检索结果-南通市图书馆

nano Research 2024年第10期17卷 9135-9140页

作者： Chia-Wei yeh nathaniel Wright Chelsea Loh nabeen Chu Yadong Wang nancy E.and Peter C.Meinig School of Biomedical Engineering Cornell UniversityKimball Hall 290Ithaca 14853USA Human Biology Healthand Society.College of Human EcologyCornell UniversityIthaca 14853USA

Controlled delivery of proteins and other biologics is a growing medium of therapy for diseases previously *** we report a self-assembling,tunable vesicle for the controlled delivery of growth factors and *** made of heparin and a biocompatible polycation,PEAD,forms the core of the vesicle;lipids form the membrane of the *** call this vesicle lipocoacervate(LipCo),which has a high affinity for growth factors and cytokines due to *** is a tunable protein delivery *** vesicle size is controlled through polymer and salt *** functionalization enables potential for targeting capabilities with long-term storage through ***,the controlled delivery of therapeutics also avoids high toxicity to treated cells in *** we report on these key principles of LipCo assembly and design.

关键词： complex coacervate drug delivery protein delivery heparin lipid particle

Geophysical fluid dynamics in the hypergravity field

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Mechanica Sinica 2024年第6期40卷 3-10页

作者： Harry yeh School of Civil&Construction Engineering Oregon State UniversityCorvallisOR97331USA

Hypergravity can be realized by creating a field imposed by centripetal acceleration in a centrifuge *** an apparatus is often used to test soil response in geotechnical engineering *** we present the potential usage of a centrifuge apparatus to study various topics in *** scaling law associated with hydrodynamics is first reviewed,and the advantage of controlling the body force is *** of the perceived disadvantages in such experiments is the unwanted presence of the Coriolis effect in the ***,we propose exploiting this effect to our advantage to study geophysical fluid-dynamic problems that occur particularly in the equatorial region.

关键词： Hypergravity Scaling Geophysical fluid dynamics Centrifuge

The impact of maternal immune activation on the morphology and electrophysiological properties of postnatally-born neurons in the offspring

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

neural Regeneration Research 2024年第2期19卷 399-400页

作者： Emilio j.Galván Angelica Zepeda Departamento de Farmacobiología CINVESTAV Unidad Sur CdMxMéxico、Centro de Investigaciones sobre el EnvejecimientoCIE-CinvestavCdMxMéxico Departamento de Medicina Genómica y Toxicología Ambiental Instituto de Investigaciones BiomédicasUniversidad Nacional Autónoma de MéxicoUNAMCdMxMéxico

Pregnancy comes with a combination of physical changes and physiological immunosuppression that increases the susceptibility of women to pathogens and in turn,rises the prevalence of infectious diseases.

关键词： prevalence activation impact

A Multi-Objective Optimization for Locating Maintenance Stations and Operator Dispatching of Corrective Maintenance

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2024年第6期79卷 3519-3547页

作者： Chao-Lung Yang Melkamu Mengistnew Teshome Yu-Zhen yeh Tamrat Yifter Meles Department of Industrial Management National Taiwan University of Science and TechnologyTaipie106Taiwan Department of Industrial Engineering University of Gondar Institute of TechnologyGondar196Ethiopia

In this study,we introduce a novel multi-objective optimization model tailored for modern manufacturing,aiming to mitigate the cost impacts of operational disruptions through optimized corrective *** to our approach is the strategic placement of maintenance stations and the efficient allocation of personnel,addressing a crucial gap in the integration of maintenance personnel dispatching and station *** model uniquely combines the spatial distribution of machinery with the expertise of operators to achieve a harmonious balance between maintenance efficiency and *** core of our methodology is the nSGA Ⅲ+Dispatch,an advanced adaptation of the non-Dominated Sorting Genetic Algorithm Ⅲ(nSGA-Ⅲ),meticulously designed for the selection of maintenance stations and effective operator *** method integrates a comprehensive coding process,crossover operator,and mutation operator to efficiently manage multiple *** empirical testing,including a detailed analysis from a taiwan region electronic equipment manufacturer,validated the effectiveness of our approach across various scenarios of machine failure frequencies and operator *** findings reveal that the proposed model significantly outperforms current practices by reducing response times by up to 23%in low-frequency and 28.23%in high-frequency machine failure scenarios,leading to notable improvements in efficiency and cost ***,it demonstrates significant improvements in oper-ational efficiency,particularly in selective high-frequency failure contexts,while ensuring substantial manpower cost savings without compromising on operational *** research significantly advances maintenance strategies in production environments,providing the manufacturing industry with practical,optimized solutions for diverse machine malfunction ***,the methodologies and principles developed in this study have pote

