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局部无缝垂直参考基准面的建立方法研究

武汉大学学报（信息科学版） 2006年第5期31卷 448-450页

作者：赵建虎张红梅 john E hughes Clarke 武汉大学测绘学院武汉市珞喻路129号430079 武汉大学动力与机械学院武汉市东湖南路8号430072 新伯伦瑞克大学图形组

为在局域建立一个无缝垂直参考基准面,提出了两步转换的思想和方法,即从大地高到正高然后到海图高。利用该方法,构造了Saint john河高程转换模型,并在该河段建立了无缝垂直参考基准面,且得到了实际验证。

关键词：大地高正常高海图基准海图基准高程

Liver retransplants using living donors:An approach for management

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Liver Research 2023年第3期7卷 252-255页

作者： Hasan Al Harakeh Christopher hughes Amit Tevar Vikram Gunabushanam Eishan Ashwat Hao Liu Abhinav Humar Starzl Transplantation Institute University of Pittsburgh Medical CenterPittsburghPAUSA

Background and aims:Many centers do not offer living donor transplants for patients in need of a liver *** aimed to study our liver retransplant outcomes using living donors and compared them with those of retransplants performed using deceased ***:This study retrospectively analyzed all retransplants performed at our center between 2009 and 2023,and outcomes of living donor retransplants were compared with deceased donor retransplants using standard statistical ***:Between january 2009 and March 2023,a total of 77 retransplants,60 with deceased donors and 17 with living donors,were *** demographic differences between the two groups included a higher model for end-stage liver disease score in the deceased donor group(32.1±6.1 vs.19.4±5.7,P<0.001)and a higher number of early retransplants(within 3 months of the initial transplant),which accounted for 35% of deceased donor transplants but 0 of living donor transplants(P<0.01).Overall,the patient and graft survival rates were comparable between the two *** patient survival rates at 1 and 3 years after transplant were 73% and 67% in the deceased donor group and 84% and 73% in the living donor group,respectively(P=0.57).The hospital length of stay and blood product use were both better in the living donor *** complications did not show significant different between the two groups(P=0.33).Conclusions:Living donors can provide acceptable outcomes for those in need of a retransplant,with results comparable to those seen with deceased donors.A systematic approach to the patient in the pre-,peri-,and post-transplantation period is important in these complicated cases.

关键词： Liver retransplant Living donor liver transplant Deceased donor Outcomes Complications

Rapid, Semi-Automated Fractionation of Freshwater Dissolved Organic Carbon Using DAX 8 (XAD 8) and XAD 4 Resins in Tandem

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Natural Science 2016年第11期8卷 487-498页

作者： David D. hughes Peter j. Holliman Timothy jones Alexander j. Butler Christopher Freeman Wolfson Carbon Capture Laboratory Bangor University Wales UK

Natural dissolved organic carbon (DOC) consists of different bio-molecular classes of compounds that are currently very difficult and time-consuming to isolate as individual compounds. However, it is possible to separate natural DOC into hydrophobic and hydrophilic fractions. Such characterisation approaches are becoming increasingly important because, over the past 20 years natural DOC concentrations have been rising rapidly in many parts of the world, most likely influenced by climate change. Higher DOC concentrations in drinking water catchments present a serious problem for the water industry because DOC can form disinfection by-products DBPs during water treatment (e.g. chlorination). Hence, there is an urgent need to better characterise natural DOC before, during and after water treatment. However, current DOC fractionation procedures are extremely laborious requiring days and continual manual monitoring to separate sufficient quantities of DOC for subsequent analysis. This seriously limits sample throughput and the parameter space which can be studied. In this paper, we propose a much more rapid semi-automated method (12.5 hours/litre/sample) which utilises readily available equipment, i.e., HPLC pump or similar and sequential columns of Amberlite DAX 8 and XAD 4 resins. The method reduces the manual input from continual attention to minutes. This paper describes the development of the method and its application in the fractionation of natural DOC from reservoir and lake samples fed from upland peat-land catchments. Recoveries are found to be comparable to those using the manual technique, with the dominant component being hydrophobic acid accounting for 35% - 40% of the natural DOC with the second largest, being hydrophilic acid at 20% - 27%.

关键词： Dissolved Organic Carbon Hydrophilic Compounds Hydrophobic Compounds Fulvic Acids Humic Acids Resins

Feasibility of pancreatectomy following high-dose proton therapy for unresectable pancreatic cancer

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World journal of Gastrointestinal Surgery 2017年第4期9卷 103-108页

作者： Kathryn E Hitchcock R Charles Nichols Christopher G Morris Debashish Bose Steven j.hughes john A Stauffer Scott A Celinski Elizabeth A johnson Robert A Zaiden Nancy P Mendenhall Michael S Rutenberg Department of Radiation Oncology University of Florida Department of Surgical Oncology UF Health Cancer Center-Orlando Health Department of Surgery University of Florida Department of Surgery Mayo Clinic Department of Surgery Baylor University Medical Center at Dallas Department of Hematology/Oncology Mayo Clinic Department of Hematology/Oncology Baptist Health

