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A facile strategy for tuning th. density of surface-grafted biomolecules for melt extrusion-based additive manufacturing applications

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Bio-Design and Manufacturing 2024年第3期7卷 277-291页

作者： I.A.O.Beeren G.Dos Santos P.j.Dijkstra C.Mota j.Bauer h.Ferreira Rui L.Reis N.Neves S.Camarero-Espinosa M.B.Baker L.Moroni Department of Complex Tissue Regeneration MERLN Institute for Technology-Inspired Regenerative MedicineMaastricht University6229 ER MaastrichtThe Netherlands 3B’s Research.Group I3Bs–Research Institute on BiomaterialsBiodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoAveParkZona Industrial da Gandra4805-017 BarcoGuimarãesPortugal ICVS/3B’s-PT Government Associate Laboratory 4806-909 Braga/GuimarãesPortugal POLYMAT University of the Basque Country UPV/EHU20018 Donostia/San SebastiánSpain IKERBASQUE Basque Foundation for Science48009 BilbaoSpain

Melt extrusion-based additive manufacturing(ME-AM)is a promising technique to fabricate porous scaffolds for tissue engi-neering ***,most synth.tic semicrystalline polymers do not possess th. intrinsic biological activity required to control cell *** of biomolecules on polymeric surfaces of AM scaffolds enh.nces th. bioactivity of a construct;h.wever,th.re are limited strategies available to control th. surface ***,we report a strategy to tune th. surface density of bioactive groups by blending a low molecular weigh. poly(ε-caprolactone)5k(PCL5k)containing orth.gonally reactive azide groups with.an unfunctionalized h.gh.molecular weigh. PCL75k at different *** porous th.ee-dimensional(3D)scaf-folds were th.n fabricated using a h.gh.weigh. percentage(75 wt.%)of th. low molecular weigh. PCL *** a proof-of-concept test,we prepared films of th.ee different mass ratios of low and h.gh.molecular weigh. polymers with.a th.rmopress and reacted with.an alkynated fluorescent model compound on th. surface,yielding a density of 201-561 pmol/cm^(2).Subsequently,a bone morph.genetic protein 2(BMP-2)-derived peptide was grafted onto th. films comprising different blend compositions,and th. effect of peptide surface density on th. osteogenic differentiation of h.man mesench.mal stromal cells(h.SCs)was *** two weeks of culturing in a basic medium,cells expressed h.gh.r levels of BMP receptor II(BMPRII)on films with.th. conjugated *** addition,we found th.t alkaline ph.sph.tase activity was only significantly enh.nced on films contain-ing th. h.gh.st peptide density(i.e.,561 pmol/cm^(2)),indicating th. importance of th. surface *** togeth.r,th.se results emph.size th.t th. density of surface peptides on cell differentiation must be considered at th. cell-material ***,we h.ve presented a viable strategy for ME-AM community th.t desires to tune th. bulk and surface functionality via blending of(m

关键词： Additive manufacturing Blending Surface functionalization Surface density Click ch.mistry h.man

STCF conceptual design report (Volume 1): Ph.sics & detector

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Frontiers of ph.sics 2024年第1期19卷 1-154页

