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电网的分散负荷安全域及其应用(二):线路静态失稳的边界-本质-形态及负荷安全域的稳定裕度

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中国电机工程学报 2024年第5期44卷 1737-1749,I0006页

作者：竺炜肖魏罗贤超于瀚翔郑超长沙理工大学电气与信息工程学院湖南省长沙市410114 中国电力科学研究院有限公司北京市海淀区100192

交流线路承载的静态稳定边界问题一直悬而未决。负荷安全域可约束线路压差、维持多级电网电压安全水平,但稳定裕度未知。传统静态功角稳定与电压稳定的概念、机理及分析方法都不相同。研究发现,针对线路两种静态稳定可形成统一的概念、... 详细信息

交流线路承载的静态稳定边界问题一直悬而未决。负荷安全域可约束线路压差、维持多级电网电压安全水平,但稳定裕度未知。传统静态功角稳定与电压稳定的概念、机理及分析方法都不相同。研究发现,针对线路两种静态稳定可形成统一的概念、机理,而全网静态稳定的充要条件是每条支路都满足静态稳定。基于线路的复变量状态方程,得到末端的复功率-电压(即P_(j)-Q_(j)-U_(j))、复功率-功角(即P_(j)-Q_(j)-θ_(ij))的独立方程;通过可解条件分析、偏导证明,得到唯一的P_(j)-Q_(j)稳定边界及其特征,证明两种失稳的同质性;通过解析几何分析,推导U_(j)和θ_(ij)的稳定边界及其特征,得到符合实际情况的失稳形态解释。基于P_(j)-Q_(j)稳定边界,提出线路负荷安全域的稳定裕度指标以及电压安全水平的修正方法。理论验证基于首端参考系线路模型分析的可行性,提出电网上下级拓扑的稳定域匹配方法。最后,基于状态可观性判据、方程独立性以及平衡点生成原理,分析线路功-角特性的局限性。算例表明,所提的稳定边界、稳定域匹配方法都与PSASP程序收敛性结果吻合。在新能源大量接入导致线路潮流波动性大的背景下,该研究更具理论价值及现实意义。

关键词：线路静态稳定稳定边界失稳形态线路负荷安全域稳定裕度

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Gene replacement therapy in Bietti crystalline corneoretinal dystrophy:an open-label,single-arm,exploratory trial

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2275-2284页

作者： jinyuan Wang jinlu Zhang Shicheng Yu Hongyan Li Shaohong Chen jingting Luo Haibo Wang Yuxia Guan Haihan Zhang Shiyi Yin Huili Wang Heping Li junle Liu jingyuan zhu Qiong Yang Ying Sha Chuan Zhang Yuhang Yang Xuan Yang Xifang Zhang Xiuli Zhao Likun Wang Liping Yang Wenbin Wei Beijing Tongren Eye Center Beijing Key Laboratory of Intraocular Tumor Diagnosis and TreatmentBeijing Ophthalmology&Visual Sciences Key LabMedical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information TechnologyBeijing Tongren HospitalCapital Medical University100730 BeijingChina School of Clinical Medicine Tsinghua University100084 BeijingChina Chigenovo Co. Ltd.102206 BeijingChina Department of Ophthalmology Peking University Third HospitalBeijing Key Laboratory of Restoration of Damaged Ocular NervePeking University Third Hospital100191 BeijingChina Department of Ophthalmology The Third People’s Hospital of Dalian116091 DalianChina Department of Biomedical Informatics School of Basic Medical SciencesPeking University Health Science Center100191 BeijingChina Institute of Systems Biomedicine Department of PathologySchool of Basic Medical SciencesPeking University Health Science Center100191 BeijingChina

