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Risk of Cardiovascular Events in Patients with Primary Biliary Cholangitis-Systematic Review

journal of Clinical and Translational Hepatology 2018年第2期6卷 119-126页

作者： Duminda Suraweera Christina Fanous Melissa jimenez Myron j.tong Sammy Saab Department of Medicine Olive-View Medical CenterSylmarCAUSA Department of Surgery at the University of California at Los Angeles Los AngelesCAUSA Huntington Research Institute PasadenaCAUSA Department of Medicine at the University of California at Los Angeles Los AngelesCAUSA

Background and Aims:Hypercholesterolemia is a common finding in patients with primary biliary cholangitis(PBC)and is a well-defined risk factor for cardiovascular ***,studies have been mixed on whether PBC patients do,in fact,have higher cardiovascular *** aim of this study is to review the current literature and provide an evidence-based assessment of cardiovascular risk in PBC ***:We performed a systematic literature search on PubMed re-garding patients with PBC and cardiovascular events from the database inception to july 1,2017.A total of 33 articles ful-filling our inclusion criteria were ***:The majority of the studies evaluated yielded no statistically significant dif-ference in cardiovascular disease in the PBC population com-pared to the general ***,some reports found a statistically significantly increase in coronary artery *** studies have looked at the specific lipid profile of pa-tients with PBC with *** these lipid ab-normalities differ by stage of disease,there is evidence to suggest that the specific lipid profile in PBC may have lower atherogenicity than in patients with hypercholesterolemia without *** looking at patients with PBC with other risk factors for cardiovascular disease,such as hypertension and metabolic syndrome,have consistently found a higher risk for cardiovascular disease in these *** treat-ment is effective in reducing lipid levels and possibly improv-ing endothelial inflammation in patients with PBC with ***:There is not enough evidence to suggest an increased risk of cardiovascular dis-ease in patients with PBC with hypercholesterolemia,except for those individuals with concomitant features of metabolic *** patients with PBC with no additional cardiovas-cular risk factors,individual risk/benefit discussion on lipid-lowering treatment should be considered.

关键词： Primary biliary cholangitis(PBC) Cardiovascular risk Hypercholesterolemia

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Hepatocellular Carcinoma

Hepatocellular Carcinoma

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第6届全国疑难及重症肝病大会

作者： Myron j.tong Liver Center Huntington Medical Research InstitutesUnited States

Hepatocellular carcinoma(HCC)is a common malignancy *** is the 5th leading cause of cancer in men and the 8th leading cause in females. Globally,HCC is the 3rd leading cause of cancer related death in men and 6th in *** and Africa are considered hi!gh prevalence areas while the United States has intermediate *** factors for HCC have geographical

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Unique microstructure and thermal insulation property of a novel waste-utilized foam ceramic

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journal of Materials Science & Technology 2020年第13期47卷 175-179页

作者： F.H.Kuang S.M.Wang C.Gao H.B.Zhang R.K.Ren j.L.Ren j.tong Y.M.Liu Department of Materials Science and Engineering University of Science&Technology BeijingBeijing 100083China China Building Materials Academy Beijing 100024China China Institute for Radiation Protection Taiyuan 030006China

A characteristic CaO-Al2O3-SiO2 based foam ceramic was prepared by melt-foaming with solid wastes as main raw *** similarity to sandwich hole wall microstructure of this novel thermal insulating material was presented and the relationships between this unique microstructure and porosity,density,thermal conductivity and strength were *** the measured and theoretical values with that of the traditional foam ceramic,it can be found that,for the matching of fine skeleton with hole wall,this original sandwich structure can reduce thermal conductivity and increase flexural strength effectively.