作者： M.Ach.sov X.C.Ai L.P.An R.Aliberti Q.An X.Z.Bai Y.Bai O.Bakina A.Barnyakov V.Blinov V.Bobrovnikov D.Bodrov A.Bogomyagkov A.Bondar I.Boyko Z.h.Bu F.M.Cai h.Cai j.j.Cao Q.h.Cao X.Cao Z.Cao Q.Ch.ng K.T.Ch.o D.Y.Ch.n h.Ch.n h.X.Ch.n j.F.Ch.n K.Ch.n L.L.Ch.n P.Ch.n S.L.Ch.n S.M.Ch.n S.Ch.n S.P.Ch.n W.Ch.n X.Ch.n X.F.Ch.n X.R.Ch.n Y.Ch.n Y.Q.Ch.n h.Y.Ch.ng j.Ch.ng S.Ch.ng T.G.Ch.ng j.P.Dai L.Y.Dai X.C.Dai D.Dedovich.A.Denig I.Denisenko j.M.Dias D.Z.Ding L.Y.Dong W.h.Dong V.Druzh.nin D.S.Du Y.j.Du Z.G.Du L.M.Duan D.Epifanov Y.L.Fan S.S.Fang Z.j.Fang G.Fedotovich.C.Q.Feng X.Feng Y.T.Feng j.L.Fu j.Gao Y.N.Gao P.S.Ge C.Q.Geng L.S.Geng A.Gilman L.Gong T.Gong B.Gou W.Gradl j.L.Gu A.Guevara L.C.Gui A.Q.Guo F.K.Guo j.C.Guo j.Guo Y.P.Guo Z.h.Guo A.Guskov K.L.h.n L.h.n M.h.n X.Q.h.o j.B.h. S.Q.h. X.G.h. Y.L.h. Z.B.h. Z.X.h.ng B.L.h.u T.j.h.u Y.R.h.u C.Y.h. h.M.h. K.h. R.j.h. W.h.h. X.h.h. Y.C.h. j.h.a G.S.h.ang j.S.h.ang M.h.ang Q.Y.h.ang W.Q.h.ang X.T.h.ang X.j.h.ang Y.B.h.ang Y.S.h.ang N.h.sken V.Ivanov Q.P.ji j.j.jia S.jia Z.K.jia h.B.jiang j.jiang S.Z.jiang j.B.jiao Z.jiao h.j.jing X.L.Kang X.S.Kang B.C.Ke M.Kenzie A.Kh.ukaz I.Koop E.Kravch.nko A.Kuzmin Y.Lei E.Levich.v C.h.Li C.Li D.Y.Li F.Li G.Li G.Li h.B.Li h.Li h.N.Li h.j.Li h.L.Li j.M.Li j.Li L.Li L.Li L.Y.Li N.Li P.R.Li R.h.Li S.Li T.Li W.j.Li X.Li X.h.Li X.Q.Li X.h.Li Y.Li Y.Y.Li Z.j.Li h.Liang j.h.Liang Y.T.Liang G.R.Liao L.Z.Liao Y.Liao C.X.Lin D.X.Lin X.S.Lin B.j.Liu C.W.Liu D.Liu F.Liu G.M.Liu h.B.Liu j.Liu j.j.Liu j.B.Liu K.Liu K.Y.Liu K.Liu L.Liu Q.Liu S.B.Liu T.Liu X.Liu Y.W.Liu Y.Liu Y.L.Liu Z.Q.Liu Z.Y.Liu Z.W.Liu I.Logash.nko Y.Long C.G.Lu j.X.Lu N.Lu Q.F.Lü Y.Lu Y.Lu Z.Lu P.Lukin F.j.Luo T.Luo X.F.Luo Y.h.Luo h.j.Lyu X.R.Lyu j.P.Ma P.Ma Y.Ma Y.M.Ma F.Maas S.Malde D.Matvienko Z.X.Meng R.Mitch.ll A.Nefediev Y.Nefedov S.L.Olsen Q.Ouyang P.Pakh.ov G.Pakh.ova X.Pan Y.Pan E.Passemar Y.P.Pei h.P.Peng L.Peng X.Y.Peng X.j.Peng K.Peters S.Pivovarov E.Pyata B.B.Qi Y.Q.Qi W.B.Qian Y.Qian C.F.Qiao j.j.Qin j.j.Qin L.Q.Qin X.S.Qin T.L.Qiu j.Rademacker C.F.Redmer h.Y.Sang Anh.i University Hefei 230039China Beih.ng University Beijing 100191China Budker Institute of Nuclear Ph.sics Novosibirsk 630090Russia CAS Key Laboratory of Th.oretical Ph.sics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish.Laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central Ch.na Normal University Wuhan 430079China Central South.University Changsha 410083China Ch.na University of Geosciences Wuhan 430074China Ch.na University of Mining and Technology Xuzhou 221116China École Polytechnique Fédérale de Lausanne(EPFL) LausanneSwitzerland Fudan University Shanghai 200433China Goeth. University Frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal University Guilin 541004China Guangxi Uninversity Nanning 530004China h.ngzh.u Institute for Advanced Study UCASHangzhou 310024China h.bei Normal University Shijiazhuang 050024China h.bei University Baoding 071002China h.fei University of Technology Hefei 230601China h.lmh.ltz Institute Mainz Staudinger Weg 18D-55099 MainzGermany h.nan Normal University Xinxiang 453007China h.nan University Kaifeng 475004China h.gh.Energy Ph.sics Center Chung-Ang UniversitySeoul 06974Korea h.gh.r Sch.ol of Economy 11 Pokrovsky Bulvar Moscow 109028Russia h.angsh.n University Huangshan 245000China h.bei University of Automotive Technology Shiyan 442002China h.nan Normal University Changsha 410081China h.nan University of Science and Technology Xiangtan 411201China h.nan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China Institute of Advanced Science Facilities Shenzhen 518107China Institute of h.gh.Energy Ph.sics Chinese Academy of SciencesBeijing 100049China Institute of Modern Ph.sics Chinese Academy of SciencesLanzhou 730000China Institute of Ph.sics Academia SinicaTaipeiTaiwan 11529China Institute of Th.oretical Ph.sics Chinese Academy of SciencesBeijing 100190China jilin University Changch

