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利用药房给出的数据测量青光眼患者用药物降眼压治疗的持续性和忠诚度

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世界核心医学期刊文摘(眼科学分册) 2006年第4期 16-16页

作者： Wilensky j. Fiscella R.G. Carlson A.M. 王海燕 Dr.University of Ilinois at Chicago 1855West Taylor Chicago IL 60612 United States

PURPOSE: Determine persistence and adherence of glaucoma patients to therapeutic regimens of prostaglandin/-prostamide-class IOP-lowering medications. DESIGN: Retrospective, population-based study. METHODS: Glaucoma patients in the IMS Health LifeLink database with a pharmacy claimfor latanoprost (n = 1567), travoprost (n = 381), or bimatoprost (n = 476) between September, 2001 and March, 2002 who had no claims for IOP-lowering medication in the previous 180 days, and who were persistent during the first 90 days of therapy. Values reported in the quantity dispensed and days supply fields of the database were used in an algorithmthat corrected anomalous data and adjusted days supply to calculate the main outcome measures, persistence, and adherence to therapy. RESULTS: The percentage of patients persistent for the 12-month observation period was 69.4%(1087/1567) for those prescribed latanoprost, 70.6%(269/381) for those prescribed travoprost, and 68.1%(324/467) for those prescribed bimatoprost. Mean adherence for patients prescribed latanoprost was 75.4%of the year, for those prescribed travoprost, 77.1%of the year, and for those prescribed bimatoprost, 78.2%of the year. The mean number of days adherent for bimatoprost-treated patients (291.2 days)was significantly greater than for latanoprost-treated patients (281.0 days), and not remarkably different from travoprost-treated patients (287.0 days). CONCLUSIONS: Overall, patients in this study who were taking IOP-lowering prostaglandin/prostamide medications had a mean adherence rate of 76%on average, suggesting that opportunities remain for improvement of adherence to therapeutic regimens for glaucoma treatment with prostamides and prostaglandins.

关键词：降眼压曲伏前列素拉坦前列素拉坦前列腺素青光眼忠诚度患者持续性药物

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老年患者巨细胞性动脉炎和心血管疾病的关系

世界核心医学期刊文摘（心脏病学分册） 2005年第7期1卷 34-34页

作者： Ray j.G. Mamdani M.M. Geerts W.H. 宁宁 Dr.Department of Medicine Inner City Health St. Michael's Hospital 30Bond StreetTorontoOnt. M5B1W8 Canada

Objective: To explore the association between giant cell arteritis(GCA) and subsequent cardiovascular disease in older adults. Design: Population based retrospective cohort study. Selling: The entire province of Ontario, Canada. Participants: Patients aged 66 years and older with newly diagnosed GCA(n=1141), osteoarthritis(n=172 953), or neither(n=200 000). Patients with neither were randomly selected from the general population and formed the control group. Main outcome measures: The primary composite outcome was based on a subsequent diagnosis or surgical treatment for coronary artery disease, stroke, peripheral arterial disease, or aneurysm or dissection of the aorta. Results: The composite end point was more common in seniors with GCA(12.1/1000 person-years) than in patients with osteoarthritis(7.3/1000 person-years) or neither condition(5.3/1000 person-years). The adjusted hazard ratio for cardiovascular disease was 1.6(95%confidence interval(CI) 1.1 to 2.2) in patients with GCA versus patients with osteoarthritis, and 2.1(95%CI 1.5 to 3.0) in patients with GCA versus unaffected controls. Conclusions: Older adults with GCA appear to be at increased risk for developing cardiovascular disease. Whether an aggressive approach to cardiovascular risk factor modification is particularly beneficial in these patients remains to be determined.

