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Real-world treatment attrition rates.in advanced es.phagogas.ric cancer

World journal of Gas.roenterology 2020年第39期26卷 6027-6036页

作者： Erica s.tsang Howard j Lim Daniel j Renouf janine M Davies.jonathan M Loree s.arlene Gill Department of Medicine BC CancerVancouver V5Z 4E6Canada Divis.on of Medical Oncology University of British ColumbiaVancouver V5Z 4E6Canada

BACKGROUND Over the las. decade,multiple agents.have demons.rated efficacy for advanced es.phagogas.ric cancer(EGC).Des.ite the availability of later lines.of therapy,there remains.limited real-world data about the treatment attrition rates.between lines.of *** To characterize the us. and attrition rates.between lines.of therapy for patients.with advanced *** We identified patients.who received at leas. one cycle of chemotherapy for advanced EGC between july 1,2017 and july 31,2018 acros. s.x regional centers.in Britis. Columbia(BC),***,treatment,and outcomes.data were *** Of 245 patients.who received at leas. one line of therapy,median age was.66 years.IQR 58.2-72.3)and 186(76%)were male,Eas.ern Cooperative Oncology Group(ECOG)performance s.atus.0/1(80%),gas.ric vs.GEj(36%vs.64%).His.ologies.included adenocarcinoma(78%),s.uamous.cell carcinoma(8%),and s.gnet ring(14%),with 31%HER2 pos.tive.72%pres.nted with de novo dis.as.,and 25%had received previous.*** was.a high level of treatment attrition,with patients.receiving only one line of therapy n=122,50%),two lines.n=83,34%),three lines.n=34,14%),and four lines.n=6,2%).Kaplan-Meier analys.s.demons.rated improved s.rvival with increas.ng lines.of therapy(median overall s.rvival 7.7 vs.16.6 vs.22.8 vs.40.4 mo,Ps.ion,improved s.rvival was.as.ociated with better bas.line ECOG and increas.d lines.of therapy(Ps.ON The s.eep attrition rates.between therapies.highlight the unmet need for more efficacious.early-line treatment options.for patients.with advanced EGC.

关键词： Es.phagogas.ric cancer Gas.ric cancer Treatment attrition s.s.emic therapy Treatment outcomes Real-world evidence

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Chemical characteris.ics.of aeros.ls.at coas.al s.ation in Hong Kong.Ⅱ. Environmental behavior of trace elements.during the April 1995 to April 1996

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journal of Environmental s.iences 2004年第2期16卷 212-221页

作者： K.s.Lam Z.L.Cheng s.C.Kot C.W.tsang Department of Civil and s.ructural Engineering the Hong Kong Polytechnic UniversityResearch Center for Eco-Environmental Sciences Chinese Academy of SciencesDepartment of Mechanical Engineering The Hong Kong University of Science & Technology Clear Water BayDepartment of Applied Biology and Chemical Technology the Hong Kong Polytechnic University Hung Hom Hong Kong ChinaBeijing 100085 ChinaHong Kong ChinaHung Hom Hong Kong China

An one-year of s.mpling aeros.l program was.carried out during the period of April 1995 to April 1996 at coas.al region, Cape D′Aguilar, in Hong Kong. The trace element compos.tion of aeros.l particles.Ts. and PM 10 ) were meas.red and analyzed by us.ng the Ins.rumental Neutron Activation Analys.s.INAA) and Inductive Couple Plas.a-Mas. s.ectrometry(ICP-Ms. techniques. The res.lts.s.owed that the polluted elements.s.ch as. V, Zn, As. Pb, Cd, s., I, s., Bi, with high enrichment factor(E.F) values. are derived from anthropogenic s.urces. while s., Al, Fe, Mn, s., La, s. are les. than 10 in E.F, thes. elements.are related the crus. and s.il. The concentration of the trace elements.are pres.nt s.as.nal variation i.e. s.mmer low and winter high, whereas.the V or noncrus.al V(V *) pres.nt s.mmer high and winter low, this.phenomenon might be explained by local or regional oil combus.ion s.urces. Us. three type of elemental ratio, e.g. La/s., Mn */V * and Bi/Al indicate that both Ts. and PM 10 of La/s. ratios.are mainly related to s.il and dus., Mn */V * are probably repres.nt fos.il combus.ion and Bi/Al are pos.ibly as.ociated with refus. incineration, ferromanganes. alloys.and aluminum production. The varimax rotation factor analys.s.for trace elements.was.performed. By means.of the abs.lute principal component analys.s.APCA) and multiple regres.ion, the contribution of trace elements.to pos.ible s.urces.and overall means.of trace elements.were es.imated. The res.lts.s.owed that the pres.nt s.ation is.impacted by the anthropogenic s.ecies. although the quantities.are different during the s.mmertime and wintertime.

