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Scorpiones,Scolopendra and Gekko Inhibit Lung Cancer Growth and Metastasis by Ameliorating Hypoxic Tumor Microenvironment via pI3K/AKT/mTOR/HIF-1αSignaling pathway

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Chinese journal of Integrative Medicine 2024年第9期30卷 799-808页

作者： MAO Qi-yuan WANG Xue-qian lin Fei YU Ming-wei FAN Hui-ting ZHENG Qi LIU Lan-chun ZHANG Chu-chu LI Dao-rui lin Hong-sheng Department of Oncology Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing100053China Department of Oncology Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing100010China Department of Cardiology Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing100053China Institute of Traditional Chinese Medicine Information China Academy of Chinese Medical SciencesBeijing100700China

Objective:To investigate whether Buthus martensii karsch(Scorpiones),Scolopendra subspinipes mutilans ***(Scolopendra)and Gekko gecko linnaeus(Gekko)could ameliorate the hypoxic tumor microenvironment and inhibit lung cancer growth and metastasis by regulating phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin/hypoxia-inducible factor-1α(pI3K/AKT/mTOR/HIF-1α)signaling ***:Male C57BL/6j mice were inoculated with luciferase labeled LL/2-luc-M38 cell suspension to develop lung cancer models,with rapamycin and cyclophosphamide as positive *** methyl cellulose solutions of Scorpiones,Scolopendra and Gekko were administered intragastrically as 0.33,0.33,and 0.83 g/kg,respectively once daily for 21 *** expression were detected every 7 days after inoculation,and tumor growth curves were *** was performed to determine CD31 and HIF-1αexpressions in tumor tissue and microvessel density(MVD)was *** blot was performed to detect the expression of pI3K/AKT/mTOR/HIF-1αsignaling pathway-related ***-linked immunosorbent assay was performed to detect serum basic fibroblast growth factor(bFGF),transforming growth factor-β1(TGF-β1)and vascular endothelial growth factor(VEGF)in ***:Scorpiones,Scolopendra and Gekko prolonged the survival time and inhibited lung cancer metastasis and expression of HIF-1α(all ppiones,Scolopendra and Gekko inhibited the phosphorylation of AKT and ribosomal protein S6 kinase(p70S6K)(pppression of CD31,MVD,bFGF,TGF-β1 and VEGF compared with the model group(pppiones,Scolopendra and Gekko all showed beneficial effects on lung cancer by ameliorating the hypoxic tumor microenvironment via pI3K/AKT/mTOR/HIF-1αsignaling pathway.

关键词： Scorpiones Scolopendra Gekko dredging collaterals and activating blood Chinese medicine of worms lung cancer hypoxic tumor microenvironment phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin/hypoxia-inducible factor-1α signaling pathway

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Frequency-dependent ferroelectric and electrocaloric properties in barium titanate-based ceramics based on Maxwell relations

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journal of Advanced Dielectrics 2024年第2期14卷 54-62页

作者： Wanting Shu Hong Li Yanli Huang Cong lin Xiao Wu Min Gao Tengfei lin Chunlin Zhao College of Materials Science and Engineering Fuzhou University Fuzhou 350108P.R.China College of photonic and Electronic Engineering Fujian Normal University Fuzhou 350117P.R.China

In this work,the frequency dependence of ferroelectric and electrocaloric properties in barium titanate-based ceramics was studied based on Maxwell *** is found that the maximum and remnant polarization will decrease while the coercive field increases a lot with rising frequency from 0.1 to 10 Hz,indicating that polarization rotation and domain switching become difficult at high *** electrocaloric properties show the different frequency dependence at different phase *** entropy change(ΔS)and adiabatic temperature change(ΔT)are similar around/above Curie temperature(TCT,showing tiny frequency ***,ΔS andΔT display the obvious frequency dependence below T_(C),especially in the orthorhombic–tetragonal phase-transition region with a stable ferroelectric phase,and this frequency dependence becomes more obvious under a low-electric *** is also found that increasing the frequency can weaken the electric field dependence of electrocaloric *** work gives a general profile of frequency dependence for electrocaloric properties in ferroelectric ceramics.

