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Compositional complexity dependence of dislocation density and mechanical properties in high entropy alloy systems

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Progress in Natural Science:Materials International 2020年第4期30卷 545-551页

作者： P.Thirathipviwat G.Song j.Bednarcik U.Kühn T.Gemming K.Nielsch j.Han Leibniz Institute of Solid State and Materials Research (IFW Dresden) Frontier Research Center for Applied Atomic Sciences Ibaraki University Division of Advanced Materials Engineering and Institute for rare metals Kongju National University Institute of Physic Pavol Jozef Safarik University in Ko?ice Deutsches Elektronen-Synchrotron (DESY) Institute of Materials Science Technische Universit?t Dresden Institute of Applied Physics Technische Universit?t Dresden Korea Institute for Rare Metals Korea Institute of Industrial Technology (KITECH)

This study focuses on a quantitative analysis of dislocation accumulation after cold plastic deformation and mechanical properties of Fe Ni Co Cr Mn and Ti Nb Hf Ta Zr high entropy alloys(HEAs) which are single phase fcc and bcc solid solutions, respectively. In order to study the role of compositional complexity from unary to quinary compositions on dislocation accumulation and mechanical properties after plastic deformation, the single solid solution phase forming sub-alloys of the two HEAs were investigated. All studied samples revealed a large plastic deformability under cold-rotary swaging process by 85–90% area reduction without intermediate annealing. The dislocation density of all studied samples, determined by Williamson-Hall method on synchrotron X-ray diffraction patterns, were between 1014-1015m-2dependent on the alloy composition. The level of dislocation density after plastic deformation is not only affected by the number of constituent element but the lattice distortion and intrinsic properties in terms of stacking fault energy, modulus misfit, and melting point also impact the dislocation storage. The level of dislocation density determines the level of mechanical properties because of a resistance to dislocation motions. The hardness and yield compressive strength of the studied samples are proportional to the level of dislocation density.

关键词： High entropy alloys Dislocation density Synchrotron XRD Mechanical properties

Laser additive manufactured high-performance Fe-based composites with unique strengthening structure

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journal of Materials Science & Technology 2021年第30期89卷 242-252页

作者： Hongyu Chen Dongdong Gu Liang Deng Tiwen Lu Uta Kühn Konrad Kosiba College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016China jiangsu Provincial Engineering Laboratory for Laser Additive Manufacturing of High-Performance Metallic Components Nanjing University of Aeronautics and AstronauticsNanjing 210016China Leibniz IFW Dresden Institute for Complex MaterialsP.O.Box 270116D-01069 DresdenGermany

Steel matrix composites(SMCs),reinforced by ceramic particles,have received a consistent attention in recent *** conventional methods to prepare SMCs is generally challenging,and the mechanical properties of conventionally fabricated SMCs are *** this study,we successfully fabricated highperformance SMCs by laser powder bed fusion(LPBF)of a composite powder consisting of Fe-based alloy powder and submicron-sized WC *** effect of laser energy density on the phase formation,microstructural evolution,overall density and resulting mechanical properties of LPBF-fabricated composites was *** present results show that a novel Fe_(2)W_(4)C carbidic network precipitates in the solidified microstructure entailing segregations along the boundaries of cellular *** presence of this carbidic network hampers the growth of sub-grains even at elevated temperatures,and hence,stabilizes the grain size though prepared at a broad range of different energy *** exact distribution of the Fe_(2)W_(4)C carbides depends on the employed laser energy densities,as for instance they are more uniformly distributed at higher energy *** density of LPBF samples reaches the maximum value of 99.4%at 150 j/mm^(3).In this parameter set,high microhardness of~753 HV,compression strength of~3350 MPa and fracture strain of~24.4%are *** enhanced mechanical properties are ascribed to less metallurgical defects,higher volume fraction of the martensitic phase and increasing pile-up dislocations resulting from the pinning effect by Fe_(2)W_(4)C carbide.

