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journal of Innovative Optical Health Sciences 2015年第1期8卷 40-59页

作者： Carl j.fisher Lothar Lilge Department of Medical Biophysics University of Toronto Princess Margaret Cancer Centre 101 College StRm.15-710 TorontoON M5G 1L7 University Health Network Princess Margaret Cancer Centre 101 College St Rm.15-310TorontoON M5G 1L7

Invasive grade III and IV maliguant gliomas remain difficult to treat with a typical survival time post-diagnosis hovering around 16 months with only minor extension thereof seen in the past decade,whereas some improvements have been obtained towards five-year survival rates for which completeness of resection is a *** techniques such as fluorescence guided resection(FGR)and photodynamic therapy(PDT)are promising adjuvant techniques to in-crease the tumor volume reduction *** has been used in combination with surgical resection or alternatively as standalone treat ment strategy with some sucoess in extending the median survival time of patients compared to surgery alone and the current standard of *** document reviews the outcome of past clinical trials and highlights the general shift in PDT therapeutic *** also looks at the current approaches for interstitial PDT and research options into increasing PDT's glioma treatment fficacy through exploiting both physical and biological based approaches to maximize PDT selectivity and therapeutic index,particularly in brain adjacent to tumor(BAT).Potential reasons for failing to demonstrate a significant survival advantage in prior PDT clinical trials will become evident in light of the improved understanding of glioma biology and PDT dosimetry.

关键词： Oncology brain tumour photodynamic dose therapeutic index photofin aminolu-velinic acid

Tunable catalytic activity of gadolinium-doped ceria nanoparticles for pro-oxidation of hydrogen peroxide

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Nano Research 2020年第9期13卷 2384-2392页

作者： Anuja Bhalkikar Tai-Sing Wu Tamra j.fisher Anandakumar Sarella Dawei Zhang Yi Gao Yun-Liang Soo Chin Li Cheung Department of Chemistry University of Nebraska-LincolnLincolnNE 68588USA Department of Physics "National Tsing Hua University"Hsinchu 30013TaiwanChina Nebraska Center for Materials and Nanoscience University of Nebraska-LincolnLincolnNEB 68588USA Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China "National Synchrotron Radiation Research Centre" Hsinchu 30076TaiwanChina

We report a study of the roles of gadolinium(lll)(Gd3+)dopants in influencing the catalytic activity of gadolinium-doped ceria nanoparticles towards the pro-oxidation of hydrogen peroxide to hydroxyl *** doped ceria nanoparticles with dopant concentrations of 0.6 wt.%,3 wt.%,and 6 wt.%Gd^3+were synthesized using an ozone-mediated method for tuning their catalytic *** Gd dopants were found to foster an increase in the percentage of Ce^3+ions in the doped ceria *** reaction kinetic study revealed that the relationship between the overall reaction rates and the Gd dopant concentrations in our doped materials followed a volcano-like *** contrast,the apparent activation energy values of these Gd-doped ceria nanoparticles were found to be positively associated with the concentrations of Gd *** overall catalytic activity trend was attributed to the interplay between the promotion and degradation effects of the Gd dopants on the properties of doped ceria nanoparticles.

关键词： ceria cerium oxide gadolinium pro-oxidation hydrogen peroxide hydroxyl radicals ozone

Development of Monodispersed Polymeric Media for Purification and Analysis of Biomacromolecules

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Development of Monodispersed Polymeric Media for Purificatio...

第十五次全国色谱学术报告会

作者： j.Maikner j.fisher A.Gehris M.Kinzey M.Vanderhoff Rohm and Haas Company. 727 Norristown Rd. Spring HousePA 19477 Rohm and Haas Company. 727 Norristown Rd. Spring HousePA 19477 Rohm and Haas Company. 727 Norristown Rd. Spring HousePA 19477 Rohm and Haas Company. 727 Norristown Rd. Spring HousePA 19477 Rohm and Haas Company. 727 Norristown Rd. Spring HousePA 19477

＜正＞We have developed a novel technology which can be used to prepare highly uniform polymeric microparticles with controlled pore structure and high rigidity. The monodispersed polymeric micorparticles have demonstrated superior performances in column chromatography separation and analysis of biomacromolecules. For example, influenza peptide M1, [H]-Gly-Ile-Leu-Gly-Phe-Val-Phe-Thr-Leu-[OH], is of interest for its utility in the area of vaccine

