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Applied Mathematics and Mechanics(English Edition) 2024年第8期45卷 1371-1386页

作者： Zeyu CHAI j.t.han Xuyuan SONG jian ZANG Yewei ZhanG Zhen ZhanG College of Aerospace Engineering Shenyang Aerospace UniversityShenyang 110136China jacobs School of Engineering University of California San DiegoSan Diego CA 92122U.S.A. Key Laboratory of Vibration and Control of Aero-Propulsion System Ministry of EducationNortheastern UniversityShenyang 110819China

A novel X-shaped variable stiffness vibration isolator(X-VSVI)is *** Runge-Kutta method,harmonic balance method,and wavelet transform spectra are introduced to evaluate the performance of the X-VSVI under various *** layer number,the installation angle of the X-shaped structure,the stiffness,and the active control parameters are systematically *** addition,a prototype of the X-VSVI is manufactured,and vibration tests are carried *** results show that the proposed X-VSVI has a superior adaptability to that of a traditional X-shaped mechanism,and shows excellent vibration isolation performance in response to different amplitudes and forms of ***,the vibration isolation efficiency of the device can be improved by appropriate adjustment of parameters.

关键词： bionic vibration isolation X-shaped structure variable stiffness structure nonlinear dynamics prototype experiment

CELLULAR AUtOMAtA MODELLING OF GRAIN COARSENING DURING REHEAtING AND VALIDAtION WItH tHE EXPERIMENtAL RESULtS

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Acta Metallurgica Sinica(English Letters) 2005年第2期18卷 113-120页

作者： W.H.Yu E.j.Palmiere S.P.Banks j.t.han SchoolofMaterialsScienceandEngineering UniversityofScienceandTechnologyBeijingBeijing100083China DepartmentofEngineeringMaterials UniversityofSheffieldSheffieldS13JDUK DepartmentofAutomaticControlandSystemsEngineering UniversityofSheffieldSheffieldS13J-DUK

A novel 2D cellular automata (CA) model has been developed for description of normal grain coarsening and abnormal grain coarsening process. the program reflects the grain coarsening quite well even through the average grain size becomes very large. Follow results have been obtained: (a) the model reflect the normal grain growth kinetics gradually increase with probability and grain growth speed can be controlled. Based on this result, temperature can be coupled in the model. (b) Abnormal grain growth is modelled successfully. (c) Methodology has been put forward to find the relationship between the experiment results and modelling results. the experimental work on the grain coarsening has been carried out. Graphical output matched the realistic microstructure in every detail. Because many physical parameters can be taken into account in the CA programme, this CA model could not only qualitatively demonstrate the grain growth process, but also quantitatively predict and analyse the grain coarsening process.

关键词： computer simulation grain growth microstructure reheating

Analysis of total energy system based on solid oxide fuel cell for combined cooling,heating and power generation

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Analysis of total energy system based on solid oxide fuel ce...

Crystallization Modulation and Holistic Passivation Enables Efficient two‑terminal Perovskite/CuIn(Ga)Se_(2)tandem Solar Cells

第九届全国氢能学术会议

作者： Z.t.Yu and j.t.han Shandong University,China

＜正＞the total Energy System（tES） is an integrating energy system that can simultaneously supply power generation and heating/cooling based on cascade utilization of energy to enhance energy conversion efficiency a...

