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Association between Helicobacter pylori infection,mismatch repair,HEr2 and tumor-infiltrating lymphocytes in gastric cancer

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World journal of Gastrointestinal Oncology 2024年第6期16卷 2487-2503页

作者： Carlos A Castaneda Miluska Castillo Luis A Bernabe joselyn Sanchez Matteo Fassan Katherine Tello Ignacio Ivan Wistuba Ivan Chavez Passiuri Eloy ruiz juvenal Sanchez Fernando Barreda Daniel valdivia Yaqueline Bazan Milagros Abad-Licham Claudio Mengoa Hugo Fuentes Paola Montenegro Ebert Poquioma raul Alatrista Claudio j Flores Luis Taxa Faculty of Health Sciences Universidad Cientifica del SurLima 15038Peru GECO PErU Grupo de Estudios Clinicos Oncologicos del PeruLima 15038Peru Department of research Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Faculty of Human Medicine Universidad Ricardo PalmaLima 15039Peru Department of Medicine Surgical Pathology&Cytopathology UnitUniversity of PaduaPadua 35121Italy Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Department of Abdominal Surgery Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Pathology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Medical Specialties Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Pathology Instituto Regional de Enfermedades Neoplasicas del NorteTrujillo 13001Peru Faculty of Human Medicine Universidad Privada Antenor OrregoTrujillo 13008Peru Department of Surgery Instituto Regional de Enfermedades Neoplasicas del SurArequipa 04002Peru Department of Medical Oncology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Epidemiology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Unidad de Investigación Básica y Traslacional Oncosalud-AUNALima 15038Peru Faculty of Medicine Universidad San Martin de PorresLima 15008Peru

BACKGrOUND The influence of Helicobacter-pylori(***)infection and the characteristics of gastric cancer(GC)on tumor-infiltrating lymphocyte(TIL)levels has not been extensively *** of infiltrating-immune-cell subtypes as well as survival is necessary to obtain comprehensive *** To determine the rates of deficient mismatch-repair(dMMr),HEr2-status and *** infection and their association with TIL levels in *** Samples from 503 resected GC tumors were included and TIL levels were evaluated following the international-TILs-working-group recommendations with assessment of the intratumoral(IT),stromal(ST)and invasive-border(IB)*** density of CD3,CD8 and CD163 immune cells,and dMMr and HEr2-status were determined by immunohistochemistry(IHC).*** infection was evaluated by routine histology and quantitative PCr(qPCr)in a subset of *** dMMr was found in 34.4%,HEr2+in 5%and ***-positive in 55.7%of *** IT-TIL was associated with grade-3(P=0.038),while ST-TIL with grade-1(Precurrence(P=0.003).dMMr was associated with high TIL levels in the ST(P=0.019)and IB(P=0.01)compartments,and STCD3(P=0.049)and ST-CD8(P=0.05)***2-was associated with high IT-CD8(P=0.009).*** was associated with high IT-TIL levels(P=0.009)when assessed by routine-histology,and with high TIL levels in the 3 compartments(P=0.002-0.047)and CD8 density in the IT and ST compartments(P=0.001)when assessed by qPCr.A longer overall survival was associated with low IT-CD163(P=0.003)and CD8/CD3(P=0.001 in IT and P=0.002 in ST)and high IT-CD3(P=0.021),ST-CD3(P=0.003)and CD3/CD163(P=0.002).CONCLUSION TIL levels were related to dMMr and *** CD8/CD3 and high CD163/CD3 were associated with lower recurrence and longer survival.

关键词： Lymphocytes Macrophages Gastric cancer Helicobacter pylori HEr2 Mismatch repair

Arrhythmogenic mechanisms in ryanodine receptor channelopathies

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Science China(Life Sciences) 2015年第1期58卷 54-58页

