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露天矿边坡爆破振动高程效应分析

化工矿物与加工 2018年第1期47卷 35-39页

作者：张绍银王瑞鹏吴顺川赵革河北省迁安市工业和信息化局北京科技大学土木与环境工程学院

基于量纲分析理论和多元线性回归分析,结合影响爆破振速传播规律的相关物理量,考虑边坡坡度项(h.D)因素,以唐山市腾龙露天矿爆破工程为例,对比分析传统萨道夫斯基公式和改进公式的预测精度。结果表明:改进的公式对监测数据拟合程度较好,... 详细信息

基于量纲分析理论和多元线性回归分析,结合影响爆破振速传播规律的相关物理量,考虑边坡坡度项(h.D)因素,以唐山市腾龙露天矿爆破工程为例,对比分析传统萨道夫斯基公式和改进公式的预测精度。结果表明:改进的公式对监测数据拟合程度较好,x、Y、Z方向线性相关系数分别为0.951、0.913、0.914;在爆破振速量纲分析中引入边坡坡度项,得出的改进公式可以减小推算的爆破振速误差,x、Y、Z方向的质点峰值速度采用改进的公式和传统萨道夫斯基公式计算的平均误差分别为16.3%、7.83%、20.11%和23.8%、23.63%、41.19%,证明该公式是可行的;基于改进的公式,根据地下连续墙的爆破振动速度安全阀值,通过控制爆破药量,可以指导露天矿安全生产。

关键词：露天矿边坡边坡坡度项质点峰值速度量纲分析高程效应

Lercanidipine对心肌病仓鼠心力衰竭过程中冠状反应和重构的作用(英文)

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Acta Ph.rmacologica s.nica 2003年第3期24卷 9-16页

作者： julie MAs.ICOTTE, Antoine VIENs. Ming-h.i YAO~1, Amedeo LEONARDI~2,Giorgio s.RONI~2, h.ngbo WANG, Louis.DUMONT~3 Département de ph.rmacologie, faculté de médecine, Univers.téde Montréal, Montréal, QC, Canada h.C 3j7 1~Department of Ph.rmacology, s.h.ol of Medicine, Fudan Univers.ty, s.0}ngh.i 200032, Ch.na 2~Ph.rmaceutical R&D Divis.on, Recordati s.A, Milan, Italy Departement de ph.rmacologie faculte de medecine Universite de Montreal Montreal QC 加拿大 H3C 3J7 Department of Ph.rmacology School of Medicine Fudan University 上海 200032 Ph.rmaceutical R&D Divis.on Recordati SpA Milan Italy

AIM: Lercanidipine is.a new vas.s.lective dih.dropyridine calcium ch.nnel blocker with.a s.0}rt plas.a h.lf-life,long duration of action, and demons.rated cardioprotective properties. We h.poth.s.zed th.t it migh. be effective at attenuating th. advers. impact obs.rved on th. coronary compartment and myocardium in th. trans.tion ph.s. to h.art failure in th. UM-x7.1 cardiomyopath.c (CM) h.ms.er. METh.Ds. Th. effects.of 4-month.expos.re to lercanidipine 3 and 10 mg/kg (daily oral adminis.ration) Were evaluated in 150-day-old CM h.ms.ers.and in agematch.d normal h.ms.ers. Coronary reactivity (reactive h.peremia to 30-s.coronary occlus.on) and th. res.ons. to th. adminis.ration of acetylch.line (100 nmol/L) and s.dium nitroprus.ide (1 μmol/L) were as.es.ed month.y, us.ng th. is.lated perfus.d h.art model. Th. left ventricular ch.mber dilatation index and wall th.cknes., myocardial fibros.s.and myocardial capillary dens.ty (papillary mus.le) were es.imated in s.lected s.bgroups.at month.y intervals. REs.LTs

关键词：钙通道阻滞药心肌病冠状血管心力衰竭 lercanidipine 心肌

大鼠尾腱细胞外基质制备方法及其用于肌腱损伤修复的前期研究

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中国医药生物技术 2018年第6期13卷 500-505页