Bietti crystalline corneoretinal dystrophy is an inherited retinal disease caused by mutations in CYP4V2,which results in blindness in the working-age population,and there is currently no available ***,we report the results of the first-in-human clinical trial(nCT04722107)of gene therapy for Bietti crystalline corneoretinal dystrophy,including 12 participants who were followed up for 180-365 *** open-label,single-arm exploratory trial aimed to assess the safety and efficacy of a recombinant adeno-associated-virus-serotype-2/8 vector encoding the human CYP4V2 protein(rAAV2/8-hCYP4V2).Participants received a single unilateral subretinal injection of 7.5×10^(10)vector genomes of rAAV2/***,73 treatment-emergent adverse events were reported,with the majority(98.6%)being of mild or moderate intensity and considered to be procedure-or corticosteroid-related;no treatment-related serious adverse events or local/systemic immune toxicities were *** with that measured at baseline,77.8%of the treated eyes showed improvement in best-corrected visual acuity(BCVA)on day 180,with a mean±standard deviation increase of 9.0±10.8 letters in the 9 eyes analyzed(p=0.021).By day 365,80%of the treated eyes showed an increase in BCVA,with a mean increase of 11.0±10.6 letters in the 5 eyes assessed(p=0.125).Importantly,the patients’improvement observed using multifocal electroretinogram,microperimetry,and Visual Function Questionnaire-25 further supported the beneficial effects of the *** conclude that the favorable safety profile and visual improvements identified in this trial encourage the continued development of rAAV2/8-hCYP4V2(named ZVS101e).

关键词： cor dystrophy crystalline

外源性硫化氢对肾小球系膜细胞缺氧/复氧损伤的影响及其机制

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中国药理学通报 2024年第1期40卷 133-138页

作者：林真亭田华李鸿珠厦门医学院基础医学部福建厦门361023 厦门大学医学院基础部福建厦门361102

目的探讨外源性硫化氢(hydrogen sulfide,H_(2)S)对肾小球系膜细胞缺氧/复氧(hypoxia/reoxygenation,H/R)损伤的影响,并阐明其相关作用机制。方法H/R诱导小鼠肾小球系膜细胞系(SV40MES13)建立细胞损伤模型。细胞增殖试剂盒(CCK8)检测细... 详细信息

目的探讨外源性硫化氢(hydrogen sulfide,H_(2)S)对肾小球系膜细胞缺氧/复氧(hypoxia/reoxygenation,H/R)损伤的影响,并阐明其相关作用机制。方法H/R诱导小鼠肾小球系膜细胞系(SV40MES13)建立细胞损伤模型。细胞增殖试剂盒(CCK8)检测细胞活力,荧光探针技术分别检测H_(2)S和活性氧(ROS)含量,生化试剂盒检测超氧化物歧化酶(SOD)活性和丙二醛(MDA)含量,Hoechst 33342染色检测细胞凋亡率;Western blot检测胱硫醚-γ-裂解酶(cystathione-gamma-lyase,CSE)、细胞凋亡相关蛋白(cleaved-caspase-3、Cyt c和Bcl-2)表达及信号通路相关蛋白(ERK1/2、Phospho-ERK1/2)活性。结果与对照(Control)组相比,缺氧/复氧(H/R)组细胞活力、内源性H_(2)S含量CSE蛋白表达、SOD活性及Bcl-2蛋白表达均明显降低;细胞凋亡率、MDA和ROS含量、Cyt c及cleaved caspase-3蛋白表达均显著升高;同时,磷酸化ERK1/2(p-ERK1/2)活性明显降低。与H/R比较,H/R+naHS(外源性H_(2)S供体)逆转了H/R对上述指标的影响。另外,PD98059(ERK1/2抑制剂)减弱了naHS对磷酸化ERK1/2的作用。结论肾小球系膜细胞H/R损伤与内源性CSE/H_(2)S系统下调有关;外源性H_(2)S通过上调ERK1/2通路抑制氧化应激和细胞凋亡,减轻肾小球系膜细胞H/R损伤。

关键词：硫化氢缺氧/复氧肾小球系膜细胞 ERK1/2通路细胞凋亡 CSE/H_(2)S系统

基于CRITIC客观赋权法的天水市生态环境脆弱性评价

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中国沙漠 2024年第3期44卷 321-331页

作者：朱荣敖泽建蒋友严甘肃省建筑设计研究院甘肃兰州730000 兰州大学资源环境学院甘肃兰州730000 甘孜藏族自治州气象局甘肃甘孜626000 兰州区域气候中心甘肃兰州730000

