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Transcription factor YY1 is essential for iNKT cell development

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Cellular & Molecular Immunology 2019年第6期16卷 547-556页

作者： Xijun ou jianxin Huo Yuhan Huang Yan-Feng Li Shengli Xu Kong-Peng Lam Immunology Group Bioprocessing Technology InstituteAgency for ScienceTechnology and ResearchSingapore 138668Singapore Department of Biology Southern University of Science and TechnologyShenzhen 518055China Department of Physiology National University of SingaporeSingapore 117599Singapore Department of Microbiology and Immunology National University of SingaporeSingapore 117599Singapore Department of Pediatrics Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117599Singapore School of Biological Sciences Nanyang Technological UniversitySingaporeSingapore

Invariant natural killer T(iNKT)cells develop from CD4+CD8+double-positive(DP)thymocytes and express an invariant Vα14–jα18 T-cell receptor(TCR)α-*** of these cells requires the prolonged survival of DP thymocytes to allow for Vα14–jα18 gene rearrangements and strong TCR signaling to induce the expression of the iNKT lineage-specific transcription factor ***,we report that the transcription factor Yin Yang 1(YY1)is essential for iNKT cell *** lacking YY1 displayed a block in iNKT cell development at the earliest progenitor ***1-deficient thymocytes underwent normal Vα14–jα18 gene rearrangements,but exhibited impaired cell *** of the apoptotic protein BIM failed to rescue the defect in iNKT cell *** immunoprecipitation and deep-sequencing experiments demonstrated that YY1 directly binds and activates the promoter of the Plzf ***,YY1 plays essential roles in iNKT cell development by coordinately regulating cell survival and PLZF expression.

关键词： NKT cell PLZF YY1 Zbtb16

EXISTENCE AND ATTRACTIVITY OF ALMOST PERIODIC SOLUTION FOR SHUNTING INHIBITORY CELLULAR NEURAL NETWORKS WITH CONTINUouSLY DISTRIBUTED DELAYS AND VARIABLE COEFFICIENTS

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Annals of Differential Equations 2005年第4期21卷 604-615页

作者： Xiang Hongjun Wang jinhua Chen anping Dept. of Math. Xiangnan University Chenzhou 423000

In this paper, a class of two-dimensional shunting inhibitory cellular neural networks with distributed delays and variable coefficients system dxij/dt=-αij（t）xij-∑↑ckl∈Nr（i,j）cij^kl（t）fkl（∫0^＋∞pkl（s）xkl（t-s）ds）xij＋Lij（t） is studied. By using the Schauder＇s fixed point theorem and Lyapunov function, we obtain some sufficient conditions about the existence and attractivity of almost periodic solutions to the above system, and all its solutions converge to such almost periodic solution. An example is given to illustrate that the conditions of our results are feasible.

关键词： distributed delay shunting inhibitory cellular neural networks almost periodic solution

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多维关联度分析驱动的数字证据链构造方法

福州大学学报（自然科学版） 2024年第4期52卷 404-412页

作者：刘延华欧振贵刘西蒙陈惠文林钟馨张明辉福州大学计算机与大数据学院福建福州350108 国网信通亿力科技有限责任公司福建福州350003

提出一种基于多维关联度的数字证据链自动构造方法.首先设计一种数字证据标准化表示方法,将数字事件与其之间的关联关系进行规范化描述.然后通过对数字事件关联关系的分析,提出多维度的非因果关联度计算方法和基本证据环的构造方法,对... 详细信息

提出一种基于多维关联度的数字证据链自动构造方法.首先设计一种数字证据标准化表示方法,将数字事件与其之间的关联关系进行规范化描述.然后通过对数字事件关联关系的分析,提出多维度的非因果关联度计算方法和基本证据环的构造方法,对数字事件因果关系进行深度分析.实验结果表明,所提出方法构造的数据证据链对于提升数字证据的证明力具有一定的应用意义.

