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Evaluation of the Antibacterial and Antifungal Capacity of Nanoemulsions Loaded with Synthetic Chalcone Derivatives Di-Benzyl Cinnamaldehyde and Benzyl 4-Aminochalcone

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journal of Renewable Materials 2024年第2期12卷 285-304页

作者： Flavia Oliveira Monteiro da Silva Abreu Taysse Holanda j.ice farias do nascim.nto Henety nascim.nto Pinheiro Rachel Menezes Castelo Hélcio Silva dos Santos Thais Benincá Patrícia da Silva Malheiros júlio César Sousa Prado Raquel de Oliveira Fontenelle Maria Madalena de Camargo Forte Natural Polymers Laboratory PPGCNState University of CearáFortaleza60.714.903Brazil Polymeric Materials Laboratory PPGE3MFederal University of Rio Grande do SulPorto Alegre91501-970Brazil Natural Product Chemistry Laboratory PPGCNState University of CearáFortaleza60.714.903Brazil Food Hygiene and Microbiology Laboratory PPGCTAFederal University of Rio Grande do SulPorto Alegre91501-970Brazil Microbiology Laboratory Medicine SchoolFederal University of CearáSobral62010-560Brazil

With the increase in antimicrobial resistance,it has become necessary to explore alternative approaches for combating and preventing ***-cinnamaldehyde(CNM)and Benzyl4-amino(B4AM)are bioactive compounds derived from chalcones but with restricted solubility in aqueous *** can enhance the solubility of compounds and can be a promising alternative in the development of novel antimicrobials,with reduced side effects and prolonged *** objective of this study was to evaluate the stability of oil-in-water nanoemulsions loaded with two distinct types of chalcones at two different dosages,to propose a stable formulation with antimicrobial *** showed that nanoemulsions presented high encapsulation efficiency,low polydispersity index(PDI)and particle size below 200 nm,indicating that emulsification was a suitable method for nanoemulsion *** with higher dosages exhibited significant antimicrobial effects when compared to free chalcones and positive ***,B4AM nanoemulsions at higher dosages showed expressive activity against Salmonella minnesota,with a 420%greater inhibitory response compared to the free form and showing equivalence to the positive *** nanoemulsions showed excellent inhibitory activity at the highest dosage,equivalent to the positive control against *** and Staphylococcus *** greater number of conjugated bonds in CNM increased the antimicrobial activity in comparison with B4AM,and the formation of nanometric domains enhanced the bioavailability,being a promising alternative for antimicrobial applications.

关键词： Polysaccharide nanoemulsions S.aureus S.minnesota chalcones alginate

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Robot-Assisted Nephrotomy as a Nephron-Sparing Approach for Completely Intraparenchymal Renal Tumors

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Open journal of Urology 2023年第10期13卷 459-467页

作者： Marcos Dall’Oglio Matheus Miranda Paiva Fabrício Golono Kaminagakura josé Augusto farias da Silva júnior jorge Ocké Urology Department of the Santa Marcelina Hospital S&#227o Paulo Brazil

Introduction: The diagnosis of small renal masses and the endophytic tumor approach have become challenging. This study aims to describe exclusively robot-assisted surgery as an alternative nephron-sparing approach for renal intraparenchymal tumors. Patients and Methods: We retrospectively analyzed all patients with completely endophytic tumors undergoing robot-assisted partial nephrectomy, treated under the Da Vinci System®, aided by intraoperative ultrasound. The patients’ demographic characteristics, perioperative and oncological outcomes were assessed. Results: From a total of 13 partial nephrectomies performed between 06/2010 and 10/2021, all patients underwent nephrotomy. The patients’ mean age was 52 years and the tumor measured mean 2.6 cm. Warm ischemia time was 24 minutes and histopathological analysis revealed that 12 patients had renal cell carcinoma. In a mean 36-month follow-up, no significant renal function alterations were found and no local or systemic recurrences occurred. Conclusion: Robot-assisted access is a safe and effective option for the nephron-sparing technique in completely intraparenchymal renal tumors.