关键词： Laser additive manufacturing Laser powder bed fusion Steel matrix composite Microstructures Mechanical properties

Microstructural Evolution and Mechanical Behaviour of Metastable Cu-Zr-Co Alloys

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journal of Materials Science & Technology 2014年第6期30卷 584-589页

作者： S.Pauly K.Kosiba P.Gargarella B.Escher K.K.Song G.Wang U.Kühn j.Eckert IFW Dresden Institut für Komplexe Materialien HelmholtzstraBe 20D-01069 Dresden Germany Laboratory for Microstructures Shanghai University TU Dresden Institut für WerkstoffwissenschaftD-01062 Dresden Germany

Three different Cu-Zr-Co alloys, namely Cu40Zr37.5Co22.5, Cu42.5Zr45Co12.5 and Cu49Zr49Co2, were obtained by rapid cooling. The microstructure and phase formation of as-cast rods with diameters of 2 mm are compared with those of the respective ingots. An increasing Co content stabilises the B2 CuZr phase and leads to the precipitation of a ternary Cu-Zr-Co phase. The variation of the cooling rate affects the size of the B2 dendrites as well as the volume fraction and the morphology of the interdendritic phases. The mechanical properties were determined in compression and all alloys show a certain plastic deformability despite the presence of several binary and ternary intermetallic phases. The deformation mechanisms are discussed on the basis of the microstructures and the constituent phases.

关键词： Bulk metallic glasses Microstructural evolution Mechanical behaviour

Targeting UDP-α-D-glucose 6-dehydrogenase alters the CNS tumor immune microenvironment and inhibits glioblastoma growth

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Genes & Diseases 2022年第3期9卷 717-730页

作者： Daqian Zhan Fatih Yalcin Ding Ma Yi Fu Shuang Wei Bachchu Lal Yunqing Li Omar Dzaye j.hn laterra Mingyao Ying Hernando Lopez-Bertoni Shuli Xia Neurology Hugo IV.Moser Research Institute at Kennedy KriegerJohns Hopkins University School of MedicineBaltimoreMD 21205USA Department of Critical Care Medicine Tongji HospitalHuazhong University of Science and TechnologyWuhanHubei 430074PR China Department of Radiology and Neuroradiology ChariteBerlin 10117Germany Russell H.Morgan Department of Radiology and Radiological Science Johns Hopkins University School of MedicineBaltimoreMD 21205USA Department of Respiratory and Critical Care Medicine Tongji HospitalHuazhong University of Science and TechnologyWuhanHubei 430074PR China University Hospital Center Schleswig Holstein Department of NeurosurgeryKielSchleswig-Holstein 24105Germany Departments of Neurology Oncology and NeuroscienceJohns Hopkins University School of MedicineBaltimoreMD 21205USA Blood and Cell Therapy Institute University of Science and Technology of ChinaAnhui Provincial HospitalHefeiAnhui 230026PR China

Glioblastoma(GBM,WHO grade IV glioma)is the most common and lethal malignant brain tumor in aduts with a dismal *** extracellular matrix(ECM)supports GBM progression by promoting tumor cell proliferation,migration,and immune *** diphosphate(UDP)-glucose 6-dehydrogenase(UGDH)is the rate-limiting enzyme that catalyzes the biosynthesis of glycosaminoglycans that are the principal component of the CNS *** investigated how targeting UGDH in GBM infuence$the GBM immune microenvironment,including tumor-associated microglia/macrophages(TAMs)and T *** are the main im-mune effector cells in GBM and can directly target tumor cells if properly *** co-cultures of GBM cells and human primary macrophages,UGDH knockdown in GBM cells pro-moted macrophage phagocytosis and M-like *** orthotropic human GBM xeno-grafts and syngeneic mouse glioma models,targeting UGDH decreased ECM deposition,increased TAM phagocytosis marker expression,reduced M2-like TAMS and inhibited tumor *** knockdown in GBM cells also promoted cytotoxic T cell ifltration and activa-tion in orthotopic syngeneic mouse glioma *** potent and in-human-use small mole-cule GAG synthesis inhibitor 4-methylumbelliferone(4-MU)was found to inhibit GBM cell proliferation and migration in vitro,mimic the macrophage and T-cell responses to UGDH knockdown in vitro and in vivo and inhibit growth of orthotopic murine *** study shows that UGDH supports GBM growth through multiple mechanisms and supports the development of ECM-based therapeutic strategies to simultaneously target tumor cells and their microenvi-ronment.