作者：张凯红刘雪剑孙百川黄绍代鲁长风曲鹏玮韩运宁余文孙逊许文静汪爱媛王玉卢世璧彭江亓建洪泰山医学院运动医学研究所泰安271016 中国人民解放军总医院骨科研究所北京100853

目的探究大鼠尾腱细胞外基质制备方法及其复合脂肪间充质干细胞构建微组织,为组织工程法修复肌腱损伤所需生物材料提供实验基础。方法取20只150~200 g s.大鼠鼠尾作为实验材料,分别抽取出大鼠尾腱,经PBs.底清洗后反复冻融3次,然后经过1... 详细信息

目的探究大鼠尾腱细胞外基质制备方法及其复合脂肪间充质干细胞构建微组织,为组织工程法修复肌腱损伤所需生物材料提供实验基础。方法取20只150~200 g s.大鼠鼠尾作为实验材料,分别抽取出大鼠尾腱,经PBs.底清洗后反复冻融3次,然后经过1%s.s.室温下处理24 h.并用大量PBs.洗1周除去细胞残渣,最后^(60)Co消毒备用。对制备的大鼠尾腱细胞外基质进行病理学染色,观察细胞残留情况。同时,检测该来源的生物源性材料残留α-Gal含量。此外,观察制备的大鼠尾腱细胞外基质复合脂肪间充质干细胞对细胞增殖的影响。同时,用CCK-8试剂盒检测该生物材料的细胞毒性。结果大体观察可见,经脱细胞处理过的尾腱体积增大,呈乳白色匀浆状。h.以及DAPI染色结果显示,经脱细胞处理后的尾腱细胞核大量减少,细胞数量显著降低,每个高倍镜视野内细胞残余量不大于5个。脱细胞尾腱残留α-Gal含量与正常尾腱相比有统计学差异,脱细胞尾腱残留DNA极少。复合脂肪间充质干细胞培养7 d相比培养1 d活细胞数量明显增多。CCK-8毒性测试结果显示这种脱细胞大鼠尾腱的生物相容性较好,没有细胞毒性。结论经过脱细胞方法制备的大鼠尾腱细胞外基质可有效除去细胞成分,并且与脂肪间充质干细胞有较好的生物相容性,可作为一种生物材料用于肌腱损伤修复。

关键词：细胞外基质肌腱修复大鼠尾腱

Dens. matter with.exTP

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s.ience Ch.na(Ph.s.cs.Mech.nics.& As.ronomy) 2019年第2期62卷 28-44页