作者： ZHAO Yan-Ting valdivia Carmen r. GUrrOLA Georgina B. HErNNDEZ jonathan j. valdivia Héctor H. Center for Arrhythmia research Department of Internal MedicineCardiovascular DivisionUniversity of Michigan

ryanodine receptors(ry rs) are the calcium release channels of sarcoplasmic reticulum(Sr) that provide the majority of calcium ions(Ca2+) necessary to induce contraction of cardiac and skeletal muscle *** their intracellular environment,ry r channels are regulated by a variety of cytosolic and luminal factors so that their output signal(Ca2+) induces finely-graded cell contraction without igniting cellular processes that may lead to aberrant electrical activity(ventricular arrhythmias) or cellular *** importance of ry r dysfunction has been recently highlighted with the demonstration that point mutations in rYr2,the gene encoding for the cardiac isoform of the ry r(ry r2),are associated with catecholaminergic polymorphic ventricular tachycardia(CPVT),an arrhythmogenic syndrome characterized by the development of adrenergically-mediated ventricular tachycardia in individuals with an apparently normal *** we summarize the state of the field in regards to the main arrhythmogenic mechanisms triggered by ry r2 channels harboring mutations linked to *** CPVT mutations characterized to date endow ry r2 channels with a gain of function,resulting in hyperactive channels that release Ca2+ spontaneously,especially during *** spontaneous Ca2+ release is extruded by the electrogenic Na+/Ca2+ exchanger,which depolarizes the external membrane(delayed afterdepolarization or DAD) and may trigger untimely action ***,a rare set of CPVT mutations yield ry r2 channels that are intrinsically hypo-active and hypo-responsive to stimuli,and it is unclear whether these channels release Ca2+ spontaneously during *** discuss novel cellular mechanisms that appear more suitable to explain ventricular arrhythmias due to ry r2 loss-of-function mutations.

关键词： ryanodine receptors CPVT sarcoplasmic reticulum cardiac arrhythmias

Isla San Pedro Nolasco as a Late Miocene intrusive record at the eastern margin of the Gulf of California:Insights from geological,geochemical and geochronological studies

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Geoscience Frontiers 2022年第3期13卷 100-114页

作者： L.A.Velderrain-rojas j.r.Vidal-Solano L.M.Alva-valdivia r.Vega-Granillo M.López-Martinez Departamento de Geología División de Ciencias Exactas y NaturalesUniversidad de SonoraC.P.83000 HermosilloSonoraMexico Laboratorio de Paleomagnetismo Instituto de GeofísicaUniversidad Nacional Autónoma de MéxicoCircuito de la Investigación CientíficaC.P.04510 MéxicoD.F.Mexico Departamento de Geología División de Ciencias de la TierraCentro de Investigación Científica y de Educación Superior de EnsenadaBaja CaliforniaMexico

Isla San Pedro Nolasco(ISPN)is a structural high bounded by inactive dextral oblique-slip faults in the east-central part of the Gulf of California rift zone and is composed of intrusive rocks not exposed on other Gulf of California *** we present the reconnaissance results from geological mapping,as well as first geochemical and geochronological data for the ISPN intrusive *** intrusive rocks compose a sheet-like body of intermediate and felsic composition intruded by an intermediate and acidic dike *** intrusive rocks(host and dikes)range in age from ca.9 Ma to 10 Ma(^(40)Ar/^(39)Ar)and show a hydrous ferromagnesian mineral association(amphibole and biotite)with a calc-alkalic and transitional *** hydrated mineralogical association has not been recognized in the coeval rocks along the onshore western margin of the North American plate(coastal Sonora).However,such hydrous mineralogical association is found in the coeval rift transitional volcanic rocks from the Baja California Microplate at Santa rosalía and Bahía de LosÁngeles–Bahía de LasÁ*** ISPN continental block,at least 40 km long,has been pulled apart by transtensional faulting of the late Miocene Gulf of California shear zone before the westward migration of the North America-Pacific plate boundary at ca.3–2 ***,ISPN became isolated as an island during the late Miocene flooding of the Gulf of California seaway.