关键词： 4-MU Extracellular matrix(ECM) Glioblastoma(GBM) Hyaluronic acid(HA) Phagocytosis T cells Tumor-associated microglia/macrophages(TAMs) UGDH

No relationship between biopsy sites near the main testicular vessels or rete testis and successful sperm retrieval using conventional or microdissection biopsies in 220 non-obstructive azoospermic men

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Asian journal of Andrology 2013年第6期15卷 795-798,I0009页

作者： j Ullrich Schwarzer Heiko Steinfatt Heiko Steinfatt Manfred Schleyer Frank M Kōhn Klaus Fiedler2, Irene von Hertwig Gottfried Krüsmann Wolfgang Würfel Andrologie Centrum MOnchen MOnchen D-81241 Germany Kinderwunsch Centrum MOnchen MOnchen D-81241 Germany Andrologicum MOnchen MOnchen D-80331 Germany

In 220 consecutive patients with non-obstructive azoospermia, sperm retrieval was attempted by a combination of conventional and microdissection testicular sperm extraction （TESE）. For sperm retrieval, 2-3 conventional biopsies were performed followed by a microdissection TESE in cases of negative conventional biopsies. During the surgery, the vasculature of the testis was assessed using the operative microscope, and the location of positive biopsies was registered in relation to the blood supply. The overall sperm retrieval rate was 58.2%. From the initial conventional biopsies, sperm could be retrieved in 46.8% of the patients. With microdissection TESE, sperm could be retrieved from an additional 11.4% of the patients. The further use of microdissection TESE improved the sperm retrieval rate significantly （P=0.017）. No significant accumulation of positive biopsies was found towards the rete testis or the main testicular vessels.

关键词： intracytoplasmic sperm injection male infertility microdissection testicular sperm extraction non-obstructiveazoospermia sperm retrieval

Phase formation of a biocompatible Ti-based alloy under kinetic constraints studied via in-situ high-energy X-ray diffraction

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Progress in Natural Science:Materials International 2020年第3期30卷 432-436页

作者： Konrad Kosiba André Rothkirch junhee Han Liang Deng Benjamin Escher Gang Wang Uta Kühn jozef Bednarcik Leibniz IFW Dresden Institute for Complex Materials DESY Photon Science 3. Korea Institute of Industrial Technology (KITECH) Korea Institute for Rare Metals 4. Fraunhofer Institute for Photonic Microsystems IPMS Department of Engineering 5. Laboratory for Microstructures Institute of Materials Shanghai University 6. J. Safarik University in Kosice Institute of Physics Department of Condensed Matter Physics

The biocompatible Ti40Cu34Pd14Zr10Sn2bulk metallic glass was rapidly heated,also known as flash-annealed,at varying heating rates up to 1579 K/***,the phase formation was characterized via advanced in-situ highenergy X-ray *** has been found that the evolving kinetic constraints can be used as a tool to deliberately alter the crystalline phase *** novel processing route permits to select phases to crystallize to a predefined fraction and,thus,to potentially design the microstructure of materials according to a specified ***,flash-annealing poses a unique synthesis route to design materials with,for instance,good biomechanical compatibility.

