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A novel model for extending international co-operation in science and education

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journal of Zhejiang University-Science A(Applied Physics & Engineering) 2004年第3期5卷 109-115页

作者： DE boer Sirp j. 邱济真 International Management Section University of Twente Enschede International Programs Office Zhejiang University

In September 1994 the University of Twente, the Netherlands, and Zhejiang University, China, decided to cooperate in the field of science, education and management. After several visits of delegations from both sides it was considered worthwhile to explore further opportunities for mutual cooperation. The directors of international cooperation on each side jointly commissioned a project to investigate the potential in a systematic way and to establish further contacts where appropriate. This paper reports on the results of the research cum matching project. To reveal promising matches between multiple departments of both academic institutions a matching model for uni-versities was designed. The study was carried out along two parallel lines. In the research line the theoretical framework was developed into a model for international university co-operation. Moreover, an analysis was carried out on internal, external and cultural aspects resulting in a set of thirty four influencing factors. In the matching line a total of seventy interviews were held in order to identify promising matches between units at both universities. This line resulted in eleven promising matches for further co-operation. The novel model appeared useful in analyzing the variety of factors and in developing matches between both univer-sities. In the further implementation of the model the issues of 搇evel of co-operation?and 搕op-down versus bottom-up?need to be addressed in more detail.

关键词： International co-operation Universities Matching Science and education

Slow Pyrolysis of Sugarcane Bagasse for the Production of Char and the Potential of Its By-Product for Wood Protection

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journal of Renewable Materials 2021年第1期9卷 97-117页

作者： Febrina Dellarose boer jérémy Valette jean-Michel Commandré Mériem Fournier Marie-France Thévenon CIRAD UR BioWooEBTA B-114/1673 Rue Jean-François BretonF-34398 MontpellierCedex 5France BioWooEB Universitéde MontpellierCIRADMontpellierFrance AgroParisTech Centre de Nancy Nancy54000France Universitéde Lorraine AgroParisTechINRAUMR SilvaNancyF-54000France

Sugarcane bagasse was pyrolyzed using a laboratory fixed bed reactor to produce char and its by-product(pyrolysis liquid).The pyrolysis experiments were carried out using different temperatures(400℃ and 500℃),heating rate(1℃/min and 10℃/min),and holding time(30 min and 60 min).Char was characterized according to its thermal properties,while the pyrolysis liquid was tested for its anti-fungal and anti-termite *** temperature and heating rate had a significant influence on the char properties and the yield of char and pyrolysis liquid,where a high-quality char and high yield of pyrolysis liquid can be obtained at a temperature of 500℃ and a heating rate of 10℃/*** yield of char and pyrolysis liquid was 28.97%and 55.46%,*** principal compounds of pyrolysis liquid were water,acetic acid,glycolaldehyde,1-hydroxy-2-propanone,methanol,formic acid,levoglucosan,furfural,followed by some phenol compounds and guaiacol *** liquid at a concentration of 0.20%and 0.25%(v/v)caused a 100%inhibition of Coniophora puteana and Trametes versicolor,respectively,when performing inhibition growth tests in Petri *** paper treated with 10%of pyrolysis liquid caused 100%of termite mortality,while only 5.65%–7.03%of the treated filter papers consumed by termites at such *** liquid is potentially effective to be used in the formulation of wood protection against fungi and termites.

关键词： Anti-fungal anti-termite biomass char pyrolysis liquid slow pyrolysis sugarcane bagasse valorization

Efficacy of thioguanine treatment in inflammatory bowel disease: A systematic review

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World journal of Gastroenterology 2016年第40期22卷 9012-9021页

作者： Berrie Meijer Chris jj Mulder Godefridus j Peters Adriaan A van Bodegraven Nanne KH de boer Department of Gastroenterology and Hepatology VU University Medical Center Department of Medical Oncology VU University Medical Center Department of Gastroenterology Geriatrics Internal and Intensive Care Medicine (Co-MIK) Zuyderland Medical Center

