检索结果-南通市图书馆

Experimental Study on LHCD Efficiency in HT-7 Tokamak

在线全文

学校读者我要写书评

暂无评论

中国核科技报告 1999年第S4期 369-369页

作者： B.j.Ding G.L.Kuang Y.X.Liu D.C.Liu G.H.Zheng j.S.wu F.K.Liu w.C.Shen j.A.Lin C.S.Yang H.D.Xu j.w.yu Y.Y.Huang L.Q.Shang Y.j.Shi Z.w.wu F.X.Yin X.D.Zhang X.N.Liu j.K.Xie Y.X.wan Academia Sinica Institute of Plasma Physics Hefei 230031 China

Lower Hybrid Current Drive (LHCD) experiments on HT-7 Tokamak have been carried out by scanning the following two parameters: central line averaged electron density (0.5～2.0)×10cmand toroidal magnetic field (B=1.62... 详细信息

关键词： Experimental Study on LHCD Efficiency in HT-7 Tokamak HT

Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 715-724页

作者： Xin Yang yu-wen Alvin Huang john Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon C.Daeschler Katelyn j.w.So Konstantin Feinberg Marina Manoraj jenny Cheung jennifer Zhang Kaveh Mirmoeini jPaul Santerre Tessa Gordon Gregory HBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal j.Goldschmidt-Clermont Aisha Khan George jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander j.P.Goldschmidt Damien D.Pearse w.Dalton Dietrich Allan D.Levi james D.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

Elastic-plastic behavior of a semicircular frame being pressed against a rigid plane

在线全文

学校读者我要写书评

暂无评论

Acta Mechanica Sinica 2008年第4期24卷 419-432页

作者： X.w.Zhang j.L.Yang T.X.yu Institute of Solid Mechanics Beihang University Beijing 100083 China Department of Mechanical Engineering Hong Kong University of Science and Technology Kowloon Hong Kong China

As a simplified structural model, a semicircular frame is used to study the crashworthiness behavior of an aircraft fuselage. The quasi-static large elastic-plastic deformation of a semicircular frame in the process of its being pressed against a rigid ground is analyzed. First, based on the linear elastic assumption, the quasi-static large deformation contact process of the frame can be divided into three phases, i.e., point contact, line contact and post-buckling. By means of a shooting method, the relations between the displacement and contact force as well as the distribution of bending moment in the three phases are obtained. Then, by assuming an elastic, perfectly-plastic moment-curvature relationship for the semi-circular frame, the contact process is analyzed in detail to reveal the plastic collapse mechanism, the traveling of plastic hinge and the force-displacement relationship. In order to verify the analysis, a preliminary experiment was conducted, in which two types of half rings with clamped ends were pressed by a rigid plate. In addition, a numerical simulation is also conducted by employing ABAQUS to analyze both rectangular cross-sectional beam and I-beam. Finally, the theoretical predictions are compared with the experimental results and numerical solutions, showing that the elastic-plastic analysis can predict the contact process very well.

关键词： Elastic-plastic·Large deformation ·Semicircular frame Contact ·Traveling hinge

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher j.O’Connell Matthew j.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA james L.winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

Formation of High-quality Advanced High-k Oxide Layers at Low Temperature by Excimer UV Lamp-assisted Photo-CVD and Sol-gel Processing

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2004年第4期20卷 396-402页

作者： yu j. j. Electronic & Electrical Engineering University College London

we have successfully demonstrated that high quality and high dielectric constant layers can be fabricated by low temperature photo-induced or -assisted processing. Ta_2O_5 and ZrO_2 have been deposited at twith the aid of excimer lamps. The UV annealing of as-grown layers was found to significantly improve their electrical properties. Low leakage current densities on the order of 10 -8 A/cm 2 at 1 MV/cm for deposited ultrathin Ta_2O_5 films and ca.10 -6 A/cm 2 for the photo-CVD ZrO_2 layers and photo-irradiated sol-gel HfO_2 layers have been readily achieved. The improvement in the leakage properties of these layers is attributed to the UV-generated active oxygen species O( 1D) which strongly oxidize any suboxides to form more stoichiometric oxides on removing certain defects, oxygen vacancies and impurities present in the as-prepared layers. The photo-CVD Ta_2O_5 films deposited across 10.16-cm Si wafers exhibit a high thickness uniformity with a variation of less than \{±2.0%\} being obtained for ultrathin ca.10 nm thick films. The lamp technology can in principle be extended to larger area wafers, providing a promising low temperature route to the fabrication of a range of high quality thin films for future ULSI technology.