关键词： PAC-NAM plate boundary Gulf of California Intrusive rocks Isla San Pedro Nolasco

Mixed Wastes Vitrification by Transferred Plasma

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Plasma Science and Technology 2007年第6期9卷 721-724页

作者： j.TAPIA-FABELA M.PACHECO-PACHECO j.PACHECO-SOTELO C.TOrrES-rEYES r.valdivia-BArrIENTOS j.BENITEZ-rEAD r.LOPEZ-CALLEjAS F.rAMOS-FLOrES S.BOSHLE G.ZISSIS Technological National Plasma and Energy Conversion Laboratory 118 Narbonne AveToulousecedex 4431062France

Thermal plasma technology provides a stable and long term treatment of mixed wastes through vitrification processes. In this work, a transferred plasma system was realized to vitrify mixed wastes, taking advantage of its high power density, enthalpy and chemical reactivity as well as its rapid quenching and high operation temperatures. To characterize the plasma discharge, a temperature diagnostic is realized by means of optical emission spectroscopy （OES）. To typify the morphological structure of the wastes samples~ scan- ning electron microscopy （SEM）, and X-ray diffraction （XrD） techniques were applied before and after the plasma treatment.

关键词： mixed wastes vitrification transferred plasma plasma characterisation

Helicobacter pylori vacA s1a and s1b alleles from clinical isolates from different regions of Chile show a distinct geographic distribution

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World journal of Gastroenterology 2005年第40期11卷 6366-6372页

作者： MI Díaz A valdivia P Martínez jL Palacios P Harris j Novales E Garrido D Valderrama C Shilling A Kirberg E Hebel j Fierro r Bravo F Siegel G Leon G Klapp A Venegas Departamento de Genética Molecular y Microbiología. Pontificia Universidad Católica de Chile. Santiago Departamento de Pediatría Centro de Diagnóstico Terapéutico Los Angeles Unidad de Gastroenterología Anatomía Patológica Centro de Endoscopía Quirúrgica Hospital Base de Linares Hospital regional de valdivia Instituto de Bioquímica Hospital regional de Punta Arenas

AIM： To establish the most common vacA alleles in Helicobacter pylori （ H pylon） strains isolated from Chilean patients and its relationship with gastritis and gastroduodenal ulcers, METHODS： Two hundred and forty five Hpyloriclinical isolates were obtained from 79 biopsies from Chilean infected patients suffedng from gastrointestinal diseases. An average of 2-3 strains per patient was isolated and the vac4 genotype was analyzed by PCr and 3% agarose electrophoresis. Some genotypes were checked by DNA sequencing. rESULTS： The most prevalent vacA genotype in Chilean patients was slb ml （76%）, followed by sla ml （21%）. In oontrast, the s2 m2 genotype was scarcely represented （3%）. The slb ml genotype was found most frequently linked to gastropathies （P〈0.05） rather than ulcers. Ulcers were found more commonly in male and older patients. Curiously, patents IMng in dties located North and far South of Santiago, thecapital and largest Chilean city, carried almost exclusively strains with the slb ml genotype. In contrast, patients from Santiago and cities located South of Santiago carded strains with either one or both sla ml and slb ml genotypes. regarding the s2 m2 genotype, comparison with GenBank sequences revealed that Chilean s2 sequence was identical to those of Australian, American, and Colombian strains but quite different from those of Alaska and India. CONCLUSION： Differences in geographic distribution of the s and m vacA alleles in Chile and a relationship of slb ml genotype with gastritis were found. Sequence data in part support a hispanic origin for the vacA genotype. Asymmetric distribution of genotypes slb ml and s2 m2 recedes H Pyloristrain distribution in Spain and Portugal.

关键词： Hpylori vacA alleles Chilean isolates s1 s2 m1 and m2 sequences

Canine Herpesvirus Latent Infection in Experimentally Infected rabbits

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Open journal of Veterinary Medicine 2020年第6期10卷 92-102页

作者： G. F. Nájera jantes j. Barrón González E. G. valdivia Lara j. I. Ángeles Solis C. Cuenca Verde G. valdivia Anda Laboratorio de Patogenicidad Microbiana Unidad de Investigación Multidisciplinaria FESC-UNAM Cuautitlán Izcalli Estado de México México

