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肺泡上皮钠离子通道在急性肺损伤模型差异表达的研究

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中国实验诊断学 2018年第6期22卷 1062-1065页

作者：张俊志张中军赵雷蔡兴涛李莹崔媛媛深圳市人民医院.暨南大学第二临床学院麻醉科广东深圳518020

目的研究肺泡上皮钠离子通道3种亚型在不同急性肺损伤模型中的差异表达。方法雄性SD大鼠40只随机分为对照组(Control组,n=10)和3种急性肺损伤模型:脂多糖诱导组(LPS组,n=10)、盐酸诱导组(HCL组,n=10)、机械通气组(VILI组,n=10)。分别检... 详细信息

目的研究肺泡上皮钠离子通道3种亚型在不同急性肺损伤模型中的差异表达。方法雄性SD大鼠40只随机分为对照组(Control组,n=10)和3种急性肺损伤模型:脂多糖诱导组(LPS组,n=10)、盐酸诱导组(HCL组,n=10)、机械通气组(VILI组,n=10)。分别检测各组支气管肺泡灌洗液蛋白浓度和白细胞计数、钠离子通道(ENaC)三种亚型(α、β、γ)mRNA的表达和蛋白的表达。结果支气管肺泡灌洗液蛋白浓度和白细胞计数LPS组、HCL组、VILI组,均明显高于Control组,差异有统计学意义(P0.05)。β-ENaCmRNA表达各组比较差异无统计学意义(P>0.05)。γ-ENaCmRNA在VILI组表达明显降低,差异有统计学意义(P0.05)。α-ENaC蛋白表达在LPS组和HCL组明显降低(P<0.05),而γ-ENaC蛋白表达在VILI组明显降低(P<0.05)。结论急性肺损伤炎症反应过程中,肺泡上皮钠离子通道参与的亚型可能和特定的肺损伤类型相关。

关键词：钠离子通道急性肺损伤炎症

大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析

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英国医学杂志中文版 2021年第8期24卷 435-442页

作者：孟夏刘聪(校) 陈仁杰郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia jan Kysely Ales Urban Hans Orru Marek Maasikmets jouni j K jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng ng Baltazar Nunes joão Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti joel Schwartz Tangchun Wu Antonio Gasparrini 复旦大学公共卫生学院、公共卫生安全教育部重点实验室(复旦大学)、卫生部卫生技术评估重点实验室(复旦大学) 中国上海北京大学公共卫生学院复旦大学公共卫生学院不详

目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高... 详细信息

目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。

关键词：总死亡率 meta分析总死亡人数死亡风险广义线性模型二氧化氮高收入国家结局指标

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ALS时脑脊液中轴突损伤标记物水平升高

世界核心医学期刊文摘(神经病学分册) 2006年第10期 46-46页

作者： Brettschneider j. Petzold A. Sü β muth S.D. H. Tumani 郭俊 department of Neurology University of Ulm Oberer Eselsberg 45 89081UlmGermany Dr.

Objective: To test whether biomarkers for axonal degeneration correlated with clinical subtypes and were of use in predicting progression of ALS. Methods: Patients with ALS (n = 69), patients with Alzheimer disease (AD; n = 73), and age- matched controls (n = 33) were included in this prospective study. CSF levels of tau protein and neurofilaments (NfHSMI35) were measured using ELISA. In 49 patients with ALS, follow- up data were available (median follow- up 7 months). Results: CSF levels of NfHSMI35 were five times higher in patients with ALS (1.7 ng/mL) than in controls (0.3 ng/mL, p ng/mL, p < 0.001). NfHSMI35 values were also higher in patients with upper motor neuron- dominant ALS than in patients with typical ALS (upper motor neuron + lower motor neuron) at p = 0.02. Values of NfHSMI35 were higher in ALS of more rapid progression. The values of NfH and tau did not correlate with CSF protein content. Conclusions: The authors propose that axonal damage markers in CSF may discriminate between subtypes of ALS and that they could be used as markers for therapeutic trials. CSF NfH was superior to tau in these discriminations.

关键词：标记物轴突损伤 ALS

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世界核心医学期刊文摘（儿科学分册） 2006年第2期2卷 24-24页

作者： Sarles j. Berthézène P. Le Louarn C. 郭战宏 Service de Pédiatrie Multidisciplinaire Hpital d' Enfants de la Timone F-13385 Marseille Cedex 05 France Dr.