关键词： Corrective maintenance multi-objective optimization non-dominated sorting genetic algorithmⅢ operator allocation maintenance station location

Wettability,reactivity,and interface structure in Mg/ni system

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

journal of Magnesium and Alloys 2024年第2期12卷 659-672页

作者： S.Terlicka n.Sobczak Ł.Maj P.Darłak j.j.Sobczak Institute of Metallurgy and Materials Science Polish Academy of Sciences25 Reymonta Str.KrakowPoland Faculty of Foundry Engineering AGH University23 Reymonta Str.KrakowPoland

The sessile drop method was applied to the experimental investigation of the wetting and spreading behaviors of liquid Mg drops on pure ni *** comparison,the experiments were performed in two variants:(1)using the Capillary Purification(CP)procedure,which allows the non-contact heating and squeezing of a pure oxide-free Mg drop;(2)by classical Contact Heating(CH)*** high-temperature tests were performed under isothermal conditions(CP:760℃for 30 s;CH:715℃for 300 s)using Ar+5 wt%H_(2) *** the sessile drop tests,images of the Mg/ni couples were recorded by CCD cameras(57 fps),which were then applied to calculate the contact angles of metal/substrate *** and transmission electron microscopy analyses,both coupled with energy-dispersive X-ray spectroscopy,were used for detailed structural characterization of the solidified *** was found that an oxide-free Mg drop obtained by the CP procedure showed a wetting phenomenon on the ni substrate(an average contact angleθnng and good wetting over the ni substrate(θ_((CP))~20°in 5 s)to form a final contact angle ofθ_(f(CP))~18°.In contrast,a different wetting behavior was observed for the CH procedure,where the unavoidable primary oxide film on the Mg surface blocked the spreading of liquid Mg showing apparently non-wetting behavior after 300 s contact at the test ***,in both cases,the deep craters formed in the ni substrates under the Mg drops and significant change in the structure of initially pure Mg drops to Mg-ni alloys suggest a strong dissolution of ni in liquid Mg and apparent values of the final contact angles measured for the Mg/ni system.

关键词： Magnesium-based alloys Sessile drop tests Capillary purification procedure Wettability Reactivity Contact angle

TransCell:In Silico Characterization of Genomic Landscape and Cellular Responses by Deep Transfer Learning

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Genomics, Proteomics & Bioinformatics 2024年第2期22卷 157-170页

作者： Shan-ju yeh Shreya Paithankar Ruoqiao Chen jing Xing Mengying Sun Ke Liu jiayu Zhou Bin Chen Department of Pediatrics and Human Development Michigan State UniversityGrand RapidsMI 49503USA Department of Pharmacology and Toxicology Michigan State UniversityGrand RapidsMI 49503USA Department of Computer Science and Engineering Michigan State UniversityEast LansingMI 48824USA

Gene expression profiling of new or modified cell lines becomes routine today;however,obtaining comprehensive molecular characterization and cellular responses for a variety of cell lines,including those derived from underrepresented groups,is not trivial when resources are *** gene expression to predict other measurements has been actively explored;however,systematic investigation of its predictive power in various measurements has not been well ***,we evaluated commonly used machine learning methods and presented TransCell,a two-step deep transfer learning framework that utilized the knowledge derived from pan-cancer tumor samples to predict molecular features and *** these models,TransCell had the best performance in predicting metabolite,gene effect score(or genetic dependency),and drug sensitivity,and had comparable performance in predicting mutation,copy number variation,and protein ***,TransCell improved the performance by over 50%in drug sensitivity prediction and achieved a correlation of 0.7 in gene effect score ***,predicted drug sensitivities revealed potential repurposing candidates for new 100 pediatric cancer cell lines,and predicted gene effect scores reflected BRAF resistance in melanoma cell ***,we investigated the predictive power of gene expression in six molecular measurement types and developed a web portal(http://***/transcell/)that enables the prediction of 352,000 genomic and cellular response features solely from gene expression profiles.