An experimental inoculation of canine Herpesvirus (HVC), strain H17, was performed in rabbits previously and simultaneously treated with dexamethasone, the behavior of the leukocyte count was followed prior and during the experimental phase. Upon death or euthanasia of the animals, a necropsy and evaluation of various organs was performed by histopathology and by nested PCr against the Herpesvirus Polymerase gene. All animals inoculated with dexamethasone showed leukopenia (p reated with dexamethasone did not show significant histological lesions, but showed amplification of the Herpesvirus Polymerase gene in various organs despite not showing clinical signs of the illness. A dolphin Herpesvirus isolate was used as a positive control as rabbits developed fatal systemic disease and lesions typical of active (lytic) infection in various organs within 72 hours post-inoculation. The absence of clinical signs, significant histological lesions, and the presence of viral DNA in some organs suggested a state of latency due to canine Herpesvirus. Dexamethasone allowed HVC infection, but did not promote viral reactivation in rabbits contrary to that observed in canines experimentally induced to the lytic cycle by HVC.

关键词： rabbit and Canine Herpesvirus Experimental Infection Dexametasone and Latency

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利用非线性模拟预测磁暴的发生

地质科学译丛 1997年第3期14卷 50-53页

作者： j.A.valdivia 曲赞 Department of Physics University of MarylandCollege ParkMaryland

众所周知,磁暴与具有南向方向的星际磁场(IMF)密切相关。这一结论是通过对线性预测滤波器的研究得出的,研究中采用的资料是 Dst 和 IMF 数据系统。然而,从一次磁暴到另一次磁暴,该方法都要求对线性滤波器作较大的改动。因此在预测磁暴... 详细信息

众所周知,磁暴与具有南向方向的星际磁场(IMF)密切相关。这一结论是通过对线性预测滤波器的研究得出的,研究中采用的资料是 Dst 和 IMF 数据系统。然而,从一次磁暴到另一次磁暴,该方法都要求对线性滤波器作较大的改动。因此在预测磁暴的活动中,线性滤波器法就显得具有一定的局限性。以前所进行的研究是将磁暴期间,磁层中电磁响应的非线性表示成环电流的衰减速率随 Dst 值而变化的关系。在此,我们提出了对 Dst 数据进行分析的非线性模拟法,这批数据是 OMNI 基站在1964～1990年期间记录下来的。若事先记录下可靠的太阳风资料的话,则就可从 Dst 和 IMF 资料中预测出磁暴的发生。然而,所记录下的大多数时段的太阳风资料并不可靠,或者只有1 h 的资料可靠,有时甚至还不足1 h。因此,我们就以 Dst 资料系统为基础提出了非线性预测模拟方法。若缺少太阳风资料,这些模拟就不能预测磁暴的发生,但可预测磁暴的发展,并且可从中等磁暴来发现强磁暴。以 IMF和 Dst 资料系统为基础的输入-输出模型和只以 Dst 资料系统为基础的自主模型两者之间的联系,可以用来进行天气预报。

关键词：磁暴非线性模拟太阳风

Phase imaging of irradiated foils at the OMEGA EP facility using phase-stepping X-ray Talbot–Lau deflectometry

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High Power Laser Science and Engineering 2023年第4期11卷 45-54页

作者： G.Pérez-Callejo V.Bouffetier L.Ceurvorst T.Goudal S.r.Klein D.Svyatskiy M.Holec P.Perez-Martin K.Falk A.Casner T.E.Weber G.Kagan M.P.valdivia Departamento de Física Teórica Atómica yÓptica Universidad de ValladolidValladolidSpain Universitéde Bordeaux-CNrS-CEA Centre Lasers Intenses et Applications(CELIA)UMR 5107TalenceFrance European XFEL GmbH SchenefeldGermany Laboratory for Laser Energetics RochesterNew YorkUSA CEA-DAM DIFArpajonFrance University of Michigan Ann ArborMichiganUSA Los Alamos National Laboratory Los AlamosNew MexicoUSA Lawrence Livermore National Laboratory LivermoreCaliforniaUSA Helmholtz-Zentrum Dresden-rossendorf DresdenGermany Technische Universität Dresden DresdenGermany Institute of Physics of the ASCr PragueCzech Republic CEA-CESTA CS 60001Le Barp CedexFrance Blackett Laboratory Imperial College LondonLondonUK Department of Astrophysics and Astronomy The Johns Hopkins UniversityBaltimoreMarylandUSA Center for Energy research University of California San DiegoSan DiegoCaliforniaUSA

