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Alternative polyadenylation events in epithelial cells sense endometritis progression in dairy cows

journal of Integrative Agriculture 2023年第6期22卷 1820-1832页

作者： Meagan j.STOTTS Yangzi ZHANG Shuwen ZHANG jennifer j.MICHAL j.an velez Bothe HANS Martin MAQUIVAR Zhihua j.anG Department of Animal Sciences and Center for Reproductive Biology Washington State UniversityPullmanWA 99164-7620USA Aurora Organic Farms PlattevilleCO 80651USA

Endometritis(inflammation of the endometrial lining) is one of the most devastating reproductive diseases in dairy cattle, resulting in substantial production loss and causing more than $650 million in lost revenue annually in the *** hypothesize that alternative polyadenylation(APA) sites serve as decisive sensors for endometrium health and disease in dairy cows. Endometrial cells collected from 18 cows with purulent vaginal discharge scored 0 to 2 were used for APA profiling with our whole transcriptome termini site sequencing(WTTS-seq) method. Overall, pathogens trigger hosts to use more differentially expressed APA(DE-APA), more intronic DE-APA, more DE-APA sites per gene and more DE-genes associated with inflammation. Host CD59 molecule(CD59), Fc fragment of IgG receptor IIa(FCGR2A), lymphocyte antigen 75(LY75) and plasminogen(PLG) may serve as initial contacts or combats with pathogens on cell surface, followed by activation of nuclear receptor subfamily 1 group H member 4(NR1H4) to regulate AXL receptor tyrosine kinase(AXL), FGR proto-oncogene, Src family tyrosine kinase(FGR), HCK protooncogene, Src family tyrosine kinase(HCK) and integrin subunit beta 2(ITGB2) for anti-inflammation. This study is the first to show significance of cilium pathways in endometrium health and animal reproduction. MIR21 and MIR30A would be perfect antagonistic biomarkers for diagnosis of either inflammation or anti-inflammation. These novel findings will set precedent for future genomic studies to aid the dairy industry develop new strategies to reduce endometritis incidence and improve fertility.

关键词： organic dairy endometritis alternative polyadenylation infection progression antagonistic biomarkers

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Adaptive Fault Detection Based on Neural Networks and Multiple Sampling Points for Distribution Networks and Microgrids

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journal of Modern Power Systems and Clean Energy 2022年第6期10卷 1648-1657页

作者： j.Marín-Quintero C.Orozco-Henao A.S.Bretas j.C.velez A.Herrada A.Barranco-Carlos W.S.Percybrooks Electric and Electronic Engineering Program Universidad Tecnológica de BolívarCartagenaColombia Electrical and Electronic Engineering Department Universidad del NorteBarranquillaColombia Distributed Systems Group Pacific Northwest National LaboratoryGainesvilleUSA

Smart networks such as active distribution network(ADN)and microgrid(MG)play an important role in power system *** design and implementation of appropriate protection systems for MG and ADN must be addressed,which imposes new technical *** paper presents the implementation and validation aspects of an adaptive fault detection strategy based on neural networks(NNs)and multiple sampling points for ADN and *** solution is implemented on an edge *** are used to derive a data-driven model that uses only local measurements to detect fault states of the network without the need for communication *** sampling points are used to derive a data-driven model,which allows the generalization considering the implementation in physical *** adaptive fault detector model is implemented on a jetson Nano system,which is a single-board computer(SBC)with a small graphic processing unit(GPU)intended to run machine learning loads at the *** proposed method is tested in a physical,real-life,low-voltage network located at Universidad del Norte,*** testing network is based on the IEEE 13-node test feeder scaled down to 220 *** validation in a simulation environment shows the accuracy and dependability above 99.6%,while the real-time tests show the accuracy and dependability of 95.5%and 100%,*** hard-to-derive parameters,the easy-to-implement embedded model highlights the potential for real-life applications.

关键词： Distribution network microgrid adaptive protection intelligent electronic device machine learning

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Hepatitis C risk assessment,testing and referral for treatment in urban primary care:Role of race and ethnicity

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World journal of Gastroenterology 2007年第7期13卷 1074-1078页

作者： Stacey B Trooskin Victor j Navarro Robert j Winn David j Axelrod A Scott McNeal Maricruz velez Steven K Herrine Simona Rossi Division of Gastroenterology and Hepatology Thomas Jefferson University Philadelphia PA 19107 United States Department of Family Medicine Thomas Jefferson University Philadelphia PA 19107 United States Division of Internal Medicine Thomas Jefferson University Philadelphia PA 19107 United States Delaware Valley Community Health Inc. Philadelphia PA 19107 United States

