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基于UPLC-MS/MS的全氟及多氟烷基化合物在斑马鱼体内的生物富集与组织分布研究

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分析测试学报 2024年第8期43卷 1189-1196页

作者：曾海深何财杨运云曾细柳谢嘉良刘宁邓洁薇栾天罡化学与精细化工广东省实验室揭阳分中心(广东省榕江实验室) 广东揭阳515200 广东工业大学生物医药学院广东广州510006 广东省科学院测试分析研究所(中国广州分析测试中心) 广东广州510070 五邑大学环境与化学工程学院广东江门529020

采用超高效液相色谱-串联质谱(UPLC-MS/MS)研究了全氟及多氟烷基化合物(PFASs)在斑马鱼体内的生物富集与组织分布。以全氟辛烷磺酸(PFOS)、全氟辛酸(PFOA)、全氟己烷磺酸(PFHxS)和全氟癸酸(PFDA)对斑马鱼联合暴露7、21、28 d,暴露浓度为... 详细信息

采用超高效液相色谱-串联质谱(UPLC-MS/MS)研究了全氟及多氟烷基化合物(PFASs)在斑马鱼体内的生物富集与组织分布。以全氟辛烷磺酸(PFOS)、全氟辛酸(PFOA)、全氟己烷磺酸(PFHxS)和全氟癸酸(PFDA)对斑马鱼联合暴露7、21、28 d,暴露浓度为100μg/L。斑马鱼不同组织器官分离后,用甲醇进行提取,以UPLC-MS/MS进行检测,负离子多反应监测(MRM)模式进行定量测定。结果表明,4种PFASs在1~200μg/L范围内线性关系良好,相关系数(r)不小于0.9974,检出限(LOD)和定量下限(LOQ)分别为0.072~0.152 ng/g和0.287~0.609 ng/g。斑马鱼暴露于4种PFASs后,其体内各器官均分布有上述4种污染物。其中PFDA和PFOS在暴露7、21、28 d的斑马鱼体内器官的积累程度相对较高;PFOA主要在肠道和肝脏中的积累量较高;PFHxS在斑马鱼体内的积累量最低,在各器官中的含量对4种污染物含量总和的相对贡献均低于13%。该研究为探索PFASs在水生生物体内的环境行为和生态风险提供了科学依据。

关键词：超高效液相色谱-串联质谱斑马鱼全氟及多氟烷基化合物生物富集组织分布

Real-world treatment attrition rates in advanced esophagogastric cancer

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World journal of Gastroenterology 2020年第39期26卷 6027-6036页

作者： erica S Tsang Howard j lim Daniel j Renouf janine M Davies jonathan M Loree Sharlene Gill Department of Medicine BC CancerVancouver V5Z 4E6Canada Division of Medical Oncology University of British ColumbiaVancouver V5Z 4E6Canada

BACKGROUND Over the last decade,multiple agents have demonstrated efficacy for advanced esophagogastric cancer(eGC).Despite the availability of later lines of therapy,there remains limited real-world data about the treatment attrition rates between lines of *** To characterize the use and attrition rates between lines of therapy for patients with advanced *** We identified patients who received at least one cycle of chemotherapy for advanced eGC between july 1,2017 and july 31,2018 across six regional centers in British Columbia(BC),***,treatment,and outcomes data were *** Of 245 patients who received at least one line of therapy,median age was 66 years(IQR 58.2-72.3)and 186(76%)were male,eastern Cooperative Oncology Group(eCOG)performance status 0/1(80%),gastric vs Gej(36%vs 64%).Histologies included adenocarcinoma(78%),squamous cell carcinoma(8%),and signet ring(14%),with 31%HeR2 positive.72%presented with de novo disease,and 25%had received previous *** was a high level of treatment attrition,with patients receiving only one line of therapy n=122,50%),two lines n=83,34%),three lines n=34,14%),and four lines n=6,2%).Kaplan-Meier analysis demonstrated improved survival with increasing lines of therapy(median overall survival 7.7 vs 16.6 vs 22.8 vs 40.4 mo,Pe Cox regression,improved survival was associated with better baseline eCOG and increased lines of therapy(Pe steep attrition rates between therapies highlight the unmet need for more efficacious early-line treatment options for patients with advanced eGC.