关键词： Foam ceramic Density Porosity Strength Thermal conductivity Sandwich structure

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多晶铂电极表面硫吸附物种的原位表面增强拉曼光谱研究(英文)

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电化学 2010年第3期16卷 255-262页

作者： In-Su Park YuYe j.tong 美国乔治敦大学化学系

本工作首次报道了在酸性或碱性电解质中高粗糙度多晶铂电极表面硫物种的吸附、电氧化过程的原位表面增强拉曼光谱研究.分别在两种情况下采集了粗糙铂电极的表面增强拉曼光谱:(a)循环伏安处理后控制一定电位(0.2V)下;(b)逐步控制不同电位... 详细信息

本工作首次报道了在酸性或碱性电解质中高粗糙度多晶铂电极表面硫物种的吸附、电氧化过程的原位表面增强拉曼光谱研究.分别在两种情况下采集了粗糙铂电极的表面增强拉曼光谱:(a)循环伏安处理后控制一定电位(0.2V)下;(b)逐步控制不同电位.酸性电解质条件下,两种情况均观察到位于300cm-1的Pt—S振动.Pt—S键较强,阻止了氢在铂电极表面的吸附,需多次循环伏安处理才能完全将表面吸附的硫去除.同时还观察到位于470cm-1处的少量多聚S物种(S8或者其他类型).这些多聚S物种仅仅微弱地键合在铂电极的表面,可以容易地除去.在碱性电解质中,同样也在(a)和(b)情况下观察到位于310cm-1的Pt—S振动吸收.本工作了获得了有关硫在粗糙多晶铂电极表面吸附和电氧化重要信息,证明了原位表面增强拉曼光谱在研究铂表面的适用性.

关键词：铂硫拉曼光谱

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Tumor growth rates and recurrence-free survival in chronic viral hepatitis patients with hepatocellular carcinoma

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Hepatoma Research 2019年第10期5卷 6-18页

作者： Myron j.tong Dahlia A.Kaki Claiborne T.Huynh Steven S.Raman David S.Lu Liver Center Huntington Medical Research InstitutesPasadenaCA 91105USA The Pfleger Liver Institute and the Division of Digestive Diseases the David Geffen School of MedicineUniversity of CaliforniaLos AngelesCA 90095USA Department of Radiological Sciences at the David Geffen School of Medicine University of CaliforniaLos AngelesCA 90095USA

Aim:Survival in patients with hepatocellular carcinoma(HCC)is impacted by stage of liver disease,tumor characteristics,and HCC surveillance in high-risk *** associated with HCC tumor growth rate(TGR)and its influence on recurrence-free survival after treatment was ***:TGR was calculated in 164 HCC patients with chronic viral hepatitis who had two consecutive magnetic resonance imaging or computed tomography scans≥30 days apart prior to treatment and who were followed prospectively to determine the rates of recurrence-free ***:The median TGR in 164 patients was 17.8%per month(mean 33.3%per month).Regression tree analysis indicated that the top three predictors of TGR were alpha-fetoprotein(AFP)levels(≥16.7 ng/mL),platelet counts(≥140,000 mm3),and serum albumin level(56 years(HR=1.08,P=0.072),hepatitis C virus(HR=1.44,P=0.091),macrovascular invasion(HR=1.94,P=0.092),and the most definitive treatments(orthotopic liver transplantation,HR 0.14,P<0.001;surgical resection,HR=0.54,P=0.072;radiofrequency ablation,HR=0.58,P=0.060)as independent predictors of recurrence-free *** all treatment modalities,slow ;TGR was significant for prolonged survival(P=0.029).The poorest survival rates were observed in patients with fast TGRs treated by transarterial ***:The TGR correlated with AFP,platelet count,and albumin *** with fast TGRs had shorter recurrence-free survival after HCC *** is a potential imaging biomarker to predict clinical outcomes in HCC.

关键词： Liver cancer growth rates hepatitis B hepatitis C hepatocellular carcinoma treatments

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Determination of the vapor pressure and prediction of the polarity for ionic liquid 1-alkyl-3-methylimidazolium propionate [Cnmim][Pro](n = 4, 5, 6)

Determination of the vapor pressure and prediction of the po...

