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Neural Regeneration Research 2021年第3期16卷 508-509页

作者： Timothy j.Kopper j.hn c.gensel Spinal cord and Brain Injury Research center Department of PhysiologyUniversity of KentuckyLexingtonKYUSA

Spinal cord injury(ScI)induces a robust inflammatory response largely mediated by resident microglia and infiltrating macrophages across the blood-brain *** these cell populations are capable of promoting repair and regenerative responses,in the days and weeks after ScI they predominately adopt pro-inflammatory profiles known to inhibit recovery and potentiate secondary injury pathways.

关键词： protective injury therapeutic

Spatio-Temporal evolutive Data Infrastructure: a Spatial Data Infrastructure for managing data flows of Territorial Statistical Information

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International journal of Digital Earth 2017年第3期10卷 257-283页

作者： camille Bernard Marlène Villanova-Oliver jérôme gensel Benoit Le Rubrus Univ.Grenoble Alpes CNRSLIGGrenobleFrance

The observation of demographical,economical or environmental indicators over time through maps is *** enables analysing territories and helps stakeholders to take ***,the understanding of Territorial Statistical Information(TSI)is compromised unless comprehensive description of both the statistical methodology used and the spatial and temporal references are ***,in this paper,we stress the importance of metadata descriptions and of their quality that helps assessing data ***,time-series of such TSI are *** enable analysing a territory over a long period of time and likewise judging the effectiveness of *** light of these observations,we present Spatio-Temporal evolutive Data Infrastructure(STeDI)an innovative Spatial Data Infrastructure(SDI)that enriches the description of a Digital Earth,providing a virtual representation of territories and of their evolution through statistics and *** aims at managing a whole dataflow of multi-dimensional,multi-scale and multi-temporal TSI,from their acquisition to their dissemination to scientists and *** content of this SDI evolves autonomously thanks to automated processes and to a Web platform that help improving the quality of datasets uploaded by ***,STeDI allows visualizing up-to-date time-series reflecting the human activities on a given *** helps policy-makers in their decision-making process.

关键词： Spatial Data Infrastructure Territorial Statistical Information metadata data quality INSPIRE

Strong coupling,charm- and bottom-quark masses from electron-positron annihilation

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chinese Physics c 2010年第6期34卷 675-679页

作者： j.H.Kühn Institut für Theoretische Teilchenphysik Karlsruhe Institute of Technology

The cross section for electron-positron annihilation into hadrons allows for a precise determination of the strong coupling constant and the charm- and bottom-quark masses. Recent theoretical and experimental results ... 详细信息

关键词： strong coupling quark masses

Status and prospects for symmetric organic redox flow batteries

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journal of Energy chemistry 2025年第1期100卷 125-143页

作者： Md Al Raihan c.Adam Dyker Department of chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage becomes imperative for the integration of renewable sources like wind, hydro, and solar with the electrical *** flow batteries, particularly those employing organic molecules, are positioned as a key technology for this purpose. This review explores the growing field of symmetric organic redox flow batteries(ORFBs) within this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric ORFBs involve a single bipolar species for both electrodes. This review highlights the benefits of a symmetric design, and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents. By providing a comprehensive overview of their cell cycling and performance characteristics, the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. This should guide new research directions and advance the development of practical symmetric ORFBs.

关键词： Redox flow battery Symmetric battery Organic battery Aqueous electrolyte Non-aqueous electrolyte

A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

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Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon c.Daeschler Katelyn j.W.So Konstantin Feinberg Marina Manoraj jenny cheung jennifer Zhang Kaveh Mirmoeini jPaul Santerre Tessa Gordon Gregory HBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

Inflammasome links traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1644-1664页