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Nano-Micro Letters 2025年第1期17卷 205-215页

作者： Cong Geng Kuanxiang Zhang Changhua Wang Chung Hsien Wu jiwen jiang Fei Long Liyuan han Qifeng han Yi‑Bing Cheng Yong Peng State Key Laboratory of Advanced technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070People’s Republic of China triumph Photovoltaic Materials Co. Ltd.No.1001 Yannan AvenueHigh‑Tech Development DistrictBengbuAnhui 233000People’s Republic of China College of Materials Science and Engineering Guilin University of TechnologyGuilin 541004People’s Republic of China State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

two-terminal(2-t)perovskite(PVK)/CuIn(Ga)Se_(2)(CIGS)tandem solar cells(tSCs)have been considered as an ideal tandem cell because of their best bandgap matching regarding to Shockley–Queisser(S–Q)***,the nature of the irregular rough morphology of commercial CIGS prevents people from improving tandem device *** this paper,D-homoserine lactone hydrochloride is proven to improve coverage of PVK materials on irregular rough CIGS surfaces and also passivate bulk defects by modulating the growth of PVK *** addition,the minority carriers near the PVK/C60 interface and the incompletely passivated trap states caused interface recombination.A surface reconstruction with 2-thiopheneethylammonium iodide and N,N-dimethylformamide assisted passivates the defect sites located at the surface and grain ***,LiF is used to create this field effect,repelling hole carriers away from the PVK and C60 interface and thus reducing *** a result,a 2-t PVK/CIGS tandem yielded a power conversion efficiency of 24.6%(0.16 cm^(2)),one of the highest results for 2-t PVK/CIGS tSCs to our *** validation underscores the potential of our methodology in achieving superior performance in PVK/CIGS tandem solar cells.

关键词： PVK/CIGS tSCs Irregular rough surfaces Modulating the growth PVK/C60 interface recombination

trends of alkaline phosphatase to prealbumin ratio in patients with hepatitis B linked to hepatocellular carcinoma development

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World journal of Gastroenterology 2025年第2期31卷 42-51页

作者： Wen-Chong Zhen jing Sun Xue-ting Bai Qian Zhang Zi-han Li Yi-Xin Zhang Rong-Xuan Xu Wei Wu Zhi-han Yao Chun-Wen Pu Xiao-Feng Li School of Public Health Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Graduate School Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Dalian Public Health Clinical Center Dalian Municipal Research Institute for Public HealthDalian 116001Liaoning ProvinceChina Department of Epidemiology and Health Statistics Dalian Medical UniversityDalian 116044Liaoning ProvinceChina

BACKGROUND Chronic hepatitis B often progresses silently toward hepatocellular carcinoma(HCC),a leading cause of mortality *** detection of HCC is crucial,yet *** to investigate the role of dynamic changes in alkaline phosphatase to prealbumin ratio(APR)in hepatitis B progression to *** Data from 4843 patients with hepatitis B(january 2015 to january 2024)were *** incidence rates in males and females were compared using the log-rank *** were evaluated using Kaplan–Meier *** Linear Mixed-Effects Model was applied to track the fluctuation of APR levels over ***,joint Modeling of Longitudinal and Survival data was employed to investigate the temporal relationship between APR and HCC *** the incidence of HCC was higher in *** ensure the model’s normality assumption,this study applied a logarithmic transformation to APR,yielding *** levels were higher in females(t=5.26,Pt increase in ratio correlated with a 2.005-fold higher risk of HCC in males(95%CI:1.653-2.431)and a 2.273-fold higher risk in females(95%CI:1.620-3.190).CONCLUSION Males are more prone to HCC,while females have higher APR *** no baseline APR link,rising APR indicates a higher HCC risk.

关键词： Alkaline phosphatase to prealbumin ratio Chronic hepatitis B patients Hepatocellular carcinoma Retrospective cohort study Linear Mixed-Effect Mode joint Modelling of Longitudinal and Survival data

Effects of Shenqi Xiangyi granules in advanced gastric cancer chemotherapy

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World journal of Gastrointestinal Oncology 2025年第1期17卷 169-175页

作者： Xiao-jing Shi Yu Song Xue-Xue Liang ting Chen Huang-Yu Hao Xue han Ya-Nan Chen Department of Oncology Zhangjiagang First People's HospitalSuzhou 215600Jiangsu ProvinceChina

