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journal of Renewable Materials 2023年第6期11卷 2647-2663页

作者： S.E.Burruel-Ibarra R.A.Esquer-Osuna R.G.Valdez-Melchor D.A.Cuevas-Acuña L.Quihui-cota j.juárez j.C.Campos-García E.Valbuena-Gregorio M.A.López-Mata Departamento de Investigación en Polímeros y Materiales Universidad de SonoraHermosilloSonoraMéxico Departamento de Ciencias de la Salud Campus CajemeUniversidad de SonoraCd.ObregónSonoraMéxico Departamento de Nutrición Pública y Salud Coordinación de NutriciónCentro de Investigación en Alimentación y DesarrolloA.C.HermosilloSonoraMéxico Departamento de Física Universidad de SonoraHermosilloSonoraMéxico

This study aimed to characterize the physical-chemical and biological properties of pectin(PC)/chia seed mucilage(CM)***/CM[100/0(control),80/20%,60/40%,and 40/60%w/w]membranes were prepared using the casting *** membranes(PC/CM)were thin,yellow,lightly opaque(≈10%)and capable of blocking light UVB(between 66 at 52%).SEM analysis showed the presence of aggregates in the shape of a sphere(≈13μm)and ovoid(≈25μm).The proportion of 80/20 showed an increase in tensile strength(29%)and elastic modulus(19%)when compared to the *** analysis exhibited intermolecular interactions between PCPC,PC-CM,and CM-CM in the *** thermal analysis(600°C)showed a slight improvement in the percentage of residual mass-loss of 3.31%(80/20)that *** 40/60 membrane showed the lowest percentage of hemolysis(2.94%)but limited human albumin adsorption *** results suggested that the blend PC/CM may be considered as a biomaterial for medical applications.

关键词： Pectin chia mucilage membrane hemolysis albumin biomaterial

Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal j.Goldschmidt-Clermont Aisha Khan George jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander j.P.Goldschmidt Damien D.Pearse W.Dalton Dietrich Allan D.Levi james D.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

Left ventricular non-compaction presenting as cardio-embolic stroke

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journal of Geriatric Cardiology 2020年第10期17卷 645-646页

作者： Andres Martinez Michael Omar Fadi Kandah jose ruiz Ahsan Niazi Department of Internal Medicine University of Florida College of Medicine-JacksonvilleFloridaUSA Department of Cardiology University of Florida College of Medicine-JacksonvilleFloridaUSA Department of Neurology University of Florida College of Medicine-JacksonvilleFloridaUSA

A 39-year-old male with no known comorbidities presented with sudden onset right-sided *** examination,blood pressure was 128/79 mmHg,National Institutes of Health Stroke Scale score was 4 and there were no signs of heart *** computerized tomography demonstrated an ischemic infarct of the left middle cerebral artery distribution and brain magnetic resonance imaging later confirmed it(Figure 1).

关键词： Cardio-embolic Cardiomyopathy Non-compaction Trabeculae

Coxsackievirus B infection presenting as a hemorrhagic pericardial effusion causing tamponade

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journal of Geriatric Cardiology 2020年第10期17卷 642-644页

作者： Fadi Kandah Pooja Dhruva jose ruiz Andres Martinez William Kogler Internal Medicine University of Florida Health JacksonvilleJacksonvilleUSA

The coxsackievirus is well known for its vastly differing clinical *** with coxsackievirus usually present with a viral prodrome which can then progress to the cardiac symptoms of chest pain and/or *** patients improv... 详细信息

关键词： Cardiac tamponade Coxsackievirus Pericarditis

Electromagnetic analysis and AC losses of triaxial cables with multiple 2G-HTS layers per phase

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Superconductivity 2023年第1期5卷 46-54页

作者： M.Clegg H.S.ruiz College of Science and Engineering&Space Park Leicester University RoadLeicester LE17RHUnited Kingdom

For an accurate estimation of the AC losses of superconducting triaxial cables,in this paper we present a two‐dimensional model capable to provide a global assessment of multi‐layer triaxial cables,validated against the reported AC‐losses measurements on single‐phase cables provided by the Russian Scientific and Research Institute of the Cable Industry(VNIIKP).Four models are presented,the first being a single‐phase cable of 50 tapes and the others being three triaxial cables made of up to 135 coated conductors distributed in up to 9 layers.A systematic study is devised,where the number of layers per phase increases from 1 to 3,with at least 14 tapes distributed across each layer of the first(innermost)phase,15 in the secondary(middle)phase,and 16 in the third(outermost)phase,***,our results reveal that the simple strategy of considering an unbalanced distribution for the amplitudes of the applied current,can generally balance the magnetic field between the three phases even for the bilayer and trilayer cables,resulting in negligible magnetic leaks in all ***,our high‐resolution simulations allow to see for the first time how the transport and magnetization currents distribute across the thickness of all the superconducting tapes,from which we have found that the AC‐losses of the 2nd phase is generally higher than at the other phases at low to moderate transport currents,I_(tr)<0:8I c,being I_(c) the critical current of the corresponding ***,depending on whether the I_(c) of the SC tapes at the 3rd phase layers is lower than the one at the 2nd phase,the layers at the third phase can exhibit a considerable increment on the AC *** is result of the considered magneto angular anisotropy of the superconducting tapes,which lead to intriguing electromagnetic features that suggest a practical threshold for the applied transport current,being it 0:8I_(c).Likewise,the relative change in the AC‐losses per adding layers,

关键词： Triaxial cables COMSOL Electromagnetic profiles H‐formulation AC losses

Macular atrophy after combined intravitreal triamcinolone and photodynamic therapy to treat choroidal neovascularization

