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An algorithm for family screening for coeliac disease

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World journal of Gastroenterology 2006年第48期12卷 7805-7809页

作者： jocelyn S fraser Alistair L King H julia Ellis Simon j Moodie Ingvar Bjarnason jill Swift Paul j Ciclitira Division of Nutritional Sciences King's College London United Kingdom Division of Nutritional Sciences King’s College London United Kingdom

AIM: To assess the level of undiagnosed coeliac disease (CD) in relatives of patients affected by the condition. METHODS: We collected blood from 914 relatives of probands. We screened these individuals by ELISA for IgA and IgG tTG antibodies, confirming any positive IgA tTG results with an IgA EMA and looked for evidence of IgA deficiency in those who were IgG tTG positive alone, and performed IgG1 EMA in these individuals. We undertook HLA typing where positive screening was found, and this confirmed a strong prevalence of HLA- DQ2 in the coeliac population. Follow-up small intestinal biopsy was undertaken in cases with positive serological screening, wherever possible. RESULTS:Use of this serological screening algorithm revealed a prevalence of undiagnosed CD in 5%-6% of first degree relatives of probands. CONCLUSION:Our data suggests that first degree relatives of individuals with CD should be screened for this condition.

关键词： Coeliac disease Screening Endomysialantibody Familial study IgA deficiency Prevalence Tissue transglutaminase

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两种轮枝菌对15种豆科牧草的致病性

植物病理学报 1995年第2期25卷 189-192页

作者：侯天爵 H.C.Huang j.fraser 中国农业科学院草原研究所呼和浩特010010 加拿大Lethbridge农业研究站

室内人工接种测定了两种轮枝菌3个菌株对15种豆科牧草的致病性,一个菌株是来自加拿大感病苜蓿上的Verticillium albo-atrum (Vaa),两个***菌株中,Vd来自加拿大感病的马铃薯,CVd来自中国的沙打旺。两次试验结果表明,3个菌株对15种豆科牧... 详细信息

室内人工接种测定了两种轮枝菌3个菌株对15种豆科牧草的致病性,一个菌株是来自加拿大感病苜蓿上的Verticillium albo-atrum (Vaa),两个***菌株中,Vd来自加拿大感病的马铃薯,CVd来自中国的沙打旺。两次试验结果表明,3个菌株对15种豆科牧草表现了不同程度的致病力。沙打旺、鹰嘴黄芪、紫花苜蓿、百脉根、埃及三叶草对3个菌株均感病,每次试验病株率都在50％以上。箭叶三叶草表现中等抗病,而白花草木樨、毛荚野豌豆、长柔毛野豌豆、波斯三叶草、杂三叶草、红三叶草和白三叶草等7种对3个菌株都表现抗病。红豆草对Vaa和CVd两个菌株感病,但抗Vd。山黛豆感染CVd,但抗Vaa和Vd。

关键词：轮枝菌豆科牧草致病性

Electromagnetic Ion Cyclotron Waves Observed by Cluster near the Plasmapause

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Electromagnetic Ion Cyclotron Waves Observed by Cluster near...

Proximal gastric response to small intestinal nutrients is abnormal in mechanically ventilated critically ill patients

第十四届全国日地空间物理学术研讨会

作者： B.j.fraser F.W.Menk Centre for Space Physics University of Newcastle NSW 2308

Electromagnetic ion cyclotron (EMIC) waves in the Pc1 ultra-low frequency wave band (0.2-5Hz) observed in the plasmasphere and magnetosphere are generated by micro-scale instabilities associated with keV energetic protons of ring current origin. This case study presents a typical EMIC wave event with frequency 1.8-3.5 Hz observed by the four Cluster spacecraft when passing through perigee (L 4:2) and moving northward on 2 November 2001 around 08 MLT. The event occurred around the magnetic equatorial plane within magnetic latitude range ±18o with a short duration of 50 minutes. The associated cold electron density data show the wave power was confined within the narrow shell of the plasmapause where the electron density gradient decreased from 30-80 cm-3 to 20 cm-3. The radial scale size of the wave region is estimated at 0:77 Re. The wave polarization was dominantly left-handed around the equatorial region and inner side of source region, but appeared right-handed close to the outer edge of the plasmapause and at higher latitudes. The Poynting flux and minimum variance analysis indicate that the wave energy was mainly transported towards high latitudes though oblique propagation was seen around the equatorial region. Enhanced H+, He+ and O+ particle energy fluxes were seen during the wave event over energy range 5eV-40keV. Unfortunately the lower energy cold plasma composition was not measured. These observations suggest the waves originated around the equatorial region in the high density outer plasmasphere-plasmapause which overlaps the ring current;ideal conditions for wave generation by the ion cyclotron instability.