作者： Gabriela Seplovich Yazan Bouchi juan Pablo de Rivero Vaccari jennifer c.Munoz Pareja Andrew Reisner Laura Blackwell Yehia Mechref Kevin K.Wang j.Adrian Tyndall Binu Tharakan Firas Kobeissy Department of Surgery Morehouse School of MedicineAtlantaGAUSA Department of Neurobiology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA Department of Neurological Surgery and the Miami Project to cure Paralysis University of Miami Miller School of MedicineMiamiFLUSA Division of Pediatric critical care Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA Department of Pediatrics Emory UniversityAtlantaGAUSA Department of Neurosurgery Children’s Healthcare of AtlantaAtlantaGAUSA Department of chemistry and Biochemistry Texas Tech UniversityLubbockTXUSA Morehouse School of Medicine AtlantaGAUSA

Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease are three distinct neurological disorders that share common pathophysiological mechanisms involving neuroinflammation. One sequela of neuroinflammation includes the pathologic hyperphosphorylation of tau protein, an endogenous microtubule-associated protein that protects the integrity of neuronal cytoskeletons. Tau hyperphosphorylation results in protein misfolding and subsequent accumulation of tau tangles forming neurotoxic aggregates. These misfolded proteins are characteristic of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease and can lead to downstream neuroinflammatory processes, including assembly and activation of the inflammasome complex. Inflammasomes refer to a family of multimeric protein units that, upon activation, release a cascade of signaling molecules resulting in caspase-induced cell death and inflammation mediated by the release of interleukin-1β cytokine. One specific inflammasome, the NOD-like receptor protein 3, has been proposed to be a key regulator of tau phosphorylation where it has been shown that prolonged NOD-like receptor protein 3 activation acts as a causal factor in pathological tau accumulation and spreading. This review begins by describing the epidemiology and pathophysiology of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease. Next, we highlight neuroinflammation as an overriding theme and discuss the role of the NOD-like receptor protein 3 inflammasome in the formation of tau deposits and how such tauopathic entities spread throughout the brain. We then propose a novel framework linking traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease as inflammasomedependent pathologies that exist along a temporal continuum. Finally, we discuss potential therapeutic targets that may intercept this pathway and ultimately minimize long-term neurological decline.

关键词： Alzheimer's disease caspase-1 chronic traumatic encephalopathy inflammasomes neurodegeneration neuroinflammation NLRP1 NLRP3 pyroptosis tauopathy traumatic brain injury

Bio-inspired tetracarbene compounds as a new family of energy saving catalysts

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journal of Energy chemistry 2023年第4期79卷 559-561页

作者： Bo Zhang Fritz E.Kühn cAS Key Laboratory of Science and Technology on Applied catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina' University of chinese Academy of Science Beijing 100049China Molecular catalysis Catalysis Research Center and Department of ChemistrySchool of Natural SciencesTechnical University of MunichLichtenbergstr 485748 Garching bei MünchenGermany

Efficient use of energy is a pressing *** of chemical processes is currently an important target for energy *** chemical processes are independent of pathways with respect to the final energy output or consumption,the application of catalysts can reduce involved activation energies considerably and therefore save large amounts of energy.

关键词： catalysis Iron carbenes Multidentate ligands

Exploring the light-quark interaction

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chinese Physics c 2009年第12期33卷 1189-1196页

作者：常雷 Ian c. cLOЁT Bruno El-BENNIcH Thomas KLhn craig D. ROBERTS Institute of Applied Physics and computational Mathematics Department of Physics University of Washington Seattle WA 98195 USA Physics Division Argonne National Laboratory Argonne Illinois 60439 USA Department of Physics Peking University

Two basic motivations for an upgraded jLab facility are the needs： to determine the essential nature of light-quark confinement and dynamical chiral symmetry breaking （DcSB）; and to understand nucleon structure and spectroscopy in terms of QcD＇s elementary degrees of freedom. During the next ten years a programme of experiment and theory will be conducted that can address these questions. We present a Dyson- Schwinger equation perspective on this effort with numerous illustrations, amongst them： an interpretation of string^breaking; a symmetry-preserving truncation for mesons; the nucleon＇s strangeness σ-term; and the neutron＇s charge distribution.