关键词： High-energy X-ray diffraction Flash-annealing Phase formation Metallic glass Biocompatible Ti alloy

Determination of the number ofψ(3686)events taken at BESⅢ

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Chinese Physics C 2024年第9期48卷 8-20页

作者： M.Ablikim M.N.Achasov P.Adlarson O.Afedulidis X.C.Ai R.Aliberti A.Amoroso Q.An Y.Bai O.Bakina I.Balossino Y.Ban H.-R.Bao V.Batozskaya K.Begzsuren N.Berger M.Berlowski M.Bertani D.Bettoni F.Bianchi E.Bianco A.Bortone I.Boyko R.A.Briere A.Brueggemann H.Cai X.Cai A.Calcaterra G.F.Cao N.Cao S.A.Cetin j.F.Chang G.R.Che G.Chelkov C.Chen C.H.Chen Chao Chen G.Chen H.S.Chen H.Y.Chen M.L.Chen S.j.Chen S.L.Chen S.M.Chen T.Chen X.R.Chen X.T.Chen Y.B.Chen Y.Q.Chen Z.j.Chen Z.Y.Chen S.K.Choi G.Cibinetto F.Cossio j.j.Cui H.L.Dai j.P.Dai A.Dbeyssi R.E.de Boer D.Dedovich C.Q.Deng Z.Y.Deng A.Denig I.Denysenko M.Destefanis F.De Mori B.Ding X.X.Ding Y.Ding Y.Ding j.Dong L.Y.Dong M.Y.Dong X.Dong M.C.Du S.X.Du Y.Y.Duan Z.H.Duan P.Egorov Y.H.Fan j.Fang j.Fang S.S.Fang W.X.Fang Y.Fang Y.Q.Fang R.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng j.H.Feng Y.T.Feng M.Fritsch C.D.Fu j.L.Fu Y.W.Fu H.Gao X.B.Gao Y.N.Gao Yang Gao S.Garbolino I.Garzia L.Ge P.T.Ge Z.W.Ge C.Geng E.M.Gersabeck A.Gilman K.Goetzen L.Gong W.X.Gong W.Gradl S.Gramigna M.Greco M.H.Gu Y.T.Gu C.Y.Guan Z.L.Guan A.Q.Guo L.B.Guo M.j.Guo R.P.Guo Y.P.Guo A.Guskov j.Gutierrez K.L.Han T.T.Han F.Hanisch X.Q.Hao F.A.Harris K.K.He K.L.He F.H.Heinsius C.H.Heinz Y.K.Heng C.Herold T.Holtmann P.C.Hong G.Y.Hou X.T.Hou Y.R.Hou Z.L.Hou B.Y.Hu H.M.Hu j.F.Hu S.L.Hu T.Hu Y.Hu G.S.Huang K.X.Huang L.Q.Huang X.T.Huang Y.P.Huang T.Hussain F.Hölzken N.Hüsken N.in der Wiesche j.jackson S.janchiv j.H.jeong Q.ji Q.P.ji W.ji X.B.ji X.L.ji Y.Y.ji X.Q.jia Z.K.jia D.jiang H.B.jiang P.C.jiang S.S.jiang T.j.jiang X.S.jiang Y.jiang j.B.jiao j.K.jiao Z.jiao S.jin Y.jin M.Q.jing X.M.jing T.johansson S.Kabana N.Kalantar-Nayestanaki X.L.Kang X.S.Kang M.Kavatsyuk B.C.Ke V.Khachatryan A.Khoukaz R.Kiuchi O.B.Kolcu B.Kopf M.Kuessner X.Kui N.Kumar A.Kupsc W.Kühn j.j.Lane P.Larin L.Lavezzi T.T.Lei Z.H.Lei M.Lellmann T.Lenz C.Li C.Li C.H.Li Cheng Li D.M.Li F.Li G.Li H.B.Li H.j.Li H.N.Li Hui Li j.R.Li j.S.Li Ke Li L.j.Li L.K.Li Lei Li M.H.Li P.R.Li Q.M.Li Q.X.Li R.Li S.X.Li T.Li W.D.Li W.G.Li X.Li X.H.Li X.L.Li X.Z.Li Xi Institute of High Energy Physics Beijing 100049China Beihang University Beijing 100191China Bochum Ruhr-University D-44780BochumGermany Budker Institute of Nuclear Physics SB RAS(BINP) Novosibirsk 630090Russia Carnegie Mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China Central South University Changsha 410083China China Center of Advanced Science and Technology Beijing 100190China China University of Geosciences Wuhan 430074China Chung-Ang University Seoul06974Republic of Korea COMSATS University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000LahorePakistan Fudan University Shanghai 200433China GSI Helmholtzcentre for Heavy Ion Research GmbH D-64291DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China Hangzhou Normal University Hangzhou 310036China Hebei University Baoding 071002China Helmholtz Institute Mainz Staudinger Weg 18D-55099MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China Henan University of Science and Technology Luoyang 471003China Henan University of Technology Zhengzhou 450001China Huangshan College Huangshan 245000China Hunan Normal University Changsha 410081China Hunan University Changsha 410082China Indian Institute of Technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati (A)INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly(B)INFN Sezione di PerugiaI-06100PerugiaItaly(C)University of PerugiaI-06100PerugiaItaly INFN Sezione di Ferrara (A)INFN Sezione di FerraraI-44122FerraraItaly(B)University of FerraraI-44122FerraraItaly Inner Mongolia University Hohhot 010021China Institute of Modern Physics Lanzhou 730000China Institute of Physics and Technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de Alta Investigación Universidad de TarapacáCasilla 7DArica 1000000Chile jilin University Changchun 130012China joha

