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Moving beyond Wastewater:Perspectives on Environmental Surveillance of Infectious Diseases for Public Health Action in Low-Resource Settings

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Environment & Health 2024年第10期2卷 684-687页

作者： jeseth delgado Vela Sarah E.Philo joe Brown Mami Taniuchi Molly Cantrell Alexandra Kossik Maya Ramaswamy Sitara SR Ajjampur Fatma Z.Guerfali Rochelle H.Holm john Scott Meschke Maria Catherine B.Otero Amy j.Pickering Mahbubur Rahman Alexander G.Shaw Abhilasha Shrestha Kwanrawee Sirikanchana Vivi Maketa Tevuzula Rolf U.Halden Alexandria B.Boehm Kyle Bibby Department of Civil and Environmental Engineering Duke UniversityDurhamNorth Carolina 27710United States Department of Civil and Environmental Engineering and Earth Sciences University of Notre DameSouth BendIndiana 46556United States Department of Civil and Environmental Engineering University of Southern California Los AngelesCA 90007USA Department of Environmental Sciences and Engineering University of North Carolina at Chapel HillChapel HillNorth Carolina 27599United States Division of Infectious Diseases and International Health University of VirginiaCharlottesvilleVirginia 22903United States Waterborne Disease Prevention Branch U.S.Centers for Disease ControlAtlantaGeorgia 30329United States The Wellcome Trust Research Laboratory Christian Medical CollegeVellore 632004India Laboratory of Transmission Control and Immunobiology of Infections(LTCII)Institut Pasteur de TunisTunis-Belvédère 1002Tunisia UniversitéTunis El Manar Tunis 1002Tunisia Christina Lee Brown Envirome Institute School of MedicineUniversity of LouisvilleLouisvilleKentucky 40202United States Department of Environmental and Occupational Health Sciences School of Public HealthUniversity of WashingtonSeattleWashington 98195United States College of Medicine University of the Philippines ManilaManila 2801Philippines Department of Civil and Environmental Engineering University of CaliforniaBerkeleyBerkeleyCalifornia 94720United States Institute of Epidemiology Disease Control and Research(IEDCR)Dhaka 1212Bangladesh Department of Infectious Disease Epidemiology Imperial College LondonLondon SW72AZU.K. Division of Environmental and Occupational Health Sciences University of Illinois Chicago School of Public HealthChicagoIllinois 60612United States Research Laboratory of Biotechnology Chulabhorn Research InstituteBangkok 10210Thailand Department of Tropical Medicine University of KinshasaKinshasa/DR 63090201Congo School of Sustainable Engineering and the Built Environment Arizona State UniversityTempe

Although testing wastewater for public health surveillance has recently received significant attention in the United States,researchers and public health professionals have long realized the tremendous promise of environmental surveillance(ES),defined as tracking pathogens of interest in fecally contaminated surface waters,soil,or fomites,in low-resource settings for public health action.1,2 The power of ES in lowresource settings is most clearly illustrated with the over 30 years of well-established and standardized polio *** part of the Global Polio Eradication Initiative,the World Health Organization(WHO)has accredited 146 laboratories within the Global Polio Lab Network(GPLN).These facilities across 92 countries process over 8,000 wastewater or fecally contaminated surface water samples per year,in addition to over 220,000 stool samples annually.3 The data generated from the GPLN are closely linked to clear public health action related to targeted vaccination *** investment and adoption of ES for polio eradication efforts serves as a use-case for other targets of *** explore the current state of the field,the National Science Foundation-funded Research Coordination Network(RCN)on Wastewater Based Epidemiology for SARS-CoV-2 and Emerging Public Health Threats held a workshop in December 2023 to discuss the opportunities and challenges for ES in low-resource settings(Figure 1).Discussions during the workshop highlighted knowledge gaps,best-practices,target selection,academic/government/private partnerships and overall public health action and sustainability of these programs.

