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国际脑血管病杂志 2017年第5期25卷 396-399页

作者： Lavine sD Cockroft k Hoh B Bambakidis N khalessi AA Woo H Riina H siddiqui A Hirsch jA Chong W Rice H Wenderoth j mitchell P Coulthard A signh Tj Phatorous C khangure m klurfan P ter Brugge k Iancu D Gunnarsson T Pongpech s Rodesch G soderman m Taylor A krings T Orbach D Picard L suh DC Zheng HQ jansen O muto m szikora I Pierot L Brouwer P Gralla j Renowden s Andersson T Fiehler j Turjman F White P januel AC spelle L kulcsar Z Chapot R Biondi A Dima s Taschner C szajner m krajina A sakai N matsumaru Y Yoshknura s Ezura m Fujinaka T Iihara k Ishii A Higashi T Hirohata m Hyodo A Ito Y kawanishi m kiyosue H kobayashi E kobayashi s kuwayama N matsumoto Y miyachi s murayama Y Nagata I Nakahara I Nemoto s Niimi Y Oishi H satomi j satow T sugiu k Tanaka m Terada T Yamagami H Diaz O Lylyk P jayaraman mV Patsalides A Gandhi CD Lee sk Abruzzo T Albani B Ansari sA Arthur As Baxter BW Bulsara kR Chen m Almandoz jE Fraser jF Heck DV Hetts sW Hussain ms klucznik RP Leslie-mawzi Tm mack Wj mcTaggart RA meyers Pm mocco j Prestigiacomo CA Pride GL Rasmussen PA starke Rm sunenshine Pj Tarr RW Frei DF Pabo m Nogueira RG Zaidat OO jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech s 许岩孙瑞郭芮兵 From the American Association of Neurological surgeons/Congress of Neurological surgeons (AANs/CNs) Rolling Meadows IL USA American society of Neuroradiology (AsNR) Oak Brook IL USA Asian Australasian Federation of lnterventional and Therapeutic Neuroradiology (AAFITN) Bali Indonesia Australian and New Zealand society of Neuroradiobgy-Conjomt Committee for Recognition of Training in Interventional Neuroradiology (CCINR) representing the RANZCR (ANZsNR) ANZAN and NSA Sydney Australia Canadian Interventional Neuro Group (CING) Edmonton AB Canada World Federation of Interventional and Therapeutic Neuroradiology (WFITN) Gold Coast Australia European society of Neuroradiology (EsNR) Milan Italy European society of minimally Invasive Neurologic Therapy (EsmINT) Nice France japanese society for Neuroendovascular therapy (jsNET) Okayama Japan sociedad Ibero Latino Americana de Neuroradiologica (sILAN) Cartagena Colombia society of Neurolnterventional surgery (sNIs) Washington DC USA society of Vascular and Interventional Neurology (sVIN) Brooklyn NY USA 南京大学医学院附属金陵医院(南京军区南京总医院)神经内科 210002 解放军第一0一医院(无锡太湖医院)神经内科无锡214004

1背景缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞（emergent large vesselocclusion，ELVO）患者都会遗留长期残疾。事实上，这些颅内大动脉闭塞经常会导致大面积脑损伤，进而造成患者死亡或严重致残。

关键词：缺血性卒中培训指南介入治疗文件学会国际血管闭塞动脉闭塞

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4种降压药血压反应的异质性:一项随机临床试验

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中华高血压杂志 2023年第7期31卷 604-604页

作者：刘青(译) 练桂丽(审) 不详

高血压是全世界过早死亡的主要危险因素。多种降压疗法可用,但通过个性化靶向药物的最大获益潜力尚不清楚。该研究旨在探讨并量化针对特定个体的特定药物的潜力,以最大限度地提高降压效果。方法:一项随机、双盲、重复交叉试验,在瑞典一... 详细信息

高血压是全世界过早死亡的主要危险因素。多种降压疗法可用,但通过个性化靶向药物的最大获益潜力尚不清楚。该研究旨在探讨并量化针对特定个体的特定药物的潜力,以最大限度地提高降压效果。方法:一项随机、双盲、重复交叉试验,在瑞典一家门诊研究诊所对心血管事件风险较低的1级高血压男性和女性进行研究。混合效应模型用于评估个体对一种治疗的反应比另一种更好的程度.

