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银柴胡的生物碱成分及其抗炎活性研究

中草药 2018年第22期49卷 5259-5263页

作者：李静敖亮延安大学附属医院免疫风湿科陕西延安716000

目的研究银柴胡Stellaria dichotoma的生物碱成分及其抗炎活性。方法利用硅胶柱色谱、mCI柱色谱和反相制备液相色谱等手段进行分离纯化,并通过1H-NmR、13C-NmR等波谱技术进行结构鉴定。采用脂多糖(LPS)诱导的小鼠巨噬细胞RAW264.7炎症... 详细信息

目的研究银柴胡Stellaria dichotoma的生物碱成分及其抗炎活性。方法利用硅胶柱色谱、mCI柱色谱和反相制备液相色谱等手段进行分离纯化,并通过1H-NmR、13C-NmR等波谱技术进行结构鉴定。采用脂多糖(LPS)诱导的小鼠巨噬细胞RAW264.7炎症反应模型,探究银柴胡中卡巴林生物碱类对巨噬细胞经LPS刺激后产生的炎症因子[肿瘤坏死因子-α(TNF-α)及白细胞介素-6(IL-6)]的影响,评价其抗炎活性。结果从银柴胡正丁醇萃取物中分离得到9个卡巴林生物碱,分别鉴定为gelebolineA(1)、gelebolineB(2)、cordysininE(3)、3,10-dihydroxy-β-carboline(4)、6-hydroxy-3-methoxycarbonyl-β-carboline (5)、 1-methyl-3-(2-hydroxypropan-2-yl)-2-(5-methoxy-9H-β-carbolin-1-yl)-cyclopentanol (6)、2-aldehydetetra-hydroharmine(7)、pegaharmine j(8)、pegaharmine K(9)。抗炎活性检测表明,化合物1～9对LPS刺激的巨噬细胞IL-6炎症因子均具有较强的抑制作用。结论所有化合物均为首次从该植物中分离得到,其中化合物1、2对炎症因子IL-6的抑制作用最强,其IC50值最小仅为5.21μg/m L,该研究首次发现银柴胡的抗炎成分。

关键词：银柴胡卡巴林生物碱抗炎 geleboline A geleboline B

Alcohol-induced Wnt signaling inhibition during bone fracture healing is normalized by intermittent parathyroid hormone treatment

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Animal models and Experimental medicine 2020年第2期3卷 200-207页

作者： Esha m.Kapania Taylor jReif Aaron Tsumura jonathan m。Eby john j.Callaci Internal medicine-Pediatric Resident Rush University Medical CenterChicagoILUSA Limb Lengthening and Complex Reconstruction Fellowship Hospital for Special SurgeryNew YorkNYUSA Department of Orthopaedic Surgery and Rehabilitation Loyola University Medical CenterMaywoodILUSA Alcohol Research Program(ARP) Loyola University Chicago Stritch School of MedicineMaywoodILUSA

Nearly half of orthopaedic trauma patients are intoxicated at the time of injury, and excess alcohol consumption increases the risk for fracture nonunion. Previous studies show alcohol disrupts fracture associated Wnt signaling required for normal bone fracture repair. Intermittent parathyroid hormone(PTH) promotes bone growth through canonical Wnt signaling, however, no studies have investigated the effect of PTH on alcohol-inhibited bone fracture repair. male C57 BL/6 mice received two-3 day alcohol binges separated by 4 days before receiving a mid-shaft tibia fracture. Postoperatively, mice received PTH daily until euthanasia. Wnt/β-catenin signaling was analyzed at 9 days post-fracture. As previously observed, acute alcohol exposure resulted in a >2-fold decrease in total and the active form of β-catenin and a 2-fold increase in inactive β-catenin within the fracture callus. Intermittent PTH abrogated the effect of alcohol on β-catenin within the fracture callus. Upstream of β-catenin, alcohol-treated animals had a 2-fold decrease in total LRP6, the Wnt co-receptor, which was restored with PTH treatment. Alcohol nor PTH had any significant effect on GSK-3β. These data show that intermittent PTH following a tibia fracture restores normal expression of Wnt signaling proteins within the fracture callus of alcohol-treated mice.

关键词： ethanol fracture callus parathyroid hormone Wnt signaling pathway

Entire Whitening of Apple Trees to Increase Chill Units in Regions of Warm Temperatures during the Fall-Winter Seasons

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American journal of Plant Sciences 2022年第8期13卷 1100-1115页

作者： Alejandro Zermeño-González j. A. gil-marín H. Ramírez-Rodríguez A. I. melendres-Alvarez m. Cadena-Zapata Departamento de Riego y Drenaje Universidad Autonóma Agraria Antonio Narro Saltillo México Departamento de Horticultura Universidad Autonóma Agraria Antonio Narro Saltillo México Departamento de maquinaria Agrícola Universidad Autonóma Agraria Antonio Narro Saltillo México

