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基于深度学习的MRI影像组学无创识别HER2低表达状态可预测乳腺癌病人的无病生存期

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国际医学放射学杂志 2024年第2期 252-253页

作者： Y.Guo X.T.Xie w.j.Tang s.Y.Chen M.Y.wang Y.H.Fan 侯唯姝

摘要目的建立基于深度学习的MRI影像组学（DLR）特征模型，以预测人表皮生长因子受体2(HER2)低表达状态，并进一步通过DLR模型验证乳腺癌病人在预后方面的

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Towards efficient strain engineering of 2D materials:A four-points bending approach for compressive strain

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Nano Research 2024年第6期17卷 5317-5325页

作者： Hao Li Félix Carrascoso Ana borrás Gloria P.Moreno Francisco j.Aparicio Ángel barranco Andrés Castellanos Gómez Campus de Cantoblanco Instituto de Ciencia de Materiales de MadridC.Sor Juana Inés de la Cruz328049 MadridSpain Nanotechnology on surfaces and Plasma Lab Instituto de Ciencia de Materiales de Sevilla(CSIC-Universidad de Sevilla).C/Americo Vespucio 49E-41092 SevilleSpain Departamento de Física Aplicada I Escuela Politécnica SuperiorUniversidad de Sevillac/Virgen deÁfrica 7E-41011 SevilleSpain

strain engineering,as a powerful strategy to tune the optical and electrical properties of two-dimensional(2D)materials by deforming their crystal lattice,has attracted significant interest in recent years.2D materials can sustain ultra-high strains,even up to 10%,due to the lack of dangling bonds on their surface,making them ideal brittle *** remarkable mechanical resilience,together with a strong strain-tunable band structure,endows 2D materials with a broad optical and electrical response upon ***,strain engineering based on 2D materials is restricted by their nanoscale and strain quantification *** this study,we have modified a homebuilt three-points bending apparatus to transform it into a four-points bending apparatus that allows for the application of both compressive and tensile strains on 2D *** approach allows for the efficient and reproducible construction of a strain system and minimizes the buckling effect caused by the van der waals interaction by adamantane encapsulation *** results demonstrate the feasibility of introducing compressive strain on 2D materials and the potential for tuning their optical and physical properties through this approach.

关键词： uniaxial compressive strain polymer encapsulation differential reflectance spectroscopy exciton tunability

超声引导“领结征”髂筋膜阻滞技术在髋关节术后镇痛中的应用效果观察

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中国临床新医学 2024年第7期17卷 783-788页

作者：吴刚汪辉陈刚王萍赵仕浩汪方清铜陵市人民医院麻醉科安徽244000 铜陵市人民医院胸外科安徽244000

目的观察超声引导“领结征”髂筋膜阻滞技术在髋关节术后镇痛中的应用效果。方法招募2020年1月至2023年5月于铜陵市人民医院择期行全髋关节置换术或人工股骨头置换术治疗的髋骨骨折患者60例,采用随机数字表法将其分为对照组和观察组,每... 详细信息

目的观察超声引导“领结征”髂筋膜阻滞技术在髋关节术后镇痛中的应用效果。方法招募2020年1月至2023年5月于铜陵市人民医院择期行全髋关节置换术或人工股骨头置换术治疗的髋骨骨折患者60例,采用随机数字表法将其分为对照组和观察组,每组30例。对照组接受术后静脉镇痛,观察组在对照组镇痛方案基础上行超声引导“领结征”髂筋膜阻滞技术。比较两组术后阿片类药物用量、离床时间、住院时间、出院时Harris评分。比较两组术后2 h(T_(0))、6 h(T_(1))、12 h(T_(2))、24 h(T_(3))和48 h(T_(4))被动视觉模拟量表(PVAs)评分和主动视觉模拟量表(IVAs)评分。比较两组睡眠满意度、镇痛满意度及术后并发症发生率。结果与对照组相比,观察组术后48 h内追加阿片类药物剂量更少,离床时间更早,住院时间更短,出院时Harris评分更高,差异有统计学意义(Ps评分、IVAs评分呈下降趋势,且观察组下降幅度更大(Ps评分、IVAs评分显著低于对照组(P0.05)。结论超声引导“领结征”髂筋膜阻滞技术可在髋关节术后中取得较好的镇痛效果,减少阿片类药物使用量,提高患者术后睡眠质量,有利于患者术后康复。