关键词：随机临床试验混合效应模型交叉试验靶向药物降压药降压效果主要危险因素男性和女性

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Genome-Wide sequencing of 41 Rice （Oryza sativa L.） mutated Lines Reveals Diverse mutations Induced by Fast-Neutron Irradiation

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molecular Plant 2016年第7期9卷 1078-1081页

作者： Li, Guotian Chern, mawsheng jain, Rashmi martin, joel A. schackwitz, Wendy s. jiang, Liangrong Vega-sanchez, miguel E. Lipzen, Anna m. Barry, kerrie W. schmutz, jeremy Ronald, Pamela C. Univ Calif Davis Dept Plant Pathol Davis CA 95616 USA Univ Calif Davis Genome Ctr Davis CA 95616 USA Lawrence Berkeley Natl Lab Feedstocks Div Joint BioEnergy Inst Berkeley CA 94720 USA Us DOE Joint Genome Inst Walnut Creek CA 94598 USA Xiamen Univ Sch Life Sci Xiamen 361102 Peoples R China HudsonAlpha Inst Biotechnol Huntsville AL 35806 USA monsanto Co Chesterfield Village Campus Chesterfield MO 63017 USA

Fast-neutron （FN） irradiation has been used to create mutagen- ized collections of many plant species （Bolon et al., 2014）, FN- induced mutagenesis has clear advantages： it is an efficient means of saturating the genome, and it does not involve time- consuming plant transformation or tissue culture. In rice, most mutant collections, although highly valuable, were generated us- ing either T-DNA insertion or transposon tagging approaches that often induce mutations unlinked to the insertion and complicating analysis （Wang et al., 2013）. Another disadvantage of some of these collections is that they were created in rice varieties that are photoperiod-sensitive and often have long generation times.

关键词： mutagenesis genome valuable

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巴西BCG卡痕阅读的敏感性与特异性

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国际结核病与肺部疾病杂志 2002年第1期 35-37页

作者： s.m.Pereira I.Dourado m.L.Barreto s.s.Cunha m.Y.T.Ichiara m.A.Hijjar j.C.L.Goes L.C.Rodrigues 安燕生 Instituto de saude Coletiva Salvador Bahia Brazil Infectious Disease and Epidemiology Unit London School of Hygiene and Tropical Medicine London England Coordenaco Regional da Fundaco Nacional de sade Salvador Bahia Centro de Referência Hélio Fraga/Cenepi/FUNAsA Rio de Janeiro Brazil Instituto de saúde Coletiva Salvador Bahia Brazil Infectious Disease and Epidemiology Unit London School of Hveiene and Tropical Medicine London England

在巴西社区的一个BCG效果评价试验的横断面调查中,培训过的人员检查儿童的上臂,同时从监护人的来信及儿童接种卡上获得信息。随后护士再对样本进行双盲抽查。两组卡痕阅读有高度的一致性(kappa=0.839)。以监护人和卡片记录的信息作为金... 详细信息

在巴西社区的一个BCG效果评价试验的横断面调查中,培训过的人员检查儿童的上臂,同时从监护人的来信及儿童接种卡上获得信息。随后护士再对样本进行双盲抽查。两组卡痕阅读有高度的一致性(kappa=0.839)。以监护人和卡片记录的信息作为金标准获得高敏感性和低特异性。当监护人与接种卡片一致时敏感性仍然高,而当两者不一致时,敏感性仍然高,而特异性非常低。(BCG)卡痕是已接种BCG的好指标。

关键词：确认敏感性特异性 BCG疫苗 BCG卡痕

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增强CT显示的肠系膜和网膜非肿块性“污垢”样改变:超声引导经皮穿刺活检的诊断功效

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国际医学放射学杂志 2011年第6期 596-596页

作者： j.k.Lee s.Y.Baek s.m.Lim k.H.Lee 伍玲 Department of Radiology and medical Research Institute School of MedicineEwha Womans University911-1 Mok-dongYangcheon-guSeoul 158-710Korea

目的评价超声引导经皮穿刺活检诊断增强CT上显示为肠系膜和网膜非肿块性"污垢"样改变的病因的功效。材料与方法本次研究得到了专业审查委员会的批准;因属于回顾性分析,免除病人书面知情同意。自2004年3月—2009年5月,增强CT显示肠系膜... 详细信息

目的评价超声引导经皮穿刺活检诊断增强CT上显示为肠系膜和网膜非肿块性"污垢"样改变的病因的功效。材料与方法本次研究得到了专业审查委员会的批准;因属于回顾性分析,免除病人书面知情同意。自2004年3月—2009年5月,增强CT显示肠系膜和网膜非肿块性"污垢"样