关键词： esophagogastric cancer Gastric cancer Treatment attrition Systemic therapy Treatment outcomes Real-world evidence

Triple combination targeting PI3K,eR,and CDK4/6 inhibits growth of eR-positive breast cancer resistant to fulvestrant and CDK4/6 or PI3K inhibitor

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Cancer Communications 2023年第6期43卷 720-725页

作者： Mikkel G.Terp Martina Tuttolomondo Neil Portman Sidse ehmsen Lene e.johansen Martin Bak elgene lim Henrik j.Ditzel Department of Cancer and Inflammation Research Institute of Molecular MedicineUniversity of Southern DenmarkOdenseDenmark Garvan Institute of Medical Research DarlinghurstSydneyNew SouthWalesAustralia St.Vincent’s Clinical School Faculty of MedicineUniversity of New SouthWales SydneySydneyNew South WalesAustralia Department of Oncology Institute of Clinical ResearchOdense University HospitalOdenseDenmark Department of Pathology Sydvestjysk SygehusEsbjergDenmark Academy of Geriatric Cancer Research(AgeCare) Odense University HospitalOdenseDenmark

Dear editor,Despite the improved outcome of advanced estrogen receptor-positive(eR+)breast cancer patients treated with endocrine therapy in combination with either a cyclindependent kinase 4/6 inhibitor(CDK4/6i)or a phosphoinositide 3-kinase inhibitor(PI3Ki),the disease will eventually progress,and the optimal treatment strategy upon progression remains undefined[1-4].To address this,we developed MCF-7-and T47D-derived PIK3CAmutated breast cancer cell lines[5]resistant to combined CDK4/6i palbociclib and fulvestrant(MPF-R and TPFR)or combined PI3Ki alpelisib and fulvestrant(MAF-R and TAF-R),respectively(Supplementary Materials and Methods).Drug-sensitive isogenic cells(M-S and T-S)grown in parallel with MPF-R and TPF-R cells and the original MCF-7/S0.5 and T47D cells were analyzed for comparison.

关键词： PIK3CA breast cancer

“玉器概论”课程中“工匠精神”的思政元素教学探索

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中国宝玉石 2024年第2期 50-56页

作者：牟云金翠玲王甜河北地质大学宝石与材料学院石家庄050031

通过分析传统思政课程的弊端及原因,根据社会需求和人才培养目标确定“玉器概论”课程的思政方向和思政目标。教师建立课程组,形成“前铺垫,后延伸”的持续教学机制,挖掘“玉器概论”课程中“工匠精神”的“思政”元素,开展线上线下混... 详细信息

通过分析传统思政课程的弊端及原因,根据社会需求和人才培养目标确定“玉器概论”课程的思政方向和思政目标。教师建立课程组,形成“前铺垫,后延伸”的持续教学机制,挖掘“玉器概论”课程中“工匠精神”的“思政”元素,开展线上线下混合教学模式,构建师生教学共同体。全面整合“玉器概论”的思政教学理念和教学方法,探索将“工匠精神”贯穿大学四年的课程思政途径。“玉器概论”课程中融入“工匠精神”将促进教师及教师队伍的思政能力提升,有助于更好的完成人才培养计划,提升学生的综合能力,是为社会培养优秀人才的有效教育方式。

关键词：玉器概论工匠精神课程思政

Chaos,Transport and Mesh Convergence for Fluid Mixing

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Acta Mathematicae Applicatae Sinica 2008年第3期24卷 355-368页

作者： H. lim Y. Yu j. Glimm X.L. Li D.H. Sharp Department of Applied Mathematics and Statistics Stony Brook University Stony Brook NY 11794-3600 USA Computational Science Center Brookhaven National Laboratory Upton N~ 11793-6000 USA Los Alamos National Laboratory Los Alamos NM USA

Chaotic mixing of distinct fluids produces a convoluted structure to the interface separating these fluids. For miscible fluids （as considered here）, this interface is defined as a 50% mass concentration isosurface. For shock wave induced （Richtmyer-Meshkov） instabilities, we find the interface to be increasingly complex as the computational mesh is refined. This interfacial chaos is cut off by viscosity, or by the computational mesh if the Kolmogorov scale is small relative to the mesh. In a regime of converged interface statistics, we then examine mixing, i.e. concentration statistics, regularized by mass diffusion. For Schmidt numbers significantly larger than unity, typical of a liquid or dense plasma, additional mesh refinement is normally needed to overcome numerical mass diffusion and to achieve a converged solution of the mixing problem. However, with the benefit of front tracking and with an algorithm that allows limited interface diffusion, we can assure convergence uniformly in the Schmidt number. We show that different solutions result from variation of the Schmidt number. We propose subgrid viscosity and mass diffusion parameterizations which might allow converged solutions at realistic grid levels.