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第十七届全国化学热力学和热分析学术会议

作者： R.j.Liu H.X.Yang C.Li j.tong j.Z.Yang Liaoning University

The ionic liquids(ILs) [Cnmim][Pro](n = 4, 5, 6)(1-alkyl-3-methylimidazolium propionate) were prepared by the neutralization method and characterized by 1H-NMR spectroscopy and differential scanning calorimetry(DSC). Using isothermogravimetrical analysis, the vapor pressures in the temperature range of 423.1563.15 K and the enthalpy of vaporization, △g lHo m(Tav), at the average temperature, Tav, for these ILs were determined [1-2]. The difference of heat capacities between the vapor phase and the liquid phase, △g lCp o m, for [Cnmim][Pro](n = 4, 5, 6) were calculated based on the statistical thermodynamics using Verevkin’s method. Therefore, in terms of △g lCp o m, the value of △g lHo m(Tav) can be transformed into △g lHo m(298). Based on Clausius-Clapeyron equation, the hypothetical temperature of normal boiling point(NBP), Tb for [Cnmim][Pro](n = 4, 5, 6) were estimated. In terms of Tb, the values of entropy and the Gibbs free energy of vaporization for these ILs were predicted at different temperatures. Based on Hildebrand’s theory a new method to predict the polarity of the ILs was put forward. The order of the predicted polarity for the ILs is in good agreement with the experiment value.

关键词： Ionic liquid Isothermogravimetrical analysis Vapor pressure Polarity

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Limited Knowledge of Acetaminophen in Patients with Liver Disease

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journal of Clinical and Translational Hepatology 2016年第4期4卷 281-287页

作者： Sarnrny Saab Peter G.Konyn Matthew R.Viramontes Melissa A.jimenez jonathan F.Grotts Wally Hamidzadah Veronica P.Dang Negin L.Esmailzadeh Gina Choi Francisco A.Durazo Mohamed M.El-Kabany Steven-Huy B.Han Myron j.tong Department of Medicine the University of California at Los Angeles Los Angeles CA USA Department of Surgery the University of California at Los Angeles Los Angeles CA USA Department of Surgery the University of California at Los Angeles Los Angeles CA USA Department of Biostatistics the University of California at Los Angeles Los Angeles CA USA Department of Surgery the University of California at Los Angeles Los Angeles CA USA California and Huntington Medical Research Institutes Pasadena CA USA

Background andAims:Unintentional acetaminophen overdose remains the leading cause of acute liver failure in the United *** with underlying liver disease are at higher risk of poor outcomes from acetaminophen *** knowledge of acetaminophen may be a preventable contributor to elevated rates of overdose and thus acute liver *** purpose of this study is to assess knowledge of acetaminophen dosing and presence of acetaminophen in common combination products in patients with liver ***:We performed a cross-sectional study of patients with liver disease at the Pfleger Liver Institute at the University of California,Los Angeles between june 2015 and August *** completed a demographic questionnaire and an acetaminophen knowledge *** information was obtained from the medical ***:Of 401 patients with liver disease,30 (15.7%) were able to correctly identify that people without liver disease can safely take up to 4 g/day of *** majority of patients (79.9%-86.8%) did not know that Norco(R) (hydrocone/acetaminophen),Vicodin(R) (hydrocone/acetaminophen) and Percocet(R) (oxycodone/acetaminophen) contained *** 45.3% of the patients knew that Tylenol(R) #3 contained ***:We conclude that patients with liver disease have critically low levels of knowledge of acetaminophen,putting them at risk both of acetaminophen overdose,as well as undermedication,and inadequate management of chronic *** recommend an increase in education efforts regarding acetaminophen dosage and its safety in the setting of liver *** education for those at risk of low acetaminophen knowledge is essential to minimizing acetaminophen overdose rates and optimizing pain management.

关键词： Acetaminophen Pain management Cirrhosis

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The specimen preparation methods for nanoindentation testing of biomaterials:a review

The specimen preparation methods for nanoindentation testing...

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2007亚洲光电子会议纳米光子学/纳米结构/纳米计量学分会场

作者： j.Y.Sun a,j.tong a,Z.j.Zhang b aKey Laboratory of Terrain-Machine Bionics Engineering(Ministry of Education,China)and bCollege of Biological and Agricultural Engineering,jilin University College of Mechanical Science and Engineering,jilin University Changchun,jilin Province,China

Nanoindenter provides an approach for assessing mechanical properties in micro-electronics devices and films based on quantitative,controlled nanoindentation of surfaces,with the convenience of modern *** is also suitable to measure mechanical properties of *** for biomaterial testing in bone and dentin was widely *** some studies of nanoindentation properties in insect were carried *** the surface roughness of natural biomaterials problem should not to be ignored in nanoindentation *** surface roughness will critically affect the precision of result of nanoindentation testing and caused error *** this paper,the biomaterials specimen preparation methods for nanoindentation testing will be reviewed.