关键词： Electrocaloric properties ferroelectric ceramics barium titanate frequency dependence

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Modelling dynamic pantograph loads with combined numerical analysis

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Railway Engineering Science 2024年第1期32卷 81-94页

作者： F.F.jackson R.Mishra j.M.Rebelo j.Santos p.Antunes j.pombo H.Magalhaes L.Wills M.Askill School of Computing and Engineering University of HuddersfieldHuddersfieldUK School of Computing and Engineering Institute of Railway ResearchUniversity of HuddersfieldHuddersfieldUK IDMEC Instituto Superior TecnicoUniversidade de LisboaLisbonPortugal ISEL Instituto Politecnico de LisboaLisbonPortugal Hitachi Rail Newton AycliffeUK Wabtec/Brecknell Willis ChardUK

Appropriate interaction between pantograph and catenary is imperative for smooth operation of electric *** heights of overhead lines to accommodate level crossings,overbridges,and tunnels pose significant challenges in maintaining consistent current collection performance as the pantograph aerodynamic profile,and thus aerodynamic load changes significantly with operational *** research aims to analyse the global flow characteristics and aerodynamic forces acting on individual components of an HSX pantograph operating in different configurations and orientations,such that the results can be combined with multibody simulations to obtain accurate dynamic insight into contact ***,computational fluid dynamics simulations are used to investigate the pantograph component loads in a representative setting,such as that of the recessed cavity on a Class 800 *** an aerodynamic perspective,this study indicates that the total drag force acting on non-fixed components of the pantograph is larger for the knuckle-leading orientation rather than the knuckle-trailing,although the difference between the two is found to reduce with increasing pantograph *** the aerodynamic loads acting on individual components with multibody tools allows for realistic dynamic insight into the pantograph *** results obtained show how considering aerodynamic forces enhance the realism of the models,leading to behaviour of the pantograph-catenary contact forces closely matching that seen in experimental tests.

关键词： pantograph-catenary interaction pantograph aerodynamics Computational fluid dynamics pantograph loads Current collection performance

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Half a century after their discovery:Structural insights into exonuclease and annealase proteins catalyzing recombineering

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Engineering Microbiology 2024年第1期4卷 39-54页

作者： Lucy j.Fitschen Timothy p.Newing Nikolas p.johnston Charles E.Bell Gökhan Tolun School of Chemistry and Molecular Bioscience and Molecular HorizonsUniversity of WollongongWollongongNSWAustralia The ARC Training Centre for Cryo-electron Microscopy of Membrane proteins University of WollongongWollongongNSWAustralia Faculty of Science University of Technology SydneyUltimoNSW 2007Australia Department of Biological Chemistry and pharmacology The Ohio State University College of MedicineColumbusOH 43210

Recombineering is an essential tool for molecular biologists,allowing for the facile and efficient manipulation of bacterial genomes directly in cells without the need for costly and laborious in vitro manipulations involving restriction *** main workhorses behind recombineering are bacteriophage proteins that promote the single-strand annealing(SSA)homologous recombination pathway to repair double-stranded DNA *** there have been several reviews examining recombineering methods and applications,comparatively few have focused on the mechanisms of the proteins that are the key players in the SSA pathway:a 5′→3′exonuclease and a single-strand annealing protein(SSAp or“annealase”).This review dives into the structures and functions of the two SSA recombination systems that were the first to be developed for recombineering in ***:the RecET system from *** Rac prophage and the𝜆Red system from bacteriophageλ.By comparing the structures of the RecT and Red𝛽annealases,and the RecE and𝜆Exo exonucleases,we provide new insights into how the structures of these proteins dictate their *** the sequence conservation of the𝜆λExo and RecE exonucleases gives more profound insights into their critical functional ***,as recombineering accelerates and evolves in the laboratory,a better understanding of the mechanisms of the proteins behind this powerful technique will drive the development of improved and expanded capabilities in the future.

关键词： Recombineering Redβ λExo RecE RecT protein structure Annealase Exonuclease

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pd pt VO_(x)/CeO_(2)-ZrO_(2):Highly efficient catalysts with good sulfur dioxide-poisoning reversibility for the oxidative removal of ethylbenzene

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journal of Environmental Sciences 2024年第4期138卷 153-166页

作者： jia Wang Yuxi Liu jiguang Deng lin jing Xiuqing Hao Xing Zhang Xiaohui Yu Hongxing Dai Beijing Key Laboratory for Green Catalysis and Separation Key Laboratory of Beijing on Regional Air Pollution ControlKey Laboratory of Advanced Functional MaterialsEducation Ministry of ChinaLaboratory of Catalysis Chemistry and NanoscienceDepartment of Chemical EngineeringFaculty of Environment and LifeBeijing University of TechnologyBeijing 100124China