构建合理的生态环境脆弱性评价体系是生态环境脆弱性评价的关键。为了提高生态承载力和生态环境质量,促进生态系统良性发展,基于Landsat 5/9卫星遥感影像、数字高程模型、土壤、气象及社会经济数据,利用CRITIC客观赋权法开展生态环境脆... 详细信息

构建合理的生态环境脆弱性评价体系是生态环境脆弱性评价的关键。为了提高生态承载力和生态环境质量,促进生态系统良性发展,基于Landsat 5/9卫星遥感影像、数字高程模型、土壤、气象及社会经济数据,利用CRITIC客观赋权法开展生态环境脆弱性评价,使用转移矩阵及障碍度模型,探讨了2000—2022年天水市生态环境脆弱性变化及其成因。结果表明:裸土指数、土地利用类型、气温和降水量是影响天水市生态环境脆弱性的主要因子;天水市生态环境脆弱性呈北高南低分布;相比于2000年,2022年天水市生态脆弱性整体降低,除武山、甘谷中北部部分区域极度脆弱区保持不变以外,总体上天水市大部分极度脆弱区降为重度或中度脆弱区,但城区周边部分区域受城市化影响由中度脆弱区升高为重度或极度脆弱区;2022年天水市极度脆弱区脆弱性降低的主要影响因素为裸土指数、土地利用类型和降水量。未来一段时间内因地制宜植树种草、提高人工影响天气能力和灌溉水平,是降低天水市生态环境脆弱性的主要手段。

关键词：生态环境脆弱性 CRITIC客观赋权法障碍度模型土地利用类型降水

A novel engineered IL-21 receptor arms T-cell receptor-engineered T cells(TCR-T cells)against hepatocellular carcinoma

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2215-2230页

作者： Wei zhu Zhiming Zhang jinzhang Chen Xiaolan Chen Lei Huang Xiaoyong Zhang Xuan Huang na Ma Weikang Xu Xuan Yi Xinyu Lu Xin Fu Siwei Li Guoheng Mo Yiyue Wang Guosheng Yuan Mengya Zang Qi Li Xiaotao jiang Yajing He Sha Wu Yukai He Yongyin Li jinlin Hou State Key Laboratory of Organ Failure Research Guangdong Provincial Key Laboratory of Viral Hepatitis ResearchDepartment of Infectious DiseasesNanfang HospitalSouthern Medical UniversityGuangzhouChina Institute of Cellular Medicine Newcastle University Medical SchoolNewcastleUK Department of Pathology The First People’s Hospital of FoshanFoshanChina Dermatology Hospital Southern Medical UniversityGuangzhouChina Department of Immunology School of Basic Medical SciencesSouthern Medical UniversityGuangzhouChina Microbiome Medicine Center Department of Laboratory MedicineZhujiang HospitalSouthern Medical UniversityGuangzhouChina Key Laboratory of Proteomics of Guangdong Province Demonstration Center for Experimental Education of Basic Medical Sciences of ChinaGuangzhouChina Medical College of Georgia Augusta University112015th StreetAugustaGAUSA

Strategies to improve T cell therapy efficacy in solid tumors such as hepatocellular carcinoma(HCC)are urgently *** common cytokine receptorγchain(γc)family cytokines such as IL-2,IL-7,IL-15 and IL-21 play fundamental roles in T cell development,differentiation and effector *** study aims to determine the combination effects of IL-21 in T cell therapy against HCC and investigate optimized strategies to utilize the effect of IL-21 signal in T cell *** antitumor function of AFP-specific T cell receptor-engineered T cells(TCR-T)was augmented by exogenous IL-21 in vitro and in ***-21 enhanced proliferation capacity,promoted memory differentiation,downregulated PD-1 expression and alleviated apoptosis in TCR-T after activation.A novel engineered IL-21 receptor was established,and TCR-T armed with the novel engineered IL-21 receptors(IL-21R-TCR-T)showed upregulated phosphorylated STAT3 expression without exogenous IL-21 ***-21R-TCR-T showed better proliferation upon activation and superior antitumor function in vitro and in ***-21R-TCR-T exhibited a less differentiated,exhausted and apoptotic phenotype than conventional TCR-T upon repetitive tumor antigen *** novel IL-21 receptor in our study programs powerful TCR-T and can avoid side effects induced by IL-21 systemic *** novel IL-21 receptor creates new opportunities for next-generation TCR-T against HCC.