关键词： Bethe-Salpeter equations bound-states confinement dynamical chiral symmetry breaking,Dyson-Schwinger equations Faddeev equation nucleon electromagnetic form factors

compositional complexity dependence of dislocation density and mechanical properties in high entropy alloy systems

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Progress in Natural Science:Materials International 2020年第4期30卷 545-551页

作者： P.Thirathipviwat G.Song j.Bednarcik U.Kühn T.Gemming K.Nielsch j.Han Leibniz Institute of Solid State and Materials Research (IFW Dresden) Frontier Research center for Applied Atomic Sciences Ibaraki University Division of Advanced Materials Engineering and Institute for rare metals Kongju National University Institute of Physic Pavol Jozef Safarik University in Ko?ice Deutsches Elektronen-Synchrotron (DESY) Institute of Materials Science Technische Universit?t Dresden Institute of Applied Physics Technische Universit?t Dresden Korea Institute for Rare Metals Korea Institute of Industrial Technology (KITECH)

This study focuses on a quantitative analysis of dislocation accumulation after cold plastic deformation and mechanical properties of Fe Ni co cr Mn and Ti Nb Hf Ta Zr high entropy alloys(HEAs) which are single phase fcc and bcc solid solutions, respectively. In order to study the role of compositional complexity from unary to quinary compositions on dislocation accumulation and mechanical properties after plastic deformation, the single solid solution phase forming sub-alloys of the two HEAs were investigated. All studied samples revealed a large plastic deformability under cold-rotary swaging process by 85–90% area reduction without intermediate annealing. The dislocation density of all studied samples, determined by Williamson-Hall method on synchrotron X-ray diffraction patterns, were between 1014-1015m-2dependent on the alloy composition. The level of dislocation density after plastic deformation is not only affected by the number of constituent element but the lattice distortion and intrinsic properties in terms of stacking fault energy, modulus misfit, and melting point also impact the dislocation storage. The level of dislocation density determines the level of mechanical properties because of a resistance to dislocation motions. The hardness and yield compressive strength of the studied samples are proportional to the level of dislocation density.

关键词： High entropy alloys Dislocation density Synchrotron XRD Mechanical properties

Hydromechanical behaviors of andesite under different stress states during fluid injection

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journal of Rock Mechanics and Geotechnical Engineering 2021年第4期13卷 727-744页

作者： Miao He Qi Li Xiaying Li Liang Xu Michael Kühn State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China University of chinese Academy of Sciences Beijing100049China Fluid Systems Modelling Section GFZ German Research Centre for GeosciencesPotsdamGermany Institute of Earth and Environmental Science University of PotsdamPotsdamGermany

Water reinjection into the formation is an indispensable operation in many energy engineering *** operation involves a complex hydromechanical(HM)coupling process and sometimes even causes unpredictable disasters,such as induced *** is acknowledged that the relative magnitude and direction of the principal stresses significantly influence the HM behaviors of rocks during ***,due to the limitations of current testing techniques,it is still difficult to comprehensively conduct laboratory injection tests under various stress conditions,such as in triaxial extension stress *** this end,a numerical study of HM changes in rocks during injection under different stress states is *** this model,the saturated rock is first loaded to the target stress state under drainage conditions,and then the stress state is maintained and water is injected from the top to simulate the formation injection *** attention is given to the difference in HM changes under triaxial compression and extension *** includes the differences in the pore pressure propagation,mean effective stress,volumetric strain,and stress-induced *** numerical results demonstrate that the differential stress will significantly affect the HM behaviors of rocks,but the degree of influence is different under the two triaxial stress *** HM changes caused by the triaxial compression stress states are generally greater than those of extension,but the differences decrease with increasing differential stress,indicating that the increase in the differential stress will weaken the impact of the stress state on the HM *** addition,the shear failure potential of fracture planes with various inclination angles is analyzed and summarized under different stress *** is recommended that engineers could design suitable injection schemes according to different tectonic stress fields versus fault occurrence to reduce the risk of

关键词： Water reinjection Stress state Hydromechanical(HM)coupling Injection-induced seismicity Numerical modeling