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中国毒理学会第六届全国毒理学大会

作者： Paul j RUSSELL Safety and Environmental Assurance Centre UnileverColworth Science ParkShambrookBedfordshireUKMK44 1LQ

＜正＞Consumer and environmental safety decisions are based on exposure and hazard data interpreted using risk assessment approaches. The Adverse Outcome Pathway （AOP）conceptual framework has been presented as a logical sequence of events or processes within biological systems which can be used to understand adverse effects and refine the current risk assessment *** originally described as an approach to ecotoxicology risk assessment, this has now been extended into the human safety *** AOP shifts the risk assessment focus from traditional toxicological apical endpoints to the development of increased mechanistic understanding of a chemical’s interactions and effects at a molecular *** the AOP framework the molecular initiating event（MIE）is defined as the first point of chemical-biological interaction within an organism which starts the adverse outcome *** MIEs can be considered as molecular interactions occurring in a dynamic and complex matrix *** properties of the matrix will strongly influence the kinetics of the reaction and the mechanisms involved through variations in pH,lipophilicity,protein content,*** interactions will in turn define the qualitative and quantitative aspects of the MIE along with the biokinetic and biodynamic profile of a *** of key MIEs can be approached from either an exposure or chemical driven approach or via a chemical’s biological *** the former,predictive chemistry techniques including quantitative structural activity relationships can be developed based on existing data and through mapping networks of chemicals, MIEs and subsequent *** develop a retrospective response based approach,in-vitro assays can be used to provide a biological signature for a *** data can be used to inform a risk assessment both from a hazard perspective and also to provide additional evidence for read-across to toxicologically similar chemicals of established

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Dietary Biofortification of Gestating Animal Diets with Natural Sources of Selenium:Whole Animal and Specific Tissue Responses

Dietary Biofortification of Gestating Animal Diets with Natu...

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The Second International Conference on Selenium in the Environment and Human Health

作者： Caton j S Center for Nutrition and Pregnancy Animal Sciences DeptNorth Dakota State UniversityND 58108USA

Introduction Selenium(Se) is an essential trace element for normal growth and development in both livestock and *** the past few decades public and scientific perceptions of Se have dramatically changed;ranging from a nutrient that is potentially dangerous and should be controlled within narrow ranges to one that has many potential health benefits. Biofortification of animal diets is the provision of additional or elevated levels of dietary *** the case of Se,biofortification of animal diets occurs either naturally because base feed ingredients are

关键词： Selenium Dietary Biofortification of Gestating Animal Diets with Natural Sources of Selenium:Whole Animal and Specific Tissue Responses

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使用单一切口技术在相同部位2次切取结缔组织进行根面覆盖治疗

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中国口腔医学继续教育杂志 2010年第4期13卷 29-32页

作者： jun-Beom park DDS, MSD, PhD 谢颖（译）欧阳翔英（审）不详北京大学口腔医学院牙周科北京海淀区中关村南大街22号 100081

本文介绍一种单一切口技术切取上皮下结缔组织．以便减小腭侧伤口．使供区达到一期愈合．从而减轻术后疼痛。有时由于组织量不足或血管解剖的限制．需要在患者腭侧的同一部位重复切取结缔组织用于移植。本病例报告了在不同时间使用单一... 详细信息

本文介绍一种单一切口技术切取上皮下结缔组织．以便减小腭侧伤口．使供区达到一期愈合．从而减轻术后疼痛。有时由于组织量不足或血管解剖的限制．需要在患者腭侧的同一部位重复切取结缔组织用于移植。本病例报告了在不同时间使用单一切口技术，在相同部位2次切取上皮下结缔组织用于根面覆盖的临床结果。使用单一切口技术在相同部位2次获取用于移植的结缔组织．将这2块组织用于根面覆盖，术后6周显示出可预测的结果．牙本质敏感减轻，无牙周袋形成或明显的并发症。当需要多次结缔组织移植时．这种方法可作为一种选择。本文报告的结果仍需在更大样本的病例系列研究或病例对照研究中证实。

关键词：结缔组织多个腭单一切口组织移植

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填土对既有浅埋隧道的安全影响及容许填土厚度确定

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铁道学报 2014年第9期36卷 79-84页

作者：卢裕杰中铁第五勘察设计院集团有限公司北京102600

既有浅埋隧道上方填土可能导致其衬砌变形、安全系数降低,甚至发生破坏,危及行车安全。以长枪岭隧道上方某拟建公园填土工程为例,选取若干典型断面,对既有浅埋隧道受不同厚度的填土影响进行数值分析,并确定容许填土厚度。结果表明:既有... 详细信息