The pdptVO_(x)/CeO_(2)-ZrO_(2)(pdptVO_(x)/CZO)catalysts were obtained by using different approaches,and their physical and chemical properties were determined by various *** activities of these materials in the presence of H_(2)O or SO_(2)were evaluated for the oxidation of ethylbenzene(EB).The pdptVO_(x)/CZO sample exhibited high catalytic activity,good hydrothermal stability,and reversible sulfur dioxide-poisoning performance,over which the specific reaction rate at 160℃,turnover frequency at 160℃(TOF_(pd or pt)),and apparent activation energy were 72.6 mmol/(g_(pt)·sec)or 124.2 mmol/(g_(pd)·sec),14.2 sec^(-1)(TOF_(pt))or 13.1 sec^(-1)(TOF_(pd)),and 58 k j/mol,*** large EB adsorption capacity,good reducibility,and strong acidity contributed to the good catalytic performance of pdptVO_(x)/*** activity of pdptVO_(x)/CZO decreased when 50 ppm SO_(2)or(1.0 vol.%H_(2)O+50 ppm SO_(2))was added to the feedstock,but was gradually restored to its initial level after the SO_(2)was cut *** good reversible sulfur dioxide-resistant performance of pdptVO_(x)/CZO was associated with the facts:(i)the introduction of SO_(2)leads to an increase in surface acidity;(ii)V can adsorb and activate SO_(2),thus accelerating formation of the SO_(x)^(2-)(x=3 or 4)species at the V and CZO sites,weakening the adsorption of sulfur species at the pdpt active sites,and hence protecting the pdpt active sites to be not poisoned by SO_(2).EB oxidation over pdptVO_(x)/CZO might take place via the route of EB→styrene→phenyl methyl ketone→benzaldehyde→benzoic acid→maleic anhydride→CO_(2)and H_(2)O.

关键词： Ceria-zirconia Supported palladium-platinum-vanadium catalyst Volatile organic compound Ethylbenzene oxidation Sulfur dioxide resistance

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Microstructure evolution and phase transformation of the mushy zone in a quenchedβ-solidifying TiAl alloy

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journal of Materials Science & Technology 2024年第2期169卷 28-41页

作者： Fuqiang Zhang Xianfei Ding Leming Xu Xin Feng Hai Nan jianping He Yongfeng Liang junpin lin State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China Cast Titanium Alloy R&D Center Beijing Institute of Aeronautical MaterialsBeijing 100095China

This study investigates the phase constitutions and transformations that occur in the mushy zone and in the adjacent phase fields of a directionally solidified Ti-44Al-8Nb-1Cr alloy via quenching *** results indicate that the mushy zone consists of unmeltedβdendrites and interdendritic liquid,whose formation can be attributed to the difference in melting point aroused by local heterogeneity in ***βdendrite is composed of numerous subgrains with various *** quenching,theβdendrite transforms into Widmanstättenαvia a precipitation reaction,owing to the decreasing cooling rate caused by heat transfer from the surrounding ***,after quenching,the interdendritic liquid is transformed intoγ*** the singleβphase field and the lower part of the mushy zone,a massive transformation ofβtoγ***,in theβ+αphase field,bothβandαphases are retained to ambient *** the heating process,the transformation ofα→βgives rise to the formation ofβvariants,which affects the orientation ofβdendrites in the mushy *** growth kinematics of theα→βtransformation was elucidated,revealing the preferential growth directions of111and112forβ***,this study presents an illustration of the formation process of the mushy zone and the microstructural evolution during the heating and quenching process.

关键词： Titanium aluminides Mushy zone Quenching Electron backscattering diffraction phase transformation

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Impact of device resistances in the performance of graphene‑based terahertz photodetectors

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Frontiers of Optoelectronics 2024年第2期17卷 87-97页

作者： O.Castelló Sofía M.López Baptista K.Watanabe T.Taniguchi E.Diez j.E.Velázquez-pérez Y.M.Meziani j.M.Caridad j.A.Delgado-Notario Department of Applied physics University of Salamanca37008 SalamancaSpain Unidad de Excelencia en Luz y Materia Estructurada(LUMES) University of Salamanca37008 SalamancaSpain Research Center for Electronic and Optical Materials National Institute for Materials Science1-1 NamikiTsukuba 305-0044Japan Research Center for Materials Nanoarchitectonics National Institute for Materials Science1-1 NamikiTsukuba 305-0044Japan Nanotechnology Group USAL-NanolabUniversity of Salamanca37008 SalamancaSpain