The number ofψ(3686)events collected by the BESⅢdetector during the 2021 run period is determined to be(2259.3±11.1)×10~6 by counting inclusiveψ(3686)hadronic *** uncertainty is systematic and the statistical uncertainty is ***,the numbers ofψ(3686)events collected during the 2009 and 2012run periods are updated to be(107.7±0.6)×10~6 and(345.4±2.6)×10~6,*** numbers are consistent with the previous measurements within one standard *** total number ofψ(3686)events in the three data samples is(2712.4±14.3)×10~6.

关键词： ψ(3686) inclusive process Hadronic events BESⅢdetector

Identification of Global DNA Methylation Signatures in Glioblastoma-Derived Cancer Stem Cells

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journal of Genetics and Genomics 2015年第7期42卷 355-371页

作者： Eun-joon Lee Prakash Rath jimei Liu Dungsung Ryu Lirong Pei Satish K.Noonepalle Austin Y.Shull Qi Feng N.Scott Litofsky Douglas C.Miller Douglas C.Anthony Mark D.Kirk j.hn laterra Libin Deng Hong-Bo Xin Xinguo Wang jeong-Hyeon Choi Huidong Shi GRU Cancer Center Georgia Regents University Department of Biology College of Art and SciencesUniversity of Missouri Office of In Vitro Diagnostics and Radiological Health Center for Devices and Radiological HealthFood and Drug Administration Department of Biochemistry and Molecular Biology Georgia Regents University Division of Neurological Surgery University of Missouri School of Medicine Department of Pathology and Anatomical Sciences University of Missouri School of Medicine Department of Pathology and Laboratory Medicine Brown University and Lifespan Academic Medical Center Department of Neurology The Hugo W.Moser Research Institute at Kennedy Krieger Inc.and The Johns Hopkins University School of Medicine Institute of Translational Medicine Nanchang University David H.Murdock Research Institute Department of Biostatistics and Epidemiology Georgia Regents University