关键词： wastewater Wastewater annually

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Magnetocaloric effect in ErNi2 melt-spun ribbons

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journal of Rare Earths 2020年第6期38卷 612-616页

作者： j.L.Sanchez Llamazares P.Ibarra-Gaytan C.F.Sanchez-Valdes D.Rlos-jara P.Alvarez-Alonso Instituto Potosino de Investigacion Ciendfica y Tecnoldgica A.C. Camino a la Presa San Jose 2055Col.Lomas 4San Luis Potosi.S.LP.78216Mexico CPM-TIP University Pavol Jozef SafarikPark Angelinum 9.04154 KosiceSlovakia Division Multidisciplinaria Ciudad UniversitariaUniversidad Aurdnoma de Ciudad Juarez(UACJ)Calle Jose de Jesus Macias Delgado#18100Ciudad Juarez 32579Chihuahua.Mexico Departamento de Fisica Universidad de OviedoCalvo Sotelo s/n33007 OviedoSpain

ErNi2 ribbons were produced by rapid solidification using the melt spinning *** structural,magnetic and magnetocaloric properties in the as-solidified state were studied by X-ray diffraction,scanning electron microscopy,magnetization and specific heat *** are single phase with the MgCu2-type crystal structure,a Curie temperature TC of 6.8 K and a saturation magnetization at2 K and 5 T of 124.0 A·m2/*** a magnetic field change μ0△H of 5 T(2 T) ribbons show a maximum magnetic entropy change |△SMpeak| of 24.1(16.9) j/(kg·K),and an adiabatic temperature change △Tadmax of8.1(4.4) K;this is similar to the previously reported literature for bulk alloys that were processed through conventional melting techniques followed by prolonged thermal *** addition,the samples also show slightly wider △SM(T) curves with respect to bulk alloys leading to a larger refrigerant capacity.

关键词： ErNi2 Laves phase Melt-spun ribbons Magnetic entropy change Adiabatic temperature change Rare Earths

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Substance Pantagonist improves both obesity and asthma in a mouse model

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世界最新医学信息文摘 2014年第7期 7-7页

作者： R.Ramalho j.Almeida M.Beltr?o A.Pirraco R.Costa O.Sokhatska L.Guard?o C.Palmares j.T.Guimar?es L.delgado A.Moreira R.Soares

Background Evidence suggests a causal relationship between obesity and asthma; however, the underlying mechanisms remain *** P (SP), involved in neurogenic inflammation by acting through its receptor NK1-R, seems to participate in obeseasthma phenotype in *** To evaluate the effect of a selective substance P receptor antagonist on a mouse model of diet-induced obesity and ***-induced obese Balb/c mice were sensitized and challenged with ovalbumin (OVA) and treated with a selective NK1-Rantagonist or placebo. Serum glucose, insulin, IL-6, resistin, and OVA-specific IgE levels were quantified. A score for peribronchial inflammation in lung histology was used. Cells were counted in bronchoalveolar lavage fluid. Adipocyte sizes were *** Ovalbumin-obese mice treated with NK1-R antagonist had lower weight (P = 0.0002), reduced daily food intake (P = 0.0021),reduced daily energy intake (P = 0.0021), reduced surface adipocyte areas (P < 0.0001), lower serum glucose (P = 0.04), lowerserum insulin (P = 0.03), lower serum IL-(P = 0.0022), lower serum resistin (P = 0.0043), lower serum OVA specific IgE (P =0.035), and lower peribronchial inflammation score (P < 0.0001) than nontreated OVA-obese mice. We observed an interaction between obesity, allergen sensitization, and treatment with NK1-R antagonist for metabolic and systemic biomarkers, and forallergen sensitization and bronchial inflammation, showing a synergy between these *** & Clinical Relevance In an experimental model of obesity and asthma in mice, NK1-R blockade improved metabolic and systemic biomarkers, as wellas allergen sensitization and bronchial inflammation. These positive effects support a common pathway in the obese–asthma phenotype and highlight SP as a target with potential clinical interest in the obese–asthma epidemics.

关键词： OVA Substance Pantagonist improves both obesity and asthma in a mouse model

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麦考酚酸吗啉乙酯和环孢素治疗中重度慢性斑块型银屑病的系列研究

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世界核心医学期刊文摘（皮肤病学分册） 2006年第10期2卷 10-10页

作者： Pedraz j. Daudén E. delgado-jiménez Y. 罗素菊 Department of Dermatology Hospital Universitario de la PrincesaDiego de León 6228006 MadridSpain