关键词： Robotic Surgical Procedures Kidney Neoplasms Organ Sparing Treatment Nephrectomy Renal Mass

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Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAS detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.j. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam Bourdarios L. Adamczyk S.V. Addepalli M.j. Addison j. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik M.N. Agaras j. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.S. Ahmed S. Ahuja X. Ai G. Aielli A. Aikot M. Ait Tamlihat B. Aitbenchikh I. Aizenberg M. Akbiyik T.P.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi j. Albert P. Albicocco G.L. Albouy S. Alderweireldt M. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi M. Algren M. Alhroob B. Ali H.M.j. Ali S. Ali S.W. Alibocus M. Aliev G. Alimonti W. Alkakhi C. Allaire B.M.M. Allbrooke j.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani M. Alvarez Estevez A. Alvarez Fernandez M. Alves Cardoso M.G. Alviggi M. Aly Y. Amaral Coutinho A. Ambler C. Amelung M. Amerl C.G. Ames D. Amidei S.P. Amor dos Santos K.R. Amos V. Ananiev C. Anastopoulos T. Andeen j.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel M.T. Anthony E. Antipov M. Antonelli F. Anulli M. Aoki T. Aoki j.A. Aparisi Pozo M.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal S.j. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena j-F. Arguin S. Argyropoulos j.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah j. Assahsah K. Assamagan R. Astalos S. Atashi R.j. Atkin M. Atkinson H. Atmani P.A. Atmasiddha K. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia M. Bahmani A.j. Bailey V.R. Bailey j.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubramanian E.M. Baldin P. Balek E. Ballabene F. Balli L.M. Baltes W.K. Balunas j. Balz E. Banas M. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak M. Barakat E.L. Barberio D. Barberis M. Barbero M.Z. Barel K.N. Barends T. Barillari M-S. Barisits T. Barklow P. Baron D.A. Baron Mo The ATLAS Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as Standard Model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAS Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAS *** taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATLAS jET QUARK GLUON TAGGING

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The descriptive epidemiology of sitting in Chilean adults: Results from the National Health Survey 2009-2010

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journal of Sport and Health Science 2019年第1期8卷 32-38页

作者： Nicolas Aguilar-farias Pia Martino-Fuentealba ANDrea Cortinez-O'Ryan Damian Chandia-Poblete Carlos A.Celis-Morales Paz Bahamondes jaime Leppe Zamora Wendy j.Brown Department of Physical Education Sports and Recreation Universidad de La Frontera BHF Glasgow Cardiovascular Research Centre Institute of Cardiovascular and Medical Science University of Glasgow School of Physiotherapy Universidad del Desarrollo School of Human Movement and Nutrition Sciences The University of Queensland

Background: Although evidence on the health effects of sedentary behavior(SB) has grown systematically in recent years, few developing countries have reported population levels of SB, especially in South America. Our objective was to describe time spent sitting in a representative sample from Chile categorized by age, gender, educational level, and body mass index(BMI).Methods: A national health survey was conducted in Chile in a nationally representative sample(n = 5411) in 2009-2010. Sitting time(ST) was measured with the Global Physical Activity Questionnaire Version ***: Data were from 5031 participants(43.26±0.41 years, mean±SE; 40.3% male). Overall, there were no gender differences in mean ST(men: 158.10±5.80 min/day, women 143.45±4.77 min/day; p = 0.05). ST was lower in those who lived in rural areas compared with urban areas(99.4 min/day vs. 160.0 min/day; p = 0.001). ST increased significantly with increasing BMI, but only in men(p = 0.009), and was positively related to years of education in both men and women(p < 0.0001).Conclusion: The findings were different from those reported in other countries and contexts, reinforcing the need for international surveillance and monitoring over time to inform policy makers. Differences in ST across different groups emphasize the need to develop tailored messages and interventions for reducing ST in different population subgroups.

关键词： Ageing Health behavior Health inequalities Lying Preventive medicine Reclining Screen time Surveillance

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Utilization of Acai Berry Residual Biomass for Extraction of Lignocellulosic Byproducts

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journal of Bioresources and Bioproducts 2021年第4期6卷 323-337页

作者： Lamia Zuniga Linan Anne C.Mendonça Cidreira Cláudia Quintino da Rocha Fabrícia farias de Menezes George j de Moraes Rocha Antônio E Macedo Paiva Departamento de Engenharia Química Universidade Federal do Maranhao(UFMA)Av.dos Portugueses 1966Bacanga-CEP65080-805Sao Luís-MABrazil Departamento de Química Universidade Federal do Maranhao(UFMA)Av.dos Portugueses 1966Bacanga-CEP65080-805Sao Luís-MABrazil Brazilian Center for Research in Energy and Materials(CNPEM)and Brazilian Biorenewables National Laboratory(LNBR) Giuseppe Máximo Scolfaro 10.000Guará-CEP13083-100 Campinas-SPBrazil Departamento de Mecânica e Materiais(DMM) Instituto Federal de EducaçãoCiência e Tecnologia do maranhão(IFMA)São Luís-MABrazil