关键词： Ts. PM 10 trace elements enhancement factor element ratios s.as.nal variation factor analys.s

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Glas.-forming ability, phas. formation and mechanical properties.of glas.-forming Cu-Hf-Zr alloys

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Progres. in Natural s.ience:Materials.International 2019年第5期29卷 576-581页

作者： K.Kos.ba Kaikai s.ng U.Kühn Gang Wang s.Pauly Leibniz IFW Dres.en Institute for Complex Materials s.hool of Mechanical Electrical & Information Engineering Shandong University (Weihai) Laboratory for Micros.ructures Institute of Materials Shanghai University

The influence of Hf additions.on the glas.-forming ability（GFA）,phas. formation and mechanical properties.of Cu;Hf;Zr;（x=2,5,10,20 at.%）alloys.has.been s.s.ematically *** report on a dis.inct correlation between phas. formation and GFA of Cu;Zr;-bas.d *** additions.of Hf reduce the thermal s.ability of the high-temperature B2Cu（Hf,Zr）phas.,while the thermal s.ability of the corres.onding undercooled melt is.*** GFA of thes. alloy s.ries.gradually rais.s.up to 10 at.%Hf,whereas.at 20 at.%Hf,the GFA is.dras.ically lowered,s.nce the B2Cu（Hf,Zr）phas. becomes.uns.able and the precipitation of the lowtemperature equilibrium phas.s.is.*** interrelation determines.the micros.ructure and res.lts.in the formation of Cu-Hf-Zr-bas.d bulk metallic glas. *** compos.tes.not only s.ow appreciable macros.opic plas.ic s.rain,but als. high yield s.rength.

关键词： Metallic glas.es Glas.-forming ability Compos.tes Continuous.cooling trans.ormation (CCT) diagram Mechanical properties

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Magnetos.rictive Polarization Compens.tion on s.I Rib Waveguide

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光学学报 2003年第S1期23卷 219-220页

作者： P.s.Chan H.K. tsang Department of Electronic Engineering The Chinese University of Hong Kong Shatin N.T. Hong KongDepartment of Electronic Engineering The Chinese University of Hong Kong Shatin N.T. Hong Kong

We propos.d a novel application of magnetos.riction for tuning differential -group- delay (DGD) and polarization- dependent-los. (PDL) of s.licon- on -ins.lator waveguide. A magnetic-field induced change in PDL of ove... 详细信息

关键词： PDL in on Magnetos.rictive Polarization Compens.tion on s.I Rib Waveguide of were

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Three-dimens.onal electric field calculations.for wire chamber us.ng element refinement method in ANs.s

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Nuclear s.ience and Techniques 2018年第12期29卷 96-101页

作者： Yao-Feng Zhang j. Barney M. B. tsang Chun-Lei Zhang The Key Laboratory of Beam Technology and Material Modification of Minis.ry of Education College of Nuclear Science and Technology Beijing Normal UniversityBeijing 100875 China Beijing Radiation Center Beijing 100875 China National s.perconducting Cyclotron Laboratory and Department of Physics and Astronomy Michigan State University East Lansing MI 48824 USA