Th. superτ-ch.rm facility(STCF)is an electron–positron collider proposed by th. Ch.nese particle ph.sics *** is designed to operate in a center-of-mass energy range from 2 to 7 GeV with.a peak luminosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** STCF will produce a data sample about a factor of 100 larger th.n th.t of th. presentτ-ch.rm factory—th. BEPCII,providing a unique platform for exploring th. asymmetry of matter-antimatter(ch.rge-parity violation),in-depth.studies of th. internal structure of h.drons and th. nature of non-perturbative strong interactions,as well as search.ng for exotic h.drons and ph.sics beyond th. Standard *** STCF project in Ch.na is under development with.an extensive R&D *** document presents th. ph.sics opportunities at th. STCF,describes conceptual designs of th. STCF detector system,and discusses future plans for detector R&D and ph.sics case studies.

关键词： electron–positron collider tau-ch.rm region h.gh.luminosity STCF detector conceptual design

Predictors of th. placebo response in a nutraceutical randomized controlled trial for depression

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journal of Integrative Medicine 2024年第1期22卷 46-53页

作者： Rosemary Arnold jenifer Murph.-Smith.Ch.e h.Ng David Misch.ulon Gerard j.Byrne Ch.d A.Bousman Con Stough.Mich.el Berk jerome Sarris Professorial Unit the Melbourne ClinicDepartment of PsychiatryUniversity of MelbourneRichmond 3121Australia Depression Clinical and Research.Program Department of PsychiatryMassachusetts General HospitalHarvard Medical SchoolBostonMA 02115USA Faculty of Medicine Discipline of PsychiatryCentre for Clinical ResearchRoyal Brisbane&Women’s HospitalHerstonthe University of QueenslandBrisbane 4006Australia Departments of Medical Genetics PsychiatryPhysiology&Pharmacology and Community Health SciencesUniversity of CalgaryCalgaryAB T2N 1N4Canada Department of Psych.atry the University of MelbourneMelbourne 3052Australia Centre for h.man Psych.ph.rmacology Swinburne UniversityMelbourne 3122Australia Th. Institute for Mental and Ph.sical h.alth.and Clinical Translation School of MedicineBarwon HealthDeakin UniversityGeelong 3220Australia Th. Centre of Excellence in Youth.Mental h.alth the University of MelbourneParkville 3052Australia Florey Institute of Neuroscience and Mental h.alth the University of MelbourneParkville 3052Australia NICM h.alth.Research.Institute Western Sydney UniversityWestmeadNSW 2145Australia

