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Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus

World journal of Gastroenterology 2013年第48期19卷 9282-9293页

作者： Fergus Noble Luke Nolan Adrian C Bateman james P byrne jamie j Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy j Iveson Tim j Underwood Andrew R Bateman Cancer Sciences Unit Faculty of Medicine University of Southampton Southampton SO16 6YD United Kingdom Department of Surgery University Hospital Southampton NHS Foundation Trust Southampton SO16 6YD United Kingdom Department of Cellular Pathology University Hospital Southampton NHS Foundation Trust Southampton SO16 6YD United Kingdom Cancer Care University Hospital Southampton NHS Foundation Trust Southampton SO16 6YD United Kingdom

AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant ***:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were *** neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 *** to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et *** addition lymph node downstaging was also *** node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery *** were followed up for 5 years post *** was defined radiologically,with or without pathological *** association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological ***:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality *** hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological *** four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,

关键词： Esophageal cancer Gastro-esophageal cancer Neoadjuvant Regression

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热化学处理过程中共析钢奥氏体的形成

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国外金属热处理 1991年第3期12卷 62-63页

作者： PO-WE KAO j.G.byrne 赵景杰常州内燃机车厂

我们已经研究过珠光体经大压下量冷轧后在短暂的高于A1温度的条件下,形成奥氏体的过程。这是人们关心的众多热化学处理(TMT)的基础,这类热处理涉及到在随后的空冷或淬火时上述奥氏体的再转变。无疑,没有经过变形的珠光体形成奥氏体的速... 详细信息

我们已经研究过珠光体经大压下量冷轧后在短暂的高于A1温度的条件下,形成奥氏体的过程。这是人们关心的众多热化学处理(TMT)的基础,这类热处理涉及到在随后的空冷或淬火时上述奥氏体的再转变。无疑,没有经过变形的珠光体形成奥氏体的速率比变形后的慢得多。但是,变形后奥氏体和珠光体界面的生长率可能要低一些,这一点是出乎人们意料的。

关键词：共析钢热化学处理奥氏体

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Effects of Obesity and Smoking on Survival in Non-Small Cell Lung Cancer

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Open journal of Epidemiology 2016年第2期6卷 128-139页

作者： Damien M. Hansra Tulay Koru-Sengul Wei Zhao Feng Miao Alicia P. Monedero Stacey L. Tannenbaum David j. Lee judith Hurley Margaret M. byrne University of Miami/jackson Memorial Hospital Miami FL USA Department of Public Health Sciences and Sylvester Comprehensive Cancer Center of University of Miami Miller School of Medicine Miami FL USA

Background: Obesity is an emerging leading cause of morbidity and mortality in the US and the relationship between obesity, tobacco, and survival in NSCLC is unclear. Methods: Data (n = 87,631) were obtained from linkage of the 1996-2007 Florida Cancer Data System to the Agency for Health Care Administration database providing procedure and diagnoses codes. Survival time was calculated from date of diagnosis to date of death. Smoking status was categorized as never, current, and former. Obesity (yes/no) = ICD9 code BMI > 30 kg/m2, cachexia = ICD9 code “wasting syndrome”, & non-obese = non-obese & non cachectic. Cox proportional regression models used to predict survival;demographic, clinical, treatment factors, & comorbidities were included in adjusted models with smoking status and obesity as the main factors. Results: The majority of patients (pts) were either former (49%) or current (40%) smokers, & non-obese (88%). 6.8% of pts were obese & 4.8% of pts were cachectic. There were significant differences between survival curves and median survival (months) for obese vs. non-obese vs. cachectic pts. (20 vs 10 vs. 7.9;P justed model was former (HR 1.08;P justed model, controlling for extensive variables and comorbidities, former (HR 1.11;P < 0.001) and current (HR 1.19;P < 0.001) smokers still had significantly worse survival vs. never

关键词： Lung Cancer Non-Small Cell Lung Cancer Tobacco Smoking Obesity

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制造音乐

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作者： (美)大卫·拜恩(David byrne)

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大便失禁患者的电话生物反馈与面对面生物反馈:两项技术在239例患者中的比较

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世界核心医学期刊文摘（胃肠病学分册） 2006年第5期2卷 21-22页

作者： byrne C.M. Solomon M.j. Rex j. 陈云茹 Royal Prince Alfred Medical Center 419/100 Carillon Avenue Newtown NSW 2042 Australia Prof.

