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Measurement of the integrated luminosity of the Phase 2 data of the Belle Ⅱ experiment

Chinese Physics C 2020年第2期44卷 1-12页

作者： F.Abudinén I.Adachi P.Ahlburg H.Aihara N.Akopov A.Aloisio F.Ameli L.Andricek N.Anh Ky D.M.Asner H.Atmacan T.Aushev V.Aushev T.Aziz K.Azmi V.Babu S.Baehr S.Bahinipati A.M.Bakich P.Bambade Sw.Banerjee S.Bansal V.Bansal M.Barrett j.Baudot A.Beaulieu j.becker P.K.Behera j.V.Bennett E.Bernieri F.U.Bernlochner M.Bertemes M.Bessner S.Bettarini V.Bhardwaj F.Bianchi T.Bilka S.Bilokin D.Biswas G.Bonvicini A.Bozek M.Bračko P.Branchini N.Braun T.E.Browder A.Budano S.Bussino M.Campajola L.Cao G.Casarosa C.Cecchi D.Červenkov M.-C.Chang P.Chang R.Cheaib V.Chekelian Y.Q.Chen Y.-T.Chen B.G.Cheon K.Chilikin H.-E.Cho K.Cho S.Cho S.-K.Choi S.Choudhury D.Cinabro L.Corona L.M.Cremaldi S.Cunliffe T.Czank F.Dattola E.De La Cruz-Burelo G.De Nardo M.De Nuccio G.De Pietro R.de Sangro M.Destefanis S.Dey A.De Yta-Hernandez F.Di Capua S.Di Carlo j.Dingfelder Z.Doležal I.Domínguez jiménez T.V.Dong K.Dort S.Dubey S.Duell S.Eidelman M.Eliachevitch T.Ferber D.Ferlewicz G.Finocchiaro S.Fiore A.Fodor F.Forti A.Frey B.G.Fulsom M.Gabriel E.Ganiev M.Garcia-Hernandez R.Garg A.Garmash V.Gaur A.Gaz U.Gebauer A.Gellrich j.Gemmler T.Geßler R.Giordano A.Giri B.Gobbo R.Godang P.Goldenzweig B.Golob P.Gomis P.Grace W.Gradl E.Graziani D.Greenwald C.Hadjivasiliou S.Halder K.Hara T.Hara O.Hartbrich K.Hayasaka H.Hayashii C.Hearty M.T.Hedges I.Heredia de la Cruz M.Hernández Villanueva A.Hershenhorn T.Higuchi E.C.Hill H.Hirata M.Hoek S.Hollitt T.Hotta C.-L.Hsu Y.Hu K.Huang T.Iijima K.Inami G.Inguglia j.Irakkathil jabbar A.Ishikawa R.Itoh M.Iwasaki Y.Iwasaki S.Iwata P.jackson W.W.jacobs D.E.jaffe E.-j.jang H.B.jeon S.jia Y.jin C.joo j.Kahn H.Kakuno A.B.Kaliyar G.Karyan Y.Kato T.Kawasaki H.Kichimi C.Kiesling B.H.Kim C.-H.Kim D.Y.Kim S.-H.Kim Y.K.Kim Y.Kim T.D.Kimmel K.Kinoshita C.Kleinwort B.Knysh P.Kodyš T.Koga I.Komarov T.Konno S.Korpar D.Kotchetkov N.Kovalchuk T.M.G.Kraetzschmar P.Križan R.Kroeger j.F.Krohn P.Krokovny W.Kuehn T.Kuhr M.Kumar R.Kumar K.Kumara S.Kurz A.Kuzmin Y.-j.Kwon S.Lacaprara Y.-T.Lai C.La Licata K.Lalwani L.Lanceri j.S.Lange K.Lautenbach I.-S.Le Beihang University Beijing 100191 Brookhaven National Laboratory UptonNew York 11973 Budker Institute of Nuclear Physics SB RAS Novosibirsk 630090 Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional Mexico City 07360 Faculty of Mathematics and Physics Charles University12116 Prague Chiba University Chiba 263-8522 Consejo Nacional de Ciencia y Tecnología Mexico City 03940 Deutsches Elektronen–Synchrotron 22607 Hamburg Duke University DurhamNorth Carolina 27708 Earthquake Research Institute University of TokyoTokyo 113-0032 Forschungszentrum jülich 52425 Jülich Department of Physics Fu Jen Catholic UniversityTaipei 24205 Key Laboratory of Nuclear Physics and Ion-beam Application(MOE)and Institute of Modern Physics Fudan UniversityShanghai 200443 II.Physikalisches Institut Georg-August-Universität Göttingen37073 Göttingen Gifu University Gifu 501-1193 The Graduate University for Advanced Studies(SOKENDAI) Hayama 240-0193 Gyeongsang National University Jinju 52828 Department of Physics and Institute of Natural Sciences Hanyang UniversitySeoul 04763 High Energy Accelerator Research Organization(KEK) Tsukuba 305-0801 j-PARC Branch KEK Theory CenterHigh Energy Accelerator Research Organization(KEK)Tsukuba 305-0801 Indian Institute of Science Education and Research Mohali SAS Nagar140306 Indian Institute of Technology Bhubaneswar Satya Nagar 751007 Indian Institute of Technology Hyderabad Telangana 502285 Indian Institute of Technology Madras Chennai 600036 Indiana University BloomingtonIndiana 47408 Institute for High Energy Physics Protvino 142281 Institute of High Energy Physics Vienna 1050 Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049 Institute of Particle Physics(Canada) VictoriaBritish Columbia V8W 2Y2 Institute of Physics Hanoi Instituto de Fisica Corpuscular Paterna 46980 INFN Laboratori Nazionali di Frascati I-00044 Frascati INFN Sezione di Napoli I-80126 Napoli INFN Sezione di Padova I-35131 Padova INFN Sezione di Perugia I-06123 Perugia