AIM To critically assess the available literature regarding the efficacy of thioguanine treatment in inflammatory bowel disease(IBD) patients, irrespective of the(hepato-) toxicity *** A systematic literature search of the MEDLINE database using Pub Med was performed using the keywords "thioguanine", "6-TG", "thioguanine", "inflammatory bowel disease", "IBD", "Crohn's disease", "Ulcerative colitis" and "effectiveness" in order to identify relevant articles published in English starting from 2000. Reference lists of the included articles were crosschecked for missing articles. Reviewed manuscripts concerning the effectiveness of thioguanine treatment in IBD were reviewed by the authors and the data were extracted. Data were subsequently analyzed with descriptive statistics. Due to the lack of standardized outcomes, a formal meta-analysis was not *** A total of 11 applicable studies were found that involved the effectiveness of thioguanine therapy in IBD. Eight studies were conducted in a prospectivemanner, in the remaining three studies, data was collected retrospectively. In total, 353 IBD-patients(225 patients with Crohn's disease, 119 with ulcerative colitis and nine with unclassified IBD) with prior azathioprine/mercaptopurine resistance and/or intolerance(n = 321) or de novo thioguanine administration(n = 32) were included for analysis, of which 228(65%) had clinical improvement on thioguanine therapy, based on standard IBD questionnaires, biochemical parameters or global physician assessments. Short-term results were based on 268 treatment years(median follow-up 9 mo, range 3-22 mo) with a median daily dose of 20 mg(range 10-80 mg). Discontinuation, mostly due to adverse events, was reported in 72 patients(20%). CONCLUSION The efficacy of thioguanine therapy in IBD patients intolerant to conventional thiopurine therapy is observed in 65%, with short term adverse events in 20% of patients.

关键词： Thiopurines Thioguanine Inflammatory bowel disease Crohn’s disease Ulcerative colitis

Wafer-scale 3D shaping of high aspect ratio structures by multistep plasma etching and corner lithography

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Microsystems & Nanoengineering 2020年第1期6卷 1176-1186页

作者： Shu Ni Erwin j.W.Berenschot Pieter j.Westerik Meint jde boer Rene Wolf Hai Le-The Han j.G.E.Gardeniers Niels R.Tas Mesoscale Chemical System Group MESA+InstituteUniversity of Twente7522 NB EnschedeThe Netherlands Inorganic Materials Science Group MESA+InstituteUniversity of Twente7522 NB EnschedeThe Netherlands NanoLab Cleanroom MESA+InstituteUniversity of Twente7522 NB EnschedeThe Netherlands Physics of Fluids Group MESA+Institute&Max Planck Center for Complex Fluid DynamicsUniversity of Twente7522 NB EnschedeThe Netherlands BIOS Lab-on-a-Chip Group MESA+Institute&Max Planck Center for Complex Fluid DynamicsUniversity of Twente7522 NB EnschedeThe Netherlands

The current progress of system miniaturization relies extensively on the development of 3D machining techniques to increase the areal structure *** this work,a wafer-scale out-of-plane 3D silicon(Si)shaping technology is reported,which combines a multistep plasma etching process with corner *** multistep plasma etching procedure results in high aspect ratio structures with stacked semicircles etched deep into the sidewall and thereby introduces corners with a proper geometry for the subsequent corner *** to the geometrical contrast between the gaps and sidewall,residues are left only inside the gaps and form an inversion mask inside the *** this mask,octahedra and donuts can be etched in a repeated manner into Si over the full wafer area,which demonstrates the potential of this technology for constructing high-density 3D structures with good dimensional control in the bulk of Si wafers.

关键词： lithography high structures

On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients

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World journal of Gastroenterology 2005年第35期11卷 5540-5544页

作者： Nanne KH de boer Luc jj Derijks Lennard PL Gilissen Daniel W Hommes Leopold GjB Engels Sybrand Y de boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton Hj Naber Chris jj Mulder Dirk j de jong Department of Gastroenterology and Hepatology VU University Medical Centre Amsterdam The Netherlands Department of Clinical Pharmacy Maxima Medical Centre Veldhoven The Netherlands Department of Gastroenterology and Hepatology Academic Hospital Maastricht The Netherlands Department of Gastroenterology and Hepatology Academic Medical Centre Amsterdam The Netherlands Department of Gastroenterology and Hepatology Maasland Hospital Sittard The Netherlands Department of Gastroenterology and Hepatology Rijnstate Hospital Arnhem The Netherlands Department of Clinical Pharmacy Maasland Hospital Sittard The Netherlands Department of Gastroenterology and Hepatology Isala Clinics Location Sophia Zwolle The Netherlands Department of Gastroenterology and Hepatology Radboud University Nijmegen Medical Centre The Netherlands

AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 ***: Database ***: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had ***: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials.

关键词： 6-Thioguanine Azathioprine 6-Mercaptopurine Crohn's disease Ulcerative colitis Side effects Tolerance Safety

Pulmonary immunization:deposition site is of minor relevance for influenza vaccination but deep lung deposition is crucial for hepatitis B vaccination

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Acta Pharmaceutica Sinica B 2019年第6期9卷 1231-1240页

作者： jasmine Tomar Wouter FTonnis Harshad P.Patil Anne H.de boer Paul Hagedoorn Rita Vanbever Henderik W.Frijlink Wouter L.j.Hinrichs Department of Pharmaceutical Technology and Biopharmacy University of GroningenGroningen 9713 AVthe Netherlands Advanced Drug Delivery and Biomaterials Louvain Drug Research Institute(LDRI)Universite catholique de LouvainBrussels 1200Belgium