Diagnosing the evolution of laser-generated high energy density(HED)systems is fundamental to develop a correct understanding of the behavior of matter under extreme ***–Lau interferometry constitutes a promising tool,since it permits simultaneous single-shot X-ray radiography and phase-contrast imaging of dense *** present the results of an experiment at OMEGA EP that aims to probe the ablation front of a laser-irradiated foil using a Talbot–Lau X-ray interferometer.A polystyrene(CH)foil was irradiated by a laser of 133 j,1 ns and probed with 8 keV laser-produced backlighter radiation from Cu foils driven by a short-pulse laser(153 j,11 ps).The ablation front interferograms were processed in combination with a set of reference images obtained ex situ using *** managed to obtain attenuation and phase-shift images of a laser-irradiated foil for electron densities above 1022 cm−*** results showcase the capabilities of Talbot–Lau X-ray diagnostic methods to diagnose HED laser-generated plasmas through high-resolution imaging.

关键词： deflectometry OMEGA EP phase-contrast imaging Talbot-Lau X-ray interferometry

Effect of Cellulose Microfibers from Sugar Beet Pulp By-product on the reinforcement of HDPE Composites Prepared by Twin‐screw Extrusion and Injection Molding

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journal of Bionic Engineering 2023年第1期20卷 349-365页

作者： Abdelghani Boussetta Anass Ait Benhamou Francisco j.Barba Nabil Grimi Mario j.Simirgiotis Amine Moubarik Laboratory of Chemical Processes and Applied Materials Poly Disciplinary FacultySultan Moulay Slimane UniversityBP 592Beni-MellalMorocco Materials Science Energy and Nanoengineering(MSN)DepartmentMohammed VI Polytechnic UniversityLot 660-Hay Moulay Rachid43150Ben GuerirMorocco Materials Science and Process Optimization Laboratory Faculty of Science SemlaliaCadi Ayyad University40000MarrakechMorocco Nutrition and Food Science Area Preventive Medicine and Public HealthFood ScienceToxicology and Forensic Medicine DepartmentFaculty of PharmacyUniversitat de ValènciaAvda.Vicent Andrés Estelléss/n46100BurjassotValènciaSpain Sorbonne Université Universitéde Technologie de CompiègneLaboratoire Transformations Intégrées de La Matière Renouvelable(UTC/ESCOMEA 4297 TIMR)Centre de recherches RoyallieuCS 6031960203Compiègne CedexFrance Campus Isla Teja Institute of PharmacyFaculty of SciencesUniversidad Austral de Chile5090000ValdiviaChile

The aims of this work turn towards the valorization of the underutilized raw Sugar Beet Pulp by-product to produce white Cellulose Microfibers(CMFs),and its potential effect as a reinforcement for the development of High-Density Polyethylene(HDPE)*** CMFs were first obtained by subjecting raw SBP to alkali and bleaching *** characterization techniques were performed to confirm the successful removal of the amorphous compounds from the surface of individual fibers,including SEM,XrD,TGA,and FT-Ir *** CMF loadings(5–10 wt%)were incorporated as bio-fillers into HDPE polymer to evaluate their reinforcing ability in comparison to raw and alkali-treated SBP using twin-screw extrusion followed by injection ***–(Ethylene–Butene)–Styrene Three-Block Co-Polymer Grafted with Maleic Anhydride was used as a compatibilizer to improve the interfacial adhesion between fibers and the ***,mechanical,and rheological properties of the produced composite samples were *** was found that the Young’s modulus were gradually increased with increasing of fibers loadings,with a maximum increase of 30%and 26%observed for composite containing 10 wt%of CMFs and raw SBP,respectively,over neat ***,the use of coupling agent enhances the ductile behavior of the *** was also found that all fiber improves the hardness and toughness behavior of all reinforced composites as well as the complex modulus particularly at 10 wt%.The thermal stability slightly increases with the addition of *** study demonstrates a new route for the valorization of SBP *** fibers can be considered as a valuable bio-fillers candidate for the development of composite materials with enhanced properties.

关键词： Sugar beet pulp By-product-Cellulose HDPE Coupling agent Composite Mechanical and rheological properties