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World journal of Gastroenterology 2006年第27期12卷 4383-4388页

作者： Nam Q Nguyen Robert j fraser Marianne Chapman Laura K Bryant Richard H Holloway Rosalie Vozzo Christine Feinle-Bisset Department of Gastroenterology Hepatology and General MedicineRoyal Adelaide HospitalSouth Australia University Department of Medicine University of AdelaideSouth Australia Department of Intensive Care Royal Adelaide HospitalSouth Australia Department of Gastroenterology Hepatology and General MedicineRoyal Adelaide HospitalSouth Australia Department of GastroenterologyUniversity of AdelaideSouth Australia

AIM： To determine the response of the proxima stomach to small intestinal nutrients in critically ill patients. METHODS： Proximal gastric motility was measured in 13 critically ill patients （49.3 ± 4.7 years） and 12 healthy volunteers （27.7 ± 2.9 years） using a barostat technique. Recordings were performed at baseline, during a 60-rain intra-duodenal infusion of Ensure^R （2 kcal/min）, and for 2 h following the infusion. Minimum distending pressure （MDP）, intra-bag volume and fundic wave activity were determined. RESULTS： The MDP was higher in patients （11.7 ± 1.1 vs 7.8 ± 0.7 mmHg; P 〈 0.01）. Baseline intrabag volumes were similar in the 2 groups. In healthy subjects, a ‘bimodal＇ proximal gastric volume response was observed. In patients, the initial increase in proximal gastric volume was small and delayed, but eventually reached a maximal volume similar to that of healthy subjects. In healthy subjects, the proximal gastric volume rapidly returned to baseline level after nutrient infusion （median 18 min）. In contrast, the recovery of volume to baseline was delayed in critically ill patients （median 106 min）. In 6 patients, the volume had not returned to baseline level 2 hours after nutrient infusion. In patients, fundic volume waves were less frequent （P 〈 0.05） and had lower amplitude （P 〈 0.001）, compared to healthy subjects. CONCLUSION： In critical illness, proximal gastric motor responses to small intestinal nutrient stimulation are abnormal.

关键词： Proximal gastric response Small intestinal nutrient Critical illness

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极隙区纬度Pc 5脉动的传播和起源

地球物理学报 2001年第Z1期44卷 8-15页

作者：刘勇华刘瑞源杨少峰贺龙松 B.j.fraser 中国极地研究所上海200129 中国极地研究所上海200129 中国科学院地质与地球物理研究所北京100101 中国极地研究所上海200129 纽卡斯尔大学澳大利亚纽卡斯尔2308

南极中山站和戴维斯站均位于极隙区纬度附近,均安装了完全相同的感应式磁力计.选择两站的数据,1997年3月和1996年6、9、12月,运用信号互谱技术进行统计分析,结果得到:在中山站-戴维斯站,Pc5脉动出现时间范围较广,但以地方时中午/磁中午... 详细信息

南极中山站和戴维斯站均位于极隙区纬度附近,均安装了完全相同的感应式磁力计.选择两站的数据,1997年3月和1996年6、9、12月,运用信号互谱技术进行统计分析,结果得到:在中山站-戴维斯站,Pc5脉动出现时间范围较广,但以地方时中午/磁中午及磁午夜附近出现频次多,其振幅、传播及发生率季节变化不大.振幅白天变化小,中午有小峰,夜间有时有大值.传播方向白天以磁中午为界,晨侧向西传播,直至磁凌晨;昏侧向东传播,约在5:00MLT处转向.夜间约以20:00 MLT为界,之前向西传播,之后向东传播,磁黄昏附近,Pc5脉动传播方向变化较多,显得不规则.这些特征,反映了Pc5脉动在不同地方时段有不同的起源.