关键词： Excimer lamp High-kdielectrics Thin film Chemical vapour deposition(CVD) Sol-gel processing

Enhanced efficiency and stability of 3.3 V Cu-Li batteries by tuning the cation-anion interaction in the electrolyte

在线全文

学校读者我要写书评

暂无评论

journal of Energy Chemistry 2023年第11期86卷 208-216,I0005页

作者： Kaiming Xue yu Zhao Huimin wang Denis Y.w.yu School of Energy and Environment City University of Hong KongKowloonHong Kong 999077China Research Center for Energy and Environmental Materials(GREEN) National Institute for Materials ScienceTsukubaIbaraki 305-0044Japan

Cu-Li battery with Cu metal cathode and Li metal anode is a candidate for next-generation energy storage *** self-discharge of the battery can be suppressed with an anion exchange membrane,the voltage polarization depends strongly on the ***,when an electrolyte with 3 M LiTFSI(lithium bis(trifluoromethanesulfonyl)imide)in dimethyl carbonate(DMC)is used,overpotential increases with *** this work,we reveal why the voltage polarization changes,and reduce and stabilize it by replacing DMC solvent with a mixed solvent composed of dimethoxyethane(DME)and propylene carbonate(PC).The new electrolyte has higher ionic conductivity and stable solvation structure with more free TFSI-anions upon cycling,which also facilitates uniform plating of metal ions on the metal *** characteristics enable a stable Cu-Li battery with minimal change in overpotential for more than 1500 cycles at a current density of 2 m A cm^(-2).

关键词： Cu-Li battery Metal cathode Electrolyte engineering Solvation structure

Synchrotron micro-scale measurement of metal distributions in Phragmites australis and Typha latifolia root tissue from an urban brownfield site

在线全文

学校读者我要写书评

暂无评论

journal of Environmental Sciences 2016年第3期28卷 172-182页

作者： Huan Feng yu Qian Frank j.Gallagher weiguo Zhang Lizhong yu Changjun Liu Keith w.jones Ryan Tappero Department of Earth and Environmental Studies Montclair State University Urban Forestry Program Department of EcologyEvolution and Natural ResourcesRutgersThe State University of New Jersey State Key Laboratory of Estuarine and Coastal Research East China Normal University Biological Environmental and Climate Sciences DepartmentBrookhaven National Laboratory Photon Sciences Directorate Brookhaven National Laboratory

Liberty State Park in New jersey,USA,is a ＂brownfield＂ site containing various levels of *** investigate metal uptake and distributions in plants on the brownfield site,Phragmites australis and Typha latifolia were collected in Liberty State Park during the growing season（May–September）in 2011 at two sites with the high and low metal loads,*** objective of this study was to understand the metal（Fe,Mn,Cu,Pb and Zn）concentration and spatial distributions in *** and *** root systems with micro-meter scale resolution using synchrotron X-ray microfluorescence（μXRF）and synchrotron X-ray computed microtomography（μCMT）*** root structure measurement by synchrotron μCMT showed that high X-ray attenuation substance appeared in the *** μXRF measurement showed that metal concentrations and distributions in the root cross-section between epidermis and vascular tissue were statistically *** correlations were found between metals（Cu,Mn,Pb and Zn）and Fe in the epidermis,implying that metals were scavenged by Fe *** results from this study suggest that the expression of metal transport and accumulation within the root systems may be element *** information derived from this study can improve our current knowledge of the wetland plant ecological function in brownfield remediation.

关键词： Phragmites australis Typha latifolia Trace metals Synchrotron radiation technique Brownfield