From April to july 2018,a data sample at the peak energy of the T(4 S) resonance was collected with the Belle Ⅱ detector at the SuperKEKB electron-positron *** is the first data sample of the Belle Ⅱ *** Bhabha and digamma events,we measure the integrated luminosity of the data sample to be(496.3±0.3±3.0) pb-1,where the first uncertainty is statistical and the second is *** work provides a basis for future luminosity measurements at Belle Ⅱ.

关键词： luminosity Bhabha digamma Belle II

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Transcriptome landscape of the early Brassica napus seed

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journal of Integrative Plant Biology 2019年第5期61卷 639-650页

作者： Dylan j.Ziegler Deirdre Khan jenna L.Kalichuk Michael G.becker Mark F.Belmonte University of Manitoba

Brassica napus L.(canola) is one of the world’s most economically important oilseeds. Despite our growing knowledge of Brassica genetics, we still know little about the genes and gene regulatory networks underlying early seed development. In this work, we use laser microdissection coupled with RNA sequencing to profile gene activity of both the maternal and filial subregions of the globular seed. We find subregions of the chalazal end including the chalazal endosperm, chalazal proliferating tissue, and chalazal seed coat, have unique transcriptome profiles associated with hormone biosynthesis and polysaccharide metabolism. We confirm that the chalazal seed coat is uniquely enriched for sucrose biosynthesis and transport, and that the chalazal endosperm may function as an important regulator of the maternal region through brassinosteroid synthesis. The chalazal proliferating tissue,a poorly understood subregion, was specifically enriched in transcripts associated with megasporogenesis and trehalose biosynthesis, suggesting this ephemeral structure plays an important role in both sporophytic development and carbon nutrient balance, respectively. Finally, compartmentalization of transcription factors and their regulatory circuits has uncovered previously unknown roles for the chalazal pole in early seed development.