关键词： hepatocellular TCR utilize

从信号到知识——基于人工智能的医学影像裸数据诊断价值初探

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Engineering 2024年第3期34卷 60-69页

作者： Bingxi He Yu Guo Yongbei zhu Lixia Tong Boyu Kong Kun Wang Caixia Sun Hailin Li Feng Huang Liwei Wu Meng Wang Fanyang Meng Le Dou Kai Sun Tong Tong Zhenyu Liu Ziqi Wei Wei Mu Shuo Wang Zhenchao Tang Shuaitong Zhang jingwei Wei Lizhi Shao Mengjie Fang juntao Li Shouping zhu Lili Zhou Shuo Wang Di Dong Huimao Zhang jie Tian Beijing Advanced Innovation Center for Big Data-Based Precision Medicine School of Engineering MedicineBeihang UniversityBeijing 100191China Key Laboratory of Big Data-Based Precision Medicine Beihang UniversityMinistry of Industry and Information TechnologyBeijing 100191China CAS Key Laboratory of Molecular Imaging Institute of AutomationChinese Academy of SciencesBeijing 100190China Department of Radiology The First Hospital of Jilin UniversityChangchun 130021China neusoft Medical Systems Co.Ltd. Shenyang 110167China neusoft Research of Intelligent Healthcare Technology Co.Ltd. Shenyang 110167China School of Life Science and Technology Xidian UniversityXi’an 710126China Engineering Research Center of Molecular and neuro Imaging Ministry of EducationXi’an 710126China School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China

Encouraging and astonishing developments have recently been achieved in image-based diagnostic *** medical care and imaging technology are becoming increasingly ***,the current diagnosis pattern of signal to image to knowledge inevitably leads to information distortion and noise introduction in the procedure of image reconstruction(from signal to image).Artificial intelligence(AI)technologies that can mine knowledge from vast amounts of data offer opportunities to disrupt established *** this prospective study,for the first time,we develop an AI-based signal-toknowledge diagnostic scheme for lung nodule classification directly from the computed tomography(CT)raw data(the signal).We find that the raw data achieves almost comparable performance with CT,indicating that it is possible to diagnose diseases without reconstructing ***,the incorporation of raw data through three common convolutional network structures greatly improves the performance of the CT models in all cohorts(with a gain ranging from 0.01 to 0.12),demonstrating that raw data contains diagnostic information that CT does not *** results break new ground and demonstrate the potential for direct signal-to-knowledge domain analysis.

关键词： Computed tomography Diagnosis Deep learning Lung cancer Raw data

酶解-动态高压微射流制备纳米淀粉及对其结构性质的影响

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食品工业科技 2024年第8期45卷 127-133页

作者：黄佳卉赵雷朱杰张书艳华南农业大学食品学院广东广州510642 东莞理工学院生命健康技术学院东莞市特色食品精准设计重点实验室中国轻工业健康食品开发与营养调控重点实验室广东东莞523808

为探究蜡质玉米淀粉(WMS)经普鲁兰酶协同动态超高压微射流技术(P-DHPM)制备纳米淀粉后对其结构及性质的变化规律,本文探讨了处理前后淀粉微观结构、结晶结构、分子结构、粒径、分子量及热性能的变化趋势。结果表明,随着酶解时间的增加,... 详细信息