Vaccination via the pulmonary route could be an attractive alternative to parenteral *** towards the best site of antigen deposition within the lungs to induce optimal immune responses has conflicting results which might be dependent on the type of vaccine and/or its physical ***,in this study,we explored whether deep lung deposition is crucial for two different vaccines,i.e.,influenza and hepatitis B *** view of this,influenza subunit vaccine and hepatitis B surface antigen were labeled with a fluorescent dye and then *** data showed that after pulmonary administration to mice the powders were deposited in the trachea/central airways when a commercially available insufflator was used while deep lung deposition was achieved when an in-house built aerosol generator was *** studies revealed that comparable immune responses were induced upon trachea/central airways or deep lung targeting of dry influenza vaccine ***,for hepatitis B vaccine,no immune responses were induced by trachea/central airways deposition whereas they were considerable after deep lung ***,we conclude that deep lung targeting is not a critical parameter for the efficacy of pulmonary administered influenza vaccine whereas for hepatitis B vaccine it is.

关键词： Inhalation Powders Deep lung deposition Influenza Hepatitis B

Al(Ga)原子择优占位对Gd_2Co_(17)化合物磁晶各向异性的影响

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材料研究学报 2004年第1期18卷 88-95页

作者：顾正飞刘正义 F.R.de boer K.H.j.Buschow 桂林电子工业学院华南理工大学 Van der Waals-Zeeman Institute University of AmsterdamThe Netherlands

用磁性测量和磁取向粉末X射线衍射方法,研究了Gd2Co17-xMx(M=Al,Ga;x≤4)化合物的磁晶各向异性与Al(Ga)原子浓度的依赖关系.随着x的增加, Gd2Co17-xAlx(x≥1)和Gd2Co17-xGax(x≥2)化合物的室温磁晶各向异性由易面转变为易轴;在Al、Ga原... 详细信息

用磁性测量和磁取向粉末X射线衍射方法,研究了Gd2Co17-xMx(M=Al,Ga;x≤4)化合物的磁晶各向异性与Al(Ga)原子浓度的依赖关系.随着x的增加, Gd2Co17-xAlx(x≥1)和Gd2Co17-xGax(x≥2)化合物的室温磁晶各向异性由易面转变为易轴;在Al、Ga原子的浓度分别为x=0.9和x=1.8附近时,室温各向异性常数K1由负变正,在x=3时达到最大值,且含Al化合物的K1最大值约为含Ga化合物的四倍根据Al(Ga)原子在Gd2Co17化合物不同Co晶位择优占位的事实,讨论了Co亚点阵磁晶各向异性的演变.结果表明, Al原子择优占据6c晶位是导致Al原子对Co亚点阵各向异性正贡献大于Ga原子的主要原因.

关键词：金属材料磁晶各向异性磁性测量择优占位稀土钴化合物

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景观生态系统的基础研究

生态学进展 1989年第2期6卷 120-121,81页

作者： boer,R.j 黄克新

Amplitude analysis of the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)

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Chinese Physics C 2024年第8期48卷 6-33页

