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3'-Sialyllactose regulates glucose and lipid metabolic disorders via the gut–liver axis in mice fed a high-fat die

Food Science and Human Wellness 2024年

作者： Wei Zhang Meizhen zhu Kelsang Dekyi Linxi Zheng Yichen Zhang Youping Lv Dongbei Guo Xiaoxuan Chen Lili Pan Xinyue Wang Hongwei Li State Key Laboratory of Vaccines for Infectious Diseases， Xiang An Biomedicine Laboratory， School of Public Health， Xiamen University State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics，national Innovation Platform for Industry-Education Integration in Vaccine Research， Xiamen University Department of nutrition， Zhongshan Hospital (Xiamen)， Fudan University Xiamen Clinical Research Center for Cancer Therapy

Recent research has indicated that sialic acid， such as free sialic acid (n-acetylneuraminic acid， neu5Ac) and bound sialic acid (3'-sialyllactose， 3'-SL)， can ameliorate disorders associated with glycolipid metabolism， although the underlying mechanisms have yet to be determined. We examined the effects of 3'-SL on glycolipid metabolism in mice fed a high-fat diet. Male C57BL/6j mice were divided into six groups: two model control groups (normal and high-fat diets) and four intervention groups [neu5Ac， and low-，moderate-， and high-dose 3'-SL]. After 8 weeks of continuous gavage intervention， mice in the 3'-SL intervention groups had lower body weight and total fat content; reduced fasting blood glucose， triglycerides， low-density lipoproteins and oxidized-low-density lipoproteins; and increased high-density lipoproteins，but no dosage-dependent of 3'-SL intervention was found， 3’-SL＿M intervention as optimal for further exploration. 3'-SL intervention could increase respiratory exchange ratio， energy expenditure， and amount of exercise performed. 3'-SL increased the colonic abundances of Akkermansia， Lactobacillus， and Bacteroides， and reduced those of Erysipelatoclostridium， Faecalibaculum， and Aldercreutzia. Changes were also observed in colonic metabolites， and liver gene transcript and metabolites， which were mainly enriched in bile secretion， taurine and hypotaurine metabolism， and insulin resistance. Additionally， 3'-SL was observed to regulate genes associated with physiological rhythms， including clock， per2， cry1， and bhihe41. Collectively， our findings indicate that 3'-SL can contribute to the prevention and control of disorders associated with glucose and lipid metabolism caused by high-fat diets. Compared with neu5Ac， 3'-SL intervention can ameliorate intestinal flora disorders， enhance bile acid circulation， increase tissue energy expenditure， and reduce lipid synthesis， thereby promoting lipid-lowering effects mediated via the liver–gut axis， and can a

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MPI+CUDA联合加速重力场反演的并行算法

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大地测量与地球动力学 2024年第4期44卷 423-428页

作者：赵锴坤朱炬波谷德峰韦春博中山大学物理与天文学院天琴中心广东省珠海市519082

针对重力场解算过程中数据量巨大的问题,联合MPI(massage passing interface)与CUDA(compute unified device architecture)提出基于最小二乘法的重力场解算过程的并行加速算法。使用MPI完成复杂过程的任务分配,实现全局层面的并行加速... 详细信息

针对重力场解算过程中数据量巨大的问题,联合MPI(massage passing interface)与CUDA(compute unified device architecture)提出基于最小二乘法的重力场解算过程的并行加速算法。使用MPI完成复杂过程的任务分配,实现全局层面的并行加速;基于CUDA编写大规模矩阵相乘的并行加速程序,并针对不同类型的矩阵进行适配,同时联合MPI将法矩阵的计算过程进一步细分,实现对分进程内存峰值的压缩。在单机上完成30阶与120阶重力场仿真解算任务,结果表明,反演30阶重力场时加速比可达180;反演120阶重力场时,并行计算单次迭代仅耗时2 h,而串行模式下无法计算。

关键词：重力场并行计算 CUDA MPI

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Comparison of the pathological characteristics of uninjured skin tissues of diabetic rodents and diabetic patients

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中华内分泌外科杂志（中英文） 2024年第3期18卷 339-345页

作者： Du juan Liu Ying zhu Anfeng Song Dongming Qu Shiguang Yuan Zhixin Emergency Critical and Translational Medicine LaboratoryJilin Province People’s HospitalChangchun 130021China Emergency Medicine Department of General Hospital of northern Theater Command Laboratory of Rescue Center of Severe Wound and Trauma PLAShenyang 110016China Department of Pathology the Centre Hospital of ChangchunChangchun 130021China Department of Emergency Surgery Jilin Province People’s HospitalChangchun 130021China