关键词： Brassica napus L.(canola) understood subregion

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Very early family-based intervention for anxiety:two case studies with toddlers

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General Psychiatry 2019年第6期32卷 349-355页

作者： Dina R Hirshfeld-becker Aude Henin Stephanie j Rapoport Timothy E Wilens Alice S Carter Child CBT Program Department of PsychiatryMassachusetts General HospitalBostonMassachusettsUSA Department of Psychiatry Harvard Medical SchoolBostonMassachusettsUSA Division of Child and Adolescent Psychiatry Department of PsychiatryMassachusetts General HospitalBostonMassachusettsUSA Department of Psychology University of Massachusetts BostonBostonMassachusettsUSA

Anxiety disorders represent the most common categor of psychiatric disorder in children and adolescents and contribute to distress,impairment and *** Anxiety disorders or their temperamental precursors are often evident in early childhood,and anxiety can impair functioning,even during preschool age and in toddlerh A growing number of investigators have shown that anxiety in preschoolers can be treated efficaciously using cognitive-behavioural therapy(CBT)administere either by training the parents to apply CBT strategies with their children or through direct intervention with parents and *** date,most investigators have drawn the line at offering direct CBT to children under the age of ***,since toddlers can also present with impairing symptoms,and since behaviour strategi can be applied in older preschoolers with poor languag ability successfully,it ought to be possible to apply CBT anxiety to younger children as *** therefore prese two cases of very young children with impairing anxiet(ages 26 and 35 months)and illustrate the combinatio parent-only and parent-child CBT sessions that compri their *** treatment was well tolerated by parents and children and showed promise for reducing anxiety symptoms and improving coping skills.

关键词： distress behaviour apply

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Structure and Function of TPC1 Vacuole SV Channel Gains Shape

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Molecular Plant 2018年第6期11卷 764-775页

作者： Rainer Hedrich Thomas D. Mueller Dirk becker Irene Marten Institute for Molecular Plant Physiology and Biophysics University of Wurzburg Julius-yon-Sachs Platz 2 97082 Wurzburg Germany

Plants and animals in endosomes operate TPCI/SV-type cation channels. All plants harbor at least one TPC1 gene. Although the encoded SV channel was firstly discovered in the plant vacuole membrane two decades ago, its biological function has remained enigmatic. Recently, the structure of a plant TPC1/SV channel protein was determined. Insights into the 3D topology has now guided site-directed mutation ap- proaches, enabling structure-function analyses of TPC1/SV channels to shed new light on earlier findings. Fou2 plants carrying a hyperactive mutant form of TPC1 develop wounding stress phenotypes. Recent studies with fou2 and mutants that lack functional TPC1 have revealed atypical features in local and long-distance stress signaling, providing new access to the previously mysterious biology of this vacuolar cation channel type in planta.

关键词： Ca^2+ sensors TPC1/SV channel vacuole membrane voltage voltage sensor

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Dendritic cell-mimicking scaffolds for ex vivo T cell expansion

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Bioactive Materials 2023年第3期21卷 241-252页

作者： Hye Sung Kim Tzu-Chieh Ho Moshe j.Willner Michael W.becker Hae-Won Kim Kam W.Leong Department of Biomedical Engineering Columbia UniversityNew YorkNYUSA Institute of Tissue Regeneration Engineering Dankook UniversityCheonanRepublic of Korea Wilmot Cancer Institute University of Rochester Medical CenterRochesterNYUSA Department of Regenerative Dental Medicine College of DentistryDankook UniversityCheonanRepublic of Korea Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center for Regenerative Medicine Dankook UniversityCheonanRepublic of Korea Mechanobiology Dental Medicine Research Center Dankook UniversityCheonanRepublic of Korea Department of Systems Biology Columbia University Irving Medical CenterNew YorkNY10032USA

