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3.0T三维各向同性肩关节MR关节成像与二维MR关节成像在诊断关节唇病变方面的比较

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国际医学放射学杂志 2009年第2期32卷 189-190页

作者： j.Y.jung Y.C.Yoon S.H.Choi j.w.kwon j.Yoo B.K.Choe 高欣 Department of Radiology and Orthopedic Surgery School of MedicineSungkyunkwan University

目的使用3．0T成像设备比较三维各向同性MR关节成像与二维MR关节成像对肩关节唇病变的诊断准确性。方法机构审查委员会批准本回顾性研究，免除了知情同意书。2006年3月—2007年1月，100例病人经3．0T成像设备进行三维各向同性和二... 详细信息

目的使用3．0T成像设备比较三维各向同性MR关节成像与二维MR关节成像对肩关节唇病变的诊断准确性。方法机构审查委员会批准本回顾性研究，免除了知情同意书。2006年3月—2007年1月，100例病人经3．0T成像设备进行三维各向同性和二维肩关节成像，随后接受关节镜手术。

关键词：成像设备诊断准确性各向同性肩关节 MR 三维二维变方

膝关节不全脱位的3 T MRI诊断:三维各向同性质子加权序列与二维序列的对比

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国际医学放射学杂志 2010年第1期 83-83页

作者： j.Y.jung Y.C.Yoon j.w.kwon j.H.Ahn B.K.Choe 李志明 Department of Radiology Samsung Medical CenterSchool of MedicineSungkyunkwan University

目的比较3.0T MR的三维各向同性快速自旋回波质子加权MRI对比二维快速自旋回波MRI在诊断膝关节不全脱位中的价值。材料与方法这项符合HIPAA要求的研究获得伦理审查委员会的批准,免除知情同意的要求。回顾性复习来自85例病人的87个膝关节... 详细信息

目的比较3.0T MR的三维各向同性快速自旋回波质子加权MRI对比二维快速自旋回波MRI在诊断膝关节不全脱位中的价值。材料与方法这项符合HIPAA要求的研究获得伦理审查委员会的批准,免除知情同意的要求。回顾性复习来自85例病人的87个膝关节MRI资料,所有病人同时接受三维各向同性序列和二

关键词： T MRI 膝关节二维序列不全脱位半脱位质子核子

A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

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Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon C.Daeschler Katelyn j.w.So Konstantin Feinberg Marina Manoraj jenny Cheung jennifer Zhang Kaveh Mirmoeini jPaul Santerre Tessa Gordon Gregory HBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

The Effect of Non-equilibrium Condensation on the Drag Coefficient in a Transonic Airfoil Flow

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journal of Thermal Science 2012年第6期21卷 518-524页

作者： I.w.Kim M.M.A.Alam S.j.Lee Y.D.kwon S.B.kwon School of Mechanical Engineering Kyungpook Nat.Uni.1370Sankyuk-dongDaegu 702-701Korea Dept.of Advanced & Control Eng.Saga Uni.japan

In this study, a transonic flow past NACA0012 profile at angle of attack α=0^0 whose aspect ratio AR is 1.0 with non-equilibrium condensation is analyzed by numerical analysis using a TVD scheme and is investigated using an intermittent indraft type supersonic wind tunnel. Transonic flows of 0.78-0.90 in free stream Mach number with the variations of the stagnation relative humidity（φ0） are tested. For the same free stream Mach number, the increase in φ0 causes decrease in the drag coefficient of profile which is composed of the drag components of form, viscous and wave. In the case of the same Moo and To, for more than φ0=30%, despite the irreversibility of process in non-equilibrium condensation, the drag by shock wave decreases considerably with the increase of φ0. On the other hand, it shows that the effect of condensation on the drag coefficients of form and viscous is negligible. As an example, the decreasing rate in the drag coefficient of profile caused by the influence of non-equilibrium condensation for the case of M∞=0.9 and φ0 =50% amounts to 34%. Also, it were turned out that the size of supersonic bubble （that is, the maximum height of supersonic zone） and the deviation of pressure coefficient from the value for M=1 decrease with the increase of φ0 for the same M∞.