In recent years,graphene field-effect-transistors(GFETs)have demonstrated an outstanding potential for terahertz(THz)photodetection due to their fast response and *** features are essential to enable emerging THz applications,including 6G wireless communications,quantum information,bioimaging and ***,the overall performance of these photodetectors may be utterly compromised by the impact of internal resistances presented in the device,so-called access or parasitic *** this work,we provide a detailed study of the influence of internal device resistances in the photoresponse of high-mobility dual-gate GFET *** dual-gate architectures allow us to fine tune(decrease)the internal resistance of the device by an order of magnitude and consequently demonstrate an improved responsivity and noise-equivalent-power values of the photodetector,*** results can be well understood by a series resistance model,as shown by the excellent agreement found between the experimental data and theoretical *** findings are therefore relevant to understand and improve the overall performance of existing high-mobility graphene photodetectors.

关键词： Graphene THz photodetector Field-effect transistor plasmonic

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Copernicrinus zamorae *** ***.,the oldest thiolliericrinid crinoid(Crinoidea,Echinodermata) from the Bajocian strata of Algeria,Africa

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journal of palaeogeography 2024年第2期13卷 237-251页

作者： Bartosz j.pιachno Madani Benyoucef Fayc al Mekki Mohammed Adaci Imad Bouchemla Sreepat jain Marcin Krajewski Mariusz A.Salamon Faculty of Biology Institute of BotanyJagiellonian University in KrakowGronostajowa Street 930-387 KrakowPoland Laboratoire de Géomatique Ecologie et EnvironnementMustapha Stambouli University of MascaraDZ-29000 MascaraAlgeria Abou Bekr Belkaid University of Tlemcen TlemcenAlgeria Department of Geological Sciences Faculty of Biological and Agricultural SciencesMouloud Mammeri University of Tizi-OuzouTizi-OuzouAlgeria Adama Science and Technology University School of Applied Natural SciencesDepartment of Applied GeologyP.O.Box 1888AdamaEthiopia Faculty of Geology Geophysics and Environmental ProtectionAGH University of Science and TechnologyAl.A.Mickiewicza 30PL-30-059KrakowPoland Faculty of Natural Sciences University of Silesia in KatowiceBedzinska Street 60PL-41-200 SosnowiecPoland

The thiolliericrinids(Thiolliericrinidae) are comatulids(Comatulida),which retained their stalks as ***,we report a centrodorsal from the Bajocian strata(Middle jurassic) of the Djebel Kérdacha area,northwestern Algeria(Africa).It is the first thiolliericrinid report from outside of Europe and also the oldest representative of the Thiolliericrinidae whose first occurrence is from the *** crinoid is assigned to Copernicrinus zamorae *** *** reported new taxon shows strong similarities with the stemless ‘true’comatulids,Solanocrinites;the only difference is the presence of a facet to the stem in *** closest comparable thiolliericrinid to Copernicrinus is the Oxfordian Thiolliericrinus,interpreted as a descendant of the *** origin and overview of all thiolliericrinid representatives are also discussed herein.

关键词： Thiolliericrinidae Crinoids Coral facies Bajocian jurassic Algeria Southern Tethys margin

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Bulking Up the Bay-position Substituents Enables Enhanced Selectivity of C_(s)‑Symmetric Boron Subphthalocyanine−Subnaphthalocyanine Hybrids

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precision Chemistry 2024年第4期2卷 161-181页

作者： Nina F.Farac Alan j.Lough Timothy p.Bender Department of Chemical Engineering and Applied Chemistry University of TorontoTorontoOntario M5S 3E5Canada Department of Chemistry University of TorontoTorontoOntario M5S 3H6Canada Department of Materials Science and Engineering University of TorontoTorontoOntario M5S 3E4Canada Department of Mechanical and Industrial Engineering University of TorontoTorontoOntario M5S 3G8Canada

