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dominant Lid Tectonics behaviour of continental lithosphere in Precambrian times:Palaeomagnetism confirms prolonged quasi-integrity and absence of supercontinent cycles

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Geoscience Frontiers 2018年第1期9卷 61-89页

作者： j.d.a.piper Geomagnetism Laboratory Department of Earth and Ocean Sciences University of Liverpool

Although Plate Tectonics cannot be effectively tested by palaeomagnetism in the Precambrian aeon due to the paucity of high precision poles spanning such a long time period,the possibility of Lid Tectonics is eminently testable because it seeks accordance of the wider dataset over prolonged intervals of time;deficiencies and complexities in the data merely contribute to *** of palaeomagnetic poles across a quasi-integral continental crust for time periods of up to thousands of millions of years,together with recognition of very long intervals characterised by minimal polar motions(～2.6-2.0,～1.5-1.25 and～0.75-0.6 Ga)has been used to demonstrate that Lid Tectonics dominated this *** new PALEOMAGIA database is used to refine a model for the Precambrian lid incorporating a large quasiintegral crescentric core running from South-Central Africa through Laurentia to Siberia with peripheral cratons subject to reorganisation at～2.1,～1.6 and～1.1 *** model explains low levels of tidal friction,reduced heat balance,unique petrologic and isotopic signatures,and the prolonged crustal stability of Earth's"Middle Age",whilst density concentrations of the palaeomagnetic poles show that the centre of the continental lid was persistently focussed near Earth's rotation axis from～2.8 to 0.6 *** exception was the～2.7-2.2 Ga interval defined by～90°polar movements which translated the periphery of the lid to the rotation pole for this quasi-static period,a time characterised by glaciation and low levels of magmatic activity;the～2.7 Ga shift correlates with key interval of mid-Archaean crustal growth to some 60-70%of the present volume and REE signatures whilst the～2.2 Ga shift correlates with the Lomagundiδ～(13)C and Great Oxygenation *** palaeomagnetic signature of breakup of the lid at～0.6 Ga is recorded by the world-wide Ediacaran development of passive margins and associated environmental signatures of new ocean *** event defined the end of a

关键词： Lid Tectonics Plate tectonics Archaean Proterozoic Palaeomagnetism PALEOMAGIA

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Continental velocity through Precambrian times:The link to magmatism,crustal accretion and episodes of global cooling

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Geoscience Frontiers 2013年第1期4卷 7-36页

作者： j.d.a.piper Geomagnetism Laboratory Geology and GeophysicsSchool of Environmental SciencesUniversity of Liverpool.Liverpool L69 7ZEUK

Quasi-integrity of continental crust between Mid-Archaean and Ediacaran times is demonstrated by conformity of palaeomagnetic poles to near-static positions between -2.7-2.2 Ga, -1.5-1.2 Ga and -0.75-0.6 Ga. Intervening data accord to coherent APW loops turning at ＂hairpins＂ focused near a continental-centric location. Although peripheral adjustments occurred during Early Proterozoic （-2.2 Ga） and Grenville （- 1.1 Ga） times, the crust retained a low order symmetrical crescent-shaped form constrained to a single global hemisphere until break-up in Ediacaran times. Conformity of palaeomagnetic data to specific Eulerian parameters enables definition of a master Precambrian APW path used to estimate the root mean square velocity （VRMS） of continental crust between 2.8 and 0.6 Ga. A long interval of little polar movement between -2.7 and 2.2 Ga correlates with global magmatic shutdown between -2.45 and 2.2 Ga, whilst this interval and later slowdown at -0.75-0.6 Ga to velocities of 〈2 cm/year correlate with episodes of widespread glaciation implying that these prolonged climatic anomalies had an internal origin; the reduced input of volcanically-derived atmospheric greenhouse gases is inferred to have permitted freeze-over conditions with active ice sheets extending into equatorial latitudes as established by low magnetic inclinations in glaciogenic deposits. VRMS vari- ations through Precambrian times correspond to the distribution of U-Pb ages in orogenic granitoids and detrital zircons and demonstrate that mobility of continental crust has been closely related to crustal tectonism and incrementation. Both periods of near-stillstand were followed by rapid VRMS recording massive heat release from beneath the continental lid at -2.2 and 0.6 Ga. The first coincided with the Lomagundi-jatuli isotopic event and led to prolonged orogenesis accompanied by continental flooding and reconfiguration of the crust on the Earth＇s surface; the second led to continental break-up and i

关键词： Continental velocity Precambrian Palaeopangaea Palaeomagnetism Magmatism Tectonics