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International journal of Ophthalmology(English edition) 2010年第2期3卷 161-163页

作者： jose M ruiz-Moreno javier A Montero Pedro Amat Francisco Lugo Department of Ophthalmology Albacete Medical SchoolUniversity of Castilla La ManchaSpain Alicante Institute of Ophthalmology Vitreo-Retinal Unit.Spain Pio del Rio Hortega University Hospital Ophthalmology UnitValladolidSpain

AIMTo report the appearance of choriocapillaris atrophy after combined high dose intravitreal triamcinolone acetonide (TA) and photodynamic therapy (PDT) to treat choroidal neovascularization (CNV) associated with age... 详细信息

关键词： age related macular degeneration choriocapillaris atrophy intravitreous triamcinolone photodynamic therapy retinal pigment epithelium atrophy

Sexual dimorphism in immune response： Testing the hypothesis in an insect species with two male morphs

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Insect Science 2013年第5期20卷 620-628页

作者： Gloria ruiz-Guzman jorge Canales-Lazcano jesus Guillermo jimenez-Cortes jorge Contreras-Garduno Centro de Investigacion Sobre Enfermedades Infecciosas Instituto Nacional de Salud Publica Av. Universidad No. 655 C. P. 62100 Cuernavaca Morelos Departamento de Biologia Divisi6n de Ciencias Naturales y Exactas Universidad de Guanajuato Guanajuato Departamento de Ecologia Evolufiva Instituto de Ecologia Universidad Nacional Autonoma de Mexico Apdo. Postal 70-275 04510 Mexico D. F. Mexico

It has been proposed that given that males should invest in sexual traits at the expense of their investment in immune response, females are better immunocompetent than males. Typically, this idea has been tested in monomorphic species, but rarely has been evaluated in polymorphic male species. We used Paraphlebia zoe, a damselfly with two male morphs： the black-winged morph （Black-W） develop black spots as sexual traits and the hyaline-winged morph （Hyaline-W） resembles a female in size and wings color. We predicted that Black-W should have a lower immune response than Hyaline-W, but that the latter males should not differ from females in this respect. Nitric oxide （NO） and phenoloxidase （PO） production, as well as hemolymph protein content, were used as immune markers. Body size （wing length） was used as an indicator of the male condition. The results show that, as we predicted, females and Hyaline-W had higher values of NO than Black-W, corresponding to differences in size. However, the opposite was found in relation to PO production. Females had the highest levels of hemolymph protein content, whereas no differences were found between Black-W and Hyaline-W. These results partially support the sexual selection hypothesis and are discussed in the context of the life history of this species. Black-W, Hyaline-W, and females could express the immune markers that are prioritized by their particular condition, and probably neither of them could express all immune markers in an elevated manner, as this would result in an excessive accumulation of free radicals.

关键词： immune response male morphs Paraphlebia zoe polymorphic species,territoriality trade-off

NUMERICAL SOLUTION OF DIFFERENTIAL EQUATIONS IN IRREGULAR PLANE REGIONS USING QUALITY STRUCTURED CONVEX GRIDS

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International journal of Modeling, Simulation, and Scientific Computing 2013年第2期4卷 115-129页

作者： F.DOM´INGUEZ-MOTA P.FERNANDEZ-VALDEZ S.MENDOZA-ARMENTA G.TINOCO-GUERRERO j.G.TINOCO-ruiz Facultad de Ciencias F´ısico Matem´aticas Universidad Michoacana de San Nicol´as de Hidalgo Edificio“B” Ciudad Universitaria C.P.58040MoreliaMexico

The variational grid generation method is a powerful tool for generating structured convex grids on irregular simply connected domains whose boundary is a polygonal jordan *** examples that show the accuracy of a finite difference approximation to the solution of a Poisson equation using this kind of structured grids have been recently *** this paper,we compare the accuracy of the numerical solution calculated using those structured grids and finite differences against the solution obtained with Delaunay-like triangulations on irregular regions.

关键词： Numerical grid generation direct generation method finite difference method finite element method Delaunay triangulation.

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage Mark L.Dell’Acqua Brian M.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Innovative circular path harvester for mechanical harvesting of irregular and large-canopy olive trees

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International journal of Agricultural and Biological Engineering 2018年第3期11卷 86-93页

作者： Rafael R.Sola-Guirado Gregorio L.Blanco-Roldan Sergio Castro-Garcia Francisco j.Castillo-ruiz jesus A.Gil-Ribes Department of Rural Engineering E.T.S.I.Agronomos y MontesUniversity of CordobaCampus de RabanalesCtra.Nacional IV Km 396CordobaSpain

The harvesting process of the olive tree is mainly performed by manual means,because traditional olive orchards(the main planting typology)are formed of irregular,large-canopy trees that are very difficult to harvest *** that reason,the cost of harvesting is very high,and it threatens the future of these plantations whose conversion to other more modern layouts is not always possible due to several *** introduction of a harvester may represent the technological change that is the key factor for improved *** main purpose of this work was to develop a harvester based on canopy shaker technology for work on irregular,large trees in a circular *** design of the harvester was based on a determination of tree geometry,together with tree *** tests were used to determine machine-tree interaction,and to evaluate the removal,catch frame and driven *** proposed innovation allowed the fully mechanical harvest of previously planted trees with a removal efficiency of over 84%,achieving an effective field capacity of 0.21 hm^(2)/*** the results so far have been promising,further improvements are advisable in machine and tree adaptation.

关键词： olive tree olive fruit canopy shaker harvester machinery design