Background:There are numerous studies that individually evaluate the efficacy/effectiveness and toxicity of drugs in the systemic treatment of *** the contrary,we can hardly find studies that compare each ***:To evaluate and compare the effectiveness and toxicity of mycophenolate mofetil and cyclosporin in chronic plaque psoriasis through a prospective,sequential,cross-over,non-randomized,two phase,open-label ***/Methods:Eight patients(five women and three men;mean age 57,range 35-78)with moderate-to-severe chronic plaque psoriasis were included in the *** were treated with oral mycophenolate mofetil(30 mg/kg/day)over a period of 16 *** a variable wash out period and after a new outbreak of the disease,oral cyclosporinwas introduced at a dose of 4 mg/kg/*** both treatment regimens,follow-up visits were performed at 3,8 and 16 ***:In both groups,the PASI started to decrease once treatment was *** was faster and statistically a lot more effective than mycophenolate mofetil,reaching a higher number of complete remissions and better percentages of PASI improvement from baseline(45.7%,60.2%and 60.5%at 3,8 and 16 weeks respectively for mycophenolate mofetil,and 89.7%,95.3%and 95.3%respectively at the same intervals for cyclosporin).Cyclosporin was also more predictable in its action as the percentage of improvement along the follow up visits had a much wider range for mycophenolate ***,the tolerability of both drugs was *** of the patients had to discontinue treatment because of an adverse *** patients treated with cyclosporin showed increased plasma levels of ***:Cyclosporin is more effective,fast,and predictable in its effect than mycophenolatemofetil to control moderate-to-severe chronic plaque *** drugs are well tolerated in short courses of treatment.

关键词：斑块型银屑病麦考酚酸环孢素 PASI 吗啉洗脱期开放性研究血浆肌酐变动范围

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光固化技术制作新型个体化下颈椎椎弓根置钉钻孔导板:一项体外研究

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中国骨科临床与基础研究杂志 2017年第3期9卷 192-192页

作者： Bundoc RC delgado GG Grozman SA 白朝晖王建华

近二十年来,随着钉棒钢板固定技术的兴起,下颈椎（C3-C7）后路固定手术得到了广泛开展。生物力学研究表明,颈椎椎弓根螺钉（cervical pedicle screw,CPS）固定较侧块螺钉有更强的稳定性,但CPS置入仍面临技术上的挑战。目前涌现出很多精... 详细信息

近二十年来,随着钉棒钢板固定技术的兴起,下颈椎（C3-C7）后路固定手术得到了广泛开展。生物力学研究表明,颈椎椎弓根螺钉（cervical pedicle screw,CPS）固定较侧块螺钉有更强的稳定性,但CPS置入仍面临技术上的挑战。目前涌现出很多精确置钉方法,包括徒手技术、X线透视引导技术、影像导航手术技术等。其中徒手技术主要基于解剖标志和形态学角度测量均值来辅助CPS置入,

关键词：颈椎椎弓根侧块螺钉后路固定 screw 生物力学解剖标志光固化技术螺钉直径钉道误置

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多层螺旋CT静脉成像评价高危急性闭合颅脑损伤病人外伤性硬脑膜静脉窦血栓发病率

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国际医学放射学杂志 2010年第4期 377-377页

作者： j.E.delgado Almandoz H.R.Kelly P.W.Schaefer M.H.Lev R.Gilberto Gonzalez j.M.Romero 庞国栋 Division of Neuroradiology Mallinckrodt Institute of RadiologyWashington University School of Medicine510 S Kingshighway BlvdCampus Box 8131St LouisMO 63110USA

目的探讨多层螺旋CT静脉成像确定高危急性闭合颅脑损伤病人外伤性硬脑膜静脉窦血栓(DVST)的发病率。材料与方法本研究遵循HIPAA,经制度评审委员会批准,不需要知情同意书。回顾

关键词：静脉成像多层螺旋外伤性颈静脉球硬脑膜静脉窦血栓病人 CT 发病率

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CT血管成像诊断急性胃肠道出血的准确性:系统评价和meta分析

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国际医学放射学杂志 2013年第4期 387-387页

作者： V.G. Blázquez A.V. Bártulos A.O. delgado M.N. Plana D. Winden j. Zamora 周丹 Clinical Biostatistics Unit University Hospital Ramón y Cajal (IRYCIS)Ctra.Colmenar km 9100 28034 Madrid Spain

目的评估CT血管成像诊断急性胃肠道出血的准确性。方法应用系统评价和meta分析评估汇集精度指标。通过双变量随机效应模型进行调整,以获得总体受试者操作特征（SROC）曲线和相应曲线下面积（AUC）。结果回顾22项研究,共672例病人（5～7... 详细信息