既有浅埋隧道上方填土可能导致其衬砌变形、安全系数降低,甚至发生破坏,危及行车安全。以长枪岭隧道上方某拟建公园填土工程为例,选取若干典型断面,对既有浅埋隧道受不同厚度的填土影响进行数值分析,并确定容许填土厚度。结果表明:既有隧道上方填土将导致衬砌整体下沉,左右两侧沉降基本对称,位移值自上而下逐渐减小;填土后的安全系数降低,但幅度不大,拱脚及仰拱处安全系数偏小,可能出现开裂;既有隧道拱顶位移值随着填土厚度的增加而近似线性增大,为满足位移控制要求,容许填土厚度应为0.3 H^0.4 H(H为原覆土厚度)。根据若干断面的分析结果可得整个填土区域的容许填土线,在此范围内进行填土施工,并采取相应的工程措施,既有隧道的运营安全可得到保证。本分析方法简单易行,满足工程精度,可用于指导工程实践,对类似工程有一定的借鉴意义。

关键词：既有隧道浅埋隧道填土数值模拟容许厚度

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肿瘤总大小对临床ⅠA期含有部分实性结节病灶的肺腺癌病人预后的影响:仅实性部分的大小有影响吗?

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国际医学放射学杂志 2019年第3期 373-373页

作者：王志炜 H.Kim j.Goo Y.Suh C.park Y.Kim Department of Radiology Seoul National University College of Medicineand Institute of Radiation MedicineSeoul National University Medical Research Center

摘要目的探讨临床放射学变量肿瘤总大小(T)和临床T分类(cTI)对含有部分实性结节(PSN)病灶的ⅠA期(TNM)肺腺癌病人预后的影响。方法该回顾性研究经机构

关键词：肺腺癌实性结节

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预测新辅助放化疗后宫颈癌进展:治疗后DWI的价值

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国际医学放射学杂志 2016年第6期 706-706页

作者： j.j.park C.K.Kim B.K.park 徐贝 Department of Radiology and Center for Imaging Science Samsung Medical CenterSungkyunkwan University School of Medicine

摘要目的探究治疗后扩散加权成像(DWI)对宫颈癌新辅助放化疗(CCRT)进展的预测价值。方法该回顾性分析包括连续100例局部进展宫颈癌在完成CCRT后1个月进

关键词： DWI 新辅助放化疗治疗后宫颈癌

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Monitoring of rice crop using ENVISAT ASAR data

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Science China Earth Sciences 2006年第7期49卷 755-763页

作者： DONG Yanfang1, 2, SUN Guoqing1,3 & PANG Yong4 1. State Key Laboratory of Remote Sensing Science, Institute of Remote Sensing Applications, Chinese Academy of Sciences, Beijing 100101, China 2. Graduate University of Chinese Academy of Sciences, Beijing 100039, China 3. Department of Geography, University of Maryland, College park, MD 20742, USA 4. Forest Remote Sensing Lab, Research Institute of Forest Resource and Information Technology, Chinese Academy of For-estry, Beijing 100091, China State Key Laboratory of Remote Sensing Science Institute of Remote Sensing Applications Chinese Academy of Sciences Beijing China Graduate University of Chinese Academy of Sciences Beijing China Department of Geography University of Maryland College Park USA Forest Remote Sensing Lab Research Institute of Forest Resource and Information Technology Chinese Academy of Forestry Beijing China

Because of the cloudy conditions during the rice growth period, rice is one of the agri-cultural crops most suited to monitoring with the SAR instruments. Backscatter response measured by SAR is correlated with rice conditions, including height, density, biomass and structure, which are variable at different growing stages. In this paper, multi-date ENVISAT ASAR Alternating Polarization Mode (APMode) imageries were acquired during the rice crop growing cycle. At the same time, the rice parameters were measured in field. A continuous canopy model was used to compute the back-scattering from rice fields during the growth cycle, and the relationship between rice parameters and radar backscattering coefficients from both ASAR and modeling was analyzed. The effects of polari-zation, incidence angle and polarization on radar backscattering coefficients were analyzed. It was found that simulated radar backscatter has similar trends as ASAR data. This will be meaningful for the further research of rice parameters estimation from ASAR data. Different features show signifi-cantly different signatures in ASAR images and they follow some certain laws, so rice area can be accurately mapped by using multi-temporal SAR images, then rice yield can be estimated.

关键词： rice, ASAR, radar backscattering, model.

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Development of internal COI primers to improve and extend barcoding of fruit flies (Diptera: Tephritidae: Dacini)

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Insect Science 2020年第1期27卷 143-158页

作者： Matt N.Krosch Francesca Strutt Mark j.Blacket jana Batovska Melissa Starkie Anthony R.Clarke Stephen L.Cameron Mark K.Schutze School of Earth Environmental&Biological SciencesQueensland University of TechnologyBrisbaneQueenslandAustralia Plant Biosecurity Co-operative Research Centre BruceAustralian Capital TerritoryAustralia Agriculture Victoria AgriBioCentre for AgriBioscienceBundooraVictoriaAustralia Department of Entomology Purdue UniversityWest LafayetteIndianaUSA Department of Agriculture&Fisheries Queensland Primary Industries Insect Collection(QDPC)Dutton ParkQueenslandAustralia