BACKGROUND Owing to the absence of specific symptoms in early-stage gastric cancer,most patients are diagnosed at intermediate or advanced *** a result,treatment often shifts from surgery to other therapies,with chemotherapy and targeted therapies being the primary options for advanced gastric cancer treatment.A total of 116 patients with advanced gastric cancer,admitted from january 2021 to December 2023,were selected and divided into two groups of 58 each using the random number table *** control group received FOLFOX4 chemothe-rapy(oxaliplatin+calcium+folinate+5-fluorouracil)combined with intravenous *** observation group received the same treatment as the control group,supplemented by oral administration of Senqi Shiyiwei *** groups underwent treatment cycles of 3 weeks,with a minimum of two *** therapeutic efficacy,immune mechanisms,and treatment-related toxicity and side effects were compared between the *** objective remission rate in the observation group(55.17%)was higher than that of the control group(36.21%)(Pter two treatment cycle,CD3+,CD4+,and CD4+/CD8+levels were higher in the observation group compared to the control group,while CD8+,regulatory t cells,and natural killer cells were lower(Ptionally,the incidence of leukopenia,nausea,and vomiting was lower in observed group(Pt differences were observed in the incidence of other adverse reactions(P>0.05).CONCLUSION Adjuvant therapy with Shenqixian granules may enhance the efficacy of simudizumab combined with FOLFOX4 chemotherapy in advanced gastric cancer and the immune function by increasing immune cell counts,making it a valuable option in clinical treatment.

关键词： Sindilizumab FOLFOX4 chemotherapy Advanced gastric cancer Ginseng Qi Xiangyi granule Clinic treatment

Human neural stem cell-derived extracellular vesicles protect against ischemic stroke by activating the PI3K/AKt/mtOR pathway

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Neural Regeneration Research 2025年第11期20卷 3245-3258页

作者： jiayi Wang Mengke Zhao Dong Fu Meina Wang Chao han Zhongyue Lv Liang Wang jing Liu Stem Cell Clinical Research Center The First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning ProvinceChina Dalian Innovation Institute of Stem Cell and Precision Medicine DalianLiaoning ProvinceChina Institute(College)of Integrative Medicine Dalian Medical UniversityDalianLiaoning ProvinceChina

Human neural stem cell-derived extracellular vesicles exhibit analogous functions to their parental cells,and can thus be used as substitutes for stem cells in stem cell therapy,thereby mitigating the risks of stem cell therapy and advancing the frontiers of stem cell-derived *** lays a foundation for the development of potentially potent new treatment modalities for ischemic ***,the precise mechanisms underlying the efficacy and safety of human neural stem cell-derived extracellular vesicles remain unclear,presenting challenges for clinical *** promote the translation of therapy based on human neural stem cell-derived extracellular vesicles from the bench to the bedside,we conducted a comprehensive preclinical study to evaluate the efficacy and safety of human neural stem cell-derived extracellular vesicles in the treatment of ischemic *** found that administration of human neural stem cell-derived extracellular vesicles to an ischemic stroke rat model reduced the volume of cerebral infarction and promoted functional recovery by alleviating neuronal *** human neural stem cell-derived extracellular vesicles reduced neuronal apoptosis by enhancing phosphorylation of phosphoinositide 3-kinase,mammalian target of rapamycin,and protein kinase B,and these effects were reversed by treatment with a phosphoinositide 3-kinase *** findings suggest that human neural stem cell-derived extracellular vesicles play a neuroprotective role in ischemic stroke through activation of phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin signaling ***,we showed that human neural stem cell-derived extracellular vesicles have a good in vivo safety ***,human neural stem cell-derived extracellular vesicles are a promising potential agent for the treatment of ischemic stroke.

