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Distinct molecular targets of ProEGCG from EGCG and superior inhibition of angiogenesis signaling pathways for treatment of endometriosis

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journal of Pharmaceutical Analysis 2024年第1期14卷 100-114页

作者： Sze Wan hung Massimiliano Gaetani Yiran Li Zhouyurong Tan Xu Zheng Ruizhe Zhang Yang Ding Gene Chi Wai Man Tao Zhang Yi Song Yao Wang jacqueline Pui Wah Chung Tak Hang Chan Roman A.Zubarev Chi Chiu Wang Department of Obstetrics&Gynaecology The Chinese University of Hong KongHong KongChina Division of Physiological Chemistry I Department of Medical Biochemistry and BiophysicsKarolinska InