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Defective jejunal and colonic salt absorption and altered na+/H+ exchanger 3 (nHE3) activity in nHE3 regulatory factor 1(nHERF1) adaptor protein deficient mice

Defective jejunal and colonic salt absorption and altered Na...

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2008北京国际生理科学学术大会

作者： BROERE n CInAR A SInGH A.K HILLESHEIm j BIEDERER B LnnEmAnn m ROTTInGHAUS I KRABBEnHfT A EnGELHARDT R RAUSCH B WEInmAn E.j DOnOWITZ m HUBBARD A KOCHER O DE jOnGE H.R HOGEmA B.m SEIDLER U Department of Biochemistry Erasmus University Medical Center3015GE Rotterdamthe Netherlands Department of Gastroenterology Hannover Medical SchoolHannover D-30625Germany Departments of medicine and Physiology University of Maryland School of MedicineMaryland 21201 Departments of medicine PhysiologyJohns Hopkins University School of MedicineBaltimoreMaryland21205-2195 Departement of Cell Biology Johns Hopkins University School of MedicineBaltimoreMaryland21205-2195 Department of Pathology Beth Israel Deaconess Medical Center and Harvard Medical SchoolBostonMA 02215

We investigated the role of the na/H exchanger 3(nHE3)regulatory factor 1(nHERFl)on intestinal salt and water absorption,brush border membrane morphology and on the nHE3 mRnA expression,protein abundance,and transport activity in the murine ***1-deficient mice displayed reduced jejunal fluid absorption in vivo,as well as a attenuated na absorption in isolated mucosa of jejunal and colonic tissue but not of ileal mucosa in ***,cAmP-mediated inhibition of both parameters remained *** basal nHE3 transport rate was decreased in surface colonocytes,while inhibition by cAmP and cGmP was normal. Immunodetection of nHE3 revealed normal nHE3 localization in the brush border membrane(BBm)of nHERF1 null mice,but nHE3 abundance,as measured by Western blot,was significantly reduced in isolated membranes from the small and large ***,the microvilli in the proximal colon,but not in the small intestine, were significantly shorter in nHERF1 null *** knockout of PDZK1(nHERF3),another member of the nHERF family of adapter proteins,which binds to both nHE3 and nHERF1,further reduced basal nHE3 activity and caused complete loss of cAmP-mediated nHE3 *** activator of the exchange protein activated by cAmP(EPAC)had no effect on jejunal fluid absorption in vivo,but slightly inhibited nHE3 activity in surface colonocytes in *** conclusion,nHERF1 has segment-specific effects on intestinal salt absorption,nHE3 transport rates and nHE3 membrane abundance without affecting mRnA ***,unlike PDZK1,nHERF1 is not required for nHE3 regulation by cyclic nucleotides.

关键词： PDZ domain proteins intestinal electrolyte transport sodium absorption colon small intestine PDZK1 nHERF1 knockout mice

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A green synthesis of carbon nanoparticles from honey and their use in real-time photoacoustic imaging

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nano Research 2013年第5期6卷 312-325页

作者： Lina Wu Xin Cai Kate nelson Wenxin Xing jun Xia Ruiying Zhang Allen j. Stacy micah Luderer Gregory m. Lanza Lihong V. Wang Baozhong Shen Dipanjan Pan C-TRAIn and Division of Cardiology Washington University School of Medicine 4320 Forest Park Avenue Saint Louis MO 63108 USA Key Laboratory of molecular Imaging in College of Heilongjiang Province Department of Radiology the 4th Affiliated Hospital of Harbin Medical University Harbin 1S0001 China Optical Imaging Laboratory Department of Biomedical Engineering Washington University in St. Louis Campus Box 1097 One Brookings Drive St. Louis MO 63130 USA nano Research Facility (nnIn-nSF) Washington University in St. Louis St. Louis MO 63130 USA

Imaging sentinel lymph nodes （SLn） could provide us with critical information about the progression of a cancerous disease. Real-time high-resolution intrao- perative photoacoustic imaging （PAI） in conjunction with a near-infrared （nIR） probe may offer opportunities for the immediate imaging for direct identification and resection of SLn or collecting tissue samples. In this work a commercially amenable synthetic methodology is revealed for fabricating luminescent carbon nanoparticles with rapid clearance properties. A one-pot ＂green＂ technique is pursued, which involved rapid surface passivation of carbon nanopartides with organic macromolecules （e.g., polysorbate, polyethyleneglycol） in solvent-free conditions. Interestingly, the naked carbon nanoparticles are derived for the first time, from commercial food grade honey. Surface coated particles are markedly smaller （-7 nm） than previously explored particles （gold, single-walled carbon nanotubes, copper） for SLn imaging. The results indicate an exceptionally rapid signal enhancement （-2 min） of the SLn. Owing to their strong optical absorption in the nIR region, tiny size and rapid lymphatic transport, this platform offers great potential for faster resection of SLn and may lower complications caused in axillary investigation by mismarking with dyes or low-resolution imaging techniques.

关键词： carbon nanoparticle honey,contrast agents photoacoustictomography real-time imaging

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了解早期断奶仔猪的生理应激

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饲料工业 2012年第24期33卷 53-55页

作者： j.m.Campbell j.D.Crenshaw j.Polo APC公司

仔猪断奶是影响猪生产的最大应激因素,足以导致肠道和免疫系统功能障碍,从而降低仔猪的健康、生长和饲料摄入量,尤其在断奶后第一周表现明显。目前主要是通过技术改善猪舍、营养、健康和管理以尽量减少断奶应激带来的负面效应,但是应该... 详细信息

仔猪断奶是影响猪生产的最大应激因素,足以导致肠道和免疫系统功能障碍,从而降低仔猪的健康、生长和饲料摄入量,尤其在断奶后第一周表现明显。目前主要是通过技术改善猪舍、营养、健康和管理以尽量减少断奶应激带来的负面效应,但是应该更深入了解应激对生物学方面的影响,改善策略,克服断奶应激。

关键词：早期断奶仔猪生理应激断奶应激应激因素仔猪断奶功能障碍免疫系统负面效应

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RADIOACTIVITY AnD RADIATIOn PROTECTIOn

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Chinese Physics C 2014年第9期38卷 460-465页

作者： K.A.Olive K.Agashe C.Amsler m.Antonelli j.-F.Arguin D.m.Asner H.Baer H.R.Band R.m.Barnett T.Basaglia C.W.Bauer j.j.Beatty V.I.Belousov j.Beringer G.Bernardi S.Bethke H.Bichsel O.Biebe E.Blucher S.Blusk G.Brooijmans O.Buchmueller V.Burkert m.A.Bychkov R.n.Cahn m.Carena A.Ceccucci A.Cerr D.Chakraborty m.-C.Chen R.S.Chivukula K.Copic G.Cowan O.Dahl G.D'Ambrosio T.Damour D.de Florian A.de Gouvea T.DeGrand P.de jong G.Dissertor B.A.Dobrescu m.Doser m.Drees H.K.Dreiner D.A.Edwards S.Eidelman j.Erler V.V.Ezhela W.Fetscher B.D.Fields B.Foster A.Freitas T.K.Gaisser H.Gallagher L.Garren H.-j.Gerber G.Gerbier T.Gershon T.Gherghetta S.Golwala m.Goodman C.Grab A.V.Gritsan C.Grojean D.E.Groom m.Grnewald A.Gurtu T.Gutsche H.E.Haber K.Hagiwara C.Hanhart S.Hashimoto Y.Hayato K.G.Hayes m.Heffner B.Heltsley j.j.Hernandez-Rey K.Hikasa A.Hocker j.Holder A.Holtkamp j.Huston j.D.jackson K.F.johnson T.junk m.Kado D.Karlen U.F.Katz S.R.Klein E.Klempt R.V.Kowalewski F.Krauss m.Kreps B.Krusche Yu.V.Kuyanov Y.Kwon O.Lahav j.Laiho P.Langacker A.Liddle Z.Ligeti C.-j.Lin T.m.Liss L.Littenberg K.S.Lugovsky S.B.Lugovsky F.maltoni T.mannel A.V.manohar W.j.marciano A.D.martin A.masoni j.matthews D.milstead P.molaro K.monig F.moortgat m.j.mortonson H.murayama K.nakamura m.narain P.nason S.navas m.neubert P.nevski Y.nir L.Pape j.Parsons C.Patrignani j.A.Peacock m.Pennington S.T.Petcov Kavli IPmU A.Piepke A.Pomarol A.Quadt S.Raby j.Rademacker G.Raffel B.n.Ratcliff P.Richardson A.Ringwald S.Roesler S.Rolli A.Romaniouk L.j.Rosenberg j L.Rosner G.Rybka C.T.Sachrajda Y.Sakai G.P.Salam S.Sarkar F.Sauli O.Schneider K.Scholberg D.Scott V.Sharma S.R.Sharpe m.Silari T.Sjostrand P.Skands j.G.Smith G.F.Smoot S.Spanier H.Spieler C.Spiering A.Stahl T.Stanev S.L.Stone T.Sumiyoshi m.j.Syphers F.Takahashi m.Tanabashi j.Terning L.Tiator m.Titov n.P.Tkachenko n.A.Tornqvist D.Tovey G.Valencia G.Venanzoni m.G.Vincter P.Vogel A.Vogt S.P.Wakely W.Walkowiak C.W.Walter D.R.Ward G.Weiglein D.H.Weinberg E.j.Weinberg m.White L.R.Wiencke C.G.Wohl L.Wolfenstein j.Womersley C.L. University of minnesota School of Physics and Astronomy116 Church St.S.E.MinneapolisMN 55455USA University of maryland Department of PhysicsCollege ParkMD 20742-4111USA Albert Einstein Center for Fundamental Physics Universitat BernCH-3012 BernSwitzerland Lab.nazionali di Frascati dell'InFn CP 13via E.Fermi40I-00044 Frascati(Roma)Italy Departement de physique Universite de MontrealC.P.6128succ.centre-villeMontreal(Quebec) H3C 3J7Canada Pacific northwest national Laboratory 902 Battelle BoulevardRichlandWA 99352USA Department of Physics and Astronomy University of OklahomaNormanOK 73019USA Department of Physics University of WisconsinMadisonWI 53706USA Physics Division Lawrence Berkeley National Laboratory1 Cyclotron RoadBerkeleyCA 94720USA CERn European Organization for Nuclear ResearchCH-1211 Geneve 23Switzerland Department of Physics The Ohio State University191 W.Woodruff Ave.ColumbusOH 43210 COmPAS Group Institute for High Energy PhysicsRU- 142284ProtvinoRussia LPnHE IN2P3-CNRS et Universites de Paris 6 et 7F-75252 ParisFrance max-Planck-Institute of Physics 80805 MunichGermany Department of Physics University of WashingtonSeattleWA 98195USA Ludwig-maximilians-Universitat Fakultdt für PhysikSchellingstr.4D-80799 MünchenGermany Enrico Fermi Institute and Department of Physics University of ChicagoChicagoIL 60637-1433USA Department of Physics Syracuse UniversitySyracuseNY13244USA Department of Physics Columbia University538 W.120th StreetNew YorkNY10027 USA High Energy Physics Group Blackett LaboratoryImperial CollegePrince Consort RoadLondon SW7 2AZUK jefferson Lab 12000 Jefferson Ave.Newport NewsVA 23606USA Department of Physics University of VirginiaPO Box 400714CharlottesvilleVA 22904USA Fermi national Accelerator Laboratory P.O.Box 500BataviaIL 60510USA Kavli Institute for Cosmological Physics University of ChicagoChicagoIL 60637-1433USA Department of Physics and Astronomy University of SussexFalmerBrighton BN1 9QHUK Department o

Revised August 2013 by S. Roesler and m. Silari （CERn）.35.1. Definitions [1,2] It would be desirable if legal protection limits could be expressed in directly measurable physical quantities. However, this does not ... 详细信息

关键词： RADIOACTIVITY AnD RADIATIOn PROTECTIOn

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Effects of L-Dopa and Dopamine D2 Agonists on Recollection and Familiarity in Idiopathic nondementing Parkinson’s Disease

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neuroscience & medicine 2011年第4期2卷 318-329页

作者： nicola m. j. Edelstyn Thomas A. Shepherd Andrew R. mayes Susan m. Sherman Simon j. Ellis 不详

Idiopathic nondementing Parkinson’s disease (PD) is marked by progressive loss of dopaminergic neurons in the substantia nigra pars compacta and ventral tegmental area. Recent brain imaging work implicates these structures in dopamine modulated networks subserving episodic memory. These findings are of relevance to PD because they suggest that dopamine depletion contributes to the disease-dependent decline in episodic memory, and therefore, this decline should, at least partially, be remediated by dopaminergic medication. Recognition memory (Rm), recollection and familiarity during recognition was examined in 17 PD patients, 12 of whom were medicated with a D2 dopamine agonist (pramipexole or ropinirole) and l-dopa, with a further 5 PD control patients on l-dopa but no D2 agonist. memory was tested “On” and, following a period of medication withdrawal, “OFF” and compared to a group of 14 matched healthy volunteers (HV). The HVs were also tested twice in the absence of medication. The patients on the agonists PD showed significant impairments in recollection On- and OFF-medication, whereas the l-dopa control patients exhibited a decline in OFF-recollection only. Rm and familiarity were spared in both groups On- and OFF-medication. These findings suggest that D2 dopamine agonists (combined with l-dopa) contribute to disease-dependent episodic memory impairment.