AIM To review surgical outcomes for patients undergoing pancreatectomy after proton therapy with concomitant capecitabine for initially unresectable pancreatic *** From April 2010 to September 2013,15 patients with initially unresectable pancreatic cancer were treated withproton therapy with concomitant capecitabine at 1000 mg orally twice daily. All patients received 59.40 Gy(RBE) to the gross disease and 1 patient received 50.40 Gy(RBE) to high-risk nodal targets. There were no treatment interruptions and no chemotherapy dose reductions. Six patients achieved a radiographic response sufficient to justify surgical exploration,of whom 1 was identified as having intraperitoneal dissemination at the time of surgery and the planned pancreatectomy was aborted. Five patients underwent resection. Procedures included:Laparoscopic standard pancreaticoduodenectomy(n = 3),open pyloris-sparing pancreaticoduodenectomy(n = 1),and open distal pancreatectomy with irreversible electroporation(IRE) of a pancreatic head mass(n = 1). RESULTS The median patient age was 60 years(range,51-67). The median duration of surgery was 419 min(range,290-484),with a median estimated blood loss of 850 cm^3(range,300-2000),median ICU stay of 1 d(range,0-2),and median hospital stay of 10 d(range,5-14). Three patients were re-admitted to a hospital within 30 d after discharge for wound infection(n = 1),delayed gastric emptying(n = 1),and ischemic gastritis(n = 1). Two patients underwent R0 resections and demonstrated minimal residual disease in the final pathology specimen. One patient,after negative pancreatic head biopsies,underwent IRE followed by distal pancreatectomy with no tumor seen in the specimen. Two patients underwent R2 resections. Only 1 patient demonstrated ultimate local progression at the primary site. Median survival for the 5 resected patients was 24 mo(range,10-30).CONCLUSION Pancreatic resection for patients with initially unresectable cancers is feasible after

关键词： Pancreatic cancer Pancreatectomy Pancreas Proton therapy Radiotherapy

Pinpointing the animal origins of SARS-CoV-2:a genomic approach

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journal of Genetics and Genomics 2022年第9期49卷 900-902页

作者： Shilei Zhao Yali Hou Xiaolong Zhang Alice hughes Na Liu Minsheng Peng Qihui Wang Yongbiao Xue Hua Chen Beijing Institute of Genomics Chinese Academy of Sciences and China National Center for BioinformationBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Center for Integrative Conservation Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMenglaYunnan 666303China National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650201China KIZ/CUHK joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650201China CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunmingYunnan 650223China

Understanding the origins of zoonoses is critical to developing the means to prevent zoonotic spillover into the *** 60% of emerging diseases in humans(jones et al.,2008),SARS-CoV-2 is likely to have zoonotic origins with possible immediate hosts(Holmes et al.,2021;Wang et al.,2021).Determination of the origin of SARS-CoV-2,that is,when,where,and how it emerges in humans through possible zoonotic transfer,facilitates prevention of the emergence and establishment of new zoonotic diseases.

关键词： origin prevention likely

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用于采矿、采石业的振动限制开关

煤炭科学技术 1993年第6期21卷 59-60页

作者： A.hughes 第一机械开关公司

工业设备出现故障的征兆是振动程度变大。因此,及时探测出这种过度振动是保障设备正常运行的有效手段。实际上,在工程及制造业中,振动作为安全监测指标已广泛应用于工厂设备的日常维护及检测中。

关键词：采矿工程采石业振动开关开关

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改性再生混凝土动力性能研究

振动与冲击 2021年第23期40卷 269-278,287页

作者：王永贵李帅鹏 hughes Peter 范玉辉高向宇河南理工大学土木工程学院河南焦作454000 河南理工大学生态建筑与环境构建河南省工程实验室河南焦作454000 北京工业大学建筑工程学院北京100122

为提高再生混凝土(RC)的力学性能,以玄武岩纤维和纳米氧化硅为增强材料对再生混凝土进行改良,形成玄武岩纤维与纳米氧化硅复合改性再生混凝土,通过静态抗压性能试验及分离式霍普金森压杆(SHPB)试验,研究了玄武岩纤维与纳米氧化硅对改性... 详细信息

为提高再生混凝土(RC)的力学性能,以玄武岩纤维和纳米氧化硅为增强材料对再生混凝土进行改良,形成玄武岩纤维与纳米氧化硅复合改性再生混凝土,通过静态抗压性能试验及分离式霍普金森压杆(SHPB)试验,研究了玄武岩纤维与纳米氧化硅对改性再生混凝土破坏形态及静动态抗压强度的影响。研究表明:随应变率增大,破坏形态由完整经破裂向粉碎过渡,动态抗压强度、动态增强因子、比能量吸收均呈增大趋势;取代率对试块破坏状态、动态抗压强度及比能量吸收不产生规律性影响,但静态抗压强度随取代率的增大而降低;玄武岩纤维有利于增强试块破坏时的整体性,提高了再生混凝土静态抗压强度、动态抗压强度、峰值应变及比能量吸收;纳米氧化硅有利于提高再生混凝土的静态抗压强度、动态抗压强度、峰值应变及比能量吸收。结果表明,玄武岩纤维与纳米氧化硅对再生混凝土的静动态力学性能及耗能性能具有较好的增强作用。