作者： M.Ablikim M.N.Achasov P.Adlarson O.Afedulidis X.C.Ai R.Aliberti A.Amoroso Q.An Y.Bai O.Bakina I.Balossino Y.Ban H.-R.Bao V.Batozskaya K.Begzsuren N.Berger M.Berlowski M.Bertani D.Bettoni F.Bianchi E.Bianco A.Bortone I.Boyko R.A.Briere A.Brueggemann H.Cai X.Cai A.Calcaterra G.F.Cao N.Cao S.A.Cetin j.F.Chang W.L.Chang G.R.Che G.Chelkov C.Chen C.H.Chen Chao Chen G.Chen H.S.Chen M.L.Chen S.j.Chen S.L.Chen S.M.Chen T.Chen X.R.Chen X.T.Chen Y.B.Chen Y.Q.Chen Z.j.Chen Z.Y.Chen S.K.Choi X.Chu G.Cibinetto F.Cossio j.j.Cui H.L.Dai j.P.Dai A.Dbeyssi R.E.de boer D.Dedovich C.Q.Deng Z.Y.Deng A.Denig I.Denysenko M.Destefanis F.De Mori B.Fang S.S.Fang W.X.Fang Y.Fang Y.Q.Fang R.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng j.H.Feng Y.T.Feng K.Fischer M.Fritsch C.D.Fu j.L.Fu Y.W.Fu H.Gao Y.N.Gao Yang Gao S.Garbolino I.Garzia P.T.Ge Z.W.Ge C.Geng E.M.Gersabeck B.Ding X.X.Ding Y.Ding Y.Ding j.Dong L.Y.Dong M.Y.Dong X.Dong M.C.Du S.X.Du Z.H.Duan P.Egorov Y.H.Fan j.Fang jA.Gilman K.Goetzen L.Gong W.X.Gong W.Gradl S.Gramigna M.Greco M.H.Gu Y.T.Gu C.Y.Guan Z.L.Guan A.Q.Guo L.B.Guo M.j.Guo R.P.Guo Y.P.Guo A.Guskov j.Gutierrez K.L.Han T.T.Han X.Q.Hao F.A.Harris K.K.He K.L.He F.H.Heinsius C.H.Heinz Y.K.Heng C.Herold T.Holtmann P.C.Hong G.Y.Hou X.T.Hou Y.R.Hou Z.L.Hou B.Y.Hu H.M.Hu j.F.Hu T.Hu Y.Hu G.S.Huang K.X.Huang L.Q.Huang X.T.Huang Y.P.Huang T.Hussain F.H\"olzken N.H\"usken N.in der Wiesche M.Irshad j.jackson S.janchiv j.H.jeong Q.ji Q.P.ji W.ji X.B.ji X.L.ji Y.Y.ji X.Q.jia Z.K.jia D.jiang H.B.jiang P.C.jiang S.S.jiang T.j.jiang X.S.jiang Y.jiang j.B.jiao j.K.jiao Z.jiao S.jin Y.jin M.Q.jing X.M.jing T.johansson S.Kabana N.Kalantar-Nayestanaki X.L.Kang X.S.Kang M.Kavatsyuk B.C.Ke V.Khachatryan A.Khoukaz R.Kiuchi O.B.Kolcu B.Kopf M.Kuessner X.Kui A.Kupsc W.K\"uhn j.j.Lane P.Larin L.Lavezzi T.T.Lei Z.H.Lei H.Leithoff M.Lellmann T.Lenz C.Li C.Li C.H.Li Cheng Li D.M.Li F.Li G.Li H.Li H.B.Li H.j.Li H.N.Li Hui Li j.R.Li j.S.Li K.Li L.j.Li L.K.Li Lei Li M.H.Li P.R.Li Q.M.Li Q.X.Li R.Li S.X.Li T.Li W.D.Li W.G.Li X.Li X.H.Li X.L.Li X.Y.Li Y Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Beihang University Beijing 100191China Bochum Ruhr-University D-44780 BochumGermany Budker Institute of Nuclear Physics SB RAS(BINP) Novosibirsk 630090Russia Carnegie Mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China Central South University Changsha 410083China China Center of Advanced Science and Technology Beijing 100190China China University of Geosciences Wuhan 430074China Chung-Ang University Seoul06974Republic of Korea COMSATS University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan University Shanghai 200433China GSI Helmholtzcentre for Heavy Ion Research GmbH D-64291 DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China Hangzhou Normal University Hangzhou 310036China Hebei University Baoding 071002China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China Henan University of Science and Technology Luoyang 471003China Henan University of Technology Zhengzhou 450001China Huangshan College Huangshan 245000China Hunan Normal University Changsha 410081China Hunan University Changsha 410082China Indian Institute of Technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly INFN Laboratori Nazionali di Frascati INFN Sezione di PerugiaI-06100PerugiaItaly INFN Laboratori Nazionali di Frascati University of PerugiaI-06100PerugiaItaly INFN Sezione di Ferrara INFN Sezione di FerraraI-44122FerraraItaly INFN Sezione di Ferrara University of FerraraI-44122FerraraItaly Inner Mongolia University Hohhot 010021China Institute of Modern Physics Lanzhou 730000China Institute of Physics and Technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de A

Using e^(+)e^(−)annihilation data corresponding to an integrated luminosity of 2.93 fb^(−1)taken at the center-of-mass energy√s=3.773 GeV with the BESIII detector,a joint amplitude analysis is performed on the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η).The fit fractions of individual components are obtained,and large interferences among the dominant components of the decays D^(0)→a_(1)(1260)π,D^(0)→π(1300)π,D^(0)→ρ(770)ρ(770),and D^(0)→2(ππ)_(S)are observed in both *** the obtained amplitude model,the CP-even fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are determined to be(75.2±1.1_(stat).±1.5_(syst.))%and(68.9±1.5_(stat).±2.4_(syst.))%,*** branching fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are measured to be(0.688±0.010_(stat.)±0.010_(syst.))%and(0.951±0.025_(stat.)±0.021_(syst.))%,*** amplitude analysis provides an important model for the binning strategy in measuring the strong phase parameters of D^(0)→4πwhen used to determine the CKM angleγ(ϕ_(3))via the B^(−)→DK^(−)decay.

关键词： BESIII D^(0)meson decays amplitude analysis CP-even fraction