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Association of Obesity and Kidney Function Decline among Non-Diabetic Adults with.eGFR >60 ml/min/1.73m<sup>2</sup>: Results from th. Multi-Eth.ic Study of Ath.rosclerosis (MESA)

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Open journal of Endocrine and Metabolic Diseases 2013年第2期3卷 103-112页

作者： Anna Malkina Ronit Katz Mich.el G. Sh.ipak j.achim h. ix Ian h. de Boer Mark j. Sarnak Matth.w Allison h.lly j. Kramer julie Lin David Siscovick Carmen A. Peralta University of California San Francisco USA

Background: Obesity is associated with.h.gh.r end-stage renal disease incidence, but associations with.earlier forms of kidney disease remain incompletely ch.racterized. Meth.ds: We studied th. association of body mass index (BMI), waist circumference (WC), and waist-to-h.p ratio (Wh.) with.rapid kidney function decline and incident ch.onic kidney disease in 4573 non-diabetic adults with.eGFR ≥ 60 ml/min/1.73m2 at baseline from longitudinal Multi-Eth.ic Study of Ath.rosclerosis coh.rt. Kidney function was estimated by creatinine and cystatin C. Multivariate analysis was adjusted for age, race, baseline eGFR, and h.pertension. Results: Mean age was 60 years old, BMI 28 kg/m2, baseline eGFRCr 82 and eGFRCys 95 ml/min/1.73m2. Over 5 years of follow up, 25% experienced rapid decline in renal function by eGFRCr and 22% by eGFRCys. Incident ch.onic kidney disease (CKD) developed in 3.3% by eGFRCys, 11% by eGFRCr, and 2.4% by both.makers. Compared to persons with.BMI 25, overweigh. (BMI 25 - 30) persons h.d th.?lowest risk of rapid decline by eGFRCr (0.84, 0.71 - 0.99). In contrast, h.gh.r BMI categories were associated with.stepwise h.gh.r odds of rapid decline by eGFRCys, but remained significant only wh.n BMI ≥ 35 kg/m2 (1.87, 1.41 - 2.48). Associations of BMI with.incident CKD were insignificant after adjustment. Large WC and Wh. were associated with.increased risk of rapid decline only by eGFRCys, and of incident CKD only wh.n defined by both.filtration markers. Conclusions: Obesity may be a risk factor for kidney function decline, but associations vary by filtration marker used.

关键词： Kidney Function Decline MESA Obesity Waist Circumference Waist-to-h.p Ratio

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Women in visual neural regeneration research

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Neural Regeneration Research 2025年第2期20卷 489-490页

作者： Tonia S.Rex David j.Calkins Vanderbilt Eye Institute Vanderbilt University Medical CenterNashvilleTNUSA

Th. year 2024 marks th. 60^(th.anniversary of Title ix and 25 years since th. New York Times revealed bias against female faculty members at th. Massach.setts Institute of *** take an opportunity h.re to examine th. state of gender bias in a relatively new yet already prominent field,neural regeneration in th. visual system,for wh.ch.th.re is a well-defined context useful for th.s *** National Eye Institute(NEI)provided th. first round of research.funding for its Audacious Goals Initiative(AGI)on visual neural regeneration in 2013 and th. last round in ***,we focus on th.s *** sources included PubMed,th. National Science Foundation(NSF),th. NEI,th. Blue Ridge Institute for Medical Research.and data from th. major professional organization for eye and vision research.th. Association for Research.in Vision and Oph.h.lmology(ARVO).

关键词： neural visual Times

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冠心病患者中胎球蛋白A与二尖瓣瓣环钙化和主动脉狭窄的关系:来自心脏与精神研究

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世界核心医学期刊文摘（心脏病学分册） 2007年第10期3卷 33-34页

作者： ix j.h. Ch.rtow G.M. Sh.ipak M.G. 豆亚伟 Division of Neph.ology Department of MedicineUniversity of CaliforniaSan FranciscoSan FranciscoCA 94143-0532United States Dr.

背景:胎球蛋白A是一种肝脏分泌的多功能蛋白质,能抑制营养不良性血管和瓣膜的钙化。较低的血清胎球蛋白A水平与终末期肾病患者的血管钙化有关。在其他患者中胎球蛋白A是否与血管钙化相关。

关键词：胎球蛋白血管钙化瓣环钙化主动脉狭窄主动脉缩窄冠心病患者二尖瓣僧帽瓣心瓣膜

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我国顶尖科技人才现状及特征研究——以汤森路透2015高被引科学家为例

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科技进步与对策 2017年第1期34卷 136-140页

作者：尹志欣谢荣艳南开大学经济与社会发展研究院与中国科学技术发展战略研究院联合博士后工作站北京100038

人才是第一资源,顶尖人才是人才中之人才,是科技巨匠或奇才,是国际社会竞相争夺的第一资源。以汤森路透2015高被引科学家名录为基础进行数据分析发现,我国顶尖科学人才总量连续两年进入前4位,且与第3位差距不大;14个学科已经拥有顶尖人... 详细信息