关键词：玄武岩纤维纳米氧化硅再生混凝土(RC) 霍普金森压杆(SHPB) 动态抗压强度

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质性方法在卫生政策和管理研究中的应用

医学与社会 2021年第1期34卷 1-9页

作者： David hughes 田楠吴奇飞(译) 斯旺西大学人类与健康科学学院英国威尔士斯旺西SA28PP 华中科技大学同济医学院医药卫生管理学院湖北武汉430030 湖北省卫生技术评估研究中心湖北武汉430030

本文通过描述深度访谈、焦点小组和参与观察这三种常见的方法,从而向有兴趣的中国学者介绍质性研究。作者阐述了为何质性研究设计对于某些课题具有优势,以及不同质性研究方法的优缺点。一般来说,参与式观察被用于特定情境下的案例研究,... 详细信息

本文通过描述深度访谈、焦点小组和参与观察这三种常见的方法,从而向有兴趣的中国学者介绍质性研究。作者阐述了为何质性研究设计对于某些课题具有优势,以及不同质性研究方法的优缺点。一般来说,参与式观察被用于特定情境下的案例研究,而访谈和焦点小组则被用来研究地理位置分散的社会群体的主观观点,但是这些方法往往同时用于单个研究中。尽管许多质性研究旨在探索研究对象的观点,但卫生政策和管理研究通常更关注卫生组织实践以及组织"黑匣子"内部的情况。本文介绍了对数据进行归纳分析的主要手段;总结了对访谈或焦点小组笔录及参与观察现场笔记进行主题分析的基础知识;讨论了质性研究人员如何致力于解决读者对此类研究信度和效度问题的传统关注。由于质性研究者与被研究者在现场会建立一定的联系并持续接触,这对研究提出了独特的伦理要求,本文也对此类问题进行了思考。

关键词：卫生政策研究卫生管理研究质性研究方法深度访谈焦点小组参与观察

High-throughput combinatorial approach expeditesthe synthesis of a lead-free relaxor ferroelectric system

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InfoMat 2024年第9期6卷 75-90页

作者： Di Zhang Katherine j.Harmon Michael j.Zachman Ping Lu Doyun Kim Zhan Zhang Nicholas Cucciniello Reid Markland Ken William Ssennyimba Hua Zhou Yue Cao Matthew Brahlek Hao Zheng Matthew M.Schneider Alessandro R.Mazza Zach hughes Chase Somodi Benjamin Freiman Sarah Pooley Sundar Kunwar Pinku Roy Qing Tu Rodney j.McCabe Aiping Chen Center for Integrated Nanotechnologies Los Alamos National LaboratoryLos AlamosNew MexicoUSA Materials Science Division Argonne National LaboratoryLemontIllinoisUSA Center for Nanophase Materials Sciences Oak Ridge National LaboratoryOak RidgeTennesseeUSA Sandia National Laboratories AlbuquerqueNew MexicoUSA Department of Materials Science and Engineering Texas A&M UniversityCollege StationTexasUSA Advanced Photon Source(APS) Argonne National LaboratoryLemontIllinoisUSA Materials Science and Technology Division Oak Ridge National LaboratoryOak RidgeTennesseeUSA Materials Science and Technology Division Los Alamos National LaboratoryLos AlamosNew MexicoUSA

Developing novel lead-free ferroelectric materials is crucial for next-generationmicroelectronic technologies that are energy efficient and ***,materials discovery and property optimization are typicallytime-consuming due to the limited throughput of traditional *** this work,we use a high-throughput combinatorial synthesisapproach to fabricate lead-free ferroelectric superlattices and solid solutions of(Ba_(0.7)Ca_(0.3))TiO_(3)(BCT)and Ba(Zr_(0.2)Ti_(0.8))O_(3)(BZT)phases with continuous variationof composition and layer ***-resolution x-ray diffraction(XRD)and analytical scanning transmission electron microscopy(STEM)demonstratehigh film quality and well-controlled compositional *** dielectric property measurements identify the“optimal propertypoint”achieved at the composition of 48BZT–*** vectormaps reveal that ferroelectric domain sizes are tunable by varying{BCT–BZT}Nsuperlattice *** high-throughput synthesis approach can be appliedto many other material systems to expedite new materials discovery and properties optimization,allowing for the exploration of a large area of phasespace within a single growth.

关键词： ferroelectrics high-resolution x-ray diffraction high-throughput combinatorial synthesis pulsed laser deposition scanning transmission electron microscopy superlattices