We propose an ex vivo T cell expansion system that mimics natural antigen-presenting cells(APCs)for adoptive cell therapy(ACT).Microfiber scaffolds coated with dendritic cell(DC)membrane replicate physicochemical properties of dendritic cells specific for T cell activation such as rapid recognition by T cells,long duration of T cell tethering,and DC-specific co-stimulatory *** DC membrane-coated scaffold is first surface-immobilized with T cell stimulatory ligands,anti-CD3(αCD3)and anti-CD28(αCD28)antibodies,followed by adsorption of releasable interleukin-2(IL-2).The scaffolds present both surface and soluble cues to T cells ex vivo in the same way that these cues are presented by natural APCs in *** demonstrate that the DC-mimicking scaffold promotes greater polyclonal expansion of primary human T cells as compared toαCD3/αCD28-func-tionalized *** importantly,major histocompatibility complex molecules derived from the DC membrane of the scaffold allow antigen-specific T cell expansion with target cell-specific killing *** addition,most of the expanded T cells(~97%)can be harvested from the scaffold by density gradient ***,the DC-mimicking scaffold offers a scalable,modular,and customizable platform for rapid expansion of highly functional T cells for ACT.

关键词： Adoptive cell therapy Ex vivo T cell expansion Cytotoxic T cell Dendritic cell membrane Cell membrane coating Scaffold

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多维时间相关单光子计数在生物医学中的应用(英文)

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深圳大学学报（理工版） 2008年第3期25卷 221-231页

作者： Wolfgang becker becker&Hickl公司 Nahmitzer Damm 30德国柏林D-12277

传统的时间相关单光子计数(Time-correlated single photon counting, TCSPC)受计数率低、一维测量和采集时间长的限制,难以在生物医学中的推广.评述TCSPC的机理和应用,指出TCSPC是探测周期光信号内的单个光子、测量光子探测时间以及构... 详细信息

传统的时间相关单光子计数(Time-correlated single photon counting, TCSPC)受计数率低、一维测量和采集时间长的限制,难以在生物医学中的推广.评述TCSPC的机理和应用,指出TCSPC是探测周期光信号内的单个光子、测量光子探测时间以及构建信号周期内光子分布与时间关系的一种技术,具有多维光子采集特性,计数率近似当前可用的探测器容量.该技术可采集光子对波长和空间座标的分布,时间尺度在皮秒量级,在实验开始时可进行二次计数.多维TCSPC技术拥有近似于理想的计数效率,其时间分辨率仅受探测器渡越时间的离散限制.故TCSPC在生物医学光谱学中极具应用价值.典型应用包括,时域光学X线断层照相、记录生物系统内的瞬态现象、荧光寿命成像显微术、活细胞内荧光共振能量转移实验,以及用荧光关联谱探索染料-蛋白复合体.

关键词：时间相关单光子计数多维探测生物医学光谱学荧光寿命成像显微术荧光共振能量转移

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Micro-Structured Fiber Interferometer as Sensitive Temperature Sensor

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Photonic Sensors 2013年第3期3卷 208-213页

作者： F. C. FAVERO M. becker, R. SPITTEL M. ROTHHARDT j. KOBELKE H. BARTELT Institute of Photonic Technology (IPHT) Albert-Einstein-Strafle-9 07745 Jena Germany

We report on a fast and sensitive temperature sensor using a micro-structured or photonic crystal fiber interferometer with a high germanium doped fiber core. The wavelength sensitivity for temperature variation was as high as △λ/△T= 78 pm/℃ up to 500℃, which was 6 times more sensitive than the fiber Bragg grating temperature sensitivity of △λ/△TT= 13pm/℃ at 1550nm. The sensor device was investigated conceming the sensitivity characteristics and response time.