Glioblastoma （GBM） is the most common and most aggressive primary brain tumor in adults. The existence of a small population of stem-like tumor cells that efficiently propagate tumors and resist cytotoxic therapy is one proposed mechanism leading to the resilient behavior of tumor cells and poor prognosis. In this study, we performed an in-depth analysis of the DNA methylation landscape in GBM- derived cancer stem ceils （GSCs）. Parallel comparisons of primary tumors and GSC lines derived from these tumors with normal controls （a neural stem cell （NSC） line and normal brain tissue） identified groups of hyper- and hypomethylated genes that display a trend of either increasing or decreasing methylation levels in the order of controls, primary GBMs, and their counterpart GSC lines, respectively. Interestingly, concurrent promoter hypermethylation and gene body hypomethylation were observed in a subset of genes including MGMT, AjAP1 and PTPRN2. These unique DNA methylation signatures were also found in primary GBM-derived xenograft tumors indicating that they are not tissue culture-related epigenetic changes. Integration of GSC-specific epigenetic signatures with gene expression analysis further identified candidate tumor suppressor genes that are frequently down-regulated in GBMs such as SPINT2, NEFM and PENK. Forced re-expression of SPINT2 reduced glioma cell proliferative capacity, anchorage independent growth, cell motility, and tumor sphere formation in vitro. The results from this study demonstrate that GSCs possess unique epigenetic signatures that may play important roles in the pathogenesis of GBM.

关键词： Glioblastoma Cancer stem cells DNA methylation SPINT2

Achieving exceptional wear resistance in a crack-free high-carbon tool steel fabricated by laser powder bed fusion without pre-heating

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journal of Materials Science & Technology 2023年第25期156卷 1-19页

作者： Konrad Kosiba Daniel Wolf Matthias Bönisch Kai Neufeld Ruben Hühne Tobias Gustmann jozef Bednarčík Hongyu Chen Xiaoliang Han Volker Hoffmann Lukas Beyer Uta Kühn Sergio Scudino Lars Giebeler julia K.Hufenbach Leibniz Institute for Solid State and Materials Research (IFW) Dresden E.V. Helmholtzstr. 20Dresden 01069Germany Department of Materials Engineering KU LeuvenKasteelpark Arenberg 44bus 2450Leuven 3001Belgium Department of Condensed Matter Physics Institute of PhysicsP.J. Safarik University in KosicePark Angelinum 9Kosice 04154Slovakia Institute of Experimental Physics Slovak Academy of ScienceWatsonova 47Kosice 040 01Slovakia Key Laboratory of Impact and Safety Engineering of Ministry of Education of China Ningbo UniversityNingbo 315211China TU Bergakademie Freiberg Institute of Materials ScienceGustav-Zeuner-Str. 5Freiberg 09599Germany

Laser powder bed fusion(LPBF)for the fabrication of dense components used for tooling applications,is highly *** stresses,which evolve in the additively manufactured part,are inherent to LPBF *** additional stress contribution in high-carbon steels arises from the austenite-to-martensite phase transformation,which may eventually lead to cracking or even *** an alternative to pre-heating the base plate,which is not striven by industry,lowering the martensite content which forms in the part,is essential for the fabrication of dense parts by LPBF of high-carbon tool steels which are then adapted to *** this study,a successful strategy demonstrates the processing of the Fe85Cr4Mo1V1W8C1(wt%)high-carbon steel by LPBF into dense parts(99.8%).The hierarchical microstructure consists of austenitic and martensitic grains separated by elemental segregations in which nanoscopic carbide particles form a network.A high density of microsegregation was observed at the molten pool boundary ultimately forming a *** LPBF-fabricated steel shows a yield strength,ultimate compressive stress,and total strain of 1210 MPa,3556 MPa,and 27.4%,*** mechanical and wear performance is rated against the industrially employed and highly wear-resistant 1.2379 tool steel taken as the *** its lower macro-hardness,the LPBF steel(58.6 HRC,0.0061 mm^(3) Nm^(-1))shows a higher wear resistance than the reference steel(62.6 HRC,0.0078 mm^(3) Nm^(-1)).This behavior results from the wear-induced formation of martensite in a microscale thick layer directly at the worn surface,as it was proven via high-energy X-ray diffraction mapping.

关键词： Additive manufacturing Laser powder bed fusion Steel Wear TRIP