关键词： specimen preparation,nanoindentation,biomaterials

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Boosting hydrocarbon conversion via Cu-doping induced oxygen vacancies on CeO2 in CO2 electroreduction

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journal of Energy Chemistry 2025年第1期100卷 66-76页

作者： Lei Xue tong Shi Chenhui Han Heng Zhang Fenrong Liu Haorun Li Yan Wang Xiaojun Gu Shanghong Zeng Inner Mongolia Key Laboratory of Chemistry and Physics of Rare Earth Materials School of Chemistry and Chemical Engineering Inner Mongolia University State Key Laboratory of Coal Conversion Institute of Coal Chemistry Chinese Academy of Sciences Institute of Catalysis Department of Chemistry Zhejiang University National Key Laboratory of Baiyunobo Rare Earth Resource Research and Comprehensive Utilization Baotou Research Institute of Rare Earths

Conversion of CO2back to hydrocarbons is the most direct way of closing the“carbon cycle”,and its significance is further enlarged if this process is driven by renewable energies such as ***,precisely controlling the product selectivity towards hydrocarbons against the competitive hydrogen evolution remains challenging,especially for Cu-based ***,we report a novel defect engineering strategy,by which Cu-doping-induced oxygen vacancies on CeO2nanorods were effectively created,with adjustable vacancy/Cu *** resulting optimum catalyst shows up to 79% catalytic current density to hydrocarbons （excluding CO）,with 49% faradaic efficiency to *** and density functional theory unveil that the ratio between oxygen vacancy and Cu affects significantly the formation of*CHO and activation of H2O,which leads to the following deep hydrogenation to *** findings may spur new insights for designing and developing more controllable chemical process relevant to CO2utilization.

关键词： Oxygen vacancy Hydrocarbon production Reaction mechanism

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Interfacial Zn2+-solvation regulator towards reversible and stable Zn anode

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journal of Energy Chemistry 2025年第1期100卷 684-692页

作者： Miao Zhou Xiongbin Luo Hang Li Shan Guo Zhuang tong Xiaotao Zhou Xu Li Zhaohui Hou Shuquan Liang Guozhao Fang College of Mechanical Engineering Key Laboratory of Hunan Province for Advanced Carbon-based Functional Materials Hunan Institute of Science and Technology School of Materials Science and Engineering Key Laboratory of Electronic Packaging and Advanced Functional Materials of Hunan Province Central South University College of Materials and Metallurgy Guizhou University National Energy Metal Resources and New Materials Key Laboratory Central South University

Aqueous zinc-ion batteries （AZIBs） are fundamentally challenged by the instability of the electrode/electrolyte interface,predominantly due to irreversible zinc （Zn） deposition and hydrogen ***,the intricate mechanisms behind the electrochemical discrepancies induced by interfacial Zn2+-solvation and deposition behavior demand comprehensive *** molecules endowed with special functional groups （such as hydroxyl,carboxyl,etc.） have the potential to significantly optimize the solvation structure of Zn2+and regulate the interfacial electric double layer （EDL）.By increasing nucleation overpotential and decreasing interfacial free energy,these functional groups facilitate a lower critical nucleation radius,thereby forming an asymptotic nucleation model to promote uniform Zn ***,this study presents a pioneering approach by introducing trace amounts of n-butanol as solvation regulators to engineer the homogenized Zn （H-Zn） anode with a uniform and dense *** interfacial reaction and structure evolution are explored by in/ex-situ experimental techniques,indicating that the H-Zn anode exhibits dendrite-free growth,no by-products,and weak hydrogen evolution,in sharp contrast to the bare ***,the H-Zn anode achieves a remarkable Zn utilization rate of approximately 20% and simultaneously sustains a prolonged cycle life exceeding 500 ***,the H-Zn//NH4V4O10（NVO） full battery showcases exceptional cycle stability,retaining 95.04%capacity retention after 400 cycles at a large current density of 5 A *** study enlightens solvation-regulated additives to develop Zn anode with superior utilization efficiency and extended operational lifespan.

关键词： Aqueous zinc-ion batteries Interfacial reaction Asymptotic nucleation model Reversible and stable Zn anode

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