检索结果-南通市图书馆

Ron receptor-dependent gene regulation in a mouse model of endotoxin-induced acute liver failure

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2012年第4期11卷 383-392页

作者： Rishikesh M Kulkarni louis W Kutcher William D Stuart Daniel j Carson Mike A Leonis Susan E Waltz Departments of Cancer and Cell Biology University of CincinnatiCincinnatiOH 45267-0521USA Biology University of CincinnatiCincinnatiOH 45267-0521USA Division of Gastroenterology Hepatology and NutritionCincinnati Children's Hospital Medical CenterCincinnatiOH 45229USA Department of Research Shriner's Hospital for Children and Cincinnati Veterans Affairs Medical CenterCincinnatiOH 45267-0521USA

BACKGROUND:Prior experimentation has shown that loss of the tyrosine kinase(TK) signaling domain of the Ron receptor leads to marked hepatocyte protection in a model of lipopolysaccharideinduced acute liver failure(ALF) in D-galactosamine(GalN)sensitized *** aim of this study was to identify the role of Ron in the regulation of hepatic gene ***:Microarray analyses were performed on liver RNA isolated sequentially from wild-type(WT) and TK-/mice during the progression of *** array data were validated using Western and immunohistochemistry analyses as well as with ex vivo culture ***:At baseline,101 genes were differentially expressed between WT and TK-/-livers,which regulate processes involved in hypoxia,proliferation,apoptosis and *** hour after ALF induction,WT livers exhibited increased cytokine expression compared to TK-/-livers,and after 4 hours,an induction of suppressor of cytokine signaling(SOCS) genes as well as jAK-STAT pathway activation were prominent in TK-/livers compared to ***:Our studies suggest a novel hepato-protective mechanism in Ron TK-/-mice wherein increased and sustained SOCS production and jAK-STAT activation in the hepatocyte may inhibit the destructive proinflammatory milieu and promote survival factors which blunt hepatic death and the ensuing development of ALF.

关键词： Mst1R suppressors of cytokine signaling Met receptor hepatocyte growth factor-like protein

Biosynthesis of Callose and Cellulose by Detergent Extracts of Tobacco Cell Membranes and Quantification of the Polymers Synthesized in vitro

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

journal of Integrative Plant Biology 2010年第2期52卷 221-233页

作者： Carolina Cifuentes vincent Bulone Anne Mie C.Emons Laboratory of Plant Cell Biology Wageningen University Division of Glycoscience School of BiotechnologyRoyal Institute of TechnologyAlbaNova University Center Department of Biomolecular Systems FOM Institute for Atomic and Molecular Physics

The conditions that favor the in vitro synthesis of cellulose from tobacco BY-2 cell extracts were determined. The procedure leading to the highest yield of cellulose consisted of incubating digitonin extracts of membranes from 11-day-old tobacco BY-2 cells in the presence of 1 mM UDP-glucose, 8 mM Ca^2＋ and 8 mM Mg^2＋. Under these conditions, up to nearly 40% of the polysaccharides synthesized in vitro corresponded to cellulose, the other polymer synthesized being callose. Transmission electron microscopy analysis revealed the occurrence of two types of structures in the synthetic reactions. The first type consisted of small aggregates with a diameter between 3 and 5 nm that associated to form fibrillar strings of a maximum length of 400 nm. These structures were sensitive to the acetic/nitric acid treatment of Updegraff and corresponded to callose. The second type of structures was resistant to the Updegraff reagent and corresponded to straight cellulose microfibrils of 2-3 nm in diameter and 200 nm to up to 5 μm in length. In vitro reactions performed on electron microscopy grids indicated that the minimal rate of microfibril elongation in vitro is 120 nm/min. Measurements of retardance by liquid crystal polarization microscopy as a function of time showed that small groups of microfibrils increased in retardance by up to 0.047 nm/min per pixel, confirming the formation of organized structures.

关键词： Biosynthesis of Callose and Cellulose by Detergent Extracts of Tobacco Cell Membranes and Quantification of the Polymers Synthesized in vitro

Emergency evacuation in a supermarket during a terrorist attack: towards a possible modelling of the influence of affordances on the evacuation behavior of agents in a complex virtual environment

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

journal of Safety Science and Resilience 2023年第2期4卷 139-150页

作者： Satya Lancel vincent Chapurlat Gérard Dray Sophie Martin EA 4556 EPSYLON Univ Paul Valery Montpelier 3EPSYLON EA 4556F34000MontpelierFrance Laboratoire des Sciences des Risques(LSR) IMT Mines AlesAlesFrance EuroMov Digital Health in Motion Univ MontpellierIMT Mines AlesAlesFrance

During a terrorist attack on a supermarket,the use of emergency exits is essential for effective evacuation and saving ***,people tend to ignore emergency *** behavior can lengthen evacuation times,endanger individuals,and even prove *** this context,we conducted a series of experiments to explore the links between cognition and the dynamics of human capabilities in a complex and changing *** a series of behavioral experiments and computer simulations,we found that active guidance by green flashing lights at emergency exits impacts the behavior of individuals in an emergency evacuation situation in a supermarket;this tested our hypothesis that changing the environment in turn changes the evacuation behavior of *** also show that environmental modification can help in decision-making in an emergency ***,the results of computer simulations support a possible modeling of the influence of affordances on the evacuation behavior of agents in a complexvirtual environment.