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晚期前寒武纪冰川作用的纬度界限

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地球与环境 1974年第11期 10-12页

作者： j.d.a.piper ,于津生

人们普遍认为晚期前寒武纪冰川作用分布较广。但是对它们为什么能够扩展到低纬度却很少有资料谈到。如果这～点能得到证明,那么就可以把晚期前寒武纪的冰碛岩当成地层标志层。近年来,地质年代学的研究对许多冰碛岩的形成年龄给出了某... 详细信息

人们普遍认为晚期前寒武纪冰川作用分布较广。但是对它们为什么能够扩展到低纬度却很少有资料谈到。如果这～点能得到证明,那么就可以把晚期前寒武纪的冰碛岩当成地层标志层。近年来,地质年代学的研究对许多冰碛岩的形成年龄给出了某些绝对的控制。根据邓恩等的资料,澳大利亚的埃根-莫里诺冰川作用是670百万年,而木恩莱特谷地-斯特尔提恩冰川作用是750百万年。苏联文德的时间跨度为675—560百万年,而普林格尔推断挪

关键词：冰川作用非洲古地磁地层前古生代前寒武纪冰川砾岩碎屑岩冰碛岩

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Kinetics of glyphosate and aminomethylphosphonic acid sorption onto montmorillonite clays in soil and their translocation to genetically modified corn

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journal of Environmental Sciences 2024年第1期135卷 669-680页

作者： Meichen Wang Kelly j Rivenbark Timothy d Phillips Veterinary Physiology and Pharmacology College of Veterinary Medicine and Biomedical SciencesTexas A&M UniversityTX 77845USA

The co-occurrence of glyphosate(GLP)and aminomethylphosphonic acid(AMPA)in contaminated water,soil,sediment and plants is a cause for concern due to potential threats to the ecosystem and human health.A major route of exposure is through contact with contaminated soil and consumption of crops containing GLP and AMPA ***,clay-based sorption strategies for mixtures of GLP and AMPA in soil,plants and garden produce have been very *** this study,in vitro soil and in vivo genetically modified corn models were used to establish the proof of concept that the inclusion of clay sorbents in contaminated soils will reduce the bioavailability of GLP and AMPA in soils and their adverse effects on plant *** of chemical concentration(1–10 mg/kg),sorbent dose(0.5%-3%in soil and 0.5%-1%in plants)and duration(up to 28 days)on sorption kinetics were *** time course results showed a continuous GLP degradation to *** inclusion of calcium montmorillonite(CM)and acid processed montmorillonite(APM)clays at all doses significantly and consistently reduced the bioavailability of both chemicals from soils to plant roots and leaves in a dose-and time-dependent manner without detectable *** treated with 0.5%and 1%APM inclusion showed the highest growth rate(p≤0.05)and lowest chemical bioavailability with up to 76%reduction in roots and57%reduction in *** indicated that montmorillonite clays could be added as soil supplements to reduce hazardous mixtures of GLP and AMPA in soils and plants.

关键词： Glyphosate AMPA Adsorption Soil remediation Plant Hydroponic system

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Generalized polynomial chaos expansion by reanalysis using static condensation based on substructuring

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Applied Mathematics and Mechanics(English Edition) 2024年第5期45卷 819-836页

作者： d.LEE S.CHANG j.LEE department of Automotive Engineering Hanyang UniversitySeoul 04763Republic of Korea School of Mechanical Engineering Chungnam National UniversityDaejeon 34134Republic of Korea department of Mechanical Robotics and Energy EngineeringDongguk UniversitySeoul 04620Republic of Korea

This paper presents a new computational method for forward uncertainty quantification(UQ)analyses on large-scale structural systems in the presence of arbitrary and dependent random *** method consists of a generalized polynomial chaos expansion(GPCE)for statistical moment and reliability analyses associated with the stochastic output and a static reanalysis method to generate the input-output data *** the reanalysis,we employ substructuring for a structure to isolate its local regions that vary due to random *** allows for avoiding repeated computations of invariant substructures while generating the input-output data *** substructuring with static condensation further improves the computational efficiency of the reanalysis without losing ***,the GPCE with the static reanalysis method can achieve significant computational saving,thus mitigating the curse of dimensionality to some degree for UQ under high-dimensional *** numerical results obtained from a simple structure indicate that the proposed method for UQ produces accurate solutions more efficiently than the GPCE using full finite element analyses(FEAs).We also demonstrate the efficiency and scalability of the proposed method by executing UQ for a large-scale wing-box structure under ten-dimensional(all-dependent)random inputs.

