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Regenerative Biomaterials 2019年第3期6卷 175-184页

作者： T.R.Christiani E.Baroncini j.stanzione A.j.Vernengo Department of Biomedical Engineering Department of Chemical Engineering Rowan University201 Mullica Hill RoadGlassboroNJ 08028USA

Tissue engineering of the annulus fibrosus(AF)is currently being investigated as a treatment for intervertebral disc degeneration,a condition frequently associated with low back *** objective of this work was to use 3D printing to generate a novel scaffold for AF repair that mimics the structural and biomechanical properties of the native ***-layer scaffolds were fabricated by depositing polycaprolactone struts in opposing angular orientations,replicating the angle-ply arrangement of the native AF *** were printed with varied strut diameter and *** constructs were characterized morphologically and by static and dynamic mechanical *** surfaces were etched with unidirectional grooves and the influence on bovine AF cell metabolic activity,alignment,morphology and protein expression was studied in ***,the axial compressive and circumferential tensile properties of the scaffolds were found to be in a similar range to the native AF *** microscopy images indicated that cells were able to attach and spread on the smooth polycaprolactone scaffolds,but the surface texture induced cellular alignment and ***,immunofluorescence analysis demonstrated the aligned deposition of collagen type I,aggrecan and the AF-specific protein marker tenomodulin on the etched ***,results demonstrated the potential for using the scaffolds as a template for AF regeneration.

关键词： surface modification scaffolds materials structure 3D printing

Functionalization of micropipette tips with hydrophobin-laccase chimera and application to the electrochemical determination of caffeic acid in tea samples

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Food Bioscience 2023年第2期52卷 1362-1368页

作者： Ilaria stanzione Anna Pennacchio Alessandra Piscitelli Paola Giardina b Estefania Costa-Rama M.Teresa Fernandez-Abedul Department of Physical and Analytical Chemistry University of OviedoSpain Department of Chemical Sciences University of Naples“Federico II”Italy

Performing on-site measurements is one of the main challenges of current(bio)chemical *** tips,which are among the most common utilities in laboratories,can be useful and cheap elements for designing out-of-the-box innovative analytical ***,most of the analytical properties of these bioplatforms depend on the immobilization of the recognition element(e.g.,enzymes).In this context,we have recently designed a chimeric protein in which laccase PoxA1b from the fungus Pleurotus ostreatus has been genetically fused to the class I hydrophobin *** ability to self-assemble at hydrophobic-hydrophilic interfaces of hydrophobin,allows an easy laccase *** this work,the Vmh2-PoxA1b fusion protein was immobilized into common polypropylene micropipette tips to develop an innovative enzymatic bioplatform that can produce fast results in a simple *** proof of applicability,the platform was applied to the determination of caffeic acid by enzymatic oxidation and further electrochemical reduction of the product on a screen-printed electrode,achieving a limit of detection of 1.4-10^(-6) *** was then used for determining caffeic acid in tea samples.

关键词： Fusion protein Laccase Micropipette tips Electrochemical detection Caffeic acid

MRI标识病灶影像组学和机器学习检测前列腺癌包膜外侵犯：一项多中心研究

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国际医学放射学杂志 2021年第6期 746-746页

作者： R.Cuocolo A.stanzione R.Faletti M.Gatti G.Calleris A.Fornari 郭虹

目的通过前列腺MRI标识病灶提取影像组学特征,建立检测前列腺癌(PCa)包膜外侵犯(EPE)的机器学习(ML)模型。方法回顾性连续收集3个机构中行前列腺癌根

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影像组学质量评分应用的系统综述：一项EuSoMII影像组学审核小组倡议

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国际医学放射学杂志 2023年第3期 365-365页

作者： G.Spadarella A.stanzione T.A.D'Antonoli A.Andreychenko S.C.Fanni L.Ugga 侯国柱

摘要目的对基于影像组学质量评分（RQS）的系统综述进行全面概述，由此突出影像组学研究应用的共同问题和挑战，同时评估RQS和综述特征之间的关系。方法根据系

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动态血压再评估可改善非透析慢性肾脏病患者的风险分层

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中华高血压杂志 2015年第7期23卷 699-699页

作者： Minutolo R Gabbai FB Chiodini P Garofalo C stanzione G Liberti ME Pacilio M Borrelli S Provenzano M Conte G Nicola L 李金凤叶鹏

在非透析慢性肾脏病风险预后评估中,动态血压比诊室血压更有效,但是动态血压再评估能否进一步明确预后尚未知。研究人员纳入间隔1年行2次动态血压测量的高血压合并非透析慢性肾脏病患者182例,分析由距离基线测量1年后获取的第2次动态血... 详细信息

在非透析慢性肾脏病风险预后评估中,动态血压比诊室血压更有效,但是动态血压再评估能否进一步明确预后尚未知。研究人员纳入间隔1年行2次动态血压测量的高血压合并非透析慢性肾脏病患者182例,分析由距离基线测量1年后获取的第2次动态血压测定值对肾病复合终点（死亡,慢性透析,估算的肾小球滤过率下降≥40%）的评估是否有帮助。

关键词：动态血压测量慢性肾脏病预后评估非透析风险患者研究人员慢性透析

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MRI影像组学鉴别前列腺癌包膜外侵犯：系统回顾和荟萃分析

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国际医学放射学杂志 2024年第4期 503-503页

作者： A.Ponsiglione M.Gambardella A.stanzione R.Green V.Cantoni C.Nappi 王笑男

摘要目的结合MRI信息的列线图可能在预测前列腺癌（PCa）的前列腺外侵犯（EPE）上出现重大突破，但敏感性和标准化程度较低是尚未解决的问题。MRI影像组学已被应

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