关键词： Human behavior in emergency situations environmental affordances multi-agent systems signage emergency exits supermarkets

Post-keratoplasty astigmatism management by relaxing incisions:a systematic review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Eye and Vision 2017年第1期4卷 174-180页

作者： Gaëlle Ho Wang Yin louis Hoffart Ophthalmology Department Aix-Marseille University-APHMHôpital de la Timone264 rue Saint Pierre13385 Marseille Cedex 5France Institut Fresnel UMR 7249 Aix Marseille UniversitéCNRSCentrale MarseilleDomaine universitaire de Saint-Jérôme Avenue Escadrille Normandie Niemen13397 Marseille cedex 20France CERIMED Aix-Marseille University27 Boulevard Jean-Moulin13385 Marseille cedex 05France Ramsay Générale de Santé Clinique Monticelli-VelodromeMarseilleFrance

Postoperative visual acuity can be limited by post-keratoplasty astigmatism,even with a clear corneal *** management can be performed by selective suture removal,adjustment of sutures,optical correction,photorefractive procedures,wedge resection,intra-ocular lens implantation,intracorneal ring segments,relaxing incisions with or without compression sutures and repeated *** incisions can be made in the graft,graft-host interface or host *** the unpredictability of the method because the flat and steep meridians are usually not orthogonal after penetrating keratoplasty,with asymmetric power distribution,all the studies showed an overall reduction of refractive,keratometric or topographic astigmatism,ranging from 30%to 72%with manual or femtosecond-assisted *** patients with astigmatism higher than 6 diopters had residual cylinder less than or equal to 3 diopters,which can be treated by laser excimer ablation or secondary intraocular lens implantation.

关键词： Penetrating keratoplasty Astigmatic keratotomy Relaxing incisions Femtosecond laser

Coronary heart disease incidence and competing risks： an important issue

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

journal of Geriatric Cardiology 2017年第7期14卷 425-429页

作者： Paolo Emilio Puddu Peter louis Amaduzzi Beatrice Ricci Department of Cardiovascular Respiratory Nephrological Anesthesiological and Geriatric Sciences Sapienza University of Rome italy Department of Experimental Diagnostics and Specialty Medicine Univerity of Bologna Italy

The estimation of lifetime morbid events is not a rare presentation of relatively old and of more recent epidemi- ological investigations, accompanied by evaluating rates, risks and predictors （more in general determinants or risk factors）. However, when the follow-up period is very long and Kaplan-Meier survival curves are adopted, or Kaplan- Meier-based more complex models such as Cox＇s analysis are used, clinical （or epidemiological） reality may well be distorted since by these survival methods risks tend to be overestimated, whereas survival tends to be reduced.

关键词： Coronary heart disease Competing risks The elderly

The“Bitcoin Generator”Scam

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Blockchain(Research and Applications) 2022年第3期3卷 70-88页

作者： Emad Badawi Guy-vincent jourdan Iosif-Viorel Onut Faculty of Engineering University of OttawaOttawaON K1N 6N5Canada IBM Centre for Advanced Studies OttawaON K1R 7Y6Canada

The“Bitcoin Generator Scam”(BGS)is a cyberattack in which scammers promise to provide victims with free cryptocurrencies in exchange for a small mining *** this paper,we present a data-driven system to detect,track,and analyze the *** works as follows:we first formulate search queries related to BGS and use search engines to find potential instances of the *** then use a crawler to access these pages and a classifier to differentiate actual scam instances from benign ***,we automatically monitor the BGS instances to extract the cryptocurrency addresses used in the scam.A unique feature of our system is that it proactively searches for and detects the scam ***,we can find addresses that have not yet received any *** data collection project spanned 16 months,from November 2019 to February *** uncovered more than 8,000 cryptocurrency addresses directly associated with the scam,hosted on over 1,000 ***,these addresses have received around 8.7 million USD,with an average of 49.24 USD per *** 70%of the active addresses that we are capturing are detected before they receive any transactions,that is,before anyone is *** also present some post-processing analysis of the dataset that we have captured to aggregate attacks that can be reasonably confidently linked to the same attacker or *** system is one of the first academic feeds to the APWG eCrime Exchange *** has been actively and automatically feeding the database since November 2020.