目的评估CT血管成像诊断急性胃肠道出血的准确性。方法应用系统评价和meta分析评估汇集精度指标。通过双变量随机效应模型进行调整,以获得总体受试者操作特征（SROC）曲线和相应曲线下面积（AUC）。结果回顾22项研究,共672例病人（5～74岁）,平均年龄为65岁。CT血管成像检测活动性急性胃肠道出血的总体敏感度为85.2%（95%CI:75.5%91.5%）。CT血管成像的总体特异度为92.1%（95%CI:76.7%97.7%）。阳性和阴性似然比的测试结果分别为10.8（95%CI:3.4～34.4）和0.16（95%CI:0.1～0.27）,AUC为0.935（95%CI:0.693～0.989）。这些差异对诊断效能没有显著影响。结论 CT检测和定位胃肠道出血的诊断准确性很高,是一种非常好的诊断工具,它具有很高的可用性,能够快速发现并定位出血点,而且是微创的。要点①CT血管成像正越来越多地用于检测严重的胃肠道出血。②本次系统评价和meta分析更新了先前的研究。③在胃肠道大量出血的病人中,CT血管成像/MDCT可以准确地检测出血。④CT血管成像有助于定位出血点和制定合理的治疗方案。

关键词：胃肠道出血 CT血管成像敏感性和特异性系统评价 Meta分析

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速度编码MRI与组织多普勒对矫正性法洛四联症右心室性能评估的比较

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国际医学放射学杂志 2011年第5期 473-473页

作者： A.E.Van der Hulst A.A.W.Roest V.delgado L.j.M.Kroft E.R.Holman N.A.Blom 付姣慧 Division of Pediatric Cardiology Department of Pediatrics J6-S.Leiden Unvversity Medical CenterAlbinusdreef Po Box96002300 RC Levdenthe Netherlands

目的比较速度编码MR(VEMR)与组织多普勒成像对矫正性法洛四联症病人及健康受试者右心室收缩期峰值速度和达峰时间的评估价值。材料与方法本研究获本地

关键词：四联症达峰时间收缩期右室游离壁右室流出道峰值速度右心室编码

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单个不伴发POEMS综合征的肾小球样血管瘤

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世界核心医学期刊文摘（皮肤病学分册） 2005年第10期1卷 15-15页

作者： Vénez Y Fraga j D. Vélez D 刘安 delgado-jimélez Hospital Universitario La Princesa C/Diego de León 62 28006 Madrid Spain

Background:The term ‘glomeruloid haemangioma’was coined by Chan et al. for a histologically distinctive cutaneous haemangioma, which they considered a specific cutaneous marker for POEMS syndrome. Glomeruloid haemangiomas appear to be specific to POEMS syndrome, because they have not been reported in patients without this syndrome. Methods:We report on an 86-year-old man without POEMS syndrome and with a solitary red papule on the face. Results:A cutaneous biopsy showed histological findings consistent with a glomeruloid haem-angioma. Physical examination of the skin did not show any other cutaneous lesion and laboratory and radiological studies ruled out the presence of POEMS syndrome. Conclusions:Glomeruloid haemangiomas could exceptionally be present as solitary vascular tumours and out of the context of POEMS syndrome. To our knowledge, this is the first case reported of glomeruloid haemangioma without POEMS syndrome. Moreover, the presentation on the face is also highly unusual.

关键词： POEMS综合征血管瘤肾小球红色丘疹皮肤症状

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Las Chumberas的圣救世主教堂和社区中心西班牙加那利群岛

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世界建筑导报 2022年第1期37卷 16-21页

作者：费尔南多·梅尼斯巴巴克·阿萨迪胡安·贝尔塞多玛丽亚·贝尔加罗伯托·德尔加多哈维尔·埃斯皮雷斯安德烈斯·费雷尔尼尔斯·海因里希亚尼拉·莱昂乔安娜·马科斯卡·泽尔斯卡保拉·曼扎诺娜塔莉亚·皮齐奥劳尔·里维拉杰拉尔多·罗德里格斯埃丝特·塞尼斯安德烈亚斯·韦纳希特朱莉娅·萨达不详

它的相关性由两个细节同等地决定。首先,该地块位于世界上最受游客欢迎的岛屿之一特内里费岛,但矛盾的是,它位于一个贫困社区,因此并不受关注。其次,这座建筑近二十年来通过捐款来获取资金。建筑的构思和建造过程,也是提高社区自身认识... 详细信息

它的相关性由两个细节同等地决定。首先,该地块位于世界上最受游客欢迎的岛屿之一特内里费岛,但矛盾的是,它位于一个贫困社区,因此并不受关注。其次,这座建筑近二十年来通过捐款来获取资金。建筑的构思和建造过程,也是提高社区自身认识以及居民重新定义身份的过程。

关键词：贫困社区加那利群岛救世主自身认识近二十年西班牙

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