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NeCAB family of neuronal calcium-binding proteins in health and disease

Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael K.e.Schafer Sudena Wang Michael j.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal eF-hand calcium-binding proteins 1–3(NeCAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one eF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NeCAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NeCAB2 interacts with predominantly striatal G-protein-coupled receptors, while NeCAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NeCAB proteins exhibit distinct subcellular localizations: NeCAB1 is found in the nucleus and cytosol, NeCAB2 resides in endosomes and the plasma membrane, and NeCAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NeCAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NeCAB proteins by controlling the availability of protein–protein interaction domains situated between the eF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium eF hand mitochondria nervous system signal transduction

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基于手机信令数据的广州市居民公园访问行为空间分异及其影响因素分析

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中山大学学报（自然科学版）（中英文） 2025年第1期64卷 195-206页

作者：刘晔叶柏麟吴景豪中山大学地理科学与规划学院广东广州510006 广东省公共安全与灾害工程技术研究中心/广东省城市化与地理环境空间模拟重点实验室广东广州510006

加快推进城市公园建设是实现人与自然和谐共生的重要抓手。既有研究大多基于问卷调查数据和访谈资料分析城市居民的公园访问行为空间分异特征,研究结论的普适性和科学性有限。手机信令数据具有大样本、覆盖范围广、信息被动提供和动态... 详细信息

加快推进城市公园建设是实现人与自然和谐共生的重要抓手。既有研究大多基于问卷调查数据和访谈资料分析城市居民的公园访问行为空间分异特征,研究结论的普适性和科学性有限。手机信令数据具有大样本、覆盖范围广、信息被动提供和动态实时性强等优点。利用手机信令数据精准刻画城市居民的公园访问行为,有助于开展城市公园的布局优化与品质提升工作。基于个体尺度的手机信令数据,本研究试图揭示广州市居民公园访问行为的空间分异特征并识别其影响因素,尤其关注城区居民和郊区居民的差别。结果表明:(1)城区居民的公园访问频率、公园访问时长和公园访问强度均高于郊区居民,前者的公园平均访问距离低于后者;(2)公园访问频率、公园访问强度、公园平均逗留时间和公园平均访问距离呈现高值集聚区/低值集聚区在城区连片分布,在郊区零星分布的空间特征;(3)公园访问行为受性别、年龄、时空约束性、社会经济地位、公园可达性、社区出行便利性和出行适宜性等因素的共同影响。本研究为相关政府部门精准开展城市公园的规划、建设与管理工作提供决策参考。

关键词：城市公园公园访问行为空间分异手机信令数据广州

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Comparative analysis of empirical and deep learning models for ionospheric sporadic e layer prediction

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earth and Planetary Physics 2025年第1期9卷 10-19页

作者： BingKun Yu PengHao Tian XiangHui Xue Christopher jScott HaiLun ye jianFei Wu Wen Yi TingDi Chen XianKang Dou Institute of Deep Space Sciences Deep Space Exploration LaboratoryHefei 230088China CAS Key Laboratory of Geospace environment School of Earth and Space SciencesUniversity of Science and Technology of ChinaHefei 230026China Hefei National Laboratory University of Science and Technology of ChinaHefei 230088China Department of Meteorology University of ReadingReading RG66BBUK

Sporadic e(es)layers in the ionosphere are characterized by intense plasma irregularities in the e region at altitudes of 90-130 *** they can significantly influence radio communications and navigation systems,accurate forecasting of es layers is crucial for ensuring the precision and dependability of navigation satellite *** this study,we present es predictions made by an empirical model and by a deep learning model,and analyze their differences comprehensively by comparing the model predictions to satellite RO measurements and ground-based ionosonde *** deep learning model exhibited significantly better performance,as indicated by its high coefficient of correlation(r=0.87)with RO observations and predictions,than did the empirical model(r=0.53).This study highlights the importance of integrating artificial intelligence technology into ionosphere modelling generally,and into predicting es layer occurrences and characteristics,in particular.