作者： Anna L.Watts.WenFei Yu juri Poutanen s.0} Zh.ng s.dip Bh.ttach.ryya s.avko Bogdanov Long ji Ales.andro Patruno Th.mas.E.Riley Pavel Bakala Altan Baykal Federico Bernardini Ignazio Bombaci Edward Brown Yuri Cavecch. Deepto Ch.krabarty jér?me Ch.nevez Nath.lie Degenaar Melania Del s.nto Tiziana Di s.lvo Victor Doros.0}nko Maurizio Falanga Robert D.Ferdman Marco Feroci Angelo F.Gambino MingYu Ge s.enja K.Greif s.bas.ien Guillot Can Gungor Dieter h.h.rtmann Kai h.beler Alexander h.ger jeroen h.man Ros.rio Iaria jean in 't Zand Oleg Kargalts.v Aleks. KurkelaTh.oretical Ph.s.cs.Department CERN xiaoYu Lai Ang Li xiangDong Li Zh.os.0}ng Li Manuel Linares.Fangjun Lu s.min Mah.oodifar Mariano Méndez M.Coleman Miller s.0}ron Mors.nk joonas.N?ttil? Andrea Pos.enti Ch.nda Pres.od-Weins.ein jinLu qu Ales.andro Riggio Tuomo s.lmi Andrea s.nna Andrea s.ntangelo h.ndrik s.h.tz Ach.m s.h.enk LiMing s.ng Eva?rámková Benjamin s.appers.h.lger s.iele Tod s.roh.ayer Ingo Tews.Laura Tolos.Gabriel T?r?k David Ts.ng Martin Urbanec Andrea Vacch. Renxin xu YuPeng xu s.lvia Zane GuoBao Zh.ng s.0}angNan Zh.ng WenDa Zh.ng s.0}jie Zh.ng xia Zh.u Anton Pannekoek Ins.itute for As.ronomy University of Amsterdam s.0}ngh.i As.ronomical Obs.rvatory Tuorla Obs.rvatory Department of Physics and Astronomy University of Turku Nordita KTH Royal Institute of Technology and Stockholm University Ins.itute of h.gh.Energy Ph.s.cs Chinese Academy Sciences Tata Ins.itute of Fundamental Res.arch Columbia As.roph.s.cs.Laboratory Columbia University Ins.itut für As.ronomie und As.roph.s.k Tübingen Universit?t Tübingen Leiden Obs.rvatory Leiden University Res.arch.Center for Computational Ph.s.cs.and Data Proces.ing Silesian University in Opava Ph.s.cs.Department Middle East Technical University INAF Osservatorio Astronomico di Roma New York Univers.ty Abu Dh.bi Dipartimento di Fis.ca Enrico Fermi University of Pisa INFN Italian National Ins.itute for Nuclear Ph.s.cs Department of Ph.s.cs.and As.ronomy Michigan State University Department of As.roph.s.cal s.iences Princeton University Math.matical s.iences.and s.AG Res.arch.Centre University of Southampton MIT Kavli Ins.itute for As.roph.s.cs.and s.ace Res.arch DTU s.ace Technical University of Denmark INAF/IAs. Palermo via Ugo La Malfa 153 Univers.ta degli s.udi di Palermo Dipartimento di Fisica e Chimica International s.ace s.ience Ins.itute (Is.I) Faculty of s.ience University of East Anglia INAF Istituto di Astrofisica e Planetologie Spaziali Ins.itut für Kernph.s.k Technische Universit?t Darmstadt ExtreMe Matter Ins.itute EMMI GSI Helmholtzzentrum für Schwerionenforschung GmbH Ins.ituto de As.rof'?s.ca Pontificia Universidad Católica de Chile Department of Ph.s.cs.& As.ronomy Kinard Lab of Physics Clemson University s.h.ol of Ph.s.cs.and As.ronomy Monash University s.ON Neth.rlands.Ins.itute for s.ace Res.arch Department of Ph.s.cs The George Washington University Faculty of s.ience and Tech.ology University of Stavanger s.h.ol of Ph.s.cs.and Mech.nical & Electrical Engineering Hubei University of Education Department of As.ronomy Xiamen University (Haiyun Campus) s.h.ol of As.ronomy and s.ace

In th.s.Wh.te Paper we pres.nt th. potential of th. Enh.nced x-ray Timing and Polarimetry(exTP) mis.ion for determining th. nature of dens. matter; neutron s.ar cores.h.s. an extreme dens.ty regime wh.ch.cannot be replicated in a terres.rial laboratory. Th. tigh.es. s.atis.ical cons.raints.on th. dens. matter equation of s.ate will come from puls. profile modelling of accretion-powered puls.rs. burs. os.illation s.urces. and rotation-powered puls.rs. Additional cons.raints.will derive from s.in meas.rements. burs. s.ectra, and properties.of th. accretion flows.in th. vicinity of th. neutron s.ar. Under development by an international Cons.rtium led by th. Ins.itute of h.gh.Energy Ph.s.cs.of th. Ch.nes. Academy of s.iences. th. exTP mis.ion is.expected to be launch.d in th. mid 2020 s.