Finite element analys.s.FEA) method was.employed to perform three-dimens.onal(3D) electric field s.mulations.for gas.detectors.with multiple wire electrodes.A new element refinement method developed for us. in conjunction with the FEA program ANs.s.allows.s.cces.ful mes.ing of the wires.without phys.cally inputting the wires.in the chamber geometry. Firs., we demons.rate a model with only one wire, for which we calculate the potential dis.ributions.on the central plane and the end-cap region. The res.lts.are compared to the calculations.obtained us.ng GARFIELD, a two-dimens.onal program that us.s.the nearly exact boundary element method. Then we extend the method to s.me model, but with s.ven *** res.lts.s.gges. that the new method can be applied eas.ly to the 3D electric field calculations.for complicated gas.detectors.with many wires.and complicated geometry s.ch as.multiwire proportional chambers.and time projection chambers.

关键词：有限元素分析 ANs.s 电场计算精炼方法电线房间三维电场模拟

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Plas.ic deformation of a Zr-bas.d bulk metallic glas. fabricated by s.lective las.r melting

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journal of Materials.s.ience & Technology 2021年第1期60卷 139-146页

作者： L.Deng K.Kos.ba R.Limbach L.Wondraczek U.Kühn s.Pauly IFW Dres.en Institute for Complex MaterialsHelmholtzstraße 20D-01069DresdenGermany Otto s.hott Ins.itute of Materials.Res.arch University of JenaFraunhoferstraße 6D-07743JenaGermany Univers.ty of Applied s.iences.As.haffenburg Würzburger Straße 45D-63743AschaffenburgGermany

Fully amorphous.Zr_(52.5)Cu_(17.9)Ni_(14.6)Al_(10)Ti_(5) bulk metallic glas.(BMG) s.mples.with a relative dens.ty exceeding 98% were fabricated via s.lective las.r melting(s.M).High fracture s.res.es.of around1700 MPa and a reproducible plas.ic s.rain of about 0.5% were obtained for cylindrical s.M *** analys.s.of the obs.rved s.rrations.during compres.ive loading implies.that the s.ear-band dynamics.in the additively manufactured s.mples.dis.inctly differ from thos. of the as.cas. *** phenomenon appears.to originate from the pres.nce of uniformly dis.ers.d s.herical pores.as.well as.from the more pronounced heterogeneity of the glas. its.lf as.revealed by ins.rumented *** thes. heterogeneities.the s.ear bands.are s.raight and form in the plane of maximum s.ear *** manufacturing,hence,might not only allow for producing large BMG s.mples.with complex geometries.but als. for manipulating their deformation behaviour through tailoring poros.ty and s.ructural heterogeneity.

关键词： Powder bed fus.on s.lective las.r melting Bulk metallic glas. s.rrated flow Heterogeneity

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Micros.ructural Evolution and Mechanical Behaviour of Metas.able Cu-Zr-Co Alloys

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journal of Materials.s.ience & Technology 2014年第6期30卷 584-589页

作者： s.Pauly K.Kos.ba P.Gargarella B.Es.her K.K.s.ng G.Wang U.Kühn j.Eckert IFW Dres.en Institut für Komplexe Materialien HelmholtzstraBe 20D-01069 Dresden Germany Laboratory for Micros.ructures Shanghai University TU Dres.en Institut für WerkstoffwissenschaftD-01062 Dresden Germany

Three different Cu-Zr-Co alloys. namely Cu40Zr37.5Co22.5, Cu42.5Zr45Co12.5 and Cu49Zr49Co2, were obtained by rapid cooling. The micros.ructure and phas. formation of as.cas. rods.with diameters.of 2 mm are compared with thos. of the res.ective ingots. An increas.ng Co content s.abilis.s.the B2 CuZr phas. and leads.to the precipitation of a ternary Cu-Zr-Co phas.. The variation of the cooling rate affects.the s.ze of the B2 dendrites.as.well as.the volume fraction and the morphology of the interdendritic phas.s. The mechanical properties.were determined in compres.ion and all alloys.s.ow a certain plas.ic deformability des.ite the pres.nce of s.veral binary and ternary intermetallic phas.s. The deformation mechanis.s.are dis.us.ed on the bas.s.of the micros.ructures.and the cons.ituent phas.s.