Objective To study uninjured diabetic skin structure and compare the pathological characteristics of skin tissue from mouse and rat models of diabetes mellitus(DM)and humans with *** Establishing the DM C57BL/6j mice skin tissue models and db/db mice skin tissue models,as well as DM rat skin tissue *** tissues were collected from the animal models and DM *** biopsy specimens were stained with hematoxylin and eosin(HE)staining,Masson trichrome staining and periodic acid-Schiff(PAS)***(1)Skin from mice with streptozotocin(STZ)-induced DM was thinner and had less hair than skin from control *** epidermis had abnormal keratinization and dermal collagen and elastin fibers were dense and significantly atrophied.(2)Compared with the control group,skin tissue from db/db mice was thinner and had less *** was no aberrant keratinization in the epidermis,and dermal collagen and elastin fibres were loose.(3)Skin tissue from rats with STZ-induced DM was significantly thinner than control *** epidermis had mildly abnormal keratinization,and the dermis layer was atrophied and partly *** focal lipofuscin was deposited.(4)Whole skin tissue from patients with diabetes was significantly thinner than skin from subjects without *** epidermis had mild hyper keratinization,and the dermal elastin fibers were atrophied,loose,irregular,and showed focal mucoid *** Uninjured DM skin tissues were thinner and more irregular than normal *** changes in rat DM skin were most like those seen in the skin of patients with DM.

关键词： Diabetes mellitus Skin Human Mouse Rat

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2-local unstable homotopy groups of indecomposable A^(2)_(3)-complexes

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Science China Mathematics 2024年第3期67卷 607-626页

作者： Zhongjian zhu jianzhong Pan College of Mathematics and Physics Wenzhou UniversityWenzhou 325035China Hua Loo-Keng Key Laboratory of Mathematics Institute of MathematicsAcademy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100049China

In this paper,we calculate the 2-local unstable homotopy groups of indecomposable A^(2)_(3)-*** main technique used is analysing the homotopy property of j(A,X),defined by Gray(1973) for a CW-pair(X,A),which is homoto... 详细信息

关键词： homotopy groups A^(2)_(n)-complexes fibration sequence relative james construction

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Lysophosphatidylcholine binds α-synuclein and prevents its pathological aggregation

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national Science Review 2024年第06期 119-128页

作者： Chunyu Zhao jia Tu Chuchu Wang Wenbin Liu jinge Gu Yandong Yin Shengnan Zhang Dan Li jiajie Diao Zheng-jiang zhu Cong Liu Interdisciplinary Research Center on Biology and Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences University of Chinese Academy of Sciences Bio-X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education Shanghai Jiao Tong University Zhangjiang Institute for Advanced Study Shanghai Jiao Tong University Department of Cancer Biology University of Cincinnati College of Medicine

Accumulation of aggregated α-synuclein(α-syn) in Lewy bodies is the pathological hallmark of Parkinson's disease(PD). Genetic mutations in lipid metabolism are causative for a subset of patients with Parkinsonism. The role of α-syn's lipid interactions in its function and aggregation is recognized, yet the specific lipids involved and how lipid metabolism issues trigger α-syn aggregation and neurodegeneration remain unclear. Here, we found that α-syn shows a preference for binding to lysophospholipids(LPLs),particularly targeting lysophosphatidylcholine(LPC) without relying on electrostatic interactions. LPC is capable of maintaining α-syn in a compact conformation, significantly reducing its propensity to aggregate both in vitro and within cellular environments. Conversely, a reduction in the production of cellular LPLs is associated with an increase in α-syn accumulation. Our work underscores the critical role of LPLs in preserving the natural conformation of α-syn to inhibit improper aggregation, and establishes a potential connection between lipid metabolic dysfunction and α-syn aggregation in PD.