关键词：超声引导髂筋膜阻滞技术髋关节镇痛

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阿哌沙班预防亚临床心房颤动患者卒中或全身栓塞的临床研究

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中国临床药理学杂志 2024年第3期40卷 424-424页

作者： HEALEY j s 戴荣源

亚临床心房颤动因持续时间短,无症状,通常只能通过起搏器或除颤器进行长期持续监测才能发现。加拿大麦克马斯特大学HEALEY团队对亚临床心房颤动患者进行了一项持续6 min至24 h的试验,按双盲、双模拟设计,患者被随机分配接受阿哌沙班,剂... 详细信息

亚临床心房颤动因持续时间短,无症状,通常只能通过起搏器或除颤器进行长期持续监测才能发现。加拿大麦克马斯特大学HEALEY团队对亚临床心房颤动患者进行了一项持续6 min至24 h的试验,按双盲、双模拟设计,患者被随机分配接受阿哌沙班,剂量为5 mg,每日2次(2.5 mg,必要时每日2次)或阿司匹林,剂量为81 mg,每日1次。如果亚临床心房颤动持续超过24 h或出现临床心房颤动,则停止试验药物并开始抗凝治疗。主要疗效结局为卒中或全身性栓塞,在意向治疗人群(所有接受随机化的患者)中进行评估;主要安全性结局为大出血,在接受治疗的人群中进行评估(所有接受随机分组并接受至少一剂指定试验药物的患者,在全因永久停止试验药物后5 d进行随访)。

关键词：持续监测无症状心房颤动麦克马斯特大学阿司匹林随机分配阿哌沙班随机化

Laboratory evaluation of toxicity of selected insecticides against egg and larval stages of cotton pink bollworm, Pectinophora gossypiella (saunders) (Lepidoptera: Gelechiidae)

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journal of Cotton Research 2024年第1期7卷 15-28页

作者： bUsNOOR Abhishek V. wADAsKAR R.M. FAND babasaheb b. TAMbE V.j. PILLAI T. MAHULE D.j. NAGRARE V.s. PRAsAD Y.G. Entomology section College of Agriculture(Dr.Panjabrao Deshmukh Krishi Vidyapeeth)Nagpur 440001MaharashtraIndia Indian Council of Agricultural Research-Central Institute for Cotton Research Nagpur 441108MaharashtraIndia

background The cryptic nature of pink bollworm Pectinophora gossypiella(saunders)larvae enables its reduced vul-nerability to insecticidal ***,the development of resistance against bacillus thuringiensis(bt)toxins posed a serious threat to transgenic cotton *** necessitated determining the critical timing of spray applications on the control *** study assessed the influence of egg age(freshly laid ***-day-old)and the loca-tion of larvae(directly exposed to the insecticide residues on the boll rind *** inside the bolls)on insecticide control *** The results revealed a significant decrease in the ovicidal activity of tested insecticides with an increase in the age of eggs from one day old to three days old(paired t-test,Psed to the insec-ticide residues on the boll rind were more susceptible(>80%mortality)than the larvae exposed after they had bur-rowed inside the bolls(bitory effects of tested insecticides on developmental biology were more pronounced in the experiment on pre-larval release insecticide treatment compared with insecticide treatment given post-larval release and entry inside the *** Egg age influences the insecticide susceptibility,as does the larval location,directly exposed vs bur-rowed inside the *** eggs and the larvae that had burrowed inside the green bolls of cotton were relatively less susceptible to the insecticide *** toxic effects of insecticides on egg and larval stages were primar-ily *** findings are significant for devising a comprehensive strategy for pink bollworm management on a sustainable basis.