PURPOSE: Biofeedback is an effective treatment for patients with fecal incontinence, yet little is known about how it works or the minimum regime necessary to provide clinical benefit. This study compares the effectiveness of a novel protocol of telephone-assisted biofeedback treatment for patients living in rural and remote areas with the standard face-to-face protocol for patients with fecal incontinence. METHODS: A new treatment program comprising an initial face-to-face assessment and treatment with transanal manometry and ultrasound biofeedback, followed by three treatments conducted via telephone and a final face-to-face assessment, was developed. Standard treatment involved five face-to-face treatment sessions with manometry and ultrasound. Patients from rural areas were offered the telephone-assisted treatment protocol. Data gathered prospectively included incontinence scores, a quality of life index, anal manometry, and external sphincter isometric and isotonic fatigue times. RESULTS: A total of 239 consecutive patients treated between july 2001 and july 2004 were enrolled. There were no significant differences in demographic details, past history, or pretreatment measures of the two groups. Forty-six of 55 patients (84 percent) treated with the telephone protocol and 129 of 184 (70 percent) treated by the standard technique completed treatment. There were substantial, significant improvements after treatment, including 54 percent mean improvement in patient’ s own rating of their incontinence in both groups; a mean decrease of 3.1 and 3.2 on the St. Mark’ s incontinence score (from 7.9 to 4.7 and 7.4 to 4.2 of 13) and relative improvements of 128 and 130 percent in the quality of life index (from 0.29 to 0.65 and 0.3 to 0.69 of 1) for the telephone-assisted and standard groups respectively. Importantly, there were no significant differences between the telephone-assisted or standard groups in any outcome. Of patients who completed treatment, 78 percent wer

关键词：生物反馈治疗大便失禁患者电话生活质量指数治疗方法标准治疗超声治疗压力测定人口统计学

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Genotyping-by-sequencing application on diploid rose and a resulting high-density SNP-based consensus map

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Horticulture Research 2018年第1期5卷 668-681页

作者： Muqing Yan David H.byrne Patricia E.Klein jizhou Yang Qianni Dong Natalie Anderson Department of Horticultural Sciences Texas A&M UniversityCollege StationTX77843USA Institute for Plant Genomics and Biotechnology Texas A&M UniversityCollege StationTX77843USA Department of Computer Science San Francisco State UniversitySan FranciscoCA94132USA Monsanto Company 700 Chesterfield Parkway WestChesterfieldMO63017USA

Roses,which have been cultivated for at least 5000 years,are one of the most important ornamental crops in the *** of the interspecific nature and high heterozygosity in commercial roses,the genetic resources available for rose are *** effectively identify markers associated with QTL controlling important traits,such as disease resistance,abundant markers along the genome and careful phenotyping are *** genotyping by sequencing technology and the strawberry genome(Fragaria vesca v2.0.a1)as a reference,we generated thousands of informative single nucleotide polymorphism(SNP)*** SNPs along with known bridge simple sequence repeat(SSR)markers allowed us to create the first high-density integrated consensus map for diploid *** maps were first created for populations j06-20-14-3×“Little Chief”(j14-3×LC),j06-20-14-3×“Vineyard Song”(j14-3×VS)and“Old Blush”×“Red Fairy”(OB×RF)and these maps were linked with 824 SNPs and 13 SSR bridge *** anchor SSR markers were used to determine the numbering of the rose linkage *** diploid consensus map has seven linkage groups(LGs),a total length of 892.2 cM,and an average distance of 0.25 cM between 3527 *** combining three individual populations,the marker density and the reliability of the marker order in the consensus map was improved over a single population *** synteny between the strawberry and diploid rose genomes was *** consensus map will serve as the tool for the discovery of marker–trait associations in rose breeding using pedigree-based *** high level of conservation observed between the strawberry and rose genomes will help further comparative studies within the Rosaceae family and may aid in the identification of candidate genes within QTL regions.

关键词： breeding crops linkage

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Loco-regional therapies for patients with hepatocellular carcinoma awaiting liver transplantation: Selecting an optimal therapy

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World journal of Transplantation 2016年第2期6卷 306-313页

作者： Thomas j.byrne jorge Rakela Division of Gastroenterology and Hepatology Mayo Clinic in Arizona

Hepatocellular carcinoma(HCC) is a common, increasingly prevalent malignancy. For all but the smallest lesions, surgical removal of cancer via resection or liver transplantation(LT) is considered the most feasible pathway to cure. Resection- even with favorable survival- is associated with a fairly high rate of recurrence, perhaps since most HCCs occur in the setting of cirrhosis. LT offers the advantage of removing not only the cancer but the diseased liver from which the cancer has arisen, and LT outperforms resection for survival with selected patients. Since time waiting for LT is time during which HCC can progress, locoregional therapy(LRT) is widely employed by transplant centers. The purpose of LRT is either to bridge patients to LT by preventing progression and waitlist dropout, or to downstage patients who slightly exceed standard eligibility criteria initially but can fall within it after treatment. Transarterial chemoembolization and radiofrequency ablation have been the most widely utilized LRTs to date, with favorable efficacy and safety as a bridge to LT(and for the former, as a downstaging modality). The list of potentially effective LRTs has expanded in recent years, and includes transarterial chemoembolization with drug-eluting beads, radioembolization and novel forms of extracorporal therapy. Herein we appraise the various LRT modalities for HCC, and their potential roles in specific clinical scenarios in patients awaiting LT.