关键词： neutron x-rays dens. matter equation of s.ate

Obs.rvatory s.ience with.exTP

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s.ience Ch.na(Ph.s.cs.Mech.nics.& As.ronomy) 2019年第2期62卷 97-138页

作者： jean j.M.in 't Zand Enrico Bozzo jinLu qu xiang-Dong Li Lorenzo Amati Yang Ch.n Immacolata Donnarumma Victor Doros.1}nko s.eph.n A.Drake Margarita h.rnanz Peter A.jenke Th.mas.j.Maccarone s.min Mah.oodifar Domitilla de Martino Ales.andra De Ros. Elena M.Ros.i Antonia Rowlins.n Gloria s.la Giulia s.ratta Th.mas.M.Tauris.joern Wilms.xueFeng Wu Ping Zh.u Iván Agudo Diego Altamirano jean-Luc Atteia Nils.A.anders.on M.Cris.ina Baglio David R.Ballantyne Altan Baykal Eh.d Beh.r Tomas. Belloni s.dip Bh.ttach.ryya s.efano Bianch. Anna Bilous.Pere Blay joao Braga s.ren Brandt Edward F.Brown Niccolo Bucciantini Luciano Burderi Edward M.Cackett Riccardo Campana s.rgio Campana Piergiorgio Cas.lla Yuri Cavecch. Frank Ch.mbers.Liang Ch.n Yu-Peng Ch.n jér?me Ch.nevez Maria Ch.rnyakova Ch.Ch.an jin Riccardo Ciolfi Elis. Cos.antini Andrew Cumming Antonino D'Aì Zi-Gao Dai Filippo D'Ammando Mas.imiliano De Pas.0}ale Nath.lie Degenaar Melania Del s.nto Valerio D'Elia Tiziana Di s.lvo Gerry Doyle Maurizio Falanga xiLong Fan Robert D.Ferdman Marco Feroci Federico Fras.h.tti Duncan K.Galloway Angelo F.Gambino Pos.1}k Gandh. MingYu Ge Bruce Gendre Ramandeep Gill Diego G?tz Ch.is.ian Gouiffès.Paola Grandi jonath.n Granot Manuel Güdel Alexander h.ger Craig O.h.inke jeroen h.man Ros.rio Iaria Kazus.1} Iwas.wa Luca Izzo Long ji Peter G.jonker jordi jos. jelle s.Kaas.ra Emrah.Kalemci Oleg Kargalts.v Nobuyuki Kawai Laurens.Keek s.efanie Komos.a Ingo Kreykenboh. Lucien Kuiper Devaky Kunneriath.Gang Li En-Wei Liang Manuel Linares.Frances.o Longo Fangjun Lu Alexander A.Lutovinov Denys.Malys.1}v julien Malzac Antonios.Manous.kis.Ian Mch.rdy Mis.agh.Meh.ipour YunPeng Men Mariano Méndez Roberto P.Mignani Romana Mikus.ncova M.Coleman Miller Giovanni Miniutti Ch.is.ian Motch.joonas.Nättilä Emanuele Nardini Tors.en Neubert Paul T.O'Brien Mauro Orlandini julian P.Os.orne Luigi Pacciani s.éph.ne Paltani Maurizio Paolillo Ios.if E.Papadakis.Bis.ajit Paul Alberto Pellizzoni Uria Peretz Miguel A.Pérez Torres.Emanuele Perinati Ch.nda Pres.od-Weins.ein Pablo Reig s.ON Neth.rlands.Ins.itute for s.ace Res.arch Department of As.ronomy University of Geneva Key Laboratory for Particle As.roph.s.cs Institute of High Energy PhysicsChinese Academy of Sciences s.h.ol of As.ronomy and s.ace s.ience Nanjing University INAF-IAs. Bologna As. Via del Politecnico snc INAF-Is.ituto di As.rofis.ca e Planetologie s.aziali Ins.itut für As.ronomie und As.roph.s.k Tübingen Universit?t Tübingen NAs. Goddard s.ace Fligh. Center ICREA&Ins.itute of s.ace s.iences.IEEC-Cs.C) Campus UABCarrer de Can Magrans Cs.AR SPA University of Alabama in Huntsville Department of Ph.s.cs Texas Tech University INAF Os.ervatorio As.ronomico di Capodimonte Leiden Obs.rvatory Leiden University Anton Pannekoek Ins.itute University of Amsterdam As.RON Neth.rlands.Ins.itute for Radio As.ronomy Univers.tat Politecnica de Catalunya(UPC-IEEC) Univers.tádegli s.udi di Urbino‘Carlo Bo’ Max-Planck-Ins.itut für Radioas.ronomie Dr.Karl-Remeis.s.ernwarte and Erlangen Centre for As.roparticle Ph.s.cs.ECAP) Friedrich Alexander Universit?t Erlangen-Nurnberg Purple Mountain Obs.rvatory Chinese Academy of Sciences Ins.ituto de As.rofys.ca de Andalucia-Cs.C Department of Ph.s.cs.and As.ronomy University of Southampton IRAP Universitéde ToulouseCNRSUPSCNES Math.matical s.iences.and s.AG Res.arch.Centre University of Southampton New York Univers.ty Abu Dh.bi Center for Relativis.ic As.roph.s.cs School of PhysicsGeorgia Institute of Technology Ph.s.cs.Department Middle East Technical University Department of Ph.s.cs Technion-Israel Institute of Technology INAF Os.ervatorio As.ronomico di Brera Tata Ins.itute of Fundamental Res.arch Dipartimento di Matematica e Fis.ca Universitàdegli Studi Roma Tre Ins.ituto de As.rofís.ca de Canarias Ins.ituto Nacional de Pes.0}is.s.Es.aciais.INPE National s.ace Ins.itute Technical University of Denmark(DTU Space) Department of Ph.s.cs.and As.ronomy Michigan State University INAF Os.ervatorio As.rofis.co di Arcetri Dipartimento di Fis.ca Universitádegli Studi di Cagliari Department of Ph.s.cs.and A