Objectives: To evaluate the performance of a strategy in which, after immunoreactive trypsinogen (IRT) determination, genetic analysis is replaced by a biological test, the pancreatitis-associated protein (PAP) enzyme-linked immunosorbent assay (ELISA). Study design: The French newborn screening program includes cystic fibrosis (CF) screening by the IRT/CFTR mutation strategy. PAP was assayed on screening cards, in parallel with IRT, in all newborns from 5 French regions (n = 204,749). Analysis of PAP values in CF and non-CF newborns with elevated IRT allowed direct comparison between the current strategy and the proposed IRT/PAP strategy. Results: A protocol in which newborns with IRT >50 ng/mL and PAP >1.8 ng/mL and those with IRT >100 ng/mL and PAP >1.0 ng/mL are directly recalled for sweat testing would have the same performance as the IRT/CFTR mutation strategy. Conclusions: The IRT/PAP strategy is an alternative for CF newborn screening, which avoids the drawbacks of genetic analysis and is cheaper and easier to implement than the current IRT/CFTR mutation strategy.

关键词：胰腺炎相关蛋白新生儿筛查囊性纤维化胰蛋白酶原蛋白测定筛查计划免疫反应酶联免疫吸附实验 CFTR 联合

校外监护对低收入中心城市居民区青少年性启蒙的作用

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世界核心医学期刊文摘（儿科学分册） 2005年第5期1卷 39-39页

作者： Roche K. M. Ellen j. Astone N. M. 虎小毅 dept. of Pop. and Fam. H lth. Sci. J. Hopkins Bloomberg Sch. Pub. Hlth. 615 N Wolfe St Baltimore MD 21205 United StatesDr.

Objective: To examine the association between patterns of outof-school care o ver time and the initiation of sex among young adolescents living in low-income urban families. design: A prospective cohort study (using a 16-month follow-u p) examining the predictive value of changes in out-of-school-care arrangemen ts on early sex initiation. Setting and Participants: By using a multistage stra tified area probability sampling strategy, we selected 494 subjects aged 11 to 1 3 years living in low-income central city neighborhoods who did not report havi ng had sexual intercourse by time *** Outcome Measure: Adolescent report of having had sexual intercourse by time ***: Bivariate results suggested th at being at home with an adult during out-of-school hours was related to less sex initiation than self-care, care at another person’s home, and attendance a t an organized/supervised activity. Adjusting for demographic attributes, parent al monitoring, parental curfews, and family routines, remaining in out-of-home care or selfcare was associated with a 2.5 times (95%confidence interval, 1. 3-5.1 times) increase in the likelihood of initiating sexual intercourse when compared with being at home with an adult at both assessment times. Conclusion: Policies and programs that enable young adolescents to spend their out-of-scho ol hours at home with an adult may help reduce the risk of early sex initiation among youth in low-income urban areas.

关键词：收入中心外监护城市居民区城市家庭早期性课外时间性交史评估阶段统计学特征自我监护

在最初血浆肌钙蛋白阴性的非ST段抬高型急性冠状动脉综合征患者中预测后期肌钙蛋白阳性:来自TIMI IIIB和GUSTO IIA研究的临床预测因素和已确定的风险评分结果

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世界核心医学期刊文摘（心脏病学分册） 2006年第6期2卷 13-13页

作者： januzzi jr. j.L. Newby L.K. Murphy S.A. 孙凯 Massachusetts General Hospital Yawkey 5800 55 Fruit Street Boston MA 02114 United States Dr.

Background: Troponin testing is useful for evaluating patients with non- ST segment elevation acute coronary syndromes(NSTE ACS); however, a significant ercentage of patients are troponin negative at presentation and develop late rise of the marker. Methods: Patients in the TIMI IIIB study were assessed with respect to their troponin I(TnI) status at presentation and 12 hours. Multivariable analysis identified independent clinical factors associated with TnI rise at 12 hours among subjects initially TnI negative. A score predicting late TnI rise in TIMI IIIB was developed using these factors and validated among patients in the GUSTO IIA study. Results: Of 1342 subjects in TIMI IIIB, 200(14.9% ) were negative at baseline, but developed an elevated TnI(≥ 0.4 ng/mL) at 12 hours. Six independent predictors of late TnI rise were identified: ST- segment deviation(odds ratio [OR] 3.52, 95% CI 2.38- 5.23, Pded angina(OR 1.65, 95% CI 1.12- 2.42, P=.01), and a history of myocardial infarction(OR 1.59, 95% CI 1.06- 2.37, P=.02). ST deviation, presentationng baseline TnI- negative patients, a rising score was paralleled by an increasing prevalence of late TnI rise from 0% (with a score of 0) to 69% (with a score of 9)(Png 855 patients in the GUSTO IIA study(Pdevelopment of late troponin rise is common in non- ST- segment elevation acute coronary syndromes. Six easily ascertained variables may be used to identify those at higher risk for late rise in troponin levels af

关键词：急性冠状动脉综合征肌钙蛋白阳性非ST段抬高型 TIMI 预测因素临床因素 IIA 患者阴性评分

先兆性偏头痛亚型患者在视觉刺激时磁共振波谱成像的改变

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世界核心医学期刊文摘（神经病学分册） 2005年第10期1卷 7-7页

作者： Sndor P.S. Dydak U. Schoenen j. 高宗恩 Neurology depar tment University Hospitals Z rich Switzerurich Frauenklinikstrasse 26 CH- 8091 Z richSwitzerland Dr.