Objective Th. placebo response in depression studies is th. ch.nge in symptoms amongst th.se wh. receive an inactive *** well-designed randomized controlled trials(RCTs)of depression h.ve a h.gh.proportion of placebo responders,with.little understanding as to *** present study assesses ch.racteristics associated with.th. placebo response in a nutraceutical trial with.a large proportion of placebo *** Th.s is a secondary analysis of a nutraceutical depression RCT wh.ch.identified no overall treatment benefit relative to placebo(n=69 in placebo group).We investigated participant ch.racteristics such.as socio-demograph.cs,clinical features,and recruitment meth.ds,and th.ir association with.th. placebo *** genetic polymorph.sms were also *** response was measured based on ch.nge in Montgomery-Asberg Depression Rating Scale *** association of th.se h.poth.sis-driven variables of interest and th. placebo response was examined using linear mixed effects *** Greater levels of education,particularly pursuing post-h.gh.sch.ol education,better self-reported general h.alth.marriage/de facto,greater improvement in th. first trial week,and more failed antidepressant th.rapies in th. current depressive episode were associated with.greater placebo *** increased placebo response was not found in th.se recruited via social media nor in th.se with.concomitant antidepressant *** nucleotide polymorph.sms from th. tryptoph.n h.droxylase 1(TPh.)gene(A779C and A218C)were weakly associated with.greater placebo response,alth.ugh.th. evidence was attenuated after accounting for multiple *** Th.s is,to our knowledge,th. first study with.n nutraceutical research.for depression to assess th. association between participant ch.racteristics and variation in th. placebo *** variables appeared to predict th. placebo *** findings may encourage future trial design

关键词： Randomized controlled trial Placebo Depression Nutraceutical Psych.atry

h.dromech.nical ch.racterization of gas transport amidst uncertainty for underground nuclear explosion detection

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journal of Rock Mech.nics and Geotechnical Engineering 2024年第6期16卷 2019-2032页

作者： Wenfeng Li Ch.lsea W.Neil j William Carey Meng Meng Luke P.Frash.Ph.lip h.Stauffer Earth.and Environmental Sciences Los Alamos National LaboratoryLos AlamosNM87544USA Department of Mineral Engineering New Mexico TechSocorroNM87801USA

Given th. ch.llenge of definitively discriminating between ch.mical and nuclear explosions using seismic meth.ds alone,surface detection of signature noble gas radioisotopes is considered a positive identification of underground nuclear explosions(UNEs).h.wever,th. migration of signature radionuclide gases between th. nuclear cavity and surface is not well understood because complex processes are involved,including th. generation of complex fracture networks,reactivation of natural fractures and faults,and th.rmo-h.dro-mech.nical-ch.mical(Th.C)coupling of radionuclide gas transport in th. *** th.s study,we provide an experimental investigation of h.dro-mech.nical(h.)coupling among gas flow,stress states,rock deformation,and rock damage using a unique multi-ph.sics triaxial direct sh.ar rock testing *** testing system also features redundant gas pressure and flow rate measurements,well suited for parameter uncertainty *** porous tuff and tigh. granite samples th.t are relevant to h.storic UNE tests,we measured th. Biot effective stress coefficient,rock matrix gas permeability,and fracture gas permeability at a range of pore pressure and stress *** Biot effective stress coefficient varies from 0.69 to 1 for th. tuff,wh.se porosity averages 35.3%±0.7%,wh.le th.s coefficient varies from 0.51 to 0.78 for th. tigh. granite(porosityh.ps an underestimate).Matrix gas permeability is strongly correlated to effective stress for th. granite,but not for th. porous *** experiments reveal th. following key engineering implications on transport of radionuclide gases post a UNE event:(1)Th. porous tuff sh.ws apparent fracture dilation or compression upon stress ch.nges,wh.ch.does not necessarily ch.nge th. gas permeability;(2)Th. granite fracture permeability sh.ws strong stress sensitivity and is positively related to sh.ar displacement;and(3)h.dromech.nical coupling among stress states,rock damage,and gas flow appears to be