关键词： Non-equilibrium condensation Transonic Moist air Drag coefficient Pressure coefficient

Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal j.Goldschmidt-Clermont Aisha Khan George jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander j.P.Goldschmidt Damien D.Pearse w.Dalton Dietrich Allan D.Levi james D.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

All-hydrocarbon,all-conjugated cycloparaphenylene-polycyclic aromatic hydrocarbon host–guest complexes stabilized by CH–πinteractions

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Nano Research 2022年第6期15卷 5545-5555页

作者： Hyejin kwon Carson.j.Bruns Paul M.Rady Department of Mechanical Engineering University of ColoradoBoulder427 UCB1111 Engineering DriveBoulderCO 80309USA ATLAS Institute 112518th St.320 UCBBoulderCO 80309USA

Polycyclic aromatic hydrocarbons(PAHs)are promising nanocarbon materials with diverse optoelectronic properties,yet they also pose concerning environmental and health *** the ubiquity of PAHs in the environment(crude oil,emissions,and biomass),most supermolecules rely on heteroatoms for *** discovered and characterized a family of all-hydrocarbon,all-π-conjugated[n]cycloparaphenylene-PAH host–guest *** built a theoretical framework to rapidly select these complexes and predict their stabilities,driven exclusively by CH–π*** than a dozen complexes were confirmed experimentally and assembled directly from commercially available *** motif offers a versatile way to combine the advantageous properties of organic semiconductors with the rich dynamic,stereochemical,stimulus-responsive,and stressdissipative behavior of host–guest complexes,while creating new opportunities for bespoke PAH separation or remediation materials.

关键词： cycloparaphenylenes density functional calculations host−guest systems hydrocarbons polycycles self-assembly supramolecular chemistry

Leader-following consensus control for networked multi-teleoperator systems with interval time-varying communication delays

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Chinese Physics B 2013年第7期22卷 96-103页

作者： M. j. Park S. M. Lee j. w. Son O. M. kwon E. j. Cha School of Electrical Engineering Chungbuk National University School of Electronic Engineering Daegu University Division of IT-Convergence Daegu Gyeongbuk Institute of Science & Technology Department of Biomedical Engineering School of MedicineChungbuk National University

we study the leader-following consensus stability and stabilization of networked multi-teleoperator systems with interval time-varying communication delays. with the construction of a suitable Lyapunov–Krasovskii functional and the utilization of the reciprocally convex approach, novel delay-dependent consensus stability and stabilization conditions for the systems are established in terms of linear matrix inequalities, which can easily be solved by various effective optimization algorithms. One illustrative example is given to illustrate the effectiveness of the proposed methods.

关键词： multi-teleoperator systems interval time-varying delay leader–following consensus problem Lyapunov method

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher j.O’Connell Matthew j.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA james L.winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

Effects of winter weather on traffic operations and optimization of signalized intersections

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journal of Traffic and Transportation Engineering(English Edition) 2019年第2期6卷 196-208页

作者： Zhengyang Lu Tae j.kwon Liping Fu Big Data Research Center Jianghan University Department of Civil and Environmental Engineering University of Alberta Department of Civil and Environmental Engineering University of Waterloo Intelligent Transportation Systems Research Center Wuhan University of Technology

Adverse winter weather has always been a cause of traffic congestion and road *** mitigate the negative impacts of winter weather, transportation agencies are under increasing pressure to introduce weather responsive traffic management ***, most traffic signal control systems are designed for normal weather conditions and are therefore suboptimal regarding efficiency and safety for controlling traffic during winter snow events due to changes in traffic patterns and driver behaviors. The main objective of this research is to explore how to modify pre-timed traffic signal control parameters under adverse weather conditions to increase traffic efficiency and road *** research consists of two main components. First, we examine the impacts of winter weather on three key traffic parameters, i.e., saturation flow rate, start-up lost time, and free flow speed. Secondly, we investigate the potential benefits of implementing weatherspecific signal control plans for uncoordinated intersections as well as coordinated corridors. Two case studies are conducted, each with varying levels of traffic demand and winter event severity, to compare the performance of different signal plans. Evaluation results from both Synchro and VISSIM show that implementing such signal plans is most beneficial for intersection with a medium level of traffic demand. It is also found that the benefit of implementing weather-responsive plans was more compelling at a coordinatedcorridor level than at an uncoordinated-intersection level.

关键词： Signal optimization Inclement weather Traffic simulation Signal coordination