关键词：数字取证数字证据链证据环关联度

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自噬与神经系统疾病

中国比较医学杂志 2024年第3期34卷 111-119页

作者：梁钰莹黄泳刘俊升欧毅琳李逸文张睿李政张治楠南方医科大学中医药学院广州510515 南方医科大学南方医院广州510515

自噬是细胞内异常聚集蛋白和受损细胞器主要的降解和循环途径,维持着细胞正常的代谢平衡及物质更新。自噬具有神经保护作用,可通过调节神经元和胶质细胞的稳态、发育和凋亡等生理过程影响神经系统的功能状态。近年来大量研究表明,神经... 详细信息

自噬是细胞内异常聚集蛋白和受损细胞器主要的降解和循环途径,维持着细胞正常的代谢平衡及物质更新。自噬具有神经保护作用,可通过调节神经元和胶质细胞的稳态、发育和凋亡等生理过程影响神经系统的功能状态。近年来大量研究表明,神经系统疾病与异常自噬密切相关,自噬的抑制或过度激活均能影响抑郁症、神经退行性疾病和精神分裂症的发生发展。了解自噬在神经系统疾病中的作用机制对于预防与治疗相关疾病具有重要意义。该文主要对当前自噬与上述神经系统疾病的研究进展进行综述,为以上疾病的进一步研究提供参考。

关键词：自噬神经系统疾病作用机制研究进展

Threshold-independent method for single-shot readout of spin qubits in semiconductor quantum dots

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Chinese Physics B 2024年第1期33卷 274-279页

作者：胡睿梓祝圣凯张鑫周圆倪铭马荣龙罗刚孔真真王桂磊曹刚李海欧郭国平 CAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China CAS Center For Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China Key Laboratory of Microelectronics Devices and Integrated Technology Institute of MicroelectronicsChinese Academy of SciencesBeijing 100029China Beijing Superstring Academy of Memory Technology Beijing 100176China Origin Quantum Computing Company Limited Hefei 230026China

The single-shot readout data process is essential for the realization of high-fidelity qubits and fault-tolerant quantum algorithms in semiconductor quantum dots. However, the fidelity and visibility of the readout process are sensitive to the choice of the thresholds and limited by the experimental hardware. By demonstrating the linear dependence between the measured spin state probabilities and readout visibilities along with dark counts, we describe an alternative threshold-independent method for the single-shot readout of spin qubits in semiconductor quantum dots. We can obtain the extrapolated spin state probabilities of the prepared probabilities of the excited spin state through the threshold-independent method. We then analyze the corresponding errors of the method, finding that errors of the extrapolated probabilities cannot be neglected with no constraints on the readout time and threshold voltage. Therefore, by limiting the readout time and threshold voltage, we ensure the accuracy of the extrapolated probability. We then prove that the efficiency and robustness of this method are 60 times larger than those of the most commonly used method. Moreover, we discuss the influence of the electron temperature on the effective area with a fixed external magnetic field and provide a preliminary demonstration for a single-shot readout of up to 0.7K/1.5T in the future.

关键词： quantum computation quantum dot quantum state readout

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提高钢轨应变灵敏度的测量方法研究

仪器仪表标准化与计量 2024年第1期 28-30页

作者：李滨区志扬麦志颛梁楚翘广州计量检测技术研究院广州市510663

本文基于剪力测试法仿真分析计算了6种不同布片组桥方案在恒定荷载作用下的应变灵敏度响应输出。仿真分析结果表明:单组桥方案中应变灵敏度响应随着测量范围的缩小而增大,不能同时实现应变灵敏度响应和测量范围的最大化。而通过将紧邻... 详细信息

本文基于剪力测试法仿真分析计算了6种不同布片组桥方案在恒定荷载作用下的应变灵敏度响应输出。仿真分析结果表明:单组桥方案中应变灵敏度响应随着测量范围的缩小而增大,不能同时实现应变灵敏度响应和测量范围的最大化。而通过将紧邻轨枕边的2组桥路应变灵敏度响应输出进行线性叠加,能显著提高近似恒定的应变灵敏度响应输出,同时能实现测量范围的最大化。这为准确获取并识别轮轨力应变信号并判断列车的运行状态和推算轮轨间作用力大小提供了有利条件,是一种切实可行的提高灵敏度的测量方法。

关键词：钢轨应变灵敏度测量方法仿真分析

Metasurface-enabled on-chip multiplexed diffractive neural networks in the visible

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Light(Science & Applications) 2022年第7期11卷 1443-1453页

作者： Xuhao Luo Yueqiang Hu Xiangnian ou Xin Li jiajie Lai Na Liu Xinbin Cheng Anlian Pan Huigao Duan National Research Center for High-Efficiency Grinding College of Mechanical and Vehicle EngineeringHunan UniversityChangsha 410082China Institute of Precision Optical Engineering School of Physics Science and EngineeringTongji UniversityShanghai 200092China Advanced Manufacturing Laboratory of Micro-Nano Optical Devices Shenzhen Research InstituteHunan UniversityShenzhen 518000China 2nd Physics Institute University of StuttgartPfaffenwaldring 5770569 StuttgartGermany Max Planck Institute for Solid State Research Heisenbergstrasse 170569 StuttgartGermany Greater Bay Area Institute for Innovation Hunan UniversityGuangzhou 511300China