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增量调制在广播中的应用

广播与电视技术 1987年第1期 51-55页

作者： G·Carter j.fisher 展望

由于数字声频系统的潜在的透明性和最终信号的高质量,对听众进行高质量信号的数字广播是具有吸引力的。用传统的脉码调制(PCM)法进行信号处理尽管性能良好,但在接收机中需要采用复杂而精确的电路,因此价格昂贵。Dolby实验室已研究出一... 详细信息

由于数字声频系统的潜在的透明性和最终信号的高质量,对听众进行高质量信号的数字广播是具有吸引力的。用传统的脉码调制(PCM)法进行信号处理尽管性能良好,但在接收机中需要采用复杂而精确的电路,因此价格昂贵。Dolby实验室已研究出一种自适应增量调制(ADM)法,采用这种方法,在接收机中使用简单得多的、廉价的译码器就可获得与PCM相当的质量。

关键词：声频系统 ADM 增量调制 △调制译码器解码器广播

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地球的过去和现在

地球的过去和现在

通过分子生物学、组织学及临床检测手段对比研究视黄醇和视黄酸作用在人体皮肤上的功效

丛书名：科技英语通俗读物

1965年

作者：（英）费希尔（j.fisher）涂云深注释

本书分为：首先简述宇宙各个星体的概况，重点放在地球的形成；其次讲述日照、降雨、风吹、植物生长等自然现象；最后讲述地球上山、川、湖泊、海洋、气候等对生物的关系等三部分。

ISBN: (纸本)9017·602

关键词：语言、文字常用外国语

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通过分子生物学、组织学及临床检测手段对比研究视黄醇和视黄酸作...

Azoospermia:vasal agenesis

第十一届中国化妆品学术研讨会

作者： Rong Kong Yilei Cui Gary j.fisher 王小娟陈银杯 Louise M. Schneider Gopa Majmudar 廖峰安利公司密歇根州大学皮肤病学部安利(中国)研发中心有限公司

目的:全反式视黄醇是视黄酸的前体,且是有效的抗衰老成分,被广泛应用于皮肤护理产品中。相比之下,视黄酸通常被认为具有更好的抗衰老效果,但关于直接对比视黄醇和视黄酸对皮肤功效的研究非常有限。通过研究,对比视黄醇和视黄酸对皮肤结... 详细信息

目的:全反式视黄醇是视黄酸的前体,且是有效的抗衰老成分,被广泛应用于皮肤护理产品中。相比之下,视黄酸通常被认为具有更好的抗衰老效果,但关于直接对比视黄醇和视黄酸对皮肤功效的研究非常有限。通过研究,对比视黄醇和视黄酸对皮肤结构,以及与皮肤功能相关的基因和蛋白质表达的影响。此外,检测视黄醇治疗对皮肤外观的作用效果。方法:通过HE染色和体内共焦显微镜进行皮肤组织学检查。此外,通过RT-PCR与免疫组化的方法分析皮肤基因与蛋白的表达水平。视黄醇改善皮肤外观效果评估是使用基于皱纹分析的图像分析方法进行的。结果:通过4周的视黄醇和视黄酸的使用,表皮厚度增加,真皮内胶原蛋白基因1型(COL1A1)和3型(COL3A1)以及他们对应的Ⅰ型、Ⅲ型前胶原蛋白表达都得到增加。同时,面部图像分析显示使用视黄醇12周后,面部皱纹呈现显著下降。结论:研究结果表明,如皮肤活检和无创图像分析所示,局部应用视黄醇可显著影响到表皮与真皮的细胞分子特性。虽然幅度相对较小,但视黄醇也如同视黄酸一样表达出类似的皮肤组织学以及基因和蛋白质表达的变化。

关键词：视黄醇视黄酸表皮厚度胶原蛋白祛皱体内共焦显微镜

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Asian journal of Andrology 2022年第1期24卷 1-4页

作者： j Sam fisher Edward D Kim Department of Urology University of TennesseeKnoxvilleTN 37920USA

SPECIFIC GENETIC TESTS(CFTR AND INTRON 8 SPLICE VARIANT TESTING)AND THEIR SIGNIFICANCE Congenital bilateral absence of the vas deferens(CBAVD)and cystic fibrosis(CF)began as separate entities with an apparent clinical *** occurs in 1%–2%of men presenting with infertility at urological departments and has an incidence of 1:1000–1:2000 in Caucasian *** example of this anatomic variant is shown in Figure 1.