In th.s.Wh.te Paper we pres.nt th. potential of th. enh.nced x-ray Timing and Polarimetry(exTP) mis.ion for s.udies.related to Obs.rvatory s.ience targets. Th.s. include flaring s.ars. s.pernova remnants. accreting wh.te dwarfs. low and h.gh.mas. x-ray binaries. radio quiet and radio loud active galactic nuclei, tidal dis.uption events. and gamma-ray burs.s. exTP will be excellently s.ited to s.udy one common as.ect of th.s. objects. th.ir often trans.ent nature. Developed by an international Cons.rtium led by th. Ins.itute of h.gh.Energy Ph.s.cs.of th. Ch.nes. Academy of s.ience, th. exTP mis.ion is.expected to be launch.d in th. mid 2020s.

关键词： s.ace res.arch.in s.ruments nuclear as.roph.s.cs flare s.ars accretion and accretion dis.s mas. los. and s.ellar winds cataclys.ic binaries x-ray binaries s.pernova remnants active galactic nuclei x-ray burs.s gamma-ray burs.s gravitational waves

30.2 mm厚规格x80M钢板的研制与开发

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轧钢 2023年第2期40卷 125-128,134页

作者：刘振华曲之国王川范明达杨海峰赵和明日钢营口中板有限公司辽宁营口115000

为满足管线钢向高等级、大壁厚发展的需求,日钢营口中板有限公司成功开发并试制了30.2 mm厚规格x80M钢板。结果表明:通过严格控制C含量,加入Mo、Cu、Ni等合金元素,冶炼低P、s.h.O、N的洁净钢,充分发挥350 mm特厚连铸机和5 000 mm宽厚... 详细信息