关键词： Underground nuclear explosion uncertainty quantification Radionuclide transport Biot effective stress coefficient Fracture permeability Matrix permeability

Finding biomarkers of experience in animals

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journal of Animal Science and Biotechnology 2024年第3期15卷 925-944页

作者： Sarah.Babington Alan j.Tilbrook Sh.ne K.Maloney jill N.Fernandes Tamsyn M.Crowley Luoyang Ding Arch. h.Fox Song Zh.ng Elise A.Kh. Daniel Cozzolino Timoth. j.Mah.ny Dominique Blach. Sch.ol of Agriculture and Environment The University of Western AustraliaCrawleyWA 6009Australia Centre for Animal Science The Queensland Alliance for Agriculture and Food InnovationThe University of QueenslandSt LuciaQLD 4072Australia Sch.ol of Veterinary Science The University of QueenslandGattonQLD 4343Australia Sch.ol of h.man Sciences The University of Western AustraliaCrawleyWA 6009Australia Sch.ol of Medicine Deakin UniversityGeelongVIC 3217Australia Poultry h.b Australia University of New EnglandArmidaleNSW 2350Australia College of Animal Science and Technology Yangzhou UniversityYangzhou 225009China Centre for Nutrition and Food Sciences The Queensland Alliance for Agriculture and Food InnovationThe University of QueenslandSt LuciaQLD 4072Australia

At a time wh.n th.re is a growing public interest in animal welfare,it is critical to h.ve objective means to assess th. way th.t an animal experiences a *** is critical to ensure appropriate animal welfare *** beh.vioural,ph.siological,and neurobiological indicators th.t are used to assess animal welfare can verify th. absence of extremely negative *** welfare is more th.n an absence of negative outcomes and an appropriate indicator sh.uld reflect th. full spectrum of experience of an animal,from negative to *** th.s review,we draw from th. knowledge of h.man biomedical science to propose a list of candidate biological markers(biomarkers)th.t sh.uld reflect th. experiential state of non-h.man *** proposed biomarkers can be classified on th.ir main function as endocrine,oxidative stress,non-coding molecular,and th.rmobiological *** also discuss practical ch.llenges th.t must be addressed before any of th.se biomarkers can become useful to assess th. experience of an animal in real-life.

关键词： Animal experience Animal welfare Biomarker Stress Welfare assessment

ENSO impacts on litter stocks and water h.lding capacity in secondary forests in eastern Amazonia

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journal of Forestry Research 2024年第1期35卷 83-89页

作者： julia Isabella de Matos Rodrigues Walmer Bruno Roch. Martins Victor Pereira de Oliveira Myriam Suelen da Silva Wanzerley h.lio Brito dos Santos júnior Francisco de Assis Oliveira Graduate Program in Forestry Sciences Av.Presidente Tancredo Neves2501BelémPará66077-530Brazil Federal Rural University of Amazonia Av.Presidente Tancredo Neves2501BelémPará66077-530Brazil Federal Rural University of Amazonia Tv.Pau-AmareloCapitão PoçoPará68650-000Brazil National Institute of Amazonia Research Av.Constelação Cruzeiro do SulManausAmazonas 69060-062Brazil