关键词：心血管疾病巨细胞性动脉炎心血管风险骨性关节炎外周动脉回顾性队列研究加拿大安大略

建立初级卒中中心的修订和更新意见来自脑卒中联盟的总结声明

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国际脑血管病杂志 2012年第7期20卷 481-495页

作者： Mark j. Alberts Richard E. Latchaw Andy jagoda Lawrence R Wechsler Todd Crocco Mary G. George E.S. Connolly Barbara Mancini Stephen Prudhomme Daryl Gress Mary E. jensen Robert Bass Robert Ruff Kathy Foell Rocco A. Armonda Marian Emr Margo Warren jim Baranski michael D. Walker 黄志超(译) 张霞(译) 尤寿江(译) 曹勇军(译) 刘春风(译) 代表脑卒中联盟苏州大学附属第二医院神经内科 215004

背景和目的自从2000年脑卒中联盟发布首份关于建立初级卒中中心的推荐意见以来，初级卒中中心的组建和认证工作已出现迅速发展。本文的目的在于修订和更新我们关于初级卒中中心的推荐意见以反映最新资料和经验。方法我们使用MEDLINE和Pu... 详细信息

背景和目的自从2000年脑卒中联盟发布首份关于建立初级卒中中心的推荐意见以来，初级卒中中心的组建和认证工作已出现迅速发展。本文的目的在于修订和更新我们关于初级卒中中心的推荐意见以反映最新资料和经验。方法我们使用MEDLINE和PubMed数据库回顾了相关文献（2000年3月至2011年1月），主要针对急性卒中的诊断、治疗和护理。如果发现有效且相关，同样对原始文献、汇总分析和其他治疗指南进行回顾并纳入分析。标明证据等级以反映当前指南发展的实际情况。结果基于文献回顾以及针对初级卒中中心的经验，一些要素的重要性已得到进一步的加强，同时增加了几个新的领域。这些内容包括：（1）急诊卒中团队的重要性；（2）配备遥测监控的卒中单元的重要性；（3）MRj和弥散加权序列进行脑成像的实施；（4）用磁共振血管成像或CT血管成像对脑血管系统进行评价；（5）心脏影像学检查；（6）康复治疗的早期启动；（7）由独立机构进行的认证，包括实地考察和疾病评价指标。结论基于上述证据，初级卒中中心的某些要素对于改善急性卒中患者的诊治特别重要。其他要素则集中于脑、脑血管系统和心脏的影像学检查。这些新的要素也许能改善在初级卒中中心接受诊治的卒中患者的治疗和转归。

关键词：脑血管病疾病管理卒中中心卒中单元

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光滑及粗糙明槽湍流流动大涡模拟

水动力学研究与进展（A辑） 2000年第2期15卷 191-201页

作者：何子干 WRodi jFrohlich 大连理工大学辽宁大连116023 InstituteofHydromechanics

采用大涡模拟 (L arge Eddy Simulation)方法和 Smagorinsky亚格子模型数值计算了光滑及粗糙明槽湍流运动。以槽高为参考长度的雷诺数分别为 30 0 0 ,2 2 80 0和 10 5,数值离散方法为有限体积法 ,自由面的处理使用了简单了刚盖假定 ,固... 详细信息

采用大涡模拟 (L arge Eddy Simulation)方法和 Smagorinsky亚格子模型数值计算了光滑及粗糙明槽湍流运动。以槽高为参考长度的雷诺数分别为 30 0 0 ,2 2 80 0和 10 5,数值离散方法为有限体积法 ,自由面的处理使用了简单了刚盖假定 ,固壁面采用了壁函数。与低雷诺数直接模拟 (Direct Simulation)和物理实验结果相比 ,本文数模呈现了良好的预测效果 ,估计的湍流宏尺度 (Macroscale of Turbulence)证实了固壁附近台劳假设的局限性。