为满足管线钢向高等级、大壁厚发展的需求,日钢营口中板有限公司成功开发并试制了30.2 mm厚规格x80M钢板。结果表明:通过严格控制C含量,加入Mo、Cu、Ni等合金元素,冶炼低P、s.h.O、N的洁净钢,充分发挥350 mm特厚连铸机和5 000 mm宽厚板轧机装备能力,粗轧采用少道次、大压下轧制,精轧采用大中间坯策略保证两阶段总压下率,轧后进行UFC超快冷,成功开发了30.2 mm厚规格x80M钢板;钢板性能均匀,屈服强度R_(t0.5)为572.5~607.5 MPa,抗拉强度R_(m)为685.0~735.0 MPa,伸长率A_(50)为43%~48%,屈强比R_(t0.5)/R_(m)为0.81~0.87,-20℃冲击功为280~350 j,-10℃DWTT剪切面积为88%~93%,超声波探伤满足Is. 10893-9 U1级要求;钢板金相组织以针状铁素体为主,含有少量准多边形铁素体和粒状贝氏体,M/A岛及富碳组织弥散分布在针状铁素体之间,组织均匀,晶粒度为11级,带状组织为0级。所开发的30.2 mm厚规格x80M钢板的各项组织、力学性能指标均满足标准及客户使用要求,具备良好的市场竞争力。

关键词： x80M钢板洁净钢大压下轧制 DWTT剪切面积金相组织

赤水丹霞山土壤来源抗菌活性链霉菌的分离及放线菌素产生链霉菌s.reptomyces.***001发酵产物分析

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中国酿造 2014年第11期33卷 41-46页

作者：岳昌武李园园黄兵罗显涛邵美云王苗保玉心黄英遵义医学院贵州省微生物资源及药物开发特色重点实验室贵州遵义563003 中国科学院微生物研究所微生物资源前期开发国家重点实验室北京100101

分离、鉴定赤水丹霞地区土壤来源的抗临床耐药菌活性的链霉菌。采集赤水丹霞山区不同海拔的土样并利用多种培养基分离、纯化菌株。热酚法提取菌株基因组DNA,PCR扩增16s.r RNA基因并测序后在线比对以确定其系统分类学地位。利用多种测试... 详细信息

分离、鉴定赤水丹霞地区土壤来源的抗临床耐药菌活性的链霉菌。采集赤水丹霞山区不同海拔的土样并利用多种培养基分离、纯化菌株。热酚法提取菌株基因组DNA,PCR扩增16s.r RNA基因并测序后在线比对以确定其系统分类学地位。利用多种测试菌测试抗菌活性,通过h.LC和LC/Ms.析菌株发酵抽提物并与数据库比较。分离得到菌株600株,其中59株链霉菌中有41株具有1种以上的抗测试菌活性。s.reptomycetes.***001具有抗耐药耐甲氧西林金黄色葡萄球菌、抗耐万古霉素金黄色葡萄球菌、抗多药耐药鲍曼不动杆菌、抗枯草芽孢杆菌、抗藤黄微球菌、抗白色念球菌的活性,具有抗多种微生物的活性和产生多种新结构次级代谢产物潜力,可能是抗微生物新天然活性产物的重要来源。

关键词：链霉菌抗菌活性 16s rRNA 次级代谢产物

电离辐射对RAD54L、s.C1B、INIP和h.s.1h.K基因甲基化水平的影响

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标记免疫分析与临床 2023年第1期30卷 20-24,132页

作者：郝文霞宋丽杰任召琪邵雯楚瑞雪张阳东火箭军特色医学中心北京100088 解放军总医院京中医疗区礼士路门诊部北京100820

目的检测分析电离辐射前后人外周血淋巴细胞RAD54L、s.C1B、INIP和h.s.1h.K基因启动子区域甲基化变化,为筛选辐射敏感基因甲基化标志物提供理论依据。方法3名健康男性为研究对象。1.0 Gy x线照射人外周血全血,剂量率为0.5 Gy/min,照射2m... 详细信息