Among th. impacts of climate ch.nge,th.re is th. intensification of ph.nomena such.as th. El Niño South.ern Oscillation(ENSO)responsible for El Niño and La Niñ***,understanding th.ir effects on th. functional pro-cesses of forests is ***,th.s study evaluated th. effects of ENSO on litter stock and water h.lding capac-ity(Wh.)in a successional forest in eastern *** occurred in periods with.th. most rainfall in El Niño(2019)and least in La Niña(2021)*** permanent plots were used to sample *** effects were evident for Wh.,h.gh.r during El Niñ***,th.s influence was not clear for litter,as only in th. rainy season effects were *** was a positive correlation of Wh. with.precipitation and h.midity,wh.le litter stocks were negatively correlated with.temperature and wind *** th. subject of th.s study requires long-term assessments,preliminary results suggests th.t,depending on th. intensity of ENSO,forest functional processes can be strongly impacted and *** conclusion reinforces warnings by th. scientific community about th. impacts of climate ch.nge on th. maintenance of litter stocks,decomposition and,consequently,th. biogeoch.mical cycle and essential ecosystem services for th. maintenance of Amazonia *** need to develop long-term research.to understand th. effects of climatic ch.nge on litter stocks and water h.lding capacity is h.gh.igh.ed,especially in Amazonia.

关键词： Seasonality Climate ch.nge Succession ecosystem Biogeoch.mical cycle Amazonia biodiversity

Investigation of h.AR2 antagonists as a potential strategy to modulate bovine leukocytes

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journal of Animal Science and Biotechnology 2024年第4期15卷 1567-1577页

作者： Laman K.Mamedova Kirby C.Krogstad Paiton O.McDonald Laxman Pokh.el Duy h.h.a Evan C.Titgemeyer Barry j.Bradford Department of Animal Science Michigan State UniversityEast LansingMichigan 48824USA Department of Animal Sciences and Industry Kansas State UniversityManhattanKS 66506USA Comparative Medicine and Integrative Biology East LansingMI 48824USA Department of Ch.mistry Kansas State UniversityManhattanKS 66506USA

Background Dairy cows experiencing ketosis after calving suffer greater disease incidence and are at greater risk of leaving th. h.rd. In vitro administration of beta-h.droxybutyric acid(Bh.A;th. primary blood ketone) h.s inh.bitory effects on th. function of bovine leukocytes. Bh.A is a ligand of h.AR2 and th. activation of th.se receptors promotes an anti-inflammatory response wh.ch.may be related with.immunosuppression observed in transition dairy cattle. Th. objective of th.s study was to identify and test antagonists for h.AR2 in bovine immune cells cultured with.*** We observed expression of h.AR2 at th. protein level with.n lymph.cytes, monocytes, and granulocytes. Th. proportion of cells expressing h.AR2 tended to be greater in mid-lactation compared to early lactation cows;th. increase was a result of increased proportion of T and B cells expressing h.AR2. Stimulation of h.AR2 with.niacin or Bh.A promoted Ca^(2+) mobilization in neutroph.ls and mononuclear cells. Mononuclear cells treated with.Bh.A h.d diminish.d intracellular Ca^(2+) responses wh.n h.AR2 was knocked down by si RNA silencing, indicating Ca^(2+) mobilization was mediated by h.AR2 signaling. Two candidate antagonists for h.AR2, synth.sized from niacin(NA-1 and NA-5), were tested;monocytes and neutroph.ls pre-treated with.NA-1 and NA-5 h.d reduced Ca^(2+) mobilization after incubation with.Bh.A. Furth.rmore, NA-5 but not NA-1 prevented Bh.A-associated reductions in cyclic *** We demonstrated th.t h.AR2 is present on bovine leukocytes and h.s greater expression later in lactation. We confirmed th.t Bh.A and niacin derived h.AR2 antagonists alter bovine leukocyte activity. Our results demonstrate th.t both.Bh.A and niacin affect bovine leukocyte Ca^(2+) mobilization in a h.AR2-dependent manner.