Accurate species-level identifications underpin many aspects of basic and applied biology;however,identifications can be hampered by a lack of discriminating morphological characters,taxonomic expertise or *** approaches,such as DNA"barcoding"of the cytochrome c oxidase(COI)gene,are argued to overcome these ***,nuclear encoding of mitochondrial genes(numts)and poor amplification success of suboptimally preserved specimens can lead to erroneous *** insect group for which these molecular and morphological problems are significant are the dacine fruit flies(Diptera:Tephritidae:Dacini).We addressed these issues associated with COI barcoding in the dacines by first assessing several"universal"COI primers against public mitochondrial genome and numt sequences for dacine *** then modified a set of four primers that more closely matched true dacine COI sequence and amplified two overlapping portions of the COI barcode *** new primers were tested alongside universal primers on a selection of dacine species,including both fresh preserved and decades-old dry ***,Bactrocera tiyoni mitochondrial and nuclear genomes were compared to identify putative *** numt clades were identified,three of which were amplified using existing universal *** contrast,our new primers preferentially amplified the"true"mitochondrial COI barcode in all dacine species *** new primers also successfully amplified partial barcodes from dry specimens for which full length barcodes were *** we recommend these new primers be incorporated into the suites of primers used by diagnosticians and quarantine labs for the accurate identification of dacine species.

关键词： Bactrocera biosecurity Dacus\minibarcodes pseudogene Zeugodacus

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滨海区浅埋嵌岩灌注桩嵌岩施工

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施工技术 2008年第S1期37卷 185-187页

作者：卢贤安宁波鄞州工业园区投资开发有限责任公司浙江宁波315000

位于滨海区的某工程中采用浅埋嵌岩桩。施工前根据工程地质条件和桩机特点选择了适合于本工程的钻机,同时进行了试桩确定了施工中的一些技术参数和施工工艺,确保正式施工顺利进行。

关键词：桩基工程滨海区浅埋嵌岩桩施工技术

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A 40-year evaluation of drivers of African rainforest change

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Forest Ecosystems 2021年第4期8卷 887-902页

作者： Colin A.Chapman Carmen Galan-Acedo jan F.Gogarten Rong Hou Michael j.Lawes Patrick A.Omeja Dipto Sarkar Anna Sugiyama Urs Kalbitzer Department of Anthropology Center for the Advanced Study of Human PaleobiologyThe George Washington University20037 WashingtonDCUSA Wilson Center 1300 Pennsylvania Avenue NW20004 WashingtonDCUSA School of Life Sciences University of KwaZulu-NatalScottsvillePietermaritzburgSouth Africa Shaanxi Key Laboratory for Animal Conservation Northwest UniversityXi’anChina Escuela Nacional de Estudios Superiores Universidad Nacional Autónoma de MéxicoMoreliaMichoacánMexico Viral Evolution and Epidemiology of Highly Pathogenic Microorganisms Robert Koch InstituteSeestraße 1013353 BerlinGermany Institute of Biodiversity and Environmental Conservation(IBEC) Universiti Malaysia Sarawak94300 Kota SamarahanSarawakMalaysia Makerere University Biological Field Station Fort PortalUganda Department of Geography and Environmental Studies Carleton UniversityOttawaCanada School of Life Sciences Harold L.Lyon ArboretumUniversity of Hawai‘i at Mānoa3190 Maile Way96822 HonoluluHIUSA Department for the Ecology of Animal Societies Max Planck Institute of Animal BehaviorRadolfzellGermany Department of Biology University of KonstanzKonstanzGermany

Background:Tropical forests are repositories of much of the world’s biodiversity and are critical for mitigation of climate ***,the drivers of forest dynamics are poorly *** is in large part due to the lack of long-term data on forest change and changes in ***:We quantify changes in tree abundance,diversity,and stand structure along transects first enumerated in 1978 and resampled 2019 in Kibale National park,*** tested five ***,based on the purported role of seed dispersal and herbivory and our quantification of changes in the abundance of frugivores and herbivores,we tested two predictions of how faunal change could have influenced forest ***,based on an evaluation of life history strategies,we tested two predictions concerning how the forest could have changed following disturbance that happened prior to written ***,based on a 50-year climate record,we evaluate the possible influence of climate change on forest ***:More trees were present on the assessed transects in 2019(508)than in 1978(436),species richness remained similar,but diversity declined as the number of dominant species *** increased by only 3 mm over the 50 years but this had not significant effect on forest changes measured *** average monthly maximum temperature increased significantly by 1.05℃ over 50 *** abundance of frugivorous and folivorous primates and elephants increased over the 50 years of *** the prediction that an increase in abundance of seed dispersing frugivores increases the abundance of their preferred fruiting tree species,nor that as an increase in folivore abundance causes a decline in their preferred species were *** predicted,light-demanding species decreased in abundance while shade-tolerant species increased as expected from Kibale being disturbed prior to historical ***,while temperature increased over the 50 years,w

关键词： Climate change Elephants Succession Primates Disturbance Forest regeneration

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