关键词： bioefficacy Cotton Insecticides Pink bollworm Pectinophora gossypiella Timings of spray

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基于电子鼻技术评定刨花板气味等级方法初探

中国人造板 2024年第4期31卷 31-36页

作者：欧雪冰林锐航黄镇森关能严小意李晓增广州质量监督检测研究院广州510110

以刨花板为研究对象,通过PEN3电子鼻对不同气味等级的刨花板样品进行气味检测和数据分析。结果表明,PEN3电子鼻结合主成分分析法(PCA)可对刨花板气味等级进行区分,但对LY/T 3236—2020《人造板及其制品气味分级及其评价方法》中的“气... 详细信息

以刨花板为研究对象,通过PEN3电子鼻对不同气味等级的刨花板样品进行气味检测和数据分析。结果表明,PEN3电子鼻结合主成分分析法(PCA)可对刨花板气味等级进行区分,但对LY/T 3236—2020《人造板及其制品气味分级及其评价方法》中的“气味明显,但气味不令人难受”“明显让人感觉难受的气味”这2个等级未能准确区分。建议扩充各气味等级刨花板样本量,并以此建立样品LY/T 3236—2020气味等级检测结果与电子鼻数据间的模型,完善刨花板气味等级电子鼻检测数据库,实现新样品气味的电子鼻快速检测。

关键词：电子鼻刨花板气味

Utilization of RNA sequencing to investigate olfactory dysfunction in chronic rhinosinusitis without nasal polyps:A pilot study

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world journal of Otorhinolaryngology-Head and Neck surgery 2024年第1期10卷 29-36页

作者： jorge A.Gutierrez III jeremy L.barth Rodney j.schlosser Thomas s.Edwards Timothy L.smith Zachary M.soler Department of Otolaryngology-Head and Neck surgery Medical University of South CarolinaCharlestonSouth CarolinaUSA Department of Regenerative Medicine&Cell biology Medical University of South CarolinaCharlestonSouth CarolinaUSA Department of Otolaryngology-Head and Neck surgery Oregon Health&Science UniversityPortlandOregonUSA

Objectives:Prior research on olfactory dysfunction in chronic rhinosinusitis(CRs)has focused on patients with polyps and suggests that direct inflammation of the olfactory cleft mucosa plays a contributory *** purpose of this study was to evaluate gene expression in superior turbinate mucosal specimens,comparing normosmic and dysosmic CRs patients without polyps(CRssNP).Methods:Tissue samples were obtained from the superior turbinates of patients with CRssNP at the time of endoscopic sinus *** subsequently underwent RNA sequencing and functional analysis to investigate biological pathways associated with differentially expressed genes between dysosmic(n=7)and normosmic(n=4)***:Differential gene expression analysis comparing dysosmic and normosmic CRssNP patients showed upregulation of 563 genes and downregulation of 327 *** stringent criteria for multiple comparisons,one upregulated gene(Immediate Early Response 3[IER3])had an false discovery rate(FDR)correction adjustedP value considered statistically significant(Psis revealed eight biological pathways significantly different between dysosmic and normosmic patients(Psignaling,IL-10 signaling,and rhodopsin-like ***:RNA sequencing of the superior turbinates in patients with CRssNP can provide valuable information regarding biological pathways and genes involved in olfactory *** study supports literature suggesting that Type 2 inflammation may play a role in olfactory dysfunction in at least some patients with *** study also prompts questions regarding the role of IL-10,rhodopsin-like receptors,andIER3 in the pathogenesis of olfactory dysfunction.

关键词： chronic rhinosinusitis without nasal polyps olfactory dysfunction RNA sequencing

2017—2022年云南曲靖地区男性HPV感染状况及亚型分布特征

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中华医院感染学杂志 2024年第17期34卷 2656-2661页

作者：胡建鹏赵垭钤李云刘红霞邹玉明耿奇熊倩杨春菊曲靖市第一人民医院检验中心云南曲靖655000 曲靖市第一人民医院麻醉科云南曲靖655000 曲靖医学高等专科学校基础医学院云南曲靖655100

目的分析云南曲靖地区男性人乳头瘤病毒(HPV)感染状况及亚型特征,为男性HPV的治疗、疫苗的选择与研发以及免疫规划政策决策提供依据。方法收集2017年1月-2022年12月于曲靖市第一人民医院行HPV分型检测的1820例男性患者检测结果,分析该... 详细信息