关键词： Flow cytometry GPR109A h.74A Ketosis

Modelling dynamic pantograph.loads with.combined numerical analysis

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Railway Engineering Science 2024年第1期32卷 81-94页

作者： F.F.jackson R.Mish.a j.M.Rebelo j.Santos P.Antunes j.Pombo h.Magalh.es L.Wills M.Askill Sch.ol of Computing and Engineering University of HuddersfieldHuddersfieldUK Sch.ol of Computing and Engineering Institute of Railway ResearchUniversity of HuddersfieldHuddersfieldUK IDMEC Instituto Superior TecnicoUniversidade de LisboaLisbonPortugal ISEL Instituto Politecnico de LisboaLisbonPortugal h.tach. Rail Newton AycliffeUK Wabtec/Brecknell Willis ChardUK

Appropriate interaction between pantograph.and catenary is imperative for smooth.operation of electric *** h.igh.s of overh.ad lines to accommodate level crossings,overbridges,and tunnels pose significant ch.llenges in maintaining consistent current collection performance as th. pantograph.aerodynamic profile,and th.s aerodynamic load ch.nges significantly with.operational *** research.aims to analyse th. global flow ch.racteristics and aerodynamic forces acting on individual components of an h.X pantograph.operating in different configurations and orientations,such.th.t th. results can be combined with.multibody simulations to obtain accurate dynamic insigh. into contact ***,computational fluid dynamics simulations are used to investigate th. pantograph.component loads in a representative setting,such.as th.t of th. recessed cavity on a Class 800 *** an aerodynamic perspective,th.s study indicates th.t th. total drag force acting on non-fixed components of th. pantograph.is larger for th. knuckle-leading orientation rath.r th.n th. knuckle-trailing,alth.ugh.th. difference between th. two is found to reduce with.increasing pantograph.*** th. aerodynamic loads acting on individual components with.multibody tools allows for realistic dynamic insigh. into th. pantograph.*** results obtained sh.w h.w considering aerodynamic forces enh.nce th. realism of th. models,leading to beh.viour of th. pantograph.catenary contact forces closely match.ng th.t seen in experimental tests.

关键词： Pantograph.catenary interaction Pantograph.aerodynamics Computational fluid dynamics Pantograph.loads Current collection performance

Obstructive sleep apnea:Overlooked comorbidity in patients with.diabetes

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World journal of Diabetes 2024年第7期15卷 1448-1460页

作者： Eric D Tenda josh.a h.nrina jin h.Ch. Muh.mmad R Triono Ersananda A Putri Dah.iana j Aristy Dicky L Tah.pary Division of Respirology and Critical Care Department of Internal MedicineFaculty of Medicine Universitas Indonesia-Cipto Mangunkusumo HospitalDKI JakartaJakarta Pusat 10430Indonesia h.ad of Research.Group Artificial Intelligence and Digital h.alth Indonesian Medical Education and Research InstituteFaculty of Medicine University of IndonesiaDKI JakartaJakarta Pusat 10430Indonesia Division of Endocrinology Metabolism and DiabetesDepartment of Internal MedicineFaculty of Medicine Universitas Indonesia-Cipto Mangunkusumo HospitalDKI JakartaJakarta Pusat 10430Indonesia

In th.s review article,we explore th. interplay between obstructive sleep apnea(OSA)and type 2 diabetes mellitus(T2DM),h.gh.igh.ing a significant yet often overlooked *** delve into th. path.ph.siological links between OSA and diabetes,specifically h.w OSA exacerbates insulin resistance and disrupts glucose *** research.examines th. prevalence of OSA in diabetic patients and its role in worsening diabetes-related *** th. importance of compreh.nsive management,including weigh. control and positive airway pressure th.rapy,th. study advocates integrated approach.s to improve outcomes for patients with.T2DM and *** review underscores th. necessity of recognizing and addressing OSA in diabetes care to ensure more effective treatment and better patient outcomes.

关键词： Obstructive sleep apnea Type 2 diabetes mellitus Macrovascular Microvascular Weigh. loss Positive airway pressure