关键词：肠系膜腹膜网膜超声引导经皮穿刺活检肿块污垢 CT

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Environmental stresses modulate Abundance and Timing of Alternatively spliced Circadian Transcripts in Arabidopsis

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molecular Plant 2015年第2期8卷 207-227页

作者： sergei A. Filichkin jason s. Cumbie Palitha Dharmawardhana Pankaj jaiswal jeff H. Chang saiprasad G. Palusa A.s.N. Reddy molly megraw Todd C. mockler Department of Botany and Plant Pathology Oregon State University Corvallis OR 97331 USA Center for Genome Research and Biocomputing Oregon State University Corvallis OR 97331 USA Department of Biology and Program in molecular Plant Biology Colorado State University Fort Collins CO 80523 USA Donald Danforth Plant science Center Saint Louis MO 63132 USA Co-corresponding author

Environmental stresses profoundly altered accumulation of nonsense mRNAs including intron-retaining （IR） transcripts in Arabidopsis. Temporal patterns of stress-induced IR mRNAs were dissected using both oscillating and non-oscillating transcripts. Broad-range thermal cycles triggered a sharp increase in the long IR CCA1 isoforms and altered their phasing to different times of day. Both abiotic and biotic stresses such as drought or Pseudomonas syringae infection induced a similar increase. Thermal stress induced a time delay in accumulation of CCA1 14Rb transcripts, whereas functional mRNA showed steady oscillations. Our data favor a hypothesis that stress-induced instabilities of the central oscillator can be in part compensated through fluctuations in abundance and out-of-phase oscillations of CCA1 IR transcripts. Taken together, our results support a concept that mRNA abundance can be modulated through altering ratios between functional and nonsense/IR transcripts. sR45 protein specifically bound to the retained CCA1 intron in vitro, suggesting that this sp!icing factor could be involved in regulation of intron retention. Transcriptomes of nonsense-mediated mRNA decay （NmD）-impaired and heat-stressed plants shared a set of retained introns associated with stress- and defense-inducible transcripts. Constitutive activation of certain stress response networks in an NmD mutant could be linked to disequilibrium between functional and nonsense mRNAs.

关键词： Arabidopsis alternative splicing circadian clock intron retention nonsense-mediated mRNA decay(NmD) environmental stress

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measurement of Inelastic Branch of a Crucial stellar 14O（α, p）17F Reaction

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近代物理研究所和兰州重离子加速器实验室年报：英文版 2009年第1期 59-60页

作者： He jianjun P. j. Woos T. Davinson m. Aliotta j. Buescher E. Clement P. Delahaye m. Hass D. G. jenkins V. kumar A. s. murphy P. Neyskens R. Raabe A. P. Robinson j. van der Walle N. Warr F. Wenander school of Physics University of Edinburgh EH9 3JZ UK. Institut voor＇kern-en stralingsfysica K.-U. Leuven B 3001 Leuven Belgium. CERN CH-1211 Geneva 23 Switzerland. Weizmann Institute of science Rehovot II 76100 Israel. University of York Heslington YO10 5DD UK. Inst. kernphysik Universitaet Koln Koln D-50937 Germany.

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Autonomous scanning probe microscopy investigations over Ws_(2)and Au{111}

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npj Computational materials 2022年第1期8卷 916-922页

作者： john C.Thomas Antonio Rossi Darian smalley Luca Francaviglia Zhuohang Yu Tianyi Zhang shalini kumari joshua A.Robinson mauricio Terrones masahiro Ishigami Eli Rotenberg Edward s.Barnard Archana Raja Ed Wong D.Frank Ogletree marcus m.Noack Alexander Weber-Bargioni molecular Foundry Lawrence Berkeley National LaboratoryBerkeleyCA94720United States Advanced Light source Lawrence Berkeley National LaboratoryBerkeleyCA94720United States Department of Physics and Nanoscience Technology Center University of Central FloridaOrlandoFL32816United States Department of materials science and Engineering The Pennsylvania State UniversityUniversity ParkPA16082United States Center for Two-Dimensional and Layered materials The Pennsylvania State UniversityUniversity ParkPA16802United States Department of Physics and Department of Chemistry The Pennsylvania State UniversityUniversity ParkPA16802United States Center for Advanced mathematics for Energy Research Applications Lawrence Berkeley National LaboratoryBerkeleyCA94720United States