关键词： forward uncertainty quantification(UQ) generalized polynomial chaos expansion(GPCE) static reanalysis method static condensation substructuring

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The secondary injury cascade after spinal cord injury:an analysis of local cytokine/chemokine regulation

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Neural Regeneration Research 2024年第6期19卷 1308-1317页

作者： daniel j.Hellenbrand Charles M.Quinn Zachariah j.piper Ryan T.Elder Raveena R.Mishra Taylor L.Marti Phoebe M.Omuro Rylie M.Roddick jae Sung Lee William L.Murphy Amgad S.Hanna department of Neurosurgery University of Wisconsin-Madison School of Medicine and Public HealthMadisonWIUSA department of Biomedical Engineering University of Wisconsin-MadisonMadisonWIUSA department of Orthopedics and Rehabilitation University of Wisconsin-MadisonMadisonWIUSA department of Materials Science and Engineering University of Wisconsin-MadisonMadisonWIUSA Forward BIO Institute University of Wisconsin-MadisonMadisonWIUSA

After spinal cord injury,there is an extensive infiltration of immune cells,which exacerbates the injury and leads to further neural ***,a major aim of current research involves targeting the immune response as a treatment for spinal cord *** much research has been performed analyzing the complex inflammatory process following spinal cord injury,there remain major discrepancies within previous literature regarding the timeline of local cytokine *** objectives of this study were to establish an overview of the timeline of cytokine regulation for 2 weeks after spinal cord injury,identify sexual dimorphisms in terms of cytokine levels,and determine local cytokines that significantly change based on the severity of spinal cord *** were inflicted with either a mild contusion,moderate contusion,severe contusion,or complete transection,7 mm of spinal cord centered on the injury was harvested at varying times post-injury,and tissue homogenates were analyzed with a Cytokine/Chemokine 27-Plex *** demonstrated pro-inflammatory cytokines including tumor necrosis factorα,interleukin-1β,and interleukin-6 were all upregulated after spinal cord injury,but returned to uninjured levels within approximately 24 hours post-injury,while chemokines including monocyte chemoattractant protein-1 remained upregulated for days *** contrast,several anti-inflammatory cytokines and growth factors including interleukin-10 and vascular endothelial growth factor were downregulated by 7 days *** spinal cord injury,tissue inhibitor of metalloproteinase-1,which specifically affects astrocytes involved in glial scar development,increased more than all other cytokines tested,reaching 26.9-fold higher than uninjured *** a mild injury,11 cytokines demonstrated sexual dimorphisms;however,after a severe contusion only leptin levels were different between female and male *** conclusion,pro-inflammatory cytokines in

关键词： astrocytes chemokines cytokines inflammation macrophages microglia secondary damage spinal cord injury

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A novel diagnostic gene region for distinguishing between two pest fruit flies:Bactrocera tryoni(Froggatt)and Bactrocera neohumeralis(Hardy)(diptera:Tephritidae)

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Insect Science 2024年第4期31卷 1285-1295页

作者： Melissa L.Starkie Elizabeth V.Fowler Alexander M.piper Xiaocheng Zhu Pauline Wyatt david Gopurenko Matt N.Krosch Francesca Strutt Karen F.Armstrong Hamish Patrick Mark K.Schutze Mark j.Blacket department of Agriculture and Fisheries BiosecurityBrisbaneQueenslandAustralia Agriculture Victoria AgriBioBundooraVictoriaAustralia department of Primary Industries Wagga Wagga Agricultural InstituteWagga WaggaNew South WalesAustralia Forensic Services Group Queensland Police ServiceBrisbaneQueenslandAustralia department of Pest-management and Conservation Lincoln UniversityLincolnNew Zealand Better Border Biosecurity(B3 B3nz.org.nz)LincolnNew Zealand

Bactrocera tryoni and Bactrocera neohumeralis are morphologically similar sibling pest fruit fly species that possess different biological attributes,geographic distributions,and host *** need to differentiate between the two species is critical for accurate pest status assessment,management,biosecurity,and maintenance of reference *** morphologically similar,adults may be separated based on subtle characters;however,some characters exhibit intraspecific variability,creating overlap between the two ***,there is currently no single molecular marker or rapid diagnostic assay that can reliably distinguish between *** and ***;therefore,ambiguous samples remain *** we report the first molecular marker that can consistently distinguish between *** and *** diagnostic region consists of two adjacent single nucleotide polymorphisms(SNPs)within the pangolin(pan)gene *** confirmed the genotypes of each species are consistent across their distributional range,then developed a tetra-primer amplification refractory mutation system(ARMS)PCR assay for rapid diagnosis of the *** assay utilizes four primers in multiplex,with two outer universal primers,and two internal primers:one designed to target two adjacent SNPs(AA)present in *** and the other targeting adjacent SNPs present in ***(GG).The assay accurately discriminates between the two species,but their SNP genotypes are shared with other nontarget tephritid fruit fly ***,this assay is most suited to adult diagnostics where species confirmation is necessary in determining ambiguous surveillance trap catches;maintaining pure colony lines;and in Sterile Insect Technique management responses.