关键词： Cryptocurrency Scam analysis Cyberattack Fraud detection Bitcoin Blockchain analysis Data mining

Former athletes’ lifestyle and self-definition changes after retirement from sports

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

journal of Sport and Health Science 2020年第4期9卷 376-383页

作者： Pierre-Luc Yao louis Laurencelle Fran¸cois Trudeau Department of Human Kinetics Universite du Quebeca Trois-RivieresTrois-RivieresQuebec 999040Canada Department of Psychology Universite duQuebeca Trois-RivieresTrois-RivieresQuebec 999040Canada

Background:Every high-level athlete will eventually see his or her sport career come to an *** former athletes will experience changes in their self-definition and everyday behaviors as they accept a nonathletic way of *** present study aimed to identify discrepancies between actual and former athletes regarding athletic identity,physical activity(PA),and nutrition ***:Actual athletes(AA;n=122),former athletes(FA;n=230),and nonathletes(NA;n=74)were asked to complete an online questionnaire on athletic identity,duration and intensity levels of occupational and leisure time PA,and nutritional ***:FA healthy nutrition score was the lowest of the 3 groups and significantly different from that of *** identity and intense and moderate PA during leisure time consistently decreased(pFA>NA).No significant difference between FA and NA was found regarding either nutritional habits or type of ***:Sport retirement may affect FA quality of nutritional habits that tends to decline below the NA level,as well as the amount of time spent practicing physical activities during leisure *** status does not ensure PA practice during sport postcareer.

关键词： Athletic identity Nutrition Physical activity Sport retirement

GeSnOI mid-infrared laser technology

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Light(Science & Applications) 2021年第12期10卷 2408-2420页

作者： Binbin Wang Emilie Sakat Etienne Herth Maksym Gromovyi Andjelika Bjelajac julien Chaste Gilles Patriarche Philippe Boucaud Frédéric Boeuf Nicolas Pauc vincent Calvo jérémie Chrétien Marvin Frauenrath Alexei Chelnokov vincent Reboud j.an-Michel Hartmann Moustafa El Kurdi UniversitéParis-Saclay CNRSC2N10 boulevard Thomas Gobert91120 PalaiseauFrance UniversitéCôte d’Azur CNRSCRHEARue Bernard Grégory06905 Sophia-AntipolisFrance STMicroelectronics Rue Jean Monnet38054 CrollesFrance UniversitéGrenoble Alpes CEAIRIG-DePhy17 rue des Martyrs38000 GrenobleFrance UniversitéGrenoble Alpes CEALeti17 rue des Martyrs38000 GrenobleFrance

GeSn alloys are promising materials for CMOS-compatible mid-infrared lasers ***,Sn alloying and tensile strain can transform them into direct bandgap *** growing laser technology however suffers from a number of limitations,such as poor optical confinement,lack of strain,thermal,and defects management,all of which are poorly discussed in the ***,a specific GeSn-on-insulator(GeSnOI)stack using stressor layers as dielectric optical claddings is demonstrated to be suitable for a monolithically integration of planar Group-IV semiconductor lasers on a versatile photonic platform for the near-and mid-infrared spectral ***-shape resonators on mesa structures were fabricated from GeSnOI,after bonding a Ge_(0.9)Sn_(0.1) alloy layer grown on a Ge strain-relaxed-buffer,itself on a Si(001)*** GeSnOI microdisk mesas exhibited significantly improved optical gain as compared to that of conventional suspended microdisk resonators formed from the as-grown *** further show enhanced vertical out-coupling of the disk whispering gallery mode in-plane radiation,with up to 30%vertical out-coupling *** a result,the GeSnOI approach can be a valuable asset in the development of silicon-based mid-infrared photonics that combine integrated sources in a photonic platform with complex lightwave engineering.

关键词： GeSn OI coupling

Variation in resource competition traits among Microcystis strains is affected by their microbiomes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

mLife 2023年第4期2卷 401-415页

作者： Dylan Baker Casey M.Godwin Muhtamim Khanam Ashley M.Burtner Gregory j.Dick vincent j.Denef Department of Ecology and Evolutionary Biology University of MichiganAnn ArborMichiganUSA Cooperative Institute for Great Lakes Research School for Environment and SustainabilityUniversity of MichiganAnn ArborMichiganUSA Department of Earth and Environmental Sciences University of MichiganAnn ArborMichiganUSA

Freshwater harmful algal blooms are often dominated by Microcystis,a phylogenetically cohesive group of cyanobacteria marked by extensive genetic and physiological *** have previously shown that this genetic diversity and the presence of a microbiome of heterotrophic bacteria influences competitive interactions with eukaryotic *** this study,we sought to explain these observations by characterizing Monod equation parameters for resource usage(maximum growth rateμmax,half-saturation value for growth Ks,and quota)as a function of N and P levels for four strains(NIES-843,PCC 9701,PCC 7806[WT],and PCC 7806ΔmcyB)in presence and absence of a microbiome derived from Microcystis isolated from Lake *** indicated limited differences in maximum growth rates but more pronounced differences in half-saturation values among Microcystis *** largest impact of the microbiome was reducing the minimal nitrogen concentration sustaining growth and reducing half saturation values,with variable results depending on the Microcystis *** strains also differed from each other in their N and P quotas and the extent to which microbiome presence affected *** data highlight the importance of the microbiome in altering Microcystis-intrinsic traits,strain competitive hierarchies,and thus bloom *** quota,μmax,and Ks are commonly used in models for harmful algal blooms,our data suggest that model improvement may be possible by incorporating genotype dependencies of resource-use parameters.

关键词： cultivation-dependent fitness harmful algal blooms host-microbe interactions phytoplankton