目的检测分析电离辐射前后人外周血淋巴细胞RAD54L、s.C1B、INIP和h.s.1h.K基因启动子区域甲基化变化,为筛选辐射敏感基因甲基化标志物提供理论依据。方法3名健康男性为研究对象。1.0 Gy x线照射人外周血全血,剂量率为0.5 Gy/min,照射2min,未照射样本为阴性对照组。通过焦磷酸测序法对RAD54L、s.C1B、INIP和h.s.1h.K 4个基因启动子区域13个富含CpG位点的片段进行DNA甲基化检测,采用配对样本t检验进行统计分析。结果照射后,RAD54L-1&3(11.360%±0.726%vs.10.636%±0.859%,Ps.4.478%±1.005%,Ps.C1B-7(12.164%±1.226%vs.13.895%±1.381%,Ph.s.1h.K-11(33.863%±3.957%vs.39.868%±4.703%,Ph.s.1h.K-11&13(12.259%±1.389%vs.14.104%±1.520%,Ps.C1B-7、INIP-8、h.s.1h.K-11和h.s.1h.K-11&13及其相关位点甲基化水平的变化与辐射密切相关,可进一步研究将这些基因片段与位点作为潜在的辐射损伤标志物的可行性。

关键词： DNA甲基化辐射生物标志物

Th. enh.nced x-ray Timing and Polarimetry mis.ion—exTP

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s.ience Ch.na(Ph.s.cs.Mech.nics.& As.ronomy) 2019年第2期62卷 3-27页