关键词： correlation. clinical Figure

Associations of self-reported and device-assessed physical activity with fatigue,quality of life,and sleep quality in adults living with and beyond cancer

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journal of Sport and Health Science 2023年第6期12卷 664-673,F0003页

作者： Phillippa Lally Natalie Ella Miller Claire Lawrence Rebecca j Beeken Abigail fisher Department of Behavioural Science and Health University College LondonLondon WC1E 6BTUK Department of Psychology University of SurreyGuildford GU27XHUK Leeds Institute of Health Sciences Leeds LS29NLUK

Background Greater physical activity is associated with improved outcomes in people living with and beyond ***,most studies in exercise oncology use self-reported measures of physical *** have explored agreement between self-reported and device-based measures of physical activity in people living with and beyond *** study aimed to describe physical activity in adults affected by cancer across self-reported and device-assessed activity,to explore levels of agreement between these measures in terms of their utility for categorizing participants as meeting/not meeting physical activity guidelines,and to explore whether meeting guidelines is associated with fatigue,quality of life,and sleep *** A total of 1348 adults living with and beyond cancer from the Advancing Survivorship Cancer Outcomes Trial completed a survey assessing fatigue,quality of life,sleep quality,and physical *** Godin-Shephard Leisure-Time Physical Activity Questionnaire was used to calculate a Leisure Score Index(LSI)and an estimate of moderate-to-vigorous physical activity(MVPA).Average daily steps and weekly aerobic steps were derived from pedometers worn by *** The percentage of individuals meeting physical activity guidelines was 44.3%using LSI,49.5%using MVPA,10.8%using average daily steps,and 28.5%using weekly aerobic ***(Cohen'sκ)between self-reported and pedometer measures ranged from 0.13(LSI *** daily steps)to 0.60(LSI ***).After adjusting for sociodemographic and health-related covariates,meeting activity guidelines using all measures was associated with not experiencing severe fatigue(odds ratios(ORs):1.43–1.97).Meeting guidelines using MVPA was associated with no quality-of-life issues(OR=1.53).Meeting guidelines using both self-reported measures were associated with good sleep quality(ORs:1.33–1.40).Conclusion Less than half of all adults affected by cancer are meeting physical activity guidelines,

关键词： Cancer survivorship Fatigue Physical activity Quality of life SleepTagedAPTARAEnd

Systems biology approaches for studying the pathogenesis of non-alcoholic fatty liver disease

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World journal of Gastroenterology 2014年第41期20卷 15070-15078页

作者： Ciarán P fisher Andrzej M Kierzek Nick j Plant j Bernadette Moore Faculty of Health and Medical Sciences University of Surrey

Non-alcoholic fatty liver disease (NAFLD) is a progressive disease of increasing public health concern. In western populations the disease has an estimated prevalence of 20%-40%, rising to 70%-90% in obese and type II diabetic individuals. Simplistically, NAFLD is the macroscopic accumulation of lipid in the liver, and is viewed as the hepatic manifestation of the metabolic syndrome. However, the molecular mechanisms mediating both the initial development of steatosis and its progression through non-alcoholic steatohepatitis to debilitating and potentially fatal fibrosis and cirrhosis are only partially understood. Despite increased research in this field, the development of non-invasive clinical diagnostic tools and the discovery of novel therapeutic targets has been frustratingly slow. We note that, to date, NAFLD research has been dominated by in vivo experiments in animal models and human clinical studies. Systems biology tools and novel computational simulation techniques allow the study of large-scale metabolic networks and the impact of their dysregulation on health. Here we review current systems biology tools and discuss the benefits to their application to the study of NAFLD. We propose that a systems approach utilising novel in silico modelling and simulation techniques is key to a more comprehensive, better targeted NAFLD research strategy. Such an approach will accelerate the progress of research and vital translation into clinic.

关键词： Non-alcoholic fatty liver disease Network Metabolism Systems biology Modelling Regulation Simulation

Multilayer network analysis:new opportunities and challenges for studying animal social systems

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Current Zoology 2021年第1期67卷 45-48页

作者： Matthew j.HASENjAGER Matthew SILk David N.fisher Department of Biological Sciences Royal HollowayUniversity of LondonEghamUK Centre for Ecology and Conservation University of ExeterExeterUK School of Biological Sciences University of AberdeenAberdeenUK

Introduction Many behavioral,ecological,and evolutionary processes are closely intertwined with patterns of social interactions,such as the evolution of cooperation(Croft et al.2006),information and disease transmission(VanderWaal et al.2014;Aplin et al.2015),predator-prey dynamics(Ioannou et al.2012),and dispersal decisions(Blumstein et al.2009).Even in species where individuals are traditionally viewed as leading a relatively solitary existence,interac-tions occur across diverse contexts,including territorial defense,resource competition,and courtship.

关键词： solitary predator network