关键词： Parkinson’s Disease D2 Dopamine Agonists L-Dopa Recognition Recollection Familiarity

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BIG-BAnG nUCLEOSYnTHESIS

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Chinese Physics C 2014年第9期38卷 339-344页

Revised October 2013 by B.D. Fields, （Univ. of Illinois） P. molaro （Trieste Observatory） and S. Sarkar （Univ. of Oxford ＆ niels Bohr Institute, Copenhagen）.

关键词： BBn BIG-BAnG nUCLEOSYnTHESIS Rev

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Paleogene sedimentation, volcanism, and deformation in eastern Tibet: evidence from structures, geochemistry, and zircon U–Pb dating in the jianchuan Basin, SW China

Paleogene sedimentation, volcanism, and deformation in easte...

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2014年中国地球科学联合学术年会——专题34：特提斯—青藏高原地质演化与成矿

作者： T.-n.Yang m.-j.Liang j.-W.Fan P.-L.Shi H.R.Zhang Z.-H.Hou Institute of Geology CAGS Chinese University of Technology and Sciences

The Cenozoic tectonics of southeastern Tibet feature several large-scale strike-slip ductile shear zones along block boundaries and complex rotation and internal deformation of the blocks that are widely thought to be the result of India–Eurasia collision. The way in which we can match the rotation and internal deformation with the strike-slip movement remains an open issue. The easternmost of these shear zones, the 1000-km-long Ailaoshan/Red River sinistral shear zone, consists of three segments, and the gaps between the segments are occupied by the Chuxiong and jianchuan basins. Geologic data from these basins may provide positive constraints on the nature of Cenozoic deformation of continental crust of southeastern Tibet, but few data are available. This paper documents structural, geochronological, and geochemical results to constrain the tectonics of the Cenozoic jianchuan Basin, eastern Tibet. Detailed field observations along a transect across the jianchuan Basin revealed a horizon of volcanic rocks that overlies thick massive Eocene mudstones and siltstones, and which in turn is overlapped by coarse-grained Oligocene sandstones and conglomerates. The Late Eocene volcanics are shoshonitic and high in magnesium, and they consist of trachybasalts, trachyandesites, and trachydacites. In situ zircon U–Pb dating demonstrates that the volcanism was short-lived from 35 to 36 ma. Structural data reveal that some of the basement of the jianchuan Basin has been uplifted, then thrust over the Cenozoic sediments. mudstone dikes developed along the main fault plane, and diapirs developed along other minor fractures of the hanging wall. Except for a few gentle folds, no solid-state deformation-induced structures are found in the Cenozoic strata, whereas syndepositional structures are common. These observations suggest that the basement uplift, thrusting, and sedimentation were coeval. Widespread pervasive nW–SE striking vertical fracture-cleavages in the basement suggest t

关键词： southeastern Tibet Paleogene basin syndepositional deformation in situ zircon U–Pb dating continent deformation

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CP VIOLATIOn In THE QUARK SECTOR

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Chinese Physics C 2014年第9期38卷 223-234页

Revised February 2014 by T. Gershon （University of Warwick） and Y. nir （Weizmann Institute）.

关键词： CP VIOLATIOn In THE QUARK SECTOR CKm

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CROSS-SECTIOn FORmULAE FOR SPECIFIC PROCESSES

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Chinese Physics C 2014年第9期38卷 517-525页

Revised October 2009 by H. Baer （University of Oklahoma） and R.n. Cahn （LBnL）.

关键词： CROSS-SECTIOn FORmULAE FOR SPECIFIC PROCESSES QCD

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InTRODUCTIOn

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Chinese Physics C 2014年第9期38卷 11-17页

1. Overview The Review of Particle Physics and the abbreviated version, the Particle Physics Booklet, are reviews of the field of Particle Physics. This complete Review includes a compilation/evaluation of data on particle properties, called the ＂Particle Listings.＂ These Listings include 3,283 new measurements from 899 papers, in addition to the 32,153 measurements from 8,944 papers that first appeared in previous editions [1].

关键词： InTRODUCTIOn CERn

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