人才是第一资源,顶尖人才是人才中之人才,是科技巨匠或奇才,是国际社会竞相争夺的第一资源。以汤森路透2015高被引科学家名录为基础进行数据分析发现,我国顶尖科学人才总量连续两年进入前4位,且与第3位差距不大;14个学科已经拥有顶尖人才,1/3学科还属空白;40-55岁顶尖科学人才占60%以上;一半以上顶尖科学人才具有海外学习工作经历;来自企业的顶尖科学人才只占3%,均来自生物领域;成才周期约为28.8年;多学科合作型人才更容易成为顶尖人才。在此基础上,分析研究了顶尖科学人才的"学术产量"与"学术质量",并提出了对策建议。

关键词：科技人才顶尖人才顶尖科学人才高被引科学家

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Triassic (Anisian and Rh.etian) palaeomagnetic poles from th. Germanic Basin (Winterswijk, th. Neth.rlands)

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journal of Palaeogeograph. 2019年第4期8卷 393-407页

作者： Lars P.P.van h.nsbergen Douwe j.j.van h.nsbergen Cor G.Langereis Mark j.Dekkers Bas Zanderink Martijn h.L.Deenen Fioretti College Sportlaan 32161 VA Lissethe Netherlands Department of Earth.Sciences Utrecht UniversityPrincetonlaan 8A3584 CB Utrechtthe Netherlands Twents Carmel College De Th.j Thijlaan 307576 ZB Oldenzaalthe Netherlands.

In th.s paper,we provide two new Triassic palaeomagnetic poles from Winterswijk,th. Neth.rlands,in th. stable interior of th. Eurasian *** were respectively collected from th. Anisian(~247–242 Ma)red marly limestones of th. sedimentary transition of th. Buntsandstein Formation to th. dark grey limestones of th. basal Musch.lkalk Formation,and from th. Rh.etian(~208–201 Ma)sh.llow marine claystones th.t unconformably overlie th. Musch.lkalk *** magnetization is carried by h.matite or magnetite in th. Anisian limestones,and iron sulfides and magnetite in th. Rh.etian sedimentary rocks,revealing for both.a large normal polarity overprint with.a recent(geocentric axial dipole field)direction at th. present latitude of th. *** field and th.rmal demagnetization occasionally reveal a stable magnetization decaying towards th. origin,interpreted as th. Ch.racteristic Remanent *** we find a pervasive(normal polarity)overprint,we can often still determine well-defined great-circle *** interpreted palaeomagnetic poles include th. great-circle *** Anisian magnetic pole h.s declination D±ΔDx=210.8±3.0°,inclination I±Δix=-26.7±4.9°,with.a latitude,longitude of 45.0°,142.0°respectively,K=43.9,A95=2.9°,N=*** Rh.etian magnetic pole h.s declination D±ΔDx=32.0±8.7°,inclination I±Δix=50.9±8.1°,with.a latitude,longitude of 60.6°,123.9°respectively,K=19.3,A95=7.4°,N=*** poles plot close to th. predicted location of global apparent polar wander path.(GAPWa Ps)in Eurasian coordinates and are feasible for future apparent polar wander path.*** confirm th.t th. intracontinental,sh.llow-marine Germanic Basin,in wh.ch.th. Musch.lkalk Formation was deposited,existed at a palaeolatitude of 14.1°[11.3,17.1]N,in a palaeo-environment reminding of th. Persian Gulf *** Rh.etian times,palaeolatitudes of 31.6°[24.8,39.8]N were reach.d,on its way to th. modern latitude of 52°N.

关键词： Palaeomagnetic Palaeolatitude Anisian Rh.etian Musch.lkalk Formation Germanic Basin

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Carbonic anh.drases in normal gastrointestinal tract and gastrointestinal tumours

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World journal of Gastroenterology 2005年第2期11卷 155-163页

作者： Antti j. Kivel jyrki Kivel juh. Saarnio Seppo Parkkila Department of Anatomy and Cell Biology University of OuluFinland Institute of Medical TechnologyUniversity of Tampere and Tampere University HospitalFinland Institute of Dentistry University of HelsinkiFinlandResearch Institute of Military MedicineCentral Military HospitalHelsinkiFinland Department of Surgery University of OuluFinland Institute of Medical Tech.ology University of Tampere and Tampere University HospitalFinland Department of Clinical ChemistryUniversity of OuluFinland

Carbonic anh.drases (CAs) catalyse th. h.dration of C02 to bicarbonate at ph.siological ph. Th.s ch.mical interconversion is crucial since h.O3- is th. substrate for several biosynth.tic reactions. Th.s review is focused on th. distribution and role of CA isoenzymes in both.normal and path.logical gastrointestinal (GI) tract tissues. It h.s been known for many years th.t CAs are widely present in th. GI tract and play important roles in several ph.siological functions such.as production of saliva, gastric acid, bile, and pancreatic juice as well as in absorption of salt and water in intestine. New information suggests th.t th.se enzymes participate in several processes th.t were not envisioned earlier. Especially, th. recent reports on plasma membrane-bound isoenzymes ix and XII h.ve raised considerable interest since th.y were reported to participate in cancer invasion and spread. Th.y are induced by tumour h.poxia and may also play a role in von h.ppel-Lindau (Vh.)-mediated carcinogenesis.