关键词： ARMS-PCR colony molecular diagnostics pangolin tetra-primer

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Insm1:orchestrating cellular mimicry in the thymus medulla

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Cellular & Molecular Immunology 2024年第4期21卷 414-416页

作者： K.d.james j.E.Cowan UCL Institute of Immunity and Transplantation The Pears BuildingRowland Hill StreetLondonNW32PPUK

The thymus is the primary production site for a functional and self-tolerant T-cell *** establishment of immune tolerance is mediated by the generation and presentation of tissue-restricted self-antigens(TRAs)by medullary thymic epithelial cells(mTECs),which screen T-cell receptors for self-reactivity to eliminate autoreactive T *** studies have extended our understanding of mTEC heterogeneity by examining the mechanisms by which mTECs mimic the peripheral self[1].

关键词： medullary eliminate restricted

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Unmixing detrital zircon U-Pb ages reveals tectonic and climatic depositional influences on the Carboniferous Ansilta Formation,Calingasta-Uspallata Basin,Western Argentina

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Geoscience Frontiers 2024年第4期15卷 61-77页

作者： j.R.Malone j.E.Malone j.L.Isbell d.H.Malone j.P.Craddock K.N.Pauls department of Geological Sciences Jackson School of GeosciencesUniversity of Texas at AustinAustinTX 78712USA Iowa Geological Survey University of IowaIowa CityIA 52240USA department of Geosciences University of Wisconsin-MilwaukeeMilwaukeeWI 53211USA department of Geography Geology and the EnvironmentIllinois State UniversityNormalIL 61790-4400USA

The Late Paleozoic Ice Age(LPIA)was a principal control of sedimentation across Gondwana from the late devonian through early *** assess the hypothesis that glacial to interglacial transitions in western Argentina were the primary control influencing sediment routing patterns among the various Carboniferous-Permian basins in western *** Carboniferous Ansilta Formation consists of glaciomarine,nearshore,and fluvial systems deposited during the LPIA along the eastern margin of the Calingasta-Uspallata Basin in *** lower,glacially influenced succession of the Ansilta Formation records at least five glacial advances;the upper succession of consists of progradational shallow marine,deltaic,and fluvial *** combine 1225 new U-Pb zircon ages from six samples of the Carboniferous Ansilta Formation in the Calingasta-Uspallata Basin with 5864 U-Pb ages from 147 pub-lished samples in the detrital Pymix forward mixture model to characterize provenance *** the glacially influenced lower Ansilta Formation,sediment was derived locally from the Protoprecordillera,which was a prominent highland with alpine glaciers flowing west and east into the Calingasta-Uspallata and Paganzo basins,***,there was little or no connection between these two basins during Serpukhovian-Bashkirian *** fluvial/deltaic upper Ansilta had distal sediment sources in the Sierras ***,our results support the collapse of the Protoprecordillera topographic barrier,enabling drainage patterns connecting the Paganzo and Calingasta-Uspallata basins by late Pennsylvanian-early Permian time.

关键词： Late Paleozoic Ice Age Argentina Calingasta-Uspallata Basin Ansilta Formation detrital zircon provenance

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Mucopolysaccharidosis typeⅢB:a current review and exploration of the AAV therapy landscape

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Neural Regeneration Research 2024年第2期19卷 355-359页

作者： Courtney j.Rouse Victoria N.jensen Coy d.Heldermon Lacerta Therapeutics AlachuaFLUSA University of Florida College of Medicine GainesvilleFLUSA

Mucopolysaccharidoses typeⅢB is a rare genetic disorder caused by mutations in the gene that encodes for *** results in the aggregation of heparan sulfate polysaccharides within cell lysosomes that leads to progressive and severe debilitating neurological *** treatment options are expensive,limited,and presently there are no approved cures for mucopolysaccharidoses typeⅢ***-associated virus gene therapy has significantly advanced the field forward,allowing researchers to successfully design,enhance,and improve potential *** group recently published an effective treatment using a codon-optimized triple mutant adeno-associated virus 8 vector that restores N-acetyl-alpha-glucosaminidase levels,auditory function,and lifespan in the murine model for mucopolysaccharidoses typeⅢB to that seen in healthy ***,we review the current state of the field in relation to the capsid landscape,adeno-associated virus gene therapy and its successes and challenges in the clinic,and how novel adenoassociated virus capsid designs have evolved research in the mucopolysaccharidoses typeⅢB field.

关键词： adeno-associated virus central nervous system gene therapy heparan sulfate immune response mucopolysaccharidoses type IIIB N-acetyl-alpha-glucosaminidase newborn screening

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