Replacing electrons with photons is a compelling route toward high-speed,massively parallel,and low-power artificial intelligence ***,diffractive networks composed of phase surfaces were trained to perform machine learning tasks through linear optical ***,the existing architectures often comprise bulky components and,most critically,they cannot mimic the human brain for ***,we demonstrate a multi-skilled diffractive neural network based on a metasurface device,which can perform on-chip multi-channel sensing and multitasking in the *** polarization multiplexing scheme of the subwavelength nanostructures is applied to construct a multi-channel classifier framework for simultaneous recognition of digital and fashionable *** areal density of the artificial neurons can reach up to 6.25×10^(6)mm^(-2) multiplied by the number of *** metasurface is integrated with the mature complementary metal-oxide semiconductor imaging sensor,providing a chip-scale architecture to process information directly at physical layers for energy-efficient and ultra-fast image processing in machine vision,autonomous driving,and precision medicine.

关键词： visible autonomous complementary

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K477合金热暴露的组织稳定性研究

热加工工艺 2020年第16期49卷 152-155页

作者：朱鸥邢辉董安平中国航发商用航空发动机有限责任公司上海200241 上海交通大学材料科学与工程学院上海200240

采用扫描电镜和图像分析软件,对K477合金在不同温度(900、940、980和1020℃)下分别热暴露200 h后的组织稳定性进行了研究。结果表明:K477合金的主要强化相γ’相随热暴露温度的升高而粗化,但体积分数随热暴露温度升高而降低,晶界分布的... 详细信息

采用扫描电镜和图像分析软件,对K477合金在不同温度(900、940、980和1020℃)下分别热暴露200 h后的组织稳定性进行了研究。结果表明:K477合金的主要强化相γ’相随热暴露温度的升高而粗化,但体积分数随热暴露温度升高而降低,晶界分布的片状γ’相长大并连接起来。晶内和晶界处的块状MC碳化物转变成M23C6碳化物,并且在表面形成γ’包膜。γ’相对碳化物和晶界的包裹阻止了碳化物的长大,同时对晶界起到了强化作用,随热暴露温度的升高,K477合金的硬度有所提高。

关键词： K477 热暴露组织稳定性 γ’相

Gasdermin D Inhibitor Necrosulfonamide Alleviates Lipopolysaccharide/D-galactosamine-induced Acute Liver Failure in Mice

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journal of Clinical and Translational Hepatology 2022年第6期10卷 1148-1154页

作者： Yi-Long Wu Wei-jie ou Ming Zhong Su Lin Yue-Yong Zhu Endoscopy Center the First Affiliated HospitalFujian Medical UniversityFuzhouFujianChina Department of Hepatol-ogy Hepatology Research Institutethe First Affiliated HospitalFujian Medical UniversityFuzhouFujianChina Endocri-nology Department Metabolic Diseases Research Institutethe First Affiliated HospitalFujian Medical UniversityFuzhouFujianChina Fujian Diabetes Research Institute the First Affiliated HospitalFujian Medical UniversityFuzhouFujianChina Clinical Research Center for Liver and Intestinal Diseases of Fujian Province FuzhouFujianChina

Background and Aims:Acute liver failure(ALF)is as-sociated with high *** D(GSDMD)is the executioner of pyroptosis and is involved in the patho-physiology of immune dysregulation This study investi-gated the role of the GSDMD inhibitor necrosulfonamide(NSA)in ***:An ALF model was established by lipopolysaccharide/D-galactosamine challenge in C57BL/6j *** were divided into four groups:normal controls(control group),ALF group(ALF group),dimethyl sulfoxide group(DMSO group),and NSA intervention group(NSA group).Survival was monitored,liver damage was de-termined by hematoxylin and eosin staining,and serum alanine aminotransferase(ALT).Underlying mechanisms were explored by quantitative real-time PCR,western blot-ting,and enzyme-linked immunosorbent ***:Pyroptosis was activated in ALF model *** treat-ed with GSDMD inhibitor NSA developed less severe liver *** reduced the expression of GSDMD,NLRP3,cleaved caspase-1,cleaved caspase-11,and secretion of interleukin-1 beta in ALF mice ***:Py-roptosis was activated in *** alleviated ALF via the pyroptosis pathway.

关键词： Liver failure Acute Pyroptosis GSDMD GSDMD-NT Necrosul-fonamide