The precise synthesis of subporphyrinoid hybrids withπ-expanded topologies and unique material properties plays a promising role in the design of functional ***,selective,and controllable routes to boron subphthalocyanine−subnaphthalocyanine hybrids,Bsub(pc_(3‑p)-Nc_(p))s,are desirable for this purpose yet synthetically challenging due to random mixtures of C_(s-),C_(3v-),and,in some cases,C_(1)-symmetric compounds that form during traditional statistical mixed ***,we addressed this issue by developing a sterically driven mixed cyclotrimerization with enhanced selectivity for the targeted C_(s)-symmetric hybrid and complete suppression of sterically crowded macrocyclic *** process,coupled with a rationally designed precursor bearing bulky phenyl substituents,enabled the synthesis and characterization of bay-position phenylated ph_(2)-(R_(p))_(8)Bsub(pc_(2)-Nc_(1))hybrids with halogens(Rp=Cl or F)in their peripheral isoindole *** selectivity ranged between 59 and 72%with remarkable yields,significantly higher than that of conventional mixed *** findings were augmented by theoretical calculations on precursor Lewis basicity as guiding principles into hybrid macrocycle ***,the incorporation of unfused phenyl groups and halogen atoms into the hybrid framework resulted in fine-tuned optical,structural,electronic,and electrochemical *** straightforward approach achieved improved selectivity and controlled narrowing of the product distribution,affording the efficient synthesis of structurally sophisticated Bsub(pc_(2)-Nc_(1))*** then expands the library of 3-dimensionalπ-extended macrocycles for use in a range of applications,such as in optoelectronic devices with precisely tailored optical properties.

关键词： subphthalocyanine hybrids low-symmetry aromatic macrocycle selective cyclotrimerization sterically driven chemistry broad absorption material properties

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Fe-N-C core-shell catalysts with single low-spin Fe(Ⅱ)-N_(4)species for oxygen reduction reaction and high-performance proton exchange membrane fuel cells

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journal of Energy Chemistry 2024年第6期93卷 538-546,I0013页

作者： Yan Wan linhui Yu Bingxin Yang Caihong Li Chen Fang Wei Guo Fang-Xing Xiao Yangming lin Xiamen Key Laboratory of Rare Earth photoelectric Functional Materials Xiamen Institute of Rare Earth MaterialsHaixi InstituteChinese Academy of SciencesXiamen 361021FujianChina CAS Key Laboratory of Urban pollutant Conversion Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021FujianChina Fujian Institute of Research on the Structure of Matter Chinese Academy of SciencesFuzhou 350002FujianChina College of Materials Science and Engineering Fuzhou UniversityNew CampusMinhou 350108FujianChina College of Chemistry and Materials Science Fujian Normal UniversityFuzhou 350117FujianChina

Fe-N-doped carbon materials(Fe-N-C)are promising candidates for oxygen reduction reaction(ORR)relative to pt-based catalysts in proton exchange membrane fuel cells(pEMFCs).However,the intrinsic contributions of Fe-N_(4)moiety with different chemical/spin states(e.g.D1,D2,D3)to ORR are unclear since various states coexist *** the present work,Fe-N-C core-shell nanocatalyst with single lowspin Fe(Ⅱ)-N_(4)species(D1)is synthesized and identified with ex-situ ultralow temperature Mossbauer spectroscopy(T=1.6 K)that could essentially differentiate various Fe-N_(4)states and invisible Fe-O *** quantifying with CO-pulse chemisorption,site density and turnover frequency of Fe-N-C catalysts reach 2.4×10^(-9)site g^(-1)and 23 e site~(-1)s^(-1)during the ORR,***-wave potential(0.915V_(RHE))of the Fe-N-C catalyst is more positive(approximately 54 mV)than that of pt/***,we observe that the performance of pEMFCs on Fe-N-C almost achieves the 2025 target of the US Department of Energy by demonstrating a current density of 1.037 A cm^(-2)combined with the peak power density of 0,685 W cm^(-2),suggesting the critical role of Fe(Ⅱ)-N_(4)site(D1).After 500 h of running,pEMFCs still deliver a power density of 1.26 W cm^(-2)at 1.0 bar H_(2)-O_(2),An unexpected rate-determining step is figured out by isotopic labelling experiment and theoretical *** work not only offers valuable insights regarding the intrinsic contribution of Fe-N_(4)with a single spin state to alkaline/acidic ORR,but also provides great opportunities for developing high-performance stable pEMFCs.

关键词： Fuel cells Oxygen reduction reaction Non-platinum group metals(pGMs) Isotopic labelling Active site TOF

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