关键词：明槽流动大涡模拟有限体积法光滑粗糙湍流

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开放教育:一个有待进一步研究的领域

中国远程教育 2021年第2期 46-58,77页

作者： [德]奥拉夫·扎瓦克奇-里克特 [加]黛安·康拉德阿拉斯·博兹库尔特坚吉兹·哈坎·艾登斯韦尼亚·贝登利耶郑仁星约阿希姆·斯图特乔治·韦利特西亚诺斯丽莎·玛丽·布拉斯科梅丽莎·邦德安德里亚·布朗斯艾丽莎·布鲁恩卡莱娜·多尔西马可·卡尔兹迈克尔·克雷斯亚萨尔·孔达奇维多利亚·马林克斯汀·梅伯格沃尔夫冈·穆斯肯斯索姆·奈杜阿德南·卡尤姆詹妮弗·罗伯茨艾伯特·桑格拉弗兰克·森约·洛各洛帕特丽夏·j.斯莱格·范·特伦肖俊洪(译) 德国奥尔登堡大学开放教育研究中心COER团队德国奥尔登堡卡尔·冯·奥西茨基大学土耳其阿纳多卢大学德国埃尔朗根-纽伦堡弗里德里希·亚历山大大学日本国际基督教大学加拿大皇家大学欧洲远程E-Learning网络协会英国伦敦大学学院德国海德堡教育大学杜伊斯堡-埃森大学中东技术大学德国汉堡大学斐济南太平洋大学美国宾夕法尼亚州立大学南非大学西班牙加泰罗尼亚奥贝塔大学美国东卡罗来纳州立大学中国汕头开放大学不详

本文阐述高等教育背景下开放教育的内容。文章首先介绍开放教育的起源及其理论基础,随后根据远程开放学习研究的宏观、中观和微观层次框架讨论远程开放学习、开放教育实践、开放学术、开放教育资源、慕课、先前学习认定、学习者特征和... 详细信息

本文阐述高等教育背景下开放教育的内容。文章首先介绍开放教育的起源及其理论基础,随后根据远程开放学习研究的宏观、中观和微观层次框架讨论远程开放学习、开放教育实践、开放学术、开放教育资源、慕课、先前学习认定、学习者特征和开放教育国际化等主题的内容。最后从宏观、中观和微观层面提出今后的研究方向。

关键词：开放教育开放学习远程教育灵活学习在线学习开放教育资源国际化

充血性心力衰竭住院患者中硫胺素缺乏症的患病率

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世界核心医学期刊文摘（心脏病学分册） 2006年第5期2卷 47-47页

作者： Hanninen S.A Darling P.B Sole M.j. M.E. Keith 王亭忠 Cardiovascular and Thoracic Surgery 8 Bond Wing St. Michael’s HospitalMB5 1W8Dr.

OBjECTIVES: The purpose of this study was to determine the prevalence of thiamin deficiency(TD) in a cross section of hospitalized congestive heart failure(CHF) patients and to investigate factors that contribute to its development. BACKGROUND: Thiamin deficiency manifests as symptoms of CHF and, therefore, may worsen existing heart failure. Congestive heart failure patients may be at increased risk for TD as a result of diuretic-induced urine thiamin excretion, disease severity, malnutrition, and advanced age. METHODS: Erythrocyte thiamin pyrophospate concentrations, using high-performance liquid chromatography,were measured in 100 CHF patients and compared to 50 control subjects. Variables including diuretics(type and dose), left ventricle dysfunction, New York Heart Association functional classification, creatinine clearance, thiamin intake(diet and supplements), malnutrition, appetite ratings, and age were related to TD using univariate statistics and multiple logistic regression analysis. RESULTS: Thiamin deficiency was more prevalent in CHF patients(33% ) compared to control subjects(12% )(p=0.007). Thiamin deficiency was related to urine thiamin loss(p=0.03), non-use of thiamin-containing supplements(p=0.06), and preserved renal function(p=0.05). Increased urinary thiamin loss(μ g/g creatinine)was found to be the only significant positive predictor of thiamin status on multiple logistic regression analysis(p=0.03). CONCLUSIONS: One-third of hospitalized CHF patients were TD. In contrast to previous studies, increased urinary losses of thiamin were predictive of improved thiamin status. Thiamin supplementation may be protective against TD in the clinical setting. Future studies are warranted to determine if thiamin supplementation improves thiamin status and disease severity in CHF patients.