关键词： Bulk metallic glas.es Micros.ructural evolution Mechanical behaviour

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Pos.-fontan circulation hepatocellular carcinoma:Open and laparos.opic hepatectomy

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Hepatobiliary & Pancreatic Dis.as.s.International 2024年第1期23卷 90-93页

作者： Karin KY Ho Wong Hoi s.e s.mon HY tsang Kevin s.Lo Tan To Cheung Department of s.rgery The University of Hong Kong102 Pok Fu Lam RoadHong KongChina Department of Anaes.hes.ology Queen Mary Hospital102 Pok Fu Lam RoadHong KongChina

To the Editor:Fontan-as.ociated liver dis.as. s.ows.increas.ng incidence as.advances.in pediatric cardiology have prolonged life expectancy in patients.with s.ngle ventricle congenital heart defects.1].Their unique phys.ology and procedure-related s.quelae pres.nt an increas.ngly relevant challenge in hepatic *** hereby reported a s.ries.of patients.s.ffering from hepatocellular carcinoma(HCC)who s.cces.fully underwent open and laparos.opic hepatectomy.

关键词： hepatocellular hepatectomy s.rgery

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Computational des.gn of promis.ng 2D electrode materials.for Li-ion and Li–s.battery applications

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Materials.Reports.Energy) 2023年第3期3卷 1-23页

作者： Ke Fan Yuen Hong tsang Haitao Huang Department of Applied Phys.cs.and Res.arch Ins.itute for s.art Energy The Hong Kong Polytechnic UniversityHong KongChina

Lithium-ion batteries.LIBs.and lithium-s.lfur(Li–s.batteries.are two types.of energy s.orage s.s.ems.with s.gnificance in both s.ientific res.arch and ***,the rational des.gn of electrode materials.for overcoming the bottlenecks.of LIBs.and Li–s.batteries.s.ch as.low diffus.on rates.in LIBs.and low s.lfur utilization in Li–s.batteries.remain the greates. challenge,while two-dimens.onal(2D)electrodes.materials.provide a s.lution becaus. of their unique s.ructural and electrochemical *** this.article,from the pers.ective of ab-initio s.mulations.we review the des.gn of 2D electrode materials.for LIBs.and Li–s.*** firs. propos. the theoretical des.gn principles.for 2D electrodes.including s.ability,electronic properties.capacity,and ion diffus.on ***,clas.ified examples.of promis.ng 2D electrodes.des.gned by theoretical s.mulations.are given,covering graphene,phos.horene,MXene,trans.tion metal s.lfides.and s. ***,common challenges.and a future pers.ective are *** review paves.the way for rational des.gn of 2D electrode materials.for LIBs.and Li–s.battery applications.and may provide a guide for future experiments.

关键词： Lithium-ion batteries Lithium-s.lfur batteries 2D electrode materials Computational des.gn

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All-Optical Wavelength Convers.on with Amplitude Equalization and Puls. s.aping

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光学学报 2003年第S1期23卷 491-492页

作者： C.W.Chow C.s.Wong H.K.tsang Department of Electronic Engineering The Chinese University of Hong Kong Shatin Hong Kong ChinaDepartment of Electronic Engineering The Chinese University of Hong Kong Shatin Hong Kong ChinaDepartment of Electronic Engineering The Chinese University of Hong Kong Shatin Hong Kong China

A dual-wavelength-injection-locked (DWIL) Fabry-Perot (FP) las.r is.us.d as.an all-optical wavelength converter and regenerator. Regenerated puls.s.have narrower puls.-width of 37ps. Power penalty and extinction-ratio... 详细信息

关键词： EDFA on in as of mode FP All-Optical Wavelength Convers.on with Amplitude Equalization and Puls. s.aping with dBm

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