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艾灸联合贝那普利对慢性心力衰竭大鼠心肌内质网应激相关蛋白磷酸化表达的影响

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针刺研究 2024年第3期49卷 231-237页

作者：汪恒夏冉高兵李凌基王祝朱梦王茎安徽中医药大学针灸推拿学院合肥230038 安徽中医药大学中医学院合肥230038 新安医学重点实验室合肥230038

目的:观察艾灸“心俞”“肺俞”联合贝那普利对慢性心力衰竭(CHF)大鼠心功能及心肌组织中蛋白激酶R样内质网激酶(PERK)、真核启动因子2α(eIF2α)蛋白磷酸化的影响,探讨艾灸联合贝那普利防治CHF的潜在机制。方法:采用腹腔注射盐酸多柔... 详细信息

目的:观察艾灸“心俞”“肺俞”联合贝那普利对慢性心力衰竭(CHF)大鼠心功能及心肌组织中蛋白激酶R样内质网激酶(PERK)、真核启动因子2α(eIF2α)蛋白磷酸化的影响,探讨艾灸联合贝那普利防治CHF的潜在机制。方法:采用腹腔注射盐酸多柔比星复制CHF大鼠模型,将造模成功的SD大鼠随机分为模型组、艾灸组、药物组、艾药组,并设立空白组,每组10只。艾灸组予以艾条温和灸双侧“心俞”“肺俞”,每次20 min;药物组予以贝那普利(0.86 mg/kg)灌胃治疗;艾药组艾灸上述穴位同时予以贝那普利灌胃治疗。各组均每日治疗1次,连续干预3周。超声心动图检测大鼠心脏射血分数(EF)、左室内径缩短率(FS);HE染色法观察心肌组织病理变化;ELISA法检测大鼠血清B型脑钠肽(BnP)和血管紧张素Ⅱ(AngⅡ)含量;Western blot法检测大鼠心肌组织磷酸化(p)-PERK、p-eIF2α的表达水平。结果:与空白组比较,模型组大鼠EF、FS降低(PnP和AngⅡ含量升高(PnP和AngⅡ含量降低(P<0.01);p-PERK、p-eIF2α蛋白表达水平降低(P<0.01);镜下可见治疗后各组大鼠心肌细胞损伤减轻。艾药联合治疗效果优于艾灸组和药物组。结论:艾灸联合贝那普利能够改善CHF,其机制与降低心肌p-PERK、p-eIF2α的蛋白表达水平,抑制心肌内质网应激反应相关。

关键词：艾灸慢性心力衰竭心功能内质网应激

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巨大芽孢杆菌在赤泥脱碱中的应用及作用机制

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中国有色金属学报 2024年第3期34卷 947-958页

作者：王林李望朱晓波燕旭东河南理工大学化学化工学院焦作454000

赤泥是氧化铝生产过程中产生的工业废渣,其强碱性使得赤泥存在环境污染风险高、资源化利用困难等问题。因此,急需寻求赤泥脱碱的有效方法和新途径。微生物脱碱法因其经济有效、无二次污染的特点而备受关注。本文利用巨大芽孢杆菌菌液对... 详细信息

赤泥是氧化铝生产过程中产生的工业废渣,其强碱性使得赤泥存在环境污染风险高、资源化利用困难等问题。因此,急需寻求赤泥脱碱的有效方法和新途径。微生物脱碱法因其经济有效、无二次污染的特点而备受关注。本文利用巨大芽孢杆菌菌液对赤泥脱碱,通过高效液相色谱(HPLC)、XRD、SEM-EDS和FT-IR分别对细菌代谢产物、脱碱前后矿物的物相组成、微观形貌和官能团结构进行分析,研究了巨大芽孢杆菌对赤泥脱碱的作用机制。结果表明:在菌量为5.67×10^(13)CFU/mL、液固比为25(mL/g)和温度为35℃的条件下可将脱碱样品的pH值降低至8.55,10 d的单次脱碱率达到30.4%,比无菌添加时的pH值降低了1.48,脱碱率提高22.6%;脱碱后赤泥中方钠石、钙霞石等碱性矿物的衍射峰强度减弱,方解石的衍射峰强度增强,赤泥表面有菌株附着,并出现明显的溶蚀形貌,一些碱性矿物的铝硅酸盐结构被溶解;巨大芽孢杆菌主要利用代谢产生的两种含量较高的有机酸(苹果酸和丙酸)与赤泥中的碱性物质发生酸碱中和,实现对赤泥的脱碱。

关键词：赤泥脱碱巨大芽孢杆菌有机酸作用机制

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Coercivity Enhancement of nd-Fe-B Thin Film Magnets through Dy Surface Diffusion Process

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journal of Materials Science & Technology 2011年第9期27卷 826-830页

作者： C.Y. You j. zhu n. Tian Z.X. Lu State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing Beijing 100083 China School of Materials Science and Engineering Xi＇an University of Technology Xi＇an 710048 China