关键词： Liver transplantation Loco-regional therapy Transarterial chemoembolization Radioembolization Hepatocellular carcinoma

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疲劳设计准则

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1982年

作者：（英）达根（T.V. Duggan）（英）伯恩（j. byrne）雷慰宗刘元镛译

本书详细介绍了应力--应变分析, 裂纹形成, 疲劳裂纹扩展和最后破坏等问题, 用以计算构件的疲劳完整性. 书中包括了一些新的硏究数据和基本理论

ISBN: (纸本)15034·2379

本书详细介绍了应力--应变分析, 裂纹形成, 疲劳裂纹扩展和最后破坏等问题, 用以计算构件的疲劳完整性. 书中包括了一些新的硏究数据和基本理论

关键词：机械设计疲劳理论

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British journal of General Practice论文摘要汇编——他汀类药物用于心血管疾病的一级预防:基于爱尔兰队列的指南和患者偏好建模

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中国全科医学 2019年第21期22卷 2523-2523页

作者：本刊编辑部 byrne P CULLINAN j GILLESPIE P

【摘要】背景心血管疾病一级预防临床指南的修订扩大了接受他汀类药物治疗的患者数量。目的分析临床指南修订的潜在影响。设计与场所基于爱尔兰老龄问题纵向研究中年龄≥ 50岁的人群,对7种欧洲连续性指南的影响进行建模。方法根据不... 详细信息

【摘要】背景心血管疾病一级预防临床指南的修订扩大了接受他汀类药物治疗的患者数量。目的分析临床指南修订的潜在影响。设计与场所基于爱尔兰老龄问题纵向研究中年龄≥ 50岁的人群,对7种欧洲连续性指南的影响进行建模。方法根据不断变化的指南建议和模拟的相关潜在成本,分析无心血管疾病史的患者他汀类药物治疗资格。为预防7 种指南中推荐的治疗最低基线风险,以及2016 年指南包含的低、中、高和极高风险患者的1种主要心血管事件,作者计算了所需治疗的患者数量。比较计算所得数据与患者报告的治疗所需数量,以证明服用日常药物的合理性。结果符合他汀类药物治疗的患者比例从1987 年的8%增加到2016年的61%;相关成本从每年1 390万欧元增加到1.071亿欧元。每种指南推荐的最低风险的需要治疗的患者数量从40增加到400。到2016年,需要治疗的最低风险的患者数量为400,而极高风险的患者数量为≤25。达到治疗所需数量的他汀类药物作为日常药物服用,符合该资格的患者比例随着指导方针的修订而下降。结论他汀类药物治疗资格的增加会影响目前大部分人口和医疗保健预算。采取和报销他汀类药物应考虑预期的成本效益和患者的可接受性。

关键词：他汀类药物心血管疾病临床指南一级预防论文摘要爱尔兰患者建模

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太极拳对健康老年人身体平衡功能影响的研究综述

太极拳对健康老年人身体平衡功能影响的研究综述

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中国康复医学会运动疗法分会第十一届全国康复学术大会学术会议

作者： Colleen A.byrne Fairlie K.Fraser Brian j.Horswill Lindsay V.Trimble 王亚昆 Elizabeth Dean B.Sc.Chemistry MPT B.Sc.Kinesiology MPT B.Music MPT B.Sc.Human Kinetics MPT B.Sc.Biology MPTFraser Health AuthorityBurnabyBC Faculty of Medicine University of British ColumbiaVancouverBritish Columbia Dr.

目的:文综合太极拳对健康老年人身体平衡功能影响的国内外研究报道,旨在促进知识和文化交流,为太极拳在该领域的研究提供方向。通过检验并比较不同的平衡功能测试,为太极拳的功效做出全面的综合描述。方法:英文文献电脑检索数据库Medlin...

目的:文综合太极拳对健康老年人身体平衡功能影响的国内外研究报道,旨在促进知识和文化交流,为太极拳在该领域的研究提供方向。通过检验并比较不同的平衡功能测试,为太极拳的功效做出全面的综合描述。方法:英文文献电脑检索数据库Medline,CINAHL,PEDro,Sport discus,Embase,EMB Reviews,检索工作始于2007年4月,止于2008年8月。检索关键词tai chi/tai ji/tai chi chuan(太极拳),postural stability/posture/postural equilibrium(姿势稳定性),balance/dynamic equilibrium(平衡),elderly/aging/aged/adult(老年人)。

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