AIM: To determine rates of hepatitis C (HCV) risk factor ascertainment, testing, and referral in urban primary care practices, with particular attention to the effect of race and ethnicity. METHODS: Retrospective chart review from four primary care sites in Philadelphia; two academic primary care practices and two community clinics was performed. Demographics, HCV risk factors, and other risk exposure information were collected. RESULTS: Four thousand four hundred and seven charts were reviewed. Providers documented histories of injection drug use (IDU) and transfusion for less than 20% and 5% of patients, respectively. Only 55% of patients who admitted IDU were tested for HCV. Overall, minorities were more likely to have information regarding a risk factor documented than their white counterparts (79% vs 68%, P < 0.0001). Hispanics were less likely to have a risk factor history documented, compared to blacks and whites (P < 0.0001). Overall, minorities were less likely to be tested for HCV than whites in the presence of a known risk factor (23% vs 35%, P = 0.004). Among patients without documentation of risk factors, blacks and Hispanics were more likely to be tested than whites (20% and 24%, vs 13%, P < 0.005, respectively). CONCLUSION: (1) Documentation of an HCV risk factor history in urban primary care is uncommon, (2)Racial differences exist with respect to HCV risk factor ascertainment and testing, (3) Minority patients, positive for HCV, are less likely to be referred for subspecialty care and treatment. Overall, minorities are less likely to be tested for HCV than whites in the presence of a known risk factor.

关键词： Hepatitis C Minority groups Urban health Primary health care Risk assessment

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Description of the immature stages of a rare Andean paramo butterfly Lymanopoda caracara Pyrcz, Willmott & j. Hall, 1999(Lepidoptera: Nymphalidae)

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Zoological Systematics 2019年第4期44卷 316-324页

作者： Pablo Padron Pierre Boyer Ariana velez Tomasz Pyrcz Laboratono de Entomologia de la Universidad del Azuay Cuenca01.01.981Ecuador McGuire Center for Lepidoptera and Biodiversity Florida Museum of Natural HistoryUniversity of FloridaGainesvilleFL USA 7 Lotissement l'Horizon13610 Le Puy Sainte ReparadeFrance Entomology Department Institute of Zoology and Biomedical ResearchJagiellonian Universityul.Gronostajowa 930-387 KrakowPoland Nature Education Centre Jagiellonian Universityul.Gronostajowa 530-387 KrakowPoland

Immature stages of Lymanopoda caracara Pyrcz,Willmott&Hall,an endemic butterfly from the paramo life zone in the Andes of Ecuador,are described and compared with those of *** Adams from *** morphology is illustrated for four *** of head chaetotaxy and setal maps are provided for the first time for the *** host plant is identified as a dwarf bamboo Chusquea villosa(Clark)(Poaceae).Striking individual variation among adults of *** is discussed.

关键词： Caterpillar Neotropic chaetotaxy Satyrinae

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Outcomes of abdominal surgery in patients with liver cirrhosis

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World journal of Gastroenterology 2016年第9期22卷 2657-2667页

作者： j.an C Lopez-Delgado josep Ballus Francisco Esteve Nelson L Betancur-Zambrano Vicente Corral-velez Rafael Manez Antoni j Betbese j.an A Roncal Casimiro javierre Hospital Universitari de Bellvitge Intensive Care Department L'Hospitalet de Llobregat 08907 Barcelona Spain IDIBELL (Institut d'Investigacio Biomedica Bellvitge Biomedical Investigation Institute of Bellvitge) Research Team of Area of Innate Immunity and Pathology of the Critical Patient L'Hospitalet de Llobregat 08908 Barcelona Spain Hospital de la Santa Creu i Sant Pau Intensive Care Department 08041 Barcelona Spain Physiological Sciences II Department Universitat de Barcelona Campus Bellvitge 08907 Barcelona Spain

Patients suffering from liver cirrhosis(LC) frequently require non-hepatic abdominal surgery,even before liver *** is an important risk factor itself for surgery,due to the higher than average associated morbidity and *** high surgical risk occurs because of the pathophysiology of liver disease itself and to the presence of contributing factors,such as coagulopathy,poor nutritional status,adaptive immune dysfunction,cirrhotic cardiomyopathy,and renal and pulmonary dysfunction,which all lead to poor *** evaluation of these factors and the degree of liver disease can help to reduce the development of complications both during and after abdominal *** the emergency setting,with the presence of decompensated LC,alcoholic hepatitis,severe/advanced LC,and significant extrahepatic organ dysfunction conservative management is preferred.A multidisciplinary,individualized,and specialized approach can improve outcomes;preoperative optimization after risk stratification and careful management are mandatory before *** techniques can also improve *** review the impact of LC on surgical outcome in non-hepatic abdominal surgeries required in this cirrhotic population before,during,and after surgery.