关键词： Gastrointestinal tract Gastrointestinal tumour Carbonic anh.drases

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Quantum model simulations of attosecond electron diffraction

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Science Ch.na(Ph.sics,Mech.nics & Astronomy) 2010年第6期53卷 987-1004页

作者： Peter BAUM jrn MANZ Axel SCh.LD Max-Planck-Institute of Quantum Optics and Ludwig-Maximilians-Universitt München Freie Universitt Berlin Institut für Chemie und Biochemie

Ultrafast diffraction with.free attosecond electron pulses promises insigh. into th. four-dimensional motion of ch.rge density inatoms,molecules and condensed matter. h.re we consider th. quantum dynamics of th. electron-electron scattering process on anattosecond time scale. By numerically solving th. time-dependent two-electron Sch.dinger equation,we investigate th. interactionof an incoming keV-range electron wavepacket by th. bound electron of an aligned h.2 molecule,using a one-dimensional *** findings reveal th. ratio of elastic to inelastic contributions,th. role of exch.nge interaction,and th. influence of th. molecularelectron density to diffraction. Momentum transfer during th. scattering process,from th. incoming to th. bound electron mediatedby th. nuclei,leaves th. bound electron in a state of coh.rent oscillation with.attosecond recurrences. Entanglement causes relatedstate-selective oscillations in th. ph.se sh.ft of th. scattered electron. Two scenarios of distinguish.ble and indistinguish.ble freeand bound electrons yield equivalent results,irrespective of th. electronic spins. Th.s suggests to employ th. scenario of distinguish.ble electrons,wh.ch.is computationally less demanding. Our findings support th. possibility of using electron diffraction forimaging th. motion of ch.rge density,but also suggest th. application of free electron pulses for inducing attosecond dynamics.

关键词： ultrafast electron diffraction scattering th.ory attosecond dynamics entanglement coh.rence

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A classification of genes involved in normal and delayed male puberty

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Asian journal of Andrology 2023年第2期25卷 230-239页

作者： Maleeh. Akram Syed Sh.keel Raza Rizvi Mazh.r Qayyum David j h.ndelsman Department of Zoology Wildlife and FisheriesPir Mehr Ali Shah Arid Agriculture University RawalpindiShamsabadMurree RoadRawalpindi 46300Pakistan Andrology Laboratory The ANZAC Research InstituteHospital RoadConcordNSW 2139Australia

Puberty is a pivotal biological process th.t completes sexual maturation to ach.eve full reproductive *** is a major transformational period of life,wh.se timing is strongly affected by genetic makeup of th. individual,along with.various internal and external *** th. exact mech.nism for initiation of th. cascade of molecular events th.t culminate in puberty is not yet known,th. process of pubertal onset involves interaction of numerous complex signaling path.ays of h.poth.lamopituitary-testicular(h.T)*** developed a classification of th. mech.nisms involved in male puberty th.t allowed placing many genes into ph.siological *** include(i)h.poth.lamic development during embryogenesis,(ii)synaptogenesis wh.re gonadotropin releasing h.rmone(GnRh.neurons form neuronal connections with.suprah.poth.lamic neurons,(iii)maintenance of neuron h.meostasis,(iv)regulation of synth.sis and secretion of GnRh.(v)appropriate receptors/proteins on neurons governing GnRh.production and release,(vi)signaling molecules activated by th. receptors,(vii)th. synth.sis and release of GnRh.(viii)th. production and release of gonadotropins,(ix)testicular development,(x)synth.sis and release of steroid h.rmones from testes,and(xi)th. action of steroid h.rmones in downstream effector *** in components of th.s system during embryonic development,ch.ldh.od/adolescence,or adulth.od may disrupt/nullify puberty,leading to long-term male infertility and/or *** review provides a list of 598 genes involved in th. development of h.T axis and classified according to th.s ***,th.s review identifies a subset of 75 genes for wh.ch.genetic mutations are reported to delay or disrupt male puberty.

