熔融法生长了Dy3 + :ThO2 晶体 ,详细研究了其光谱特性。通过 12K下格位选择激发下的发射光谱测量 ,利用晶场理论 ,确定了Dy3 + 在ThO2 中的格位对称性为C3v。列表给出了Dy3 + :ThO2 的晶场能级结构。测量和讨论了 4 F9/ 2 能级的寿命。

关键词： Dy^3+:ThO2晶体选择激发光谱能级寿命熔融法二氧化钍镝掺杂

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Delta Ⅲ prosthesis for acute fractures in elderly population with a 1-to 14-year follow-up

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中国组织工程研究与临床康复 2008年第52期12卷 10201-10205页

作者： j.F.Cazeneuve Department of Orthopedic Surgery Central Hospital Laon 02000 France

完整三角肌带动DeltaⅢ半限制式反向球窝人工肩进行功能活动。文章拟评估老年肱骨近端急性复杂骨折研究结果。41枚DeltaⅢ反向人工肩关节假体以前外侧入路方式分别植入1993/2007入院治疗的31例三、四部分骨折患者和10例骨折-脱臼患者。... 详细信息

完整三角肌带动DeltaⅢ半限制式反向球窝人工肩进行功能活动。文章拟评估老年肱骨近端急性复杂骨折研究结果。41枚DeltaⅢ反向人工肩关节假体以前外侧入路方式分别植入1993/2007入院治疗的31例三、四部分骨折患者和10例骨折-脱臼患者。男3例,女38例,平均75岁。用Constant分数评估临床结果,取前后位和侧位X射线平片。术后死亡9例,失访2例,剩余30例纳入结果分析。平均随访6.5年,随访结果显示患者手术侧Constant分数为59分,健侧为80分。其中疼痛14.2分,活动度14.4分,关节强度14.2分,前段上升7.5分,外展6.5分,外旋1分,内旋2.2分。影像学随访结果显示1例无菌关节窝松动(随访12年),17例肩胛下切迹,14例内刺,4例内侧肱骨近端骨丢失,2例外侧肱骨近端骨丢失,2例肱骨内侧有透明骨折线,1例染毒性肱骨松动。DeltaⅢ假体功能可靠,对传统固定方法不理想的急性复杂近端肱骨骨折老年患者来说是一个可以选择的办法。临床结果显示DeltaⅢ假体旋转性较差,但X射线平片显示肩胛切迹和肱骨近端溶解较明显。

关键词：创伤肱骨近端反向人工肩

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