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Photoionisation detection of a single Er3+ ion with sub-100-ns time resolution

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National science Review 2024年第4期11卷 38-45页

作者： Yangbo Zhang Wenda Fan jiliang Yang Hao Guan Qi Zhang Xi Qin Changkui Duan Gabriele G.de Boo Brett C.johnson jeffrey C.mc Callum Matthew j.sellars sven Rogge Chunming Yin jiangfeng Du CAs Key Laboratory of Microscale Magnetic Resonance and school of Physical sciences University of Science and Technology of China CAs Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of China Hefei National Laboratory University of Science and Technology of China Centre of Excellence for Quantum Computation and Communication Technology School of Physics University of New South Wales Centre of Excellence for Quantum Computation and Communication Technology School of Engineering RMIT University Centre of Excellence for Quantum Computation and Communication Technology School of Physics University of Melbourne Centre of Excellence for Quantum Computation and Communication Technology Research School of Physics and Engineering Australian National University

Efficient detection of single optical centres in solids is essential for quantum information processing, sensing and single-photon generation *** this work,we use radio-frequency（RF） reflectometry to electrically detect the photoionisation induced by a single Er3+ion in *** high bandwidth and sensitivity of the RF reflectometry provide sub-100-ns time resolution for the photoionisation *** this technique,the optically excited state lifetime of a single Er3+ion in a si nano-transistor is measured for the first time to be 0.49±0.04μ*** results demonstrate an efficient approach for detecting a charge state change induced by Er excitation and *** approach could be used for fast readout of other single optical centres in solids and is attractive for large-scale integrated optical quantum systems thanks to the multi-channel RF reflectometry demonstrated with frequency multiplexing techniques.

关键词： single optical centres erbium ions RF reflectometry photoionisation detection

Combinatorial therapies for spinal cord injury repair

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Neural Regeneration Research 2025年第5期20卷 1293-1308页

作者： Carla s.sousa Andreia Monteiro António j.salgado Nuno A.silva Life and Health sciences Research Institute(ICVs) School of MedicineUniversity of MinhoCampus de Gualtar-gualtarBragaPortugal ICVs/3B’s Associate Lab PT Government Associated LabCampus de Gualtar-gualtarBragaPortugal

spinal cord injuries have profound detrimental effects on individuals, regardless of whether they are caused by trauma or non-traumatic events. The compromised regeneration of the spinal cord is primarily attributed to damaged neurons, inhibitory molecules, dysfunctional immune response, and glial scarring. Unfortunately, currently, there are no effective treatments available that can fully repair the spinal cord and improve functional outcomes. Nevertheless, numerous pre-clinical approaches have been studied for spinal cord injury recovery, including using biomaterials, cells, drugs, or technological-based strategies. Combinatorial treatments, which target various aspects of spinal cord injury pathophysiology, have been extensively tested in the last decade. These approaches aim to synergistically enhance repair processes by addressing various obstacles faced during spinal cord regeneration. Thus, this review intends to provide scientists and clinicians with an overview of pre-clinical combinatorial approaches that have been developed toward the solution of spinal cord regeneration as well as update the current knowledge about spinal cord injury pathophysiology with an emphasis on the current clinical management.

关键词： electric stimulation neural tissue regeneration neuroprotection polytherapy spinal cord injury

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Aberrant post-translational protein modifications in the pathogenesis of alcohol-induced liver injury

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World journal of Gastroenterology 2016年第27期22卷 6192-6200页

作者： Natalia A Osna Wayne G Carter Murali Ganesan Irina A Kirpich Craig j mc clain Dennis R Petersen Colin T shearn Maria L Tomasi Kusum K Kharbanda Research service Veterans Affairs Nebraska-Western Iowa Health Care System Omaha NE 68105 United States Department of Internal Medicine 982000 Nebraska Medical Center Omaha NE 68198 United States school of Medicine University of Nottingham Royal Derby Hospital Centre Derby DE22 3DT United Kingdom Division of Gastroenterology Hepatology and Nutrition Department of Medicine Department of Medicine and Pharmacology and Toxicology University of Louisville Louisville KY 40202 United States University of Colorado Denver School of Pharmacy Department of Pharmaceutical Sciences Aurora CO 80045 United States Division of Gastroenterology Department of Medicine Davis research building suite 2096/2035 Cedars-Sinai Medical Center Los Angeles CA 90048 United States Department of Biochemistry and Molecular Biology 985870 Nebraska Medical Center Omaha NE 68198 United States

It is likely that the majority of proteins will undergo post-translational modification, be it enzymatic or non-enzymatic. These modified protein(s) regulate activity, localization and interaction with other cellular molecules thereby maintaining cellular hemostasis. Alcohol exposure significantly alters several of these post-translational modifications leading to impairments of many essential physiological processes. Here, we present new insights into novel modifications following ethanol exposure and their role in the initiation and progression of liver injury. This critical review condenses the proceedings of a symposium at the European society for the Biomedical Research on Alcoholism Meeting held september 12-15, 2015, in Valencia, spain.