关键词： ionospheric sporadic e layer radio occultation ionosondes numerical model deep learning model artificial intelligence

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Bullous pemphigoid associated with acquired hemophilia A: A case report

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World journal of Clinical Cases 2025年第4期13卷 28-33页

作者： Su-ye Hu Meng-Can Li Zi-jia Hao Xu-Ya Chai Pei-Sai Li Yang Liu Li-Xia Liu Ying Xu Pan-Pan Yang Ling-e Li Department of Dermatology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina Graduate School Hebei University of Traditional Chinese MedicineShijiazhuang 050051Hebei ProvinceChina Department of Pathology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina

BACKGROUND Acquired hemophilia A (AHA) is a rare and potentially severe bleeding disordercaused by circulating autoantibodies against factor Ⅷ (FⅧ). In approximately50% of the patients, the condition is associated with autoimmune diseases,cancers, medication use, pregnancy, and the post-partum period. Bullous pemphigoid(BP) is a chronic autoimmune subepidermal blistering disease associatedwith tissue-bound and circulating autoantibodies against BP antigens 180 (BP180)and 230 (BP230). AHA-associated BP has a high mortality rate;hence, the understandingof this disease must *** SUMMARY A 69-year-old man presented with erythema, blisters, blood blisters, and crustsaccompanied by severe pruritus for more than 20 days, and ecchymosis andswelling on his left upper arm for 3 days. Pathological examination revealed asubepidermal blister that contained eosinophils. Laboratory tests showed that theBP180 autoantibody levels had increased, isolated activated partial thromboplastintime was notably prolonged (115.6 s), and coagulation FⅧ activity wasextremely low (ermore, the FⅧ inhibitor titer had greatlyincreased (59.2 Bethesda units). Therefore, the patient was diagnosed as having BP associated with AHA, prescribed 0.05% topical halometasone cream, and transferred to a higher-level hospitalfor effective treatment;however, he died after 2 *** AHA associated BP is rare, dangerous, and has a high mortality rate. Therefore, its timely diagnosis and effectivetreatment are necessary.

关键词： Bullous pemphigoid Acquired hemophilia A Acquired hemophilia A FactorⅧ Case report

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The compound(e)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer's disease

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Neural Regeneration Research 2025年第11期20卷 3330-3344页

作者： Xueyan Liu Wei Wu Xuejuan Li Chengyan Wang Ke Chai Fanru Yuan Huijuan Zheng Yuxing Yao Chenlu Li Zu-Cheng ye Daijun Zha Department of Medicinal Chemistry School of PharmacyFujian Medical UniversityFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Institute of Laboratory Animal Center Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina Department of Hyperbaric Oxygen National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina

Previous studies have shown that the compound(e)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one(D30),a pyromeconic acid derivative,possesses antioxidant and anti-inflammatory properties,inhibits amyloid-β aggregation,and alleviates scopolamine-induced cognitive impairment,similar to the phase Ⅲ clinical drug *** this study,we established a mouse model of Alzheimer's disease via intracerebroventricular injection of fibrillar amyloid-β to investigate the effect of D30 on fibrillar amyloid-β-induced *** results showed that D30 alleviated fibrillar amyloid-β-induced cognitive impairment,promoted fibrillar amyloid-β clearance from the hippocampus and cortex,suppressed oxidative stress,and inhibited activation of microglia and astrocytes.D30 also reversed the fibrillar amyloid-β-induced loss of dendritic spines and synaptic protein ***,we demonstrated that exogenous fibrillar amyloid-βintroduced by intracerebroventricular injection greatly increased galectin-3 expression levels in the brain,and this increase was blocked by *** the role of D30 in clearing amyloid-β,inhibiting neuroinflammation,protecting synapses,and improving cognition,this study highlights the potential of galectin-3 as a promising treatment target for patients with Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β astrocyte cognitive impairment D30 dendritic spines galectin-3 microglia neuroinflammation neuron

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Constraints on what controls millennial-scale basin-wide denudation across mountain belts, Asia

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Science China earth Sciences 2025年第1期 74-93页

作者： ye YANG Steven A.BINNIe Sheng XU Cong-Qiang LIU Tibor j.DUNAI Institute of Surface-earth System Science School of Earth System Science Tianjin University Institute of Geology and Mineralogy University of Cologne