关键词：极隙区,Pc5脉动,磁中午,传播,南极中山站.

IMF By and Bz Effect on Propagation of Pc3-4Waves at the Cusp Latitude

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IMF By and Bz Effect on Propagation of Pc3-4Waves at the Cus...

Pc 3 waves observed by the Cluster-ll and ground stations near the cusp:（1）Spectra and Propagation

中国空间科学学会空间物理学专业委员会第十五届全国日地空间物理学研讨会

作者： Y.H.Liu F.W.Menk B.j.fraser Department of Polar Atmospheric and Space Physics Polar Research Institute of China Centre for Space Physics University of NewcastleNSW 2308Australia

Wave number is one of the key parameters to identify wave’s propagation modes and source ***3-4 waves with source regions locating at upstream solar wind usually appear an anti-sunward propagation,westward in the morning and eastward in the afternoon and changed direction around the magnetic local noon as indicated by reversal of the wave number *** on magnetic observation from Antarctic Zhongshan and Davis stations,however,this case occurs only under IMF Bz>*** this case,the reversal location of the propagation direction varied with IMF By component,moving eastward when IMF By>0 and westward IMF By<*** IMF Bz<0,the derived azimuthal wave number shows an ambiguous propagation without clear direction *** results can be explained by that both Zhongshan and Davis stations are located at the cusp latitude near the open-closed boundary of the geomagnetic field lines whose location is associated with IMF Bz and can be further driven by the IMF By component in east-west direction.

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Pc 3 waves observed by the Cluster-ll and ground stations ne...

Optical coherence tomography in optic disc drusen

第十二届全国日地空间物理学术讨论会

作者： B．j．fraser S．T．Able M．Dunlop Waterman The University of Newcastle University DriveCallaghan NSW 2308AUSTRALLA The Rutherford Appleton Laboratory ChiltonDIDCOTOxfordshireOX11 0QXUK Institute of Meteorology Danish

＜正＞Ground observations of Pc3 ULF waves at high latitude show enhanced pulsation activity near the *** investigate this,typical Pc3 pulsation events from 0920 to 1010UT on 01 April 2004 have been selected that are simultaneously observed by the Cluster-Ⅱ satellites and Zhongshan Station,Antarctica, when Cluster-Ⅱ was located on closed field lines equatorward of the exterior northern cusp and Zhongshan

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Annals of Eye Science 2020年第1期5卷 22-34页

作者： j.Alexander fraser Lulu L.C.D.Bursztyn Department of Clinical Neurological Sciences Western UniversityLondonONCanada Department of Ophthalmology Western UniversityLondonONCanada

Optic disc drusen (ODD) are hyaline deposits in the optic nerve head, occurring in approximately 2% of the population. ODD may be superficial and visible, or buried and either invisible or seen only as elevation of the optic disc, mimicking optic disc edema. Advanced optic nerve imaging, including optical coherence tomography (OCT) can be used to diagnose and characterize ODD with very high resolution. Enhanced depth imaging (EDI-OCT) in particular has emerged as the optimal modality to directly visualize ODD. This modality has led to a greater ability to differentiate ODD from optic disc edema and prevent misdiagnosis or invasive testing. We review the characteristic findings of ODD on OCT, their distinguishing features, and the use of OCT as a biomarker in the neuro-ophthalmic assessment of ODD.

关键词： Drusen optic disk tomography optical coherence

钾镁煌斑岩和金伯利岩的 Sr、Nd、Pb 同位素及少量元素地球化学

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地球与环境 1986年第9期 34-41页

作者： K.j.fraser 徐步台浙江省地质科学研究所

一、引言最近五年,有些研究者已不采用两组分（地壳和亏损地幔）简单模式来解释幔源岩石中放射成因同位素的变化。大陆下地幔中捕虏体的 ∈;、∈;和Pb同位素比值变化很大,这种情况被认为是大陆岩石圈内古老地幔物质

关键词： Pb 西澳大利亚钾镁煌斑岩金云火山岩同位素金伯利岩角砾云母橄榄岩超基性岩 Nd Sr