关键词： Micro-structured optical fiber fiber interferometer fiber temperature sensor

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无菌培养条件下不同碳素和NH_4^+水平对刺线虫生活史的影响

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华南农业大学学报 2004年第3期25卷 48-50页

作者：罗大民王博方文珍 S.j.becker j.O.becker 厦门大学生命科学学院福建厦门361005 厦门市环保局福建厦门361006 Department of Nematology University of CaliforniaRiverside

在24℃无菌、无光照、不同碳素和氮素水平培养条件下,观察了以玉米切根根尖为食的长尾刺线虫 Belono-laimus longicaudatus的发育.结果表明,刺线虫完成生活史所需的最短时间没有明显受到不同碳素水平的影响.碳素缺乏时,刺线虫的存活率... 详细信息

在24℃无菌、无光照、不同碳素和氮素水平培养条件下,观察了以玉米切根根尖为食的长尾刺线虫 Belono-laimus longicaudatus的发育.结果表明,刺线虫完成生活史所需的最短时间没有明显受到不同碳素水平的影响.碳素缺乏时,刺线虫的存活率和成虫的比率明显下降.在5-10倍于标准B5培养基中NH4+水平的环境下,没有观察到NH4+对刺线虫的发育有不良影响.

关键词：无菌培养碳素氨根离子刺线虫生活史发育

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Molecular Plant 2012年第4期5卷 951-954页

作者： Giuseppe Ortu Raffaella Balestrini Patricia A. Pereira jorg D. becker Helge Kuste Paola Bonfante Department of Life Science and Systems Biology University of Torino Italy Istituto per la Protezione delle Piante--CNR Torino Italy Instituto Gulbenkian de Ciencia 2780-156 Oeiras Portugal Institut for Pflanzengenetik Leibniz Universitat Hannover Herrenhauser Str. 2 D-30419 Hannover Germany

Dear Editor, Phytohormones are essential regulators of plant develop- ment, but their role in the signaling processes between plants and fungi during arbuscular mycorrhizal （AM） establishment is far from being understood （Ludwig-M011er, 2010）. AM coloni- zation leads to extensive effects on host metabolism, as revealed by transcriptome studies of AM plants （Hogekamp et al., 2011）. Some genes have been specified as an AM core set, since they are mycorrhizal-responsive, irrespective of the identity of the plant,

关键词： AM真菌植物激素相关基因早期阶段调节过程生物合成相互作用赤霉素

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Fertility,genome stability,and homozygosity in a diverse set of resynthesized rapeseed lines

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The Crop journal 2023年第2期11卷 468-477页

作者： Elizabeth Ihien Katche Antje Schierholt Heiko C.becker jacqueline Batley Annaliese S.Mason Plant Breeding Department The University of Bonn53115 BonnGermany Department of Plant Breeding Justus Liebig University35392 GiessenGermany Department of Crop Sciences Division of Plant Breeding MethodologyGeorg-August University Göttingen37073 GöttingenGermany School of Biological Sciences The University of Western AustraliaPerthWA 6009Australia

Rapeseed(Brassica napus,AACC)was formed by hybridization between progenitor species Brassica rapa(AA)and Brassica oleracea(CC).As a result of a limited number of hybridization events between specific progenitor genotypes and strong breeding selection for oil quality traits,rapeseed has limited genetic *** production of resynthesized *** lines via interspecific hybridization of the diploid progenitor species *** and *** is one possible way to increase genetic variation in ***,most resynthesized lines produced so far have been reported to be meiotically unstable and infertile,in contrast to established *** *** hinders both maintenance and use of this germplasm in breeding *** characterized a large set of 140 resynthesized lines produced by crosses between *** and ***,as well as between *** and wild C genome species(***,***,***,***,*** and ***)for purity(homozygosity),fertility,and genome ***-pollinated seed set,seeds per ten pods as well as percentage pollen viability were used to estimate *** genotyping was performed using the Illumina Infinium Brassica 60K array for 116 genotypes,with at least three individuals per *** of the material which had been advanced through multiple generations was no longer pure,with heterozygosity detected corresponding to unknown parental contributions via *** and genome stability were both *** lines had high numbers of copy number variants(CNVs),indicative of meiotic instability,and high numbers of CNVs were significantly associated with reduced *** putatively stable resynthesized *** lines were *** investigation of these lines may reveal the mechanisms underlying this *** results suggest that selection of stable resynthesized lines for breeding purposes is possible.

关键词： Fertility Genome stability Copy number variants SNP genotyping Resynthesized lines

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