The terrestrial cosmogenic nuclide dataset consisting of 123310Be measurements of fluvial sediment samples across the Asian mountain belts is used to constrain the influence of climate,tectonics and topography on earth-surface denudation processes.10Be-derived basin-wide denudation rates were recalculated using a Monte Carlo simulation approach that relied on pixel-by-pixel production *** rates derived span four orders of magnitude,from 7.4±0.7 mm kyr-1（1σ;Central Tibetan Plateau） to 9,646744+777mm kyr-1（1σ;Southern Tibetan Plateau）,with a median of 186 mm *** our results with the traditional basin-wide production rate scaling model using a centroid coordinate and mean elevation,suggests that 96.6%of production rates will be underestimated using the latter method,especially for basins with a large *** bias between both methods reaches as large as 40%,caused by basin hypsometry and the nonlinear scaling of production rate with elevation and *** of the correlations between uniformly recalculated denudation rates and tectonics,climate,topography and rock lithology will facilitate the extrapolation of denudation rates in unknown basins using available *** the perspective of local scales,precipitation coupled with neotectonics-driven landslides is likely the most influential factor in subtropical Taiwan Island,while topography primarily constrains surface denudation rates in the eastern Tibetan Plateau within a narrow range of *** highland regions with glacier coverage,such as the Pamir,central and southern Tibetan Plateau high denudation rates are affected by glaciation,whereas lower precipitation and high erosion base level may limit river incision and evolving relief in the Central Tibetan *** contrast to local-scale findings highlighting a dominant factor constraining denudation rate,our large-scale quantitative analyses across the Asian mountain belts finds that （1） topographic metrics including

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Risk of Tropical Cyclones and Floods to Power Grids in Southeast and east Asia

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International journal of Disaster Risk Science 2024年第4期15卷 494-507页

作者： Mengqi ye Philip j.Ward Nadia Bloemendaal Sadhana Nirandjan elco e.Koks Institute for environmental Studies Vrije Universiteit Amsterdam1081 HV AmsterdamThe Netherlands Deltares 2629 HV DelftThe Netherlands Royal Netherlands Meteorological Institute(KNMI) 3731 GA De BiltThe Netherlands

Power grids play a critical role in modern society, serving as the lifeline of a well-functioning economy. This article presents a first large-scale study on the risk estimation of tropical cyclone(TC)-induced winds and coastal floods, which can widely impact power grids in Southeast and east Asia. Our comprehensive risk model incorporates detailed infrastructure data from OpenStreetMap(OSM) and government power grid maps, along with global hazard maps and vulnerability curves. The results reveal that the estimated expected annual damages from TCs and coastal floods to OSM-mapped assets account for approximately 0.07%(0.00–0.38%) and 0.02%(0.00–0.02%) of the total GDP of the study area, respectively. We analyzed the main sources of uncertainty in the risk model and emphasized the importance of understanding asset *** results highlight the urgent need to strengthen power infrastructure to withstand the impacts of natural hazards, and the significance of reliable risk information for improving power grid design and planning. Focusing on developing more region-specific infrastructure data and vulnerability curves will improve the accuracy of risk estimation and provide valuable insights not only for the electricity sector but also for customers of other infrastructure systems that heavily rely on a stable supply of electricity.

关键词： Asset level Coastal foods Power grids Risk analysis Tropical cyclones Vulnerability curves

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Quantifying Information via Shannon entropy in Spatially Structured Optical Beams

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Research 2021年第1期2021卷 780-788页

作者： Maria Solyanik-Gorgone jiachi ye Mario Miscuglio Andrei Afanasev Alan e.Willner Volker j.Sorger Department of electrical and Computer engineering The George Washington UniversityWashingtonDC 20052USA Department of Physics The George Washington UniversityWashingtonDC 20052USA Department of electrical engineering at University of Southern California Los AngelesCalifornia 90089USA

While information is ubiquitously generated,shared,and analyzed in a modern-day life,there is still some controversy around the ways to assess the amount and quality of information inside a noisy optical channel.A number of theoretical approaches based on,e.g.,conditional Shannon entropy and Fisher information have been developed,along with some experimental *** of these approaches are limited to a certain alphabet,while others tend to fall short when considering optical beams with a nontrivial structure,such as Hermite-Gauss,Laguerre-Gauss,and other modes with a nontrivial ***,we propose a new definition of the classical Shannon information via the Wigner distribution function,while respecting the Heisenberg *** this definition,we calculate the amount of information in Gaussian,Hermite-Gaussian,and LaguerreGaussian laser modes in juxtaposition and experimentally validate it by reconstruction of the Wigner distribution function from the intensity distribution of structured laser *** experimentally demonstrate the technique that allows to infer field structure of the laser beams in singular optics to assess the amount of contained *** the generality,this approach of defining information via analyzing the beam complexity is applicable to laser modes of any topology that can be described by well-behaved *** Shannon information,defined in this way,is detached from a particular alphabet,i.e.,communication scheme,and scales with the structural complexity of the *** a synergy between the Wigner distribution function encompassing the information in both real and reciprocal space and information being a measure of disorder can contribute into future coherent detection algorithms and remote sensing.