关键词： behavior exosome extracellular vesicles ischemic stroke mammalian target of rapamycin(mtOR) middle cerebral artery occlusion neural stem cells neuronal apoptosis phosphoinositide 3-kinase(PI3K) protein kinase B(AKt)

Unveiling mitochondrial mysteries:Exploring novel tRNA variants in type 2 diabetes mellitus

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World journal of Diabetes 2025年第1期16卷 1-6页

作者： Chun-han Cheng Wen-Rui Hao tzu-Hurng Cheng Department of Medical Education Linkou Chang Gung Memorial HospitalTaoyuan 33305Taiwan Division of Cardiology Department of Internal MedicineShuang Ho HospitalMinistry of Health and WelfareTaipei Medical UniversityNew Taipei 23561Taiwan Division of Cardiology Department of Internal MedicineSchool of MedicineCollege of MedicineTaipei Medical UniversityTaipei 11002Taiwan Department of Biochemistry School of MedicineCollege of MedicineChina Medical UniversityTaichung 404328Taiwan

the recent study of Ding et al provides valuable insights into the functional implications of novel mitochondrial tRNAtrp and tRNASer(AGY)variants in type 2 diabetes mellitus(t2DM).this editorial explores their findings,highlighting the role of mitochondrial dysfunction in the pathogenesis of *** examining the molecular mechanisms through which these tRNA variants contribute to disease progression,the study introduces new targets for therapeutic *** discuss the broader implications of these results,emphasizing the importance of understanding mitochondrial genetics in addressing t2DM.

关键词： Mitochondrial tRNA variants type 2 diabetes mellitus Mitochondrial dysfunction Genetic markers therapeutic strategies

tHEOREtICAL StUDY OF HEAt tRANSFER ENhanCEMENt IN PIPE WItH POROUS BODY

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journal of Hydrodynamics 2001年第1期13卷 111-116页

作者： Gong, W.P. han, j.t. Cheng, F. Dep. of Power Eng. Shandong Univ. Jinan 250061 China

A theoretical investigation on the fluid flow and heat transfer in a pipe with porous body of high porosity twisted by metal wire was carried out. A theoretical model of a circular pipe with porous matrix attached at the channel wall and extended inward the centerline was set up. through analyzing the flow in the porous matrix by the Brinkman-extended-Darcy equation and through including the effect of dispersion by adding the dispersion coefficient into the energy equation, the theoretical solutions of velocity distribution and temperature fields were obtained. Finally the effect of the properties of the porous matrix on the flow and heat transfer in the porous body was studied, which indicates that dispersion can really enhance the heat transfer in pipe.

关键词： Computer simulation Dispersions Mathematical models Pipe flow Porosity Porous materials

资源支持、组织能力与价值创造:社区互助养老服务可持续生产的驱动路径

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海南大学学报（人文社会科学版） 2025年第1期43卷 107-118页

作者：翟绍果韩煜西北大学公共管理学院陕西西安710127

社区互助养老服务何以可持续生产,基于“环境-组织-价值”分析框架,以我国37个社区互助养老典型案例为样本,运用模糊集定性比较分析方法;(fsQCA)探究社区互助养老服务可持续生产的组态驱动路径。研究表明:;(1)外部支持、社区资源、主体... 详细信息

社区互助养老服务何以可持续生产,基于“环境-组织-价值”分析框架,以我国37个社区互助养老典型案例为样本,运用模糊集定性比较分析方法;(fsQCA)探究社区互助养老服务可持续生产的组态驱动路径。研究表明:;(1)外部支持、社区资源、主体协同、制度化水平、技术赋能与价值创造通过组态效应影响社区互助养老服务的可持续生产;(2)外部支持与社区资源、制度化水平与技术赋能具有潜在替代性,社区资源和价值创造是组态形成的关键因素;(3)党政统合型、社区自组织型、技术嵌入型和协同驱动型是驱动社区互助养老服务可持续生产的4种优化路径。实现社区互助养老服务高水平的可持续生产应坚持系统联动思维,释放多元组态的复合驱动效应,重视社区资源和价值创造的关键作用,选择适宜不同地区发展基础的互助养老模式。

关键词：社区互助养老可持续生产驱动路径