According to the National Company of Supplying(CONAB)in 2017 alone,the national production of acai pulp reached 219855 t,equating to 180 million dollar(USD).Almost 85%of the weight of fruit is constituted by residual biomass,even though researches have highlighted important applications for this biomass,most of it is discarded as organic ***,it is relevant to envisage in-depth studies about how to use these residues,particularly regarding the environmental impact of its target *** cellulose(CNC)and lignin are organic derivatives obtained through the physical-chemical treatment of lignocellulosic *** are abundant and currently considered as biopolymers because of their structural characteristics and their diverse applications in food and the medical *** work presents the mass yields achieved and the physical-chemical characteristics of the lignocellulosic derivatives extracted from the fiber of the acai berry.A statistical design was used to define the influence of process variables as temperature,reaction time and fiber size on the yield of these byproducts.A maximum yield close to 64%of type I CNC,with 45%of crystallinity degree was achieved at the minimum condition of temperature and fiber ***,through rheological analysis,it was possible to predict the nanocrystal aspect ratios,ranging from 71 to *** extracted lignin was rich in methoxy groups,p-coumaryl alcohol and p-coumaric acid,and its structural unit’s low state of aggregation can be an indication of low molecular weight,which envisions an appropriate use for this lignin to produce commodity chemicals.

关键词： Acai berry Residual biomass Cellulose nanocrystal(CNC) Lignin rheological characterization Physical-chemical characterization

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Difficulties Faced by Physicians in the Diagnosis of Endometriosis in the Brazilian Public Health System

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Health 2023年第7期15卷 788-795页

作者： Carla Patrícia Alves Barbosa Tayná Maria Dantas Carozo Calumby Ana Paula Portela Andrade júlia de Araújo Gomes Maria Renata Suyane Silva de farias Maria Eduarda Dantas donald Gabrielly Pinheiro Marinho Antônia Iva Sampaio Bisneta Francisco Expedito Ramos Aguiar Sobrinho Elizabeth Bacha Centro Universitário Tiradentes (UNIT) Maceió Brasil Universidade de Pernambuco (UPE) Recife Brasil

Endometriosis is a clinical and recurrent condition characterized by the presence of functional endometrial tissue outside the uterine cavity and myometrium. It is estimated that 6% to 10% of women of reproductive age, 50% to 60% of adolescents and adults with pelvic pain, and up to 50% of women with infertility are pregnant from the condition. However, this proportion tends to be even greater due to the difficulty in diagnosing it: because it presents different symptoms, lack of information from health professionals, and a high-cost diagnostic test. Another aggravating factor is the average time from the onset of symptoms to the medical diagnosis, which even today ranges from five to ten years;this delay has consequences for disease progression, as it prevents early treatment, which is important for improving pain levels and physical and psychological well-being. Aware of these mishaps, it is therefore important to assess the difficulties faced by doctors in the diagnosis of endometriosis in the public health system, in Brazil, the Unified Health System (SUS). With this purpose, a cross sectional was carried out, developed in the virtual environment using traffic in Google forms, with the difficulties quantified in the Likert scale. Participating physicians pointed out a medium difficulty for patients with endometriosis to access the consultation (58%) and moderate difficulty (52%) to perform an ultrasound examination;also signaled great difficulty in performing magnetic resonance imaging (77%) and laparotomy (61%) in these patients. It is hoped that knowledge about the difficulties faced by physicians in the diagnosis of endometriosis in the SUS will give these physicians a voice and corroborate, even if minimally, so that there is more research that provokes the search for these difficulties, in order to improving the quality of life of these women.