关键词： distribution Spatial complexity

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A Novel 3D Supramolecular Network Constructed from [Cu(4,4'-bipyridine)(O_2CMe)_2]_2 Molecular Ladders by Hydrogen Bonding

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Chinese journal of Structural Chemistry 2006年第11期25卷 1365-1368页

作者： YANG e WANG Xiao-Qin QIN ye-Yan College of Chemistry ＆ Materials Science Fujian Normal University Fuzhou 350007 China Fujian Institute of Research on the Structure of Matter The Chinese Academy of Sciences Fuzhou 350002 China

The title complex, {[Cu2（4,4＇-bipyridine）2（μ-O2CMe）2（O2CMe）2],H2O}n 1, was synthesized and structurally characterized by X-ray crystallography. It crystallizes in monoclinic, space group C2/c with a = 13.4474（5）, b = 11.7566（2）, c = 19.5380（6）A, β = 92.930（2）°, V = 3084.84（16） A^3, Z = 4, Cu2C28N409H30, Mr = 693.64, Dc = 1.494 g/cm^3, F（000） = 1424 and μ（MoKα） = 1.436 mm^-1. With the use of 2062 observed reflections （I 〉 2σ（I））, the structure was refined to R = 0.0769 and wR = 0.2154. In complex 1, the dimeric copper acetate units are linked through 4,4’-bipyridine to yield ID molecular ladders. These ladders are connected via O-H…O hydrogen bonds to generate 2D layers, which are further linked through C-H…O hydrogen bonds to give a 3D supramolecular network.

关键词： molecular ladder dimeric copper acetate 3D supramolecular network

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Dissecting the cell microenvironment of ovarian endometrioma through single-cell RNA sequencing

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Science China Life Sciences 2025年第1期 116-129页

作者： jiangpeng Wu Siyu Xia Wenting ye Yan Sun jing Cai Fubing Yu Haiping Wen Xiuwei Yi Taikang Li Mingwei Chen jiayun Chen Ge Song Chuanbin Yang Yali Song jigang Wang Department of Reproductive Medicine Dongguan Maternal and Child Health Care Hospital Department of Urology and Shenzhen Clinical Research Centre for GeriatricsShenzhen People's HospitalSouthern University of Science and Technology State Key Laboratory for Quality ensurance and Sustainable Use of Dao-di Herbs Artemisinin Research Centerand Institute of Chinese Materia MedicaChina Academy of Chinese Medical Sciences Reproductive Medicine Center Foshan Women and Children Hospital State Key Laboratory of Antiviral Drugs School of PharmacyHenan University

Ovarian endometrioma（Oe）, also known as “chocolate cysts,” is a cystic mass that develops in the ovaries due to endometriosis and is a common gynecological condition characterized by the growth of endometrial tissue outside the uterus, leading to symptoms such as dysmenorrhea, pelvic pain, and infertility. However, the precise molecular and cellular mechanisms driving this pathophysiology remain largely unknown, posing challenges for diagnosis and treatment. Here, we employed integrated single-cell transcriptomic profiling of over 52,000 individual cells from endometrial tissues of Oe patients and healthy donors and identified twelve major cell populations. We identified notable alterations in cell type-specific proportions and molecular signatures associated with Oe. Notably, the activation of IGFBP5+macrophages with pro-inflammatory properties, NK cell exhaustion, and aberrant proliferation of IQCG+and KLF2+epithelium are key features and may be the potential mechanisms underlying the pathogenesis of Oe. Collectively, our data contribute to a better understanding of Oe at the single cell level and may pave the way for the development of novel therapeutic strategies.

关键词： ovary high-throughput sequencing transcriptomics gene expression analysis ligand-receptor analysis

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