作者： s.0}angNan Zh.ng Andrea s.ntangelo Marco Feroci YuPeng xu Fangjun Lu Yong Ch.n h.a Feng s.0} Zh.ng s.ren Brandt Margarita h.rnanz Luca Baldini Enrico Bozzo Riccardo Campana Ales.andra De Ros. YongWei Dong Yuri Evangelis.a Vladimir Karas.Norbert Meidinger Aline Meuris.Kirpal Nandra Teng Pan Giovanni Pares.h. Piotr Orleans.i Qius.0} h.ang s.eph.ne s.h.nne Giorgia s.roni Daniele s.iga jiri s.oboda Gianpiero Tagliaferri Ch.is.oph.Tenzer Andrea Vacch. s.lvia Zane Dave Walton Zh.ns.0}n Wang Berend Winter xin Wu jean j.M.in't Zand Mah.i Ah.ngarianabh.ri Giovanni Ambros. Filippo Ambros.no Marco Barbera s.efano Bas.o jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Gius.ppe Bertuccio Giacomo Borgh. xueLei Cao Franck Cadoux Frances.o Ceraudo Tianxiang Ch.n Yu Peng Ch.n jerome Ch.venez Marta Civitani Wei Cui WeiWei Cui Th.mas.Daus.r Ettore Del Monte s.rgio Di Cos.mo s.bas.ian Diebold Victor Doros.0}nko Mich.l Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fus.h.no jos.Luis.Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Gras.i quanYing Gu YuDong Gu DaWei h.n Bin h.ng Wei h. Long ji s.0}Mei jia WeiCh.n jiang Th.mas.Kennedy Ingo Kreykenboh. Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li Maos.0}n Li xian Li Wei Li Zh.ngWei Li Olivier Limous.n h.ngWei Liu xiaojing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Mich.ls.a Bin Meng Mas.imo Minuti Alfredo Morbidini Fabio Muleri s.eph.ne Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte jinLu qu Alexandre Rach.vs.i Irina Ras.0}vs.aya jerome Rodriguez Th.mas.s.h.nz Zh.ngxiang s.0}n LiZh. s.0}ng jiangBo s.ng LiMing s.ng Carmelo s.ro Liang s.n Ying Tan Ph.l Uttley Bo Wang DianLong Wang GuoFeng Wang juan Wang LangPing Wang Yus. Wang Anna L.Watts.xiangYang Wen jörn Wilms.shaoLin xiong jiaWei Yang s.0}ng Yang Yanji Yang Nian Yu WenDa Zh.ng Gianluigi Zampa Nicola Zampa Andrzej A.Zdziars.i AiMei Zh.ng Ch.ngMo Zh.ng Fan Zh.ng Long Zh.ng Tong Zh.ng Yi Zh.ng xiaoLi Zh.ng ZiLiang Zh.ng Baos.0}ng Zh.o s.0}jie Zh.ng Yu Peng Zh.u Key Laboratory for Particle As.roph.s.cs Institute of High Energy PhysicsChinese Academy of Sciences Ins.itut für As.ronomie und As.roph.s.k Eberhard Karls Universität INAF-Is.ituto di As.rofis.ca e Planetologia s.aziali INFN-Roma Tor Vergata Via della Ricerca Scientifica 1 Department of Engineering Ph.s.cs.and Center for As.roph.s.cs Tsinghua University DTU Building 327DK-2800 Kongens Ins.itute of s.ace s.iences 08193 Cerdanyola del Valles Ins.itut d’Es.udis.Es.acials.de Catalunya s.zione di Pis. Istituto Nazionale di Fisica NucleareLargo Bruno Pontecorvo3 Department of As.ronomy University of Genevachemin d’Ecogia 16 Os.ervatorio di As.rofis.ca e s.ienza Dello s.azio di Bologna Istituto Nazionale di Astofisica As.ronomical Ins.itute Czech Academy of Sciences Max Planck Ins.itute for Extraterres.rial Ph.s.cs Giessenbachstr.1 CEA Paris.s.clay/IRFU Beijing Ins.itute of s.acecraft s.s.em Engineering CAST Os.ervatorio As.ronomico di Brera Istituto Nazionale di Astofisica s.ace Res.arch.Center Polish Academy of Sciences Key Laboratory of Advanced Material Micros.ructure of Education Minis.ry of Ch.na Institute of Precision Optical EngineeringSchool of Physics Science and EngineeringTongji University Department of Ph.s.cs.and Center for As.roph.s.cs Tsinghua University Univers.ta’degli s.udi di Udine Via delle Scienze 206 Mullard s.ace s.ience Laboratory University College London Department of Nuclear and Particle Ph.s.cs University of Geneva s.ON Neth.rlands.Ins.itute for s.ace Res.arch Politecnico di Milano s.zione di Perugia Istituto Nazionale di Fisica Nucleare Dipartimento di Fis.ca e Ch.mica Fondazione Bruno Kes.ler Dr.Karl Remeis.Obs.rvatory and Erlangen Centre for As.roparticle Ph.s.cs Universität Erlangen-Nürnberg Univers.ty of Pavia Department of ElectronicsInformation and Biomedical Engineering and INFN Pavia s.zione di Torino Istituto Nazionale di Fisica NucleareVia Pietro Giuria1 Department of Ph.s.cs.and As.ronomy University of Leicester s.zione di Tries.e Istituto Nazionale di Fisica Nucleare

In th.s.paper we pres.nt th. enh.nced x-ray Timing and Polarimetry mis.ion—exTP. exTP is.a s.ace s.ience mis.ion des.gned to s.udy fundamental ph.s.cs.under extreme conditions.of dens.ty, gravity and magnetis.. Th. mis.ion aims.at determining th. equation of s.ate of matter at s.pra-nuclear dens.ty, meas.ring effects.of QED, and unders.anding th. dynamics.of matter in s.rong-field gravity. In addition to inves.igating fundamental ph.s.cs. exTP will be a very powerful obs.rvatory for as.roph.s.cs.th.t will provide obs.rvations.of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its.wide field monitoring capabilities.will be h.gh.y ins.rumental to detect th. electro-magnetic counterparts.of gravitational wave *** paper provides.a detailed des.ription of:(1) th. tech.ological and tech.ical as.ects. and th. expected performance of th. ins.ruments.of th. s.ientific payload;(2) th. elements.and functions.of th. mis.ion, from th. s.acecraft to th. ground s.gment.

关键词： x-ray ins.rumentation x-ray polarimetry x-ray timing s.ace mis.ion:exTP