为探究蜡质玉米淀粉(WMS)经普鲁兰酶协同动态超高压微射流技术(P-DHPM)制备纳米淀粉后对其结构及性质的变化规律,本文探讨了处理前后淀粉微观结构、结晶结构、分子结构、粒径、分子量及热性能的变化趋势。结果表明,随着酶解时间的增加,淀粉圆球形颗粒变碎片状、结晶结构逐渐消失、淀粉短程有序性增加、分子量显著(Pj/g;酶解淀粉进一步经微射流处理后,粒径降低至纳米级,淀粉颗粒变成更加无规则的小碎片,糊化峰值温度(T_p)降低至55.37℃,糊化焓值(ΔH)增大至14.13 j/g。通过酶解-微射流技术处理WMS淀粉,可制备得到粒径可控且具有短程有序的纳米尺寸淀粉颗粒,提供了一种环境友好、操作简单的制备方法,同时为继续探讨其在淀粉纳米乳液及淀粉基活性包装材料中的应用奠定基础。

关键词：酶解动态超高压微射流纳米淀粉结构热学性能

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端壁移动对悬臂静子气动性能的影响

航空动力学报 2024年第4期39卷 193-204页

作者：安广丰范竹于贤君刘宝杰北京航空航天大学航空发动机研究院北京100191 北京航空航天大学航空发动机气动热力国家级重点实验室北京100191

为了探究端壁移动对悬臂静子性能的影响,对轮毂移动与否、轮毂移动速度大小以及移动轮毂情况下间隙大小对某一低速轴流压气机悬臂静子内部流动及压气机性能的影响进行了详细的研究。结果表明,随着端壁移动速度的增加或者端壁移动情况下... 详细信息

为了探究端壁移动对悬臂静子性能的影响,对轮毂移动与否、轮毂移动速度大小以及移动轮毂情况下间隙大小对某一低速轴流压气机悬臂静子内部流动及压气机性能的影响进行了详细的研究。结果表明,随着端壁移动速度的增加或者端壁移动情况下叶根间隙的减小,静子近轮毂区域的流动堵塞/流动损失减小、压气机性能得到提升,造成这一现象的主要原因是端壁移动情况下二次流的消失以及参与掺混的泄漏流流量的减小;端壁移动也会影响静子进口流场,进而影响转子的特性,但相对于对静子特性的影响,转子特性的变化幅值较小。

关键词：端壁移动悬臂静子气动性能泄漏流轴流压气机

超声引导下输刺夹脊穴治疗腰椎间盘突出症的随机对照试验

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中国组织工程研究 2024年第36期28卷 5852-5857页

作者：朱曦陶宇洪黄鹏李丹北京中医药大学第三附属医院针灸科北京市100029 解放军医学院北京市100853 解放军总医院第四医学中心骨科医学部北京市100853

背景:在腰椎间盘突出症的研究中大多数针刺治疗由CT引导或非引导,对位点的精准控制及针刺有效部位不够明确。目的:观察超声引导下输刺夹脊穴治疗腰椎间盘突出症的临床疗效。方法:选择于解放军总医院及北京中医药大学第三附属医院就诊的... 详细信息

背景:在腰椎间盘突出症的研究中大多数针刺治疗由CT引导或非引导,对位点的精准控制及针刺有效部位不够明确。目的:观察超声引导下输刺夹脊穴治疗腰椎间盘突出症的临床疗效。方法:选择于解放军总医院及北京中医药大学第三附属医院就诊的腰椎间盘突出症患者70例,男36例,女34例,年龄18-65岁,采用随机数表法分成试验组与对照组,每组35例。对照组患者予输刺夹脊穴治疗,试验组患者在超声引导下予输刺夹脊穴治疗,于就诊当天及就诊后4,7 d各治疗1次。治疗前后进行目测类比评分、Oswestry功能障碍指数、日本骨科协会(jOA)评分及健康调查简表(SF-36)评估。结果与结论:①与治疗前相比,两组患者治疗后的目测类比评分均降低(PjOA评分均升高(PjOA评分升高(P0.05)。⑤结果表明,输刺夹脊穴对腰椎间盘突出症具有疗效,并且超声引导能够提升输刺夹脊穴治疗腰椎间盘突出症的疗效。

关键词：腰椎间盘突出症超声引导针刺夹脊穴临床观察针灸治疗