关键词：充血性心力衰竭患者住院患者硫胺素患病率缺乏症 Logistic回归分析高效液相色谱法左心室功能不全 CHF患者营养不良

AME证据系列001--转化医学协会:脓毒症诊断和早期识别的临床实践指南

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临床与病理杂志 2016年第10期36卷 1467-1476页

作者： Zhongheng Zhang Nathan j.Smischney Haibo Zhang Sven Van Poucke Panagiotis Tsirigotis jordi Rello Patrick M.Honore Win Sen Kuan juliet june Ray jiancang Zhou You Shang Yuetian Yu Christian jung Chiara Robba Fabio Silvio Taccone Pietro Caironi David Grimaldi Stefan Hofer George Dimopoulos Marc Leone Sang-Bum Hong Mabrouk Bahloul Laurent Argaud Won Young Kim Herbert D.Spapen jose Rodolfo Rocco 张建成(译) 尚游(译) 钟鸣(校) Department of Emergency Medicine Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016 Department of Critical Care Medicine Jinhua Hospital of Zhejiang UniversityJinhua Zhejiang 321000 Department of Anesthesiology Mayo ClinicRochesterMNUSA Keenan Research Center for Biomedical Science of St.michael's Hospital Departments of Anesthesia and PhysiologyInterdepartmental Division of Critical Care MedicineUniversity of TorontoTorontoONCanada Departments of Anesthesiology Critical CareEmergency Medicine and Pain TherapyZiekenhuis Oost-Limburgy GenkBelgium 2nd Department of Internal Medicine Attikcon University HospitalMedical SchoolNational and Kapodistrian University of AthensAthensGreece CIBERES Vall d'Hebron Institut of ResearchUniversitat Autonoma de BarcelonaSpain Universitair Ziekenhuis Brussely Vrije Universiteit Brussel Brussels BrusselsBelgium Emergency Medicine Department National University HospitalNational University Health SystemSingapore and the Department of SurgeryYong Loo Lin School of MedicineNational University of SingaporeSingapore DeWitt Daughtry Family Department of Surgery Jackson Memorial HospitalUniversity of Miami Leonard M.Miller School of MedicineMiamiFLUSA Department of Critical Care Medicine Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016 Department of Critical Care Medicine Union HospitalTongji Medical CollegueHuazhong University of Science and TechnologyWuhan 430022 Department of Critical Care Medicine Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200001 University Hospital Dusseldorf Heinrich-Heine-University DusseldorfMedical FacultyDivision of CardiologyPulmonology and Vascular MedicineDusseldorfGermany Neurosciences Critical Care Unit Addenbrooke's HospitalCambridgeUK Department of Intensive Care Hopital ErasmeUniversite Libre de Bruxelles(ULB)BrusselsBelgium Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti Fondazione IRCCS Ca'Granda-Ospedale

脓毒症是一种由感染引起的异质性疾病,感染触发了一系列复杂的局部或者全身的免疫炎症反应,引起多器官功能衰竭,发病率和病死率显著升高。由于至今仍然没有诊断脓毒症的金标准,所以脓毒症的临床诊断仍是一个难题。因此,脓毒症的临床诊... 详细信息

脓毒症是一种由感染引起的异质性疾病,感染触发了一系列复杂的局部或者全身的免疫炎症反应,引起多器官功能衰竭,发病率和病死率显著升高。由于至今仍然没有诊断脓毒症的金标准,所以脓毒症的临床诊断仍是一个难题。因此,脓毒症的临床诊断需要不断改变来满足临床和研究的要求。然而,尽管有许多新型的生物标记和筛选工具去预测脓毒症发生的风险,但是这些措施的诊断价值和有效性不足以让人满意,并且没有充分的证据去建议临床使用这些新技术。因此,脓毒症的临床诊断标准需要定期更新去适应不断产生的新证据。这篇综述旨在呈现当前脓毒症的诊断和早期识别方面的最新研究证据。临床运用不同的诊断方法的推荐意见依赖于推荐、评价、发展和评估分级体系(Grades of Recommendation Assessment,Development and Evaluation,GRADE),因为大部分的研究是观察性研究,并没有对这些方法进行可靠评估,采用的是两步推理方法。未来需要更多研究来确认或者反驳某一特殊的指标检测,同时应该直接采用相关病人的结果数据。