Different studies have shown that global warming and climate change have increased the planet’s temperature in different locations. For the apple-growing farmers, this may have a negative impact on the accumulations of chill units when the air temperature during the fall-winter season increases. When the entire trees are covered with a reflective material, the wood temperature may decrease. Therefore, the objective of this study was to evaluate the effect of whitening (with calcium hydroxide) the entire apple trees (malus domestica Borkh) after defoliation, on the branches and trunks’ internal temperature (under the bark), the accumulation of chill units (CU), its effects on fruit yield and quality and the relation with the use of thidiazuron (TDZ) (inducer of budbreak). The study was conducted during the fall-winter seasons of 2019-2020 and 2020-2021. The results of this study showed that at the hours of the highest incidence of solar radiation, the internal temperature of the whitened trunks and leaves decreases up to 9°C and 6°C respectively. The accumulated CU during the time of the study, of the whitened branches were up to 81% higher than the ones recorded on the branches with no whitening;while the CU was lost at the hours of highest solar radiation (due to a high temperature) were up to 37.2% smaller. Entire tree whitening increased up to 26% of the yield per tree compared to the application of TDZ. No statistical difference in fruit quality was observed between whitened trees and those with no whitening but with the application of thidiazuron.

关键词： malus domestica Borkh Chill Units Whitening Calcium Hydroxide Budbreak

Fractionation of Zn,Cd and Pb in a Tropical Soil After Nine-Year Sewage Sludge Applications

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Pedosphere 2010年第5期20卷 545-556页

作者： T.A.R.NOGUEIRA W.j.mELO I.m.FONSECA S.A.mARCUSSI G.m.P.mELO m.O.mARQUES Department of Plant Nutrition Center for Nuclear Energy in AgricultureUniversity of Sao Paulo Department of Technology Sao Paulo State University

A long-term field experiment was carried out in the experiment farm of the Sao Paulo State University,Brazil,to evaluate the phytoavailability of Zn,Cd and Pb in a Typic Eutrorthox soil treated with sewage sludge for nine consecutive years,using the sequential extraction and organic matter fractionation *** 2005-2006,maize(Zea mays L.) was used as test plants and the experimental design was in randomized complete blocks with four treatments and five *** treatments consisted of four sewage sludge rates(in a dry basis):0.0(control,with mineral fertilization),45.0,90.0 and 127.5 t ha-1,annually for nine *** maize sowing,the sewage sludge was manually applied to the soil and incorporated at 10 cm *** samples(0-20 cm layer) for Zn,Cd and Pb analysis were collected 60 days after *** successive applications of sewage sludge to the soil did not affect heavy metal(Cd and Pb) fractions in the soil,with exception of Zn *** Zn,Cd and Pb distributions in the soil were strongly associated with humin and residual fractions,which are characterized by stable chemical ***,Cd and Pb in the soil showed low phytoavailability after nine-year successive applications of sewage sludge to the soil.

关键词： heavy metals humic substance sequential extraction Zea mays L.

medicinal mushroom Growth as Affected by Non-Axenic Casing Soil

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Pedosphere 2011年第2期21卷 146-153页

作者： D.C.ZIED m.T.A.mINHONI j.KOPYTOWSKI-FILHO L.BARBOSA m.C.N.ANDRADE Departamento de Produc ao Vegetal (Defesa Fitossanit'aria) Faculdade de Ci encias Agron omicasUniversidade Estadual Paulista18603-970 Botucatu (Brazil) Departamento de Bioestat' stica Instituto de Bioci encia de BotucatuUniversidade Estadual Paulista18618-000 Botucatu (Brazil) Instituto Nacional de Pesquisa da Amaz onia INPA69060-001 Manaus (Brazil)

Ten different casing soils were collected from two soils at two depths （0.2 and 2.0 m below soil surface） to examine the relationships between the physical properties of non-axenic casing soil and yield, number and weight of the medicinal mushroom Agamcua blaaei ss. Heinemann. The results showed that soil clay content and bulk density were negatively correlated with the mushroom yield, respectively, but soil silt content and water-holding capacity were found to be positively correlated with the yield. The number of mushrooms was negatively correlated with soil water-holding capacity but positively correlated with soil clay, bulk density and porosity. The weight of mushroom was positively correlated with the content of soil fine sand and negatively correlated with the contents of soil coarse sand, total sand and clay. Neither soil depth nor different soil combinations affected the yield and number of mushrooms, but the mushroom weight was affected by the soil combinations and soil depth, so interplay in the fructification process with the physical characteristics of casing is complicated.

关键词： Agaricus blazei casing layer quality factors soil depth soil particles

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衍射光栅和光学象差

应用光学 1987年第5期 23-26+22页

作者： j. m. Simon mirta A. gil 李其聘

本文计算平面衍射栅在准平面光束入射时所引起的对衍射波的一些影响。这些影响以前未见讨论过。

关键词：衍射光栅象差波前光栅衍射波解析表达式

Cambrian to early Silurian ophiolite and accretionary processes in the Beishan collage,NW China:implications for the architecture of the Southern Altaids

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Cambrian to early Silurian ophiolite and accretionary proces...