目的分析云南曲靖地区男性人乳头瘤病毒(HPV)感染状况及亚型特征,为男性HPV的治疗、疫苗的选择与研发以及免疫规划政策决策提供依据。方法收集2017年1月-2022年12月于曲靖市第一人民医院行HPV分型检测的1820例男性患者检测结果,分析该地区男性HPV感染状况及亚型分布特征。结果在1820例患者中检出HPV阳性感染者935例,总体感染率为51.37%,其中发生单一、双重、三重和四重及以上感染的比例分别为37.53%、9.62%、2.58%和1.65%;受检的27种亚型中,检出率最高5种低危型HPV分别为HPV6、11、43、61和55型,分别为25.93%、20.88%、1.92%、1.65%和1.10%,检出率最高5种高危型HPV分别为HPV16、59、52、18和58型,分别为2.58%、2.09%、1.59%、1.48%和1.48%;总体而言,曲靖地区男性单纯低危、单纯高危和高低危混合感染比例分别为74.33%、6.74%和18.93%;感染年龄特异性呈双峰“U”分布。结论曲靖地区男性HPV感染以HPV6、11、43、16、59型最常见,>59岁组和≤19岁组感染率最高,总体表现为感染率高且易多重感染,以低危型感染为主,二价疫苗覆盖率低。

关键词：人乳头瘤病毒男性尖锐湿疣基因型曲靖地区流行病学人乳头瘤病毒疫苗

Further investigation on the fusion of ^(6)Li with ^(209)bi target at near-barrier energies

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Chinese Physics C 2024年第7期48卷 106-117页

作者：张高龙焦振威张广鑫 M.R.Cortes 胡世鹏钱建强 D.Mengoni 屈卫卫李聪博郑云张焕乔孙慧斌王楠张春雷 j.j.Valiente-Dobón D.Testov M.Mazzocco A.Gozzelino C.Parascandolo D.Pierroutsakou M.La Commara A.Goasduff D.bazzacco D.R.Napoli F.Galtarossa F.Recchia A.Illana s.bakes I.Zanon s.Aydin G.de Angelis M.siciliano R.Menegazzo s.M.Lenzi j.L.Ferreira j.Rangel serkan Akkoyun L.F.Canto j.Lubian school of Physics Beihang UniversityBeijing 100191China sino-French Institute of Nuclear Engineering and Technology Sun Yat-Sen UniversityZhuhai 519082China Instituto de Física Universidade Federal Fluminense24210-340NiteróiRio de JaneiroBrazil Institute for Advanced study in Nuclear Energy&safety Shenzhen UniversityShenzhen 518060China shenzhen Key Laboratory of Research and Manufacture of High Purity Germanium Materials and Fetectors Shenzhen UniversityShenzhen 518060China INFN Sezione di PadovaPadovaItaly Dipartimento di fisica Astronomia dell'Universita di padova PadovaItaly state Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and ProtectionSoochow UniversitySuzhou 215123China China Institute of Atomic Energy Beijing 102413China The Key Laboratory of beam Technology and Material Modification of Ministry of Education College of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China INFN Laboratori Nazionali di LegnaroI-35020 LegnaroItaly INFN Sezione di NapoliI-80126 NapoliItaly Dipartimento di Farmacia Universitàdi Napoli"Federico II"I-80131 NapoliItaly Department of Natural and Mathematical sciences Faculty of EngineeringTarsus University33480 MersinTurkiye Physics Division Argonne National LaboratoryLemont-ILUSA Departamento de Matemaética Física e Computaç˜ao Universidade do Estado do Rio de JaneiroFaculdade de Tecnologia27537-000ResendeRio de JaneiroBrazil Department of Physics Sivas Cumhuriyet UniversitySivasTurkey Instituto de Física Universidade Federal do Rio de JaneiroCP 6852821941-972Rio de JaneiroBrazil

The complete and incomplete fusion cross sections for ^(6)Li+^(209)bi were measured using the in-beamγ-ray method around the Coulomb *** cross sections of(deuteron captured)incomplete fusion(ICF)products were re-quantified experimentally for this reaction *** results reveal that the ICF cross section is equivalent to that of complete fusion(CF)above the Coulomb barrier and dominant near or below the Coulomb barrier.A theoretical calculation based on the continuum discretized coupled channel(CDCC)method was performed for the aforementioned CF and ICF cross sections;the result is consistent with the *** universal fusion function(UFF)was also compared with the measured CF cross section for different barrier parameters,demonstrating that the CF suppression factor is significantly influenced by the choice of potential,which can reflect both dynamic and static effects of breakup on the fusion process.

关键词： cross section incomplete fusion suppression factor weakly bound nuclei