关键词：脓毒症早期识别诊断

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欧洲中央银行（ECB）

城市环境设计 2020年第4期 162-173页

作者：沃尔夫·狄·普瑞克斯 Magdalena Baczkowska Markus Baumann michael Beckert johannes Behrens Hilde Benda Marcelo Bernardi Nico Boyer jan Brosch Timo Carl Anna Rita Cedroni jasmin Dieterle Sabrina Dlugosch jan Ruben Fischer Brigitte Fuchs Sergio Gonzales Gesine G?rlich Martin Gruber Guthu Hallstein Sebastian Haffner Simone Hainz Sascha Hempel Rob Henderson Emanuele Iacono Martin jelinek Rashmi Krishna jois Ivana jug Frank Pascal Kaul Matt Kirkham Daniela Kr?hnert Bernward Krone Christian Labud Anke Lammert Monika Lyzyczka Steven M Christian Maeder Dimitra Mamou Ariane Marx Christoph Maurer Matthias Niemeyer Martin Oberascher Ross Olson Renate Ott Gerhard Pfeiler Ellen Pietrzyk james Pike Robert Pippan jakob Przybylo Anna Ptaszynska Stephanie Rathgeber Carmen Renz Salome Reves Donna Riedel Akvile Rimantaite Pete Rose Penelope Rüttimann Stefan Rutzinger Oliver Sachse Kristina Schinegger Benjamin Schmidt Marita Schnepper Thomas Siegl Ebru Simsek-Lenk Denise Sokolowski Augustin Solorzano Anja Sorger Andrea St?llenwerk Ernst Stockinger Crystal K.H Tang jürgen Tiltmann Markus Tritthart josef Tr?ster Günther Weber Andreas Weissenbach Clemens Werb judith Werkh?user Markus Wings Eva Wolf Barbara Zeleny Thomas Zengger Zeyneb Badur Fabien Barthelemey Oliver Cassik Alejandro Corena Alexander Daxb?ck Mario Dign?ss Helmut Fr?tscher Annegret Haider Christian Halm Gregor Kassl Gernot K?fer Alexander Laber Anita Lischka Rangel Malinov Oliver Martinz Philipp Munz Barbara Roller Nicole Rumpler Wolfgang Ruthensteiner Stefan Salchinger Stefan Schadenb?ck Thomas Schwed Hannes Schwed Eckart Schwerdtfeger Sylvia Spernbauer Christoph Treberspurg johannes Weigl Paul Raftery European Central Bank/RobertMetsch Markus Pillhofer

项目大事记/CHRONOLOGY竞赛/Competition:第一阶段/Phase 1:2003;第二阶段/Phase 2:2003-2004;修改阶段/Revision Phase:2004;优化阶段/Optimization Phase:2005规划设计起始时间/Start of Planning:2005前期工程/Preliminary Site Works:2008主体施工/Main Construction Works:2010竣工/Completion:2014项目参数/PROjECT DATA用地面积/Site Area:120 000m2建筑毛面积/Gross Floor Area:185 000m2