关键词： Schmidt number mass diffusion turbulence multiphase flow

Bioregeneration of spent activated carbon:Review of key factors and recent mathematical models of kinetics

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Chinese journal of Chemical engineering 2018年第5期26卷 893-902页

作者： Kwok-Yii Leong Siew-Leng Loo Mohammed j.K.Bashir Wen-Da Oh Pasupuleti Visweswara Rao jun-Wei lim Centre for Water Research Department of Civil and Environmental Engineering National University of Singapore Singapore Membrane Technology Centre Nanyang Environment and Water Research Institute Nanyang Technological University Department of environmental engineering Faculty of Engineering and Green Technology (FEGT) Universiti Tunku Abdul Rahman Residues & Resource Reclamation Centre Nanyang Environment and Water Research Institute (NEWRI) Nanyang Technological University Bio Product Development Program Faculty of Agro-Based Industry Universiti Malaysia Kelantan Institute of Food Security and Sustainable Agriculture Universiti Malaysia Kelantan Department of Fundamental and Applied Sciences Universiti Teknologi PETRONAS

The disposal of spent activated carbon(AC) will inevitably create secondary pollution. In overcoming this problem, the spent AC can be regenerated by means of biological approach. Bioregeneration is the phenomenon in which through the action of microorganisms, the adsorbed pollutants on the surface of the AC will be biodegraded and this enables further adsorption of pollutants to occur with time elapse. This review provides the challenges and perspectives for effective bioregeneration to occur in biological activated carbon(BAC)column. Owing to very few reported works on the bioregeneration rate in BAC column, emphasis is put forward on the recently developed models of bioregeneration kinetic in batch system. All in all, providing potential solutions in increasing the lifespan of AC and the enhancement of bioregeneration rate will definitely overcome the bottlenecks in spent AC bioregeneration.

关键词： Bioregeneration Spent activated carbon Modeling of bioregeneration kinetic Concentration gradient exoenzyme

Locally recurrent penile apocrine carcinoma initially diagnosed as metastatic adenocarcinoma of colon

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Chinese journal of Cancer Research 2013年第6期25卷 777-780页

作者： Ok-jun Lee Seok-joong yun Wun-j.e Kim Song-Yi Choi Ho-Chang Lee Hyung-Geun Song Sung-Nam lim Ki-Hyeong Lee Seung-Taik Kim Hye-Suk Han Department of Pathology College of MedicineChungbuk National University Department of Urology College of MedicineChungbuk National University Department of Internal Medicine College of MedicineChungbuk National University Department of Internal Medicine College of MedicineChungbuk National University

Apocrine carcinoma is a rare malignant adnexal neoplasm. The differential diagnosis between apocrine carcinoma and cutaneous metastasis is often difficult. Here, we report a case of locally recurrent penile apocrine carcinoma initially diagnosed as metastatic adenocarcinoma of the colon. A 75-year-old man with a history of surgical resection due to sigmoid colon cancer and penile metastasis two years prior to this study presented with a nodule at the left penile base. He underwent a wide local resection of the penile mass under a suggested preoperative diagnosis of extra-mammary Paget＇s disease （eMPD） associated with previous sigmoid colon cancer. However, the previously and currently resected penile masses were identified as primary apocrine carcinoma upon hematoxylin and eosin （H＆e） staining and immunohistochemical staining. Although the incidence is extremely rare, both clinicians and pathologists should be alert to the possibility of synchronous double primary apocrine carcinoma in cancer patients with malignant cutaneous lesions.

关键词： Apocrine glands carcinoma colon cancer penis

A general result on precise asymptotics for linear processes of positively associated sequences

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Applied Mathematics(A journal of Chinese Universities) 2008年第2期23卷 190-196页

作者： TAN Xi-li YANG Xiao-yun Dept. of Math Beihua Univ. Jilin 132013 China Institute of Math. Jilin Univ.（Qianwei Campus） Changchun 130012 China

Let {εt; t ∈ Z^＋} be a strictly stationary sequence of associated random variables with mean zeros, let 0〈eε1^2〈∞ and σ^2=eε1^2＋1∑j=2^∞ eε1εj with 0〈σ^2〈∞.{aj;j∈Z^＋} is a sequence of real numbers satisfying ∑j=0^∞｜aj｜〈∞.Define a linear process Xt=∑j=0^∞ ajεt-j,t≥1,and Sn=∑t=1^n Xt,n≥*** that e｜ε1｜^2＋δ′〈 for some δ′〉0 and μ（n）=O（n^-ρ） for some ρ〉*** paper achieves a general law of precise asymptotics for {Sn}.

关键词： PA sequence linear process general law precise asymptotics.

On multivariable Zassenhaus formula

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Frontiers of Mathematics in China 2019年第2期14卷 421-433页

作者： Linsong WANG yun GAO Naihuan jING School of Mathematics South China University of Technology Guangzhou 510640 China Departmen t of Mathema tics and Statis tics York Uni vers 辻 y Toronto ON M3J 1P3 Canada Department of Mathematics North Carolina State University Raleigh NC 27695 USA

We give a recursive algorithm to compute the multivariable Zassenhaus formula e^X1+X2+…+Xn=e^X1eX2…e^Xn∏∞k=2e^Wk and derive an effective recursion formula of Wk.

关键词： Baker-Campbell-Hausdorff formula Zassenhaus formula