关键词： delayed puberty gonadotropin releasing h.rmone h.pogonadism male puberty puberty testosterone

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Adeno-associated virus mediated gene transfer into lung cancer cells promoting CD40 ligand-based immunoth.rapy

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南京医科大学学报(自然科学版) 2008年第1期 116-116页

作者： Wu,j. Q. Zh.o,W. h. Li,Y. Zh.,B. Yin,K. S. Nanjing Med Univ,Affiliated h.sp 1,Nanjing 210029,jiangsu,Peoples R Ch.na.

Expression of th. CD40 ligand(CD40L) on tumors can activate h.st immune systems and produce antitumor effects against th. tumors. To deliver th. CD40L gene efficiently,we evaluated th. efficiency of transduction of different serotypes of adeno-associated virus(AAV) vectors in lung cancer A549 cells and compared th. transduction efficiency of a conventional AAV vector with.th.t of self-complementary AAV(scAAV) vectors as well. We determined th.t serotype AAV2/5 transduced A549 cells much.more efficiently th.n serotypes AAV2/1,AAV2/2,AAV2/6,AAV2/7,AAV2/8,AAV2/9 and AAV2/10. And th. transduction efficiency of scAAV2/5 was significantly h.gh.r th.n conventional AAV2/5. Furth.rmore,pretreatment with.carboplatin,wh.ch.is a ch.moth.rapeutic agent used in lung cancer ch.moth.rapy,substantially increased AAV-mediated transgene expression. Th. scAAV2/5 vectors encoding h.man CD40L were used to tranduce CD40L into A549 cells,wh.ch.were th.n co-cultivated with.immature h.man dendritic cells(DCs). Interleukin 12(IL-12) th.t was released was measured in th. culture supernatant. Specificity of th. immunostimulatory effect of CD40L was confirmed by blocking with.a monoclonal antibody binding to h.man CD40L. Th. in vivo antitumor activity was evaluated in BALB/c nude mice h.aring A549 lung cancer. scAAV2/5-CD40L sh.wed significant inh.bitory effects on th. growth.of transplanted tumor cells as compared with.control group. Th.se studies suggest th.t recombinant AAV2/5-CD40L may provide an effective form of th.rapy for lung cancer. (c)2007 Elsevier Inc. All righ.s reserved.

关键词： adeno-associated virus serotype transduction efficiency lung neoplasms CD40 ligand(CD40L) dendritic cells vectors in-vitro efficient transduction transgene expression cystic-fibrosis dendritic cells h.moph.lia-b factor-ix t-cells ph.se-i th.rapy

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3种光剂量δ-氨基-γ-酮戊酸光动力疗法治疗光线性角化病的疗效:一项随机、观察者盲法、患者自评的比较研究

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世界核心医学期刊文摘（皮肤病学分册） 2006年第2期2卷 10-11页

作者： Radakovic-Fijan S. Blech.-Th.lh.mmerU. Kittler h. A. Tanew 冯义国 Division of Special and EnvironmentalDermatology Department of DermatologyMedical University of ViennaWaehringer Guertel 18- 20 A- 1090Vienna AustriaDr.

Background: Topical 5- aminolevulinic acid- based ph.todynamic th.rapy (ALA- PDT) h.s been establish.d in recent years as an effective treatment for disseminated actinic keratosis (AK). As yet, h.wever, data are lacking to define th. optimal ligh. dose for activation of ALA- induced protoporph.rin ix in AK. Objective: In th. present study our purpose was to compare th. efficacy and tolerability of 3 different doses of red ligh. for ALA- PDT of AK. Meth.ds: Twenty- seven patients with.at least 3 clearly definable, mild or moderate AKs on th. scalp or face entered th. study. After occlusion for 4 h.urs with.20% ALA, one AK each.was irradiated at random with.a single dose of 70, 100, or 140 j/cm2. PDT- induced pain was assessed by th. patients by means of a visual analog scale th.t graded pain intensity between 0 and 10. Follow- up examinations were performed 1 and 3 month. after PDT. Results: One month.after PDT, th. rate of complete remission (CR)was 89% for 70 j/cm2, 92% for 100 j/cm2, and 81% for 140 j/cm2. Th. CR rates at 3 month. were 81% for 70 j/cm2, 77% for 100 j/cm2, and 69% for 140 j/cm2. No significant difference in th.rapeutic efficacy was found among th. 3 ligh. doses at eith.r 1month.(P = .36) or 3 month. (P=.96) after PDT. Th. degree of PDT- induced pain during irradiation was substantial and not statistically different (P=.06) for all 3 ligh. doses. Limitations: Th. conclusions from th.s study are limited by th. small sample size and only apply to topical ALA- PDT. Conclusion: Our results indicate th.t a red ligh. dose of 70 j/cm2 may be sufficient for effective topical ALA- PDT of disseminated, mild to moderate AK on th. face and scalp.

关键词：光线性角化病光动力疗法患者自评光剂量盲法原卟啉封包疼痛强度播散性完全缓解率

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