关键词： Endometriosis Diagnosis Public Health System

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Activation of the pattern recognition receptor NOD1 augments colon cancer metastasis

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Protein & Cell 2020年第3期11卷 187-201页

作者： Henry Y.jiang Sara Najmeh Guy Martel Elyse MacFadden-Murphy Raquel farias Paul Savage Arielle Leone Lucie Roussel jonathan Cools-Lartigue Stephen Gowing julie Berube Betty Giannias France Bourdeau Carlos HFChan jonathan D.Spicer Rebecca McClure Morag Park Simon Rousseau Lorenzo E.Ferri Thoracic and Upper GI Cancer Research Laboratories Research Institute of McGill University Health Centre1001 Decarie BoulevardBlock ELab#E02-4134MontrealQC H4A 3J1Canada Department of Experimental Surgery and Department of Surgery McGill University1650 Cedar AvenueMontrealQC H3G 1A4Canada Meakins-Christie Laboratories Research Institute of McGill University Health Centre1001 Decarie BoulevardMontrealQC H4A 3J1Canada The Rosalind and Morris Goodman Cancer Research Centre McGill University1160 Pine AvenueMontrealQC H3A 1A3Canada Department of Surgery Roy J.and Lucille A.Carver College of MedicineUniversity of IowaUniversity of Iowa Hospitals and Clinics200 Hawkins DriveIowa CityIA 52242USA Department of Pathology Health Sciences North41 Ramsey Lake RoadSudburyONCanada

While emerging data suggest nucleotide oligomerization domain receptor 1(NOD1),a cytoplasmic pattern recognition receptor,may play an important and complementary role in the immune response to bacterial infection,its role in cancer metastasis is entirely ***,we sought to determine the effects of NOD1 on ***1 expression in paired human primary colon cancer,human and murine colon cancer cells were determined using immunohistochemistry and immunoblotting(WB).Clinical significance of NOD1 was assessed using TCGA survival data.A series of in vitro and in vivo functional assays,including adhesion,migration,and metastasis,was conducted to assess the effect of NOD1.C12-iE-DAP,a highly selective NOD1 ligand derived from gram-negative bacteria,was used to activate ***130,a specific NOD1 inhibitor,was used to block C12-iE-DAP *** knockdown(KD)of NOD1 in human colon cancer cells(HT29)was constructed with shRNA lentiviral transduction and the functional assays were thus ***,the predominant signaling pathway of NOD1-activation was identified using WB and functional assays in the presence of specific kinase *** data demonstrate that NOD1 is highly expressed in human colorectal cancer(CRC)and human and murine CRC cell ***,we demonstrate that this increased NOD1 expression negatively impacts survival in patients with ***,we identify NOD1 activation by C12-iE-DAP augments CRC cell adhesion,migration and *** effects are predominantly mediated via the p38 mitogen activated protein kinase(MAPK)*** is the first study implicating NOD1 in cancer metastasis,and thus identifying this receptor as a putative therapeutic target.

关键词： NOD1 iE-DAP ML130 colon cancer metastasis cancer-extracellular matrix adhesion cancer migration p38 MAPK activation intravital microscopy survival analysis

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What is a species in fungal plant pathogens?

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Fungal Diversity 2021年第4期109卷 239-266页

作者： Ruvishika S.jayawardena Kevin D.Hyde Antonio Roberto Gomes de farias Chitrabhanu S.Bhunjun Himashi S.Ferdinandez Dimuthu S.Manamgoda Dhanushka Udayanga Indunil S.Herath Kasun M.Thambugala Ishara S.Manawasinghe Achala j.Gajanayake Binu C.Samarakoon Digvijayini Bundhun Deecksha Gomdola Naruemon Huanraluek Ya-ru Sun Xia Tang Itthayakorn Promputtha Marco Thines Innovative Institute of Plant Health Zhongkai University of Agriculture and EngineeringHaizhu DistrictGuangzhou 510225People’s Republic of China Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand Departamento de Genética Universidade Federal de PernambucoAv.Prof.Moraes Rego1235Cidade UniversitáriaRecifePE 50670-901Brazil Department of Botany Faculty of Applied SciencesUniversity of Sri JayewardenepuraNugegodaSri Lanka Department of Biosystems Technology Faculty of TechnologyUniversity of Sri JayewardenepuraPitipanaHomagama 10200Sri Lanka Genetics and Molecular Biology Unit Faculty of Applied SciencesUniversity of Sri JayewardenepuraGangodawilaNugegodaSri Lanka School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Department of Biological Sciences Institute of EcologyEvolution and DiversityGoethe UniversityMax-von-Laue-Str.1360486 Frankfurt am MainGermany Senckenberg Biodiversity and Climate Research Centre Senckenberganlage 2560325 Frankfurt am MainGermany