关键词：

Sub-percent precision measurement of neutrino oscillation parameters with jUNO

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Chinese Physics C 2022年第12期46卷 28-49页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad Rizwan Ahmed Sebastiano Aiello Muhammad Akram Abid Aleem Fengpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop joão Pedro Athayde Marcondes de André Didier Auguste Weidong Bai Nikita Balashov Wander Baldini Andrea Barresi Davide Basilico Eric Baussan Marco Bellato Antonio Bergnoli Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano jose Busto Ilya Butorov Anatael Cabrera Barbara Caccianiga Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Riccardo Callegari Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao jun Cao Rossella Caruso Cédric Cerna Chi Chan jinfan Chang Yun Chang Guoming Chen Pingping Chen Po-An Chen Shaomin Chen Xurong Chen Yixue Chen Yu Chen Zhiyuan Chen Zikang Chen jie Cheng Yaping Cheng Yu Chin Cheng Alexey Chetverikov Davide Chiesa Pietro Chimenti Artem Chukanov Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Flavio Dal Corso Olivia Dalager Christophe De La Taille Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Dmitry Dolzhikov Georgy Donchenko jianmeng Dong Evgeny Doroshkevich Marcos Dracos Frédéric Druillole Ran Du Shuxian Du Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Donghua Fan Lei Fan jian Fang Wenxing Fang Marco Fargetta Dmitry Fedoseev Zhengyong Fei Li-Cheng Feng Qichun Feng Richard Ford Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Arsenii Gavrikov Marco Giammarchi Nunzio Giudice Maxim Gonchar Guanghua Gong Hui Gong Yuri Gornushkin Alexandre Göttel Marco Grassi Vasily Gromov Minghao Gu Xiaofei Gu Yu Gu Mengyun Guan Yuduo Guan Nunzio Guardone Cong Guo jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yang Han Miao He Wei He Tobias Heinz Patrick Hellmuth Yuekun Heng Rafael Herrera YuenKeung Ho Yerevan Physics Institute YerevanArmenia UniversiéLibre de Bruxelles BrusselsBelgium Universidade Estadual de Londrina LondrinaBrazil Pontificia Universidade Catolica do Rio de janeiro Rio de JaneiroBrazil Pontificia Universidad Católica de Chile SantiagoChile Universidad Tecnica Federico Santa Maria ValparaisoChile Beijing Institute of Spacecraft Environment Engineering BeijingChina Beijing Normal University BeijingChina China Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North China Electric Power University BeijingChina School of Physics Peking UniversityBeijingChina Tsinghua University BeijingChina University of Chinese Academy of Sciences BeijingChina jilin University ChangchunChina College of Electronic Science and Engineering National University of Defense TechnologyChangshaChina Chongqing University ChongqingChina Dongguan University of Technology DongguanChina jinan University GuangzhouChina Sun Yat-Sen University GuangzhouChina Harbin Institute of Technology HarbinChina University of Science and Technology of China HefeiChina The Radiochemistry and Nuclear Chemistry Group in University of South China HengyangChina Wuyi University JiangmenChina Shandong University JinanChinaand Key Laboratory of Particle Physics and Particle Irradiation of Ministry of EducationShandong UniversityQingdaoChina Institute of Modern Physics Chinese Academy of SciencesLanzhouChina Nanjing University NanjingChina Guangxi University NanningChina East China University of Science and Technology ShanghaiChina School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina Wuhan University WuhanChina Xi'an jiaotong University Xi'anChina Xiamen University XiamenChina School of Physics and Microelectronics Zhengzhou UniversityZhengzhou

jUNO is a multi-purpose neutrino observatory under construction in the south of *** publication presents new sensitivity estimates for the measurement of the △m_(31)^(2),△m_(21)^(2),sin^(2)θ_(12),and sin^(2)θ_(13) oscillation parameters using reactor antineutrinos,which is one of the primary physics goals of the *** sensitivities are obtained using the best knowledge available to date on the location and overburden of the experimental site,the nuclear reactors in the surrounding area and beyond,the detector response uncertainties,and the reactor antineutrino spectral shape constraints expected from the TAO satellite *** is found that the △m_(21)^(2) and sin^(2)θ_(12) oscillation parameters will be determined to 0.5%precision or better in six years of data *** the same period,the △m_(31)^(2) parameter will be determined to about 0.2%precision for each mass ordering *** new precision represents approximately an order of magnitude improvement over existing constraints for these three parameters.

关键词： neutrino oscillation reactor antineutrino precision measurement jUNO