关键词： Liver cirrhosis Outcomes Coagulopathy Nutritional status Abdominal surgery Adaptive immune dysfunction Cirrhotic cardiomyopathy

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Self-organized metal-semiconductor epitaxial graphene layer on off-axis 4H-SiC（0001）

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Nano Research 2015年第3期8卷 1026-1037页

作者： Debora Pierucci Haikel Sediri Mahdi Hajlaoui Emilio velez-Fort Yannick j. Dappe Mathieu G. Silly Rachid Belkhou Abhay Shukla Fausto Sirotti Noelle Gogneau Abdelkarim Ouerghi CNRS- Laboratoire de Photonique et de Nanostructures Route de Nozay 91460 Marcoussis France Synchrotron-SOLEIL Saint-Aubin BP48 F91192 Gifsur Yvette Cedex France Universite Pierre et Marie Curie (CNRS - IMPMC) 4 PI. Jussieu 75005 Paris France Service de Physique de rEtat Condense (CNRS URA2464) IRAMIS CEA Saclay 91191 Gif-Sur-Yvette France

The remarkable properties of graphene have shown promise for new perspectives in future electronics, notably for nanometer scale devices. Here we grow graphene epitaxially on an off-axis 4H-SiC（0001） substrate and demonstrate the formation of periodic arrangement of monolayer graphene on planar （0001） terraces and Bernal bilayer graphene on （1120） nanofacets of SiC. We investigate these lateral superlattices using Raman spectroscopy, atomic force microscopy/ electrostatic force microscopy （AFM/EFM） and X-ray and angle resolved photoemission spectroscopy （XPS/ARPES）. The correlation of EFM and ARPES reveals the appearance of permanent electronic band gaps in AB-stacked bilayer graphene on （1120） SiC nanofacets of 150 meV. This feature is confirmed by density functional theory （DFT） calculations. The charge transfer between the substrate and graphene bilayer results in an asymmetric charge distribution between the top and the bottom graphene layers opening an energy gap. This surface organization can be thus defined as self-organized metal-semiconductor graphene.

关键词： epitaxial graphene layer monolayer bilayer band gap opening Bernal stacking off-axis silicon carbide electronic properties

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A facile,branched DNA assay to quantitatively measure glucocorticoid receptor auto-regulation in T-cell acute lymphoblastic leukemia

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Chinese journal of Cancer 2012年第8期31卷 381-391页

作者： jason R.Schwartz Purvaba j.Sarvaiya Lily E.Leiva Maria C.velez Tammuella C.Singleton Lolie C.Yu Wayne V.Vedeckis Department of Biochemistry and Molecular Biology Stanley S.Scott Cancer Center Department of Pediatrics Louisiana State University Health Science CenterNew OrleansLA 70112USA Department of Pediatric Hematology/Oncology Children's HospitalNew OrleansLA 70112USA

Glucocorticoid(GC) steroid hormones are used to treat acute lymphoblastic leukemia(ALL) because of their pro-apoptotic effects in hematopoietic ***,not all leukemia cells are sensitive to GC,and no assay to stratify patients is *** the GC-sensitive T-cell ALL cell line CEM-C7,auto-up-regulation of RNA transcripts for the glucocorticoid receptor(GR) correlates with increased apoptotic *** study aimed to determine if a facile assay of GR transcript levels might be promising for stratifying ALL patients into hormone-sensitive and hormone-resistant *** GR transcript profiles of various lymphoid cell lines and 4 bone marrow samples from patients with T-cell ALL were analyzed using both an optimized branched DNA(bDNA) assay and a real-time quantitative reverse transcription-polymerase chain reaction *** were significant correlations between both assay platforms when measuring total GR(exon 5/6) transcripts in various cell lines and patient samples,but not for a probe set that detects a specific,low abundance GR transcript(exon 1A3).Our results suggest that the bDNA platform is reproducible and precise when measuring total GR transcripts and,with further development,may ultimately offer a simple clinical assay to aid in the prediction of GC-sensitivity in ALL patients.

关键词：糖皮质激素受体淋巴细胞白血病 DNA检测自动调节定量测量 T细胞支链急性

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Is device-measured vigorous physical activity associated with health-related outcomes in children and adolescents? A systematic review and meta-analysis

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journal of Sport and Health Science 2021年第3期10卷 296-307页

作者： Antonio Garcia-Hermoso Yasmin Ezzatvar Robinson Ramirez-velez jordi Olloquequi Mikel Izquierdo Navarrabiomed Navarra Hospital Complex(CHN)Public University of Navarra(UPNA)IdiSNAPamplona 31008Spain University of Santiago of Chile(USACH) Sciences of Physical ActivitySports and Health SchoolSantiago 71783-5Chile Exercise Intervention for Health Research Group(EXINH-RG) Department of PhysiotherapyUniversitat de ValenciaValencia 46010Spain Institute of Biomedical Sciences Faculthy of Health SciencesUniversidad Autonoma de ChileTalca 3460000Chile