The Dy capping layer was deposited at different temperatures on the nd-Fe-B thin films to investigate the mechanism of the coercivity enhancement through the Dy surface diffusion. The highest coercivity of 2005 kA/m （25.2 kOe） was obtained at the Dy deposition temperature of 460℃, which was significantly higher than the value of 1297 kA/m （16.3 kOe） without Dy capping layer. By performing the transmission electron microscopy （TEM） analysis, it was found that some of the grain boundaries were enriched with nd element, which could be partly ascribed to the promotion by the Dy surface diffusion. In comparison to the evolution of the spin reorientation temperature of nd2Fe14B phase after the deposition of the Dy capping layer, it is concluded that structural modification plays a significant role in the coercivity enhancement due to the Dy surface diffusion.

关键词： nd-Fe-B thin film Coercivity enhancement Dy layer Microstructure

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Effect of L-theanine combined with geniposide on depression-like behavior induced by the chronic unpredictable mild stress(CUMS) in mice

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Food Science and Human Wellness 2024年

作者： Qi-Ming Yu Yan zhu Tao jiang Ying Gao nan Ling na Wang john Shi Wei-Chun Pan Qi-Zhen Du jun-Feng Yin Tea Research Institute Chinese Academy of Agricultural Sciences， Key Laboratory of Tea Biology and Resources Utilization， Ministry of Agriculture College of Food and Health Sciences， Zhejiang A & F University Zhejiang Gongshang University Guelph Food Research Center， Agriculture and Agri-Food Canada College of Public Health， Guilin Medical University

Depression is a prevalent mental disorder with limited effective treatments， posing a significant global issue. This study explored L-theanine and geniposide， key components in "food-medicine homology" materials， to determine if their combination (TG) could alleviate depression-like behaviors and hippocampal neuronal damage in a chronic unpredictable mild stress (CUMS) mouse model. Male C57BL/6j mice were divided into control， CUMS model， and CUMS+TG groups with varying doses. The CUMS group displayed depression-like behaviors， including reduced activity and sucrose preference. TG treatment partially reversed these changes， significantly increasing antioxidant enzyme activities， decreasing pro-inflammatory cytokine levels， and improving neuromodulator levels. RnA-seq analysis identified the transthyretin (TTR) gene， upregulated in the model group but downregulated after TG treatment. TG treatment modulated intestinal microbiota composition compared to the CUMS group， including increased Firmicutes， reduced Bacteroidetes and Prevotella， and variable changes in Bifidobacterium abundance. In conclusion， our study indicates that CUMS exposure upregulates stress hormones and TTR expression， associated with neuroinflammation， oxidative stress， monoamine depletion， depression-like behaviors， and intestinal microbiota dysbiosis. TG treatment alleviates these effects and modulates intestinal microbiota， suggesting L-theanine and geniposide’s potential as a novel depression therapy.

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经济高质量发展的“引擎”——高端制造业发展、人力资本配置和经济增长

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数量经济技术经济研究 2024年第4期41卷 48-67页

作者：朱兰吴紫薇王勇中国社会科学院数量经济与技术经济研究所中国社会科学院经济大数据与政策评估实验室中国社会科学院大学应用经济学院全国社会保障基金理事会北京大学新结构经济学研究院

比较东亚和拉美不同增长绩效的经济体,本文发现东亚经济体实现工业化过程中推动制造业高端化且高技能劳动力流向高端制造业,而拉美经济体出现制造业“低端锁定”且高技能劳动力更多流向服务业。为对上述产业结构变迁与劳动力配置现象提... 详细信息

比较东亚和拉美不同增长绩效的经济体,本文发现东亚经济体实现工业化过程中推动制造业高端化且高技能劳动力流向高端制造业,而拉美经济体出现制造业“低端锁定”且高技能劳动力更多流向服务业。为对上述产业结构变迁与劳动力配置现象提供一个统一的解释,本文构建包含劳动力异质性的三部门一般均衡模型,刻画不同行业高技能劳动力配置下的产业结构变迁路径,发现“基础制造业-高端制造业”路径下的人力资本积累和经济增长绩效明显优于“基础制造业-服务业”路径。然后,通过模型模拟分析不同政策效果,发现动态调整的产业政策比固定产业政策更有效,单一的教育政策结合产业政策更有效。本文不仅拓展了产业结构转型相关理论研究,突出高端制造业发展和人力资本配置的重要性,也为深入推进新型工业化、促进产业链人才链深度融合提供理论支撑和决策参考。

关键词：高端制造业人力资本配置产业结构变迁有为政府

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