关键词： Alcohol Acetylation Liver Carbonylation methylation Dysfunction Methylation Glycosylation Phosphorylation Ubiquitination sumoylation Betaine Post-translational protein modification

Mineral concentrations of chickpea and lentil cultivars and breeding lines grown in the *** Northwest

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The Crop journal 2018年第3期6卷 253-262页

作者： George j.VANDemark Michael A.Grusak Rebecca j.mc Gee UsDA-ARs Grain Legume Genetics and Physiology Research Unit UsDA-ARs Red River Valley Agricultural Research Center

Diseases and health complications caused by mineral deficiencies afflict billions of people globally. Developing pulse crops with elevated seed mineral concentrations can contribute to reducing the incidence of these deficiencies. The objectives of this study were to estimate variance components conditioning seed mineral concentrations of chickpea and lentil grown in Washington and Idaho, determine correlations between different mineral concentrations and between mineral concentrations and yield, 100-seed weight, and days to flowering, and compare seed mineral concentrations between chickpeas and lentils grown in adjacent plots. Genotype effects, although significant in chickpea and lentil for all minerals except selenium, tended to be minimal compared to location, year, and their interaction effects. In both chickpeas and lentils high positive correlations were observed between seed concentrations of phosphorus and potassium, phosphorus and zinc, and potassium and zinc. Correlations between mineral concentration and yield, and mineral concentration and days to 50% flowering were similar for chickpeas and lentils across the majority of minerals. These results may reflect similarities between the two crops in physiological processes for mineral uptake and partitioning. Lentils had higher concentrations of iron and zinc than chickpea when the two crops were grown in adjacent plots,whereas chickpeas had higher concentrations of calcium and manganese. Plant genotypes that are more efficient at obtaining minerals from growing environments will be useful as parental materials to develop improved chickpea and lentil cultivars that have good yield potential coupled with high seed mineral concentrations.

关键词： Chickpea Lentil Mineral Nutrition Pulse

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无颅内病变的成年病人行增强MRI后脑内钆剂沉积

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国际医学放射学杂志 2018年第1期 95-96页

作者： R.j.mc Donald j.s.mc Donald D.F.Kallmes M.E.jentoft M.A.Paolini D.L.Murray 张俊峰 Departments of Radiology Neurosurgeryand Laboratory Medicine and PathologyCollege of MedicineMayo Clinic

摘要目的通过研究无颅内病理改变的病人,明确颅内异常的病人中神经组织钆剂沉积是否与血脑屏障结构完整性相关。材料与方法本研究已获得机构伦理委员会批准和

关键词： MRI 神经组织

Outcomes of tenodesis of the long head of the biceps tendon more than three months after rupture

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世界骨科杂志：英文版 2016年第3期7卷 188-194页

作者： Patrick j mc Mahon Andrea speziali mcMahon Orthopedics and Rehabilitation University of Pittsburgh Department of Bioen-gineering University of Pittsburgh Institute of Orthopaedics and Traumatology Catholic University Agostino Gemelli’s Hospital

AIM: To demonstrate that long head of the biceps tendon(LHBT) tenodesis is possible more than 3 mo after rupture. METHODs: From september 2009 to january 2012 we performed tenodesis of the LHBT in 11 individuals(average age 56.9 years, range 42 to 73) more than 3 mo after rupture. All patients were evaluated by Disabilites of the Arm shoulder and Hand(DAsH) and Mayo outcome scores at an average follow-up of 19.1 mo. We similarly evaluated 5 patients(average age 58.2 years, range 45 to 64) over the same time treated within 3 mo of rupture with an average follow-up of 22.5 ***: Tenodesis with an interference screw was possible in all patients more than 3 mo after rupture and 90% had good to excellent outcomes but two had recurrent rupture. All of those who had tenodesis less than 3 mo after rupture had good to excellent outcomes and none had recurrent rupture. No statistical difference was found for DAsH and Mayo outcome scores between the two groups(P sION: Tenodesis of LHBT more than 3 mo following rupture had outcomes similar to tenodesis done within 3 mo of rupture but recurrent rupture occurred in 20%.