Objective:This study sought to analyze the prospective association between vigorous-intensity physical activity(VPA)and health-related outcomes in children and ***:Studies reporting associations between device-measured VPA and health-related factors in children and adolescents aged 318 years were identified through database searches(MEDLINE,EMBASE,and SPORTDiscus).Correlation coefficients were pooled if outcomes were reported by at least 3 studies,using DerSimonian-Laird random effects ***:Data from 23 studies including 13,674 participants were pooled using random effects *** associations were found between VPA at baseline and overall adiposity(r=0.09,95%confidence interval(95%CI):0.15 to0.03;p=0.002;I^(2)=89.8%),cardiometabolic risk score(r=0.13,95%CI:0.24 to0.02,p=0.020;I^(2)=69.6%),cardiorespiratory fitness(r=0.25,95%CI:0.150.35;p<0.001;I^(2)=57.2%),and total body bone mineral density(r=0.16,95%CI:0.06 to 0.25;p=0.001;I^(2)=0%).Conclusion:VPA seems to be negatively related to adiposity and cardiometabolic risk score and positively related to cardiorespiratory fitness and total body bone mineral density among children and adolescents at ***,our findings support the need to strengthen physical activity recommendations regarding VPA due to its health benefits in children and adolescents.

关键词： Accelerometry Adiposity Fitness Physical activity

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儿童早期发展的投资与干预:国际的实证依据

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基础教育 2017年第5期14卷 11-22页

作者：池瑾 Eduardo velez 北京师范大学/联合国教科文组织国际农村教育研究与培训中心北京100875 乔治城大学外交学院华盛顿20057

近十多年来,儿童早期健康、营养、社会保障、入学公平以及有质量的保育和教育逐渐受到全球的关注。儿童早期保育与教育已经纳入2030可持续发展目标之中。政府为幼儿制定全面的政策、为家长提供有质量的服务、提供必要的公共资金逐渐成... 详细信息

近十多年来,儿童早期健康、营养、社会保障、入学公平以及有质量的保育和教育逐渐受到全球的关注。儿童早期保育与教育已经纳入2030可持续发展目标之中。政府为幼儿制定全面的政策、为家长提供有质量的服务、提供必要的公共资金逐渐成为发展的紧迫要求。本文基于世界不同国家、不同政治经济和社会文化背景的实证依据,呈现对处境不利儿童及早干预的重要性,早期投资对个体和经济社会发展的益处,以及不同早期干预措施的影响力。进一步比较了当前儿童早期发展实际的和最佳的投资模式特征,介绍了近年来发展中国家儿童早期发展的实践项目及其干预研究结果。强调政府需要重视并衡量儿童早期保育与教育的质量,参照国际经验开展政策的制定工作。由于儿童早期发展项目的实施涉及到公共和私营部门的诸多利益相关方,需要建立支持儿童早期发展的制度架构,建立协调机制,促进政策的设计、制定、实施和评估。

关键词：儿童早期干预儿童早期投资国际实证依据

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Lanzarote火山与地球动力学实验场的地壳变形、地热流动态监测研究

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地震地质 2003年第B12期25卷 99-108页

作者：蔡惟鑫 Vieira R 谭适龄 Arnoso j 申重阳 velez E j 中国地震局地震研究所武汉430071 西班牙天文大地测量研究所马德里28040

主要介绍中国、西班牙两国在Lanzarote火山与地球动力学实验场 12年的合作监测研究。1991年以来 ,中西双方共同在Lanzarote岛火山活动地区建立了Cueva和Timanfaya 2个监测站 ,进行地壳变动和地热流动态监测研究。对合作研制的 2 9台 (... 详细信息

主要介绍中国、西班牙两国在Lanzarote火山与地球动力学实验场 12年的合作监测研究。1991年以来 ,中西双方共同在Lanzarote岛火山活动地区建立了Cueva和Timanfaya 2个监测站 ,进行地壳变动和地热流动态监测研究。对合作研制的 2 9台 (套 )监测仪器开展长期稳定实验 ,积累了大量观测资料和数据。初步分析表明 :仪器运行良好 ,记录长期稳定可靠 ;Cueva站的仪器记录主要反映区域或全球地球物理环境或动力学效应 (如海潮、固体潮等 ) ,应变潮汐和倾斜潮汐的O1波、M2 波具有较高精度 ,显示火山目前活动微弱 ;Timanfaya站的仪器记录主要反映局部的火山活动信息 ,显示火山仍在活动但呈下降趋势。

关键词：火山地球动力学地壳变形地热流

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