Scientific names are crucial for communicating knowledge concerning fungi and fungus-like *** plant pathology,they link information regarding biology,host range,distribution and potential risk to agriculture and food *** the past,delimitation among pathogenic taxa was primarily based on morphological *** to distinct species sharing overlapping characteristics,the morphological identification of species is often neither straightforward nor ***,the phylogenetic species concept based on molecular phylogenetic reconstructions gained *** present opinion discusses what a fungal species is and how identification of species in plant pathology has changed over the past *** this context,host-specialization and species complexes are ***,species concepts in plant pathology are examined using case studies from Bipolaris,Colletotrichum,Curvularia,Diaporthe,Diplodia,Meliola,Plasmopara,rust fungi and *** entry contains a brief introduction to the genus,concepts used in species identification so far and the problems in describing a species followed by *** importance of correctly naming and identifying a species is addressed in the context of recent introductions,and we also discuss whether the introduction of new species in pathogenic genera has been *** also provide guidelines to be considered when introducing a new species in a plant pathogenic genus.

关键词： Dual nomenclature Host-specificity Polyphasic approach Pathology Phylogeny Species delimitation Systematics

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Human Centered Design of the Interfaces of a Radiation Monitoring System

Human Centered Design of the Interfaces of a Radiation Monit...

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第十七届国际工效学大会暨中国人类工效学会成立20周年庆...

作者： Isaac j.A.Luquetti dos Santos Marcos S.farias Paulo Victor R.Carvalho Cláudio H.S.Grecco Maurício A.Aghina National Nuclear Energy Commission Nuclear Engineering Institute

Inadequate human-system integration reduces the safety,increases the overall complexity of the system,the time needed to perform tasks,the probability of human errors occurrence and complicates training and maintenance of the *** is imperative to understand and to incorporate the requirements related to the operators,their needs and ability,the current work practices of the operators,the requirements of workplace environment and the organizational aspects of the job into the life cycle of the *** aim is to guarantee the involvement of the users in all phases of the system development,to improve the operational reliability,to design reliable and robust system,so that the task demands can be compatible with human capabilities and *** monitoring systems are critical systems that operate twenty-four hours a day,monitoring the radiation condition in work environments inside a nuclear *** data signals from radiation detectors installed at work site are transmitted to a central control room where radiation levels and alarm activated are operated and monitored on *** this paper is proposed a methodological framework,applied to the design of the human-system interfaces,that includes the analysis of the reference systems,the functional requirements analysis,the functions allocation,the task analysis,the job analysis,the analysis of the work context and the analysis of the users *** case study is based on the development of the interfaces of the radiation monitoring supervisory system to be installed in a research nuclear reactor.

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Water requirements and single and dual crop coefficients of sugarcane grown in a tropical region, Brazil

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Agricultural Sciences 2012年第2期3卷 274-286页

作者： Vicente de P. R. da Silva Cícera j. R. Borges Carlos H. A. farias Vijay P. Singh Walker G. Albuquerque Bernardo Barbosa da Silva Academic Unity of Atmospheric Sciences Center of Technology and Natural Resources Federal University of Campina Grande Campina Grande Brazil Department of Biological and Agricultural Engineering & Department of Civil & Engineering Texas A&M University College Station USA Federal University of Pernambuco Recife Brazil Miriri Alimentos e Bioenergia S/A Capim Brazil

A field experiment was conducted throughout 2009/2010 in a sugarcane field of a commercial distillery located on the coastal area of Paraiba state, Brazil. The objectives were to determine sugarcane water requirements and to test the single and dual crop coefficients by comparing the calculated values of ET with measured ones. Crop evapotranspiration was determined by field water balance, reference evapotranspiration (ETo) by the Penman-Monteith approach, while single and dual crop coefficients were computed through the standard FAO-56 methodology. The experimental area was cultivated with irrigation applied weekly by a centre pivot system in addition to rainfall and the irrigation scheduling was based on 100% ETo. Three statistical tests, mean bias difference (MBD), normalized root mean square difference (NRMSD) and regression analysis, were used to evaluate the performance of single and dual crop coefficients. Results showed that there was a notable symmetry between ET measured and ET calculated by Kc dual. The ET values, calculated from Kc single, underestimated those obtained from soil water balance measurements by 36%.

关键词： Crop Coefficient Evapotranspiration Rainfed Rainfall Water Stress

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