关键词： Popeye deformity Chronic rupture Biceps tenodesis Muscular spasm Interference screw Long head of biceps tendon

血管生成素样蛋白3基因抑制、脂质与心血管代谢风险

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中华高血压杂志（中英文） 2024年第3期32卷 204-204页

作者： Gobeilé Bourgault j Mitchell PL Houessou U Gagnon E Girard A Paulin A Manikpurage HD CoteV Couture C Marceau s Boss Y Th riault s Mathieu P Vohl mc Tchernof A Arsenault Bj 袁源(译) 郑武洪(审校) 不详

基于RNA、抗体和基因组编辑的治疗正在研究当中,以明确血管生成素样蛋白3(angiopoietin-like protein-3,ANGPTL3)抑制能否降低脂蛋白-脂质水平和动脉粥样硬化心血管疾病(atherosclerotic cardiovascular disease,AsCVD)风险。采用孟德... 详细信息

基于RNA、抗体和基因组编辑的治疗正在研究当中,以明确血管生成素样蛋白3(angiopoietin-like protein-3,ANGPTL3)抑制能否降低脂蛋白-脂质水平和动脉粥样硬化心血管疾病(atherosclerotic cardiovascular disease,AsCVD)风险。采用孟德尔随机(Mendelian randomisation,MR)明确通过基因变异影响ANGPTL3肝脏基因表达、血液水平和蛋白结构,能否影响甘油三脂和载脂蛋白B(apolipoprotein B,apoB)水平。

关键词：血管生成素样蛋白3 心血管疾病动脉粥样硬化基因变异基因组编辑载脂蛋白B 孟德尔脂蛋白

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Hepatic lipogranulomas in patients with chronic liver disease: Association with hepatitis C and fatty liver disease

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World journal of Gastroenterology 2010年第40期16卷 5065-5069页

作者： Hongfa Zhu Henry C Bodenheimer David j clain Albert D Min Neil D Theise Department of Pathology Mount Sinai School of MedicineNewYorkNY10029United States Department of Medicine (Divisions of Digestive Diseases)Beth Israel Medical Center Albert Einstein College of Medicine Department of Pathology Beth Israel Medical CenterAlbert Einste in College of MedicineNew YorkNY 10003United States

AIM: To study the significance and clinical implication of hepatic lipogranuloma in chronic liver diseases, including fatty liver disease and hepatitis C. METHODs: A total of 376 sequential, archival liver biopsy specimens were reviewed. Lipogranuloma, steatosis and steato-fibrosis were evaluated with combined hematoxylin and eosin and Masson’s trichrome staining. REsULTs: Fifty-eight (15.4%) patients had lipogranuloma, including 46 patients with hepatitis C, 14 patients with fatty liver disease, and 5 patients with other diseases. Hepatic lipogranuloma was more frequently seen in patients with hepatitis C (21%) and fatty liver disease (18%), and its incidence was significantly higher than that in control group (P spectively). In addition, 39 out of the 58 patients with lipogranuloma were associated with steatosis and/or steato-fibrosis. Of the 18 lipogranuloma patients with clinical information available for review, 15 (83%) had risk factors associated with fatty liver disease, such as alcohol use, obesity, hyperlipidemia, and diabetes mellitus. Although the incidence of these risk factors was greater in patients with lipogranuloma than in control group (60%), it did not reach statistical significance. CONCLUsION: Hepatic lipogranuloma is not limited to mineral oil use and commonly associated with hepatic steatosis, hepatitis C and fatty liver disease. With additional histological features of steato-fibrosis, lipogranuloma can also be used as a marker of prior hepatic steatosis.

关键词： Lipogranuloma Hepatitis C Fatty liver disease steatosis steato-fibrosis

孤立肾是增强CT后急性肾损伤的独立危险因素吗

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国际医学放射学杂志 2016年第2期 179-180页

作者： j.s.mc Donald R.W.Katzberg R.j.mc Donald E.E.Williamson D.F. Kallmes 原媛 Department of Radiology Mayo Clinic

摘要目的确定是否孤立肾病人的对比剂引发的急性肾损伤的风险高于具有双肾的病人。材料与方法本回顾性研究符合HIPAA要求,并经机构伦理委员会批准。收集2004

关键词：肾损伤病人孤立肾单肾双肾 CT