Individual atomic defects in 2D materials impact their macroscopic *** the interplay is challenging,however,intelligent hyperspectral scanning tunneling spectroscopy(sTs)mapping provides a feasible solution to this technically difficult and time consuming ***,dense spectroscopic volume is collected autonomously via Gaussian process regression,where convolutional neural networks are used in tandem for spectral *** data enable defect segmentation,and a workflow is provided for machine-driven decision making during experimentation with capability for user *** provide a means towards autonomous experimentation for the benefit of both enhanced reproducibility and *** investigations on Ws_(2)sulfur vacancy sites are explored,which is combined with local density of states confirmation on the Au{111}herringbone *** vacancies,pristine Ws_(2),Au face-centered cubic,and Au hexagonal close-packed regions are examined and detected by machine learning methods to demonstrate the potential of artificial intelligence for hyperspectral sTs mapping.

关键词： autonomous consuming packed

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separate locations of urocortin and its receptors in mouse testis： Function in male reproduction and the relevant mechanisms

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南京医科大学学报（自然科学版） 2007年第10期27卷 510-510页

作者： Tao, j. Lin, m. sha, j. H. Tan, G. soong, T. W. Li, s. N. Nanjing med Univ Dept Pharmacol Key Lab Reprod Med Nanjing 210029 Peoples R China Natl Univ singapore Dept Physiol Ion Channel ＆ Transporter Lab Singapore 0511 Singapore

Urocortin (UCN), a newly identified co rticotrophin-releasing-factor (CRF) related peptide, has been demonstrated to play important roles in female reproductive system。However, few studies were reported about its effects on male reproduction。This study aimed to investigate the expression profile of UCN and CRF receptors (CRFR) in mouse testis and functions of UCN in male reproduction。

关键词：睾丸促肾上腺皮质激素相关因子精子活力顶体反应精原细胞钙离子通道受体

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The Introduction of Bedaquiline Regimen for Drug-Resistant Tuberculosis in the Philippines: An Operational study

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journal of Tuberculosis Research 2022年第4期10卷 205-219页

作者： Vincent m. Balanag jr. Vivian s. Lofranco mariquita j. mantala mary Rosary T. santiago Patrice jamie E. Cabasis Arnyl G. Araneta Anna marie Celina G. Garfin Lung Center of the Philippines National Center for Pulmonary Research Quezon Philippines Department of Health National Tuberculosis Control Program Management Office Manila Philippines Philippine Business for social Progress The Global Fund Project Manila Philippines Department of Health Disease Prevention and Control Bureau Manila Philippines

Objectives: Bedaquiline (BDQ) is the first new anti-tuberculosis (TB) drug introduced to the market after 45 years. Recent studies have shown the potential benefits of adding bedaquiline to regimens for drug-resistant TB (DR-TB). In search of more effective regimens for DR-TB, bedaquiline was introduced in the TB program in the Philippines under operational research to assess its effectiveness, safety, and tolerability when given with background regimens among patients with multi-or extensively DR-TB (mDR/XDR-TB). Design: A prospective cohort study of patients with mDR/XDR-TB was given with a bedaquiline-containing regimen from june 2016 to may 2017. Demographic data, presence of comorbidities, and microbiologic profile on entry were recorded. Bedaquiline was administered at the recommended dose of 400 mg once daily for 14 days, then 200 mg three times a week for 22 weeks together with World Health Organization (WHO)-compliant background regimen. The time to culture conversion, interim outcomes at the 6th month of treatment, end-of-treatment outcomes, and post-treatment follow-up outcomes after one year was determined. The frequency and severity of adverse events (sAE) were recorded as part of pharmacovigilance. Results: seventy-five patients were given with bedaquiline-containing regimen during the study period. Forty-two (56.0%) had second-line injectable resistance, 23 (30.7%) had fluoroquinolone-resistance, 6 (8.0%) had mDR-TB, and 4 (5.3%) had XDR-TB. In the 6th month of post-enrolment, 79% were culture-negative. The treatment success rate was 65.3% (37 were cured and 12 completed treatment), 7 (9.3%) died, 17 (22.7%) lost to follow-up, and 2 (2.7%) were withdrawn from treatment. Adverse events included vomiting (80%), dizziness (69%), nausea (52%), cough (44%), and headache (36%). The post-treatment follow-up of 49 patients in the 12th month showed 92% were culture-negative while 8% of TBC were not done. Conclusion: Bedaquiline-containing regimens for patients

关键词： Bedaquiline Drug-Resistant TB XDR-TB

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