中国科学院地质与地球物理研究所2012年度（第12届）学术年会

作者： S.j.ao W.j.XIao C.m.HAN X.H.LI j.F.QU j.E.ZHANG Q.Q.GUO Z.H.TIAN Stale Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of Sciences State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of Sciences Institute of Geology Chinese Academy of Geological Sciences

The mechanism of continental growth of the Altaids is currently under debate between models invoking continuous subduction-accretion or punctuated accretion by closure of multiple ocean *** use the Yueyashan-Xichangjing ophiolite belt of the Beishan collage(southern Altaids) to constrain the earliest oceanic crust in the southern Palaeo-Asian *** lithotectonic units were identified from S to N:the Huaniushan block,a sedimentary passive margin,the structurally incoherent Yueyashan-Xichangjing ophiolite complex,a coherent sedimentary package and the mazongshan island arc with granitic *** present a structural analysis of the accretionary complex,which is composed of the incoherent ophiolitic melange and coherent sedimentary rocks,to work out the tectonic polarity.A new weighted mean pb-U age of 533±1.7 ma from a plagiogranite in the Yueyashan-Xichangjing ophiolite indicates that the ocean floor formed in early Cambrian time. Furthermore,we present new geochemical data to constrain the tectonic setting of the YueyashanXichangjing *** Yueyashan-Xichangjing ophiolite was emplaced as a result of northward subduction of an oceanic plate beneath the mazongshan island arc to the north in late Ordovician to early Silurian *** with data from the literature,our work demonstrates that multiple overlapping periods of accretion existed in the Palaeozoic in the northern and southern ***,a model of multiple accretion by closure of several ocean basins is most viable.

关键词： Beishan Yueyashan-Xichangjing ophiolite accretionary complex Altaids.

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基于优先规则的复杂并行机调度问题研究

系统工程理论与实践 2016年第3期36卷 779-786页

作者：王东军刘翱刘克刘波中国科学院数学与系统科学研究院北京100190 中国船舶工业系统工程研究院北京100094 武汉科技大学管理学院武汉430081

研究一类从实际指挥控制系统提炼的具有工件释放时间、机器可用时间和机器适用限制等约束的并行同速机调度问题.首先针对该问题建立混合整数规划模型;其次考虑到该问题的NPhard性以及实时调度的要求,提出基于优先规则的调度算法框架从... 详细信息

研究一类从实际指挥控制系统提炼的具有工件释放时间、机器可用时间和机器适用限制等约束的并行同速机调度问题.首先针对该问题建立混合整数规划模型;其次考虑到该问题的NPhard性以及实时调度的要求,提出基于优先规则的调度算法框架从而可以快速获得可行解;最后将该算法框架应用到实际案例并分析比较不同优先规则的效果,发现与工件释放时间相关的优先规则(如ERD,EFD)效果更好.值得一提的是,本文首次研究具有多重约束的并行机调度问题Pm|r_j,a_i,m_j|C_(max),TC.

关键词：并行同速机调度工件释放时间机器可用时间机器适用限制优先规则

A culture model to analyze the acute biomaterial-dependent reaction of human primary neutrophils in vitro

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生物活性材料(英文) 2023年第2期20卷 627-637页

作者： marinus A.Wesdorp Andrea Schwab Ezgi Irem Bektas Roberto Narcisi David Eglin martin j.Stoddart Gerjo j.V.m.Van Osch matteo D’Este ao Research Institute Davos AO FoundationDavos PlatzSwitzerland Department of Orthopaedics and Sports medicine Erasmus MCUniversity Medical Center Rotterdamthe Netherlands mines Saint-Étienne Univ LyonUniv Jean MonnetINSERMU1059 SainbioseSaint-ÉtienneFrance Department of Biomaterials Science and Technology University of TwenteEnschedethe Netherlands Department of Otorhinolaryngology Erasmus MCUniversity Medical Center Rotterdamthe Netherlands Department of Biomechanical Engineering Faculty of MechanicalMaritimeand Materials EngineeringDelft University of Technologythe Netherlands Department of Oral and maxillofacial Surgery Erasmus MCUniversity Medical Center Rotterdamthe Netherlands

Neutrophils play a pivotal role in orchestrating the immune system response to biomaterials,the onset and resolution of chronic inflammation,and macrophage ***,the neutrophil response to biomaterials and the consequent impact on tissue engineering approaches is still scarcely ***,we report an in vitro culture model that comprehensively describes the most important neutrophil functions in the light of tissue *** isolated human primary neutrophils from peripheral blood and exposed them to a panel of hard,soft,naturally-and synthetically-derived *** overall trend showed increased neutrophil survival on naturally derived constructs,together with higher oxidative burst,decreased myeloperoxidase and neutrophil elastase and decreased cytokine secretion compared to neutrophils on synthetic *** culture model is a step to better understand the immune modulation elicited by *** studies are needed to correlate the neutrophil response to tissue healing and to elucidate the mechanism triggering the cell response and their consequences in determining inflammation onset and resolution.

关键词： inflammation healing culture