关键词： Genomics Transcriptomics Cancer dependency Drug repurposing Transfer learning

A hydrodynamic modelling of wave-activated bodies for wavelet marine regions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Clean Energy 2024年第2期8卷 35-47页

作者： j.S.Peh Mohammed W.Muhieldeen n.H.Shuaib Mechanical Engineering Department Faculty of EngineeringTechnology&Built EnvironmentUCSI UniversityKuala Lumpur56000Malaysia MTC Engineer Sdn.Bhd Shah AlamSelangorMalaysia

Recently,most wave energy research has targeted sea areas with high power density under extreme wave conditions for *** trend often leads to higher energy costs for wave power ***,many marine areas with low power density,characterized by wavelet conditions and less destructive forces than extreme wave conditions,remain ***,this study aimed to propose a wave-activated body model for sea regions with wavelet *** wave-activated body design process encompassed site selection,parameter determination,geometry design,comparison and performance evaluation using the AnSYS®AQWA *** results indicated that the proposed device achieved the desired heave motion,with an amplitude range of 1.2 to-2.5 m,validating its potential for deployment in marine regions with wavelet ***,while the proposed design is optimized for wavelet conditions,it was found to have potential limitations in extreme wave *** observation emphasizes the challenge of formulating a generalized design suitable for both ***,it is pivotal for wave-activated body designs to be customized based on the specific ocean conditions they target,underscoring the need for specialized designs of wave energy converters that consider the unique wave characteristics of their deployment sites.

关键词： wave energy converter South China sea renewable and sustainable energy wavelet AnSYS AQWA hydrodynamic wave-activated bodies

Mucopolysaccharidosis typeⅢB:a current review and exploration of the AAV therapy landscape

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

neural Regeneration Research 2024年第2期19卷 355-359页

作者： Courtney j.Rouse Victoria n.jensen Coy D.Heldermon Lacerta Therapeutics AlachuaFLUSA University of Florida College of Medicine GainesvilleFLUSA

Mucopolysaccharidoses typeⅢB is a rare genetic disorder caused by mutations in the gene that encodes for *** results in the aggregation of heparan sulfate polysaccharides within cell lysosomes that leads to progressive and severe debilitating neurological *** treatment options are expensive,limited,and presently there are no approved cures for mucopolysaccharidoses typeⅢ***-associated virus gene therapy has significantly advanced the field forward,allowing researchers to successfully design,enhance,and improve potential *** group recently published an effective treatment using a codon-optimized triple mutant adeno-associated virus 8 vector that restores n-acetyl-alpha-glucosaminidase levels,auditory function,and lifespan in the murine model for mucopolysaccharidoses typeⅢB to that seen in healthy ***,we review the current state of the field in relation to the capsid landscape,adeno-associated virus gene therapy and its successes and challenges in the clinic,and how novel adenoassociated virus capsid designs have evolved research in the mucopolysaccharidoses typeⅢB field.

关键词： adeno-associated virus central nervous system gene therapy heparan sulfate immune response mucopolysaccharidoses type IIIB n-acetyl-alpha-glucosaminidase newborn screening

Subsequent bilateral acute carpal tunnel syndrome due to tophaceous infiltration:A case report

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World journal of Clinical Cases 2024年第2期12卷 418-424页

作者： Soon-Chin Yeoh Wen-Tien Wu jui-Tien Shih Wen-Chin Su Kuang-Ting yeh School of Medicine Tzu Chi UniversityHualien 970374TaiwanChina Department of Orthopedics Hualien Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationHualien 970473TaiwanChina Department of Orthopaedic Surgery Taoyuan Armed Forces General HospitalTaoyuan 325208TaiwanChina Department of Clinical Education Hualien Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationHualien 970473TaiwanChina Graduate Institute of Clinical Pharmacy Tzu Chi UniversityHualien 970374TaiwanChina

BACKGROUnD Acute carpal tunnel syndrome(ACTS)is commonly caused by repetitive strain,trauma,or inflammatory ***,ACTS due to tophaceous gout is a clinical event that remains poorly understood and *** rare manifestation necessitates prompt diagnosis and intervention to prevent irreversible *** SUMMARY A 51-year-old man who had poorly controlled hyperuricemia presented with ACTS secondary to tophaceous *** of rapid symptom progression symptoms and severe median nerve compression within 3 mo,the patient underwent emergency decompression surgery for both wrists at different time ***,he exhibited complete recovery of sensory and motor functions,with no recurrence at long-term *** outcomes were achieved through immediate decompression surgery,anti-inflammatory medications,postoperative active and passive range-of-motion exercises,and intermittent wrist *** diagnosis and surgical intervention,when necessary,are crucial for preventing long-term complications and obtaining favorable outcomes in patients with *** optimal gout management strategy involving pharmacologic therapy and lifestyle modifications may help minimize ACTS recurrence and improve clinical *** Prompt surgical intervention and optimal gout management are crucial for preventing irreversible nerve damage and ACTS recurrence.

关键词： Acute carpal tunnel syndrome Gout Surgical decompression Range-of-motion exercises Case report