Migraine pathophysiology possibly involves deficient mitochondrial energy res erve and diminished cortical habituation. Using functional magnetic resonance sp ectroscopic imaging (fMRSI), we studied cortical lactate changes during prolonge d visual stimulation to search for different pathophysiological mechanisms in cl inically distinct subgroups of migraine with aura. Eleven healthy volunteers (HV ) and 10 migraine patients were investigated interictally: five with visual aura (MA) and five with visual symptoms and at least one of the following: paraesthe sia, paresis or dysphasia (MAplus). Using MRSI (Philips, 1.5 T) 1H- spectra wer e repeatedly obtained from a 25 mm- thick slice covering visual and non- visua l cortex, with the first and fifth measurements in darkness and the second to fo urth with 8- Hz checkerboard stimulation. In MAplus lactate increased only duri ng stimulation, only in visual cortex; in MA resting lactate was high in visual cortex, without further increase during stimulation. This is compatible with an abnormal metabolic strain during stimulation in MAplus, possibly due to dishabit uation, and a predominant mitochondrial dysfunction in MA.

关键词：视觉刺激磁共振波谱成像病理生理机制发作间期视觉症状视觉皮质能量储备健康受试者重复测量言语障碍

经导管动脉化疗栓塞成功转化的初始不可切除肝癌术前预测模型的临床研究

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介入放射学杂志 2022年第7期31卷 670-674页

作者：徐李刚张巍钱晟瞿旭东颜志平王建华刘萍萍王栋杨国威刘嵘上海复旦大学附属华山医院静安分院介入科 200040 复旦大学附属中山医院介入科

目的了解经导管动脉化疗栓塞(TACE)联合补救性肝切除(SLR)治疗初始不可切除肝细胞癌(HCC)的疗效及其影响因素,构建SLR术前选择性预后预测模型。方法回顾性分析2010年1月至2016年12月在复旦大学附属中山医院接受TACE+SLR治疗的119例初... 详细信息

目的了解经导管动脉化疗栓塞(TACE)联合补救性肝切除(SLR)治疗初始不可切除肝细胞癌(HCC)的疗效及其影响因素,构建SLR术前选择性预后预测模型。方法回顾性分析2010年1月至2016年12月在复旦大学附属中山医院接受TACE+SLR治疗的119例初始不可切除HCC患者的临床资料。随访36个月,存活时间≥36个月患者82例(长期存活组),存活时间20 ng/mL、癌灶数目≥4个、TACE治疗后肿瘤负荷降低10 cm等是影响预后、增加死亡风险的SLR术前关键因素。基于上述5个关键因素构建新的SLR前预后预测Nomogram模型,其C指数=0.781(95%CI:0.714~0.848),具有较好的预测患者生存的准确性和区分能力。结论 TACE联合SLR治疗初始不可切除肝癌患者疗效确切。基于SLR前AFP水平、癌灶数目、肿瘤负荷下降水平、PVTT、主瘤最大径构建的Nomogram模型能较好地预测初始不可切除HCC患者接受TACE+SLR治疗的预后。

关键词：不可切除肝癌补救性肝切除经导管动脉化疗栓塞预测模型

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煤液化残渣中硫的氧化规律

中国粉体技术 2018年第2期24卷 44-51页

作者：常卫科徐洁孙伟袁桂梅陈胜利张胜振中国石油大学(北京)重质油国家重点实验室北京102249 北京低碳清洁能源研究所北京102211

利用四氢呋喃溶解煤液化残渣,将煤液化残渣分离为油相和四氢呋喃不溶物固体,之后测定其中各形态硫的含量,发现煤液化残渣中98%(质量分数)的硫存在于四氢呋喃不溶物固体中,且主要以磁黄铁矿的形式存在。故此以四氢呋喃不溶物为原料进行... 详细信息

利用四氢呋喃溶解煤液化残渣,将煤液化残渣分离为油相和四氢呋喃不溶物固体,之后测定其中各形态硫的含量,发现煤液化残渣中98%(质量分数)的硫存在于四氢呋喃不溶物固体中,且主要以磁黄铁矿的形式存在。故此以四氢呋喃不溶物为原料进行空气氧化,研究其中硫的氧化转化规律。结果表明,干空气氧化四氢呋喃不溶物,四氢呋喃不溶物总含硫量减少,氧化过程中生成硫酸盐和单质硫,其中单质硫在氧化过程中进入气相而脱离四氢呋喃不溶物固体;湿空气氧化四氢呋喃不溶物,四氢呋喃不溶物总含硫量基本不变,反应过程中仅有硫酸盐生成。实验条件下,氧化过程由磁黄铁矿颗粒上覆盖的硫酸盐产物层中的氧扩散控制,扩散活化能为26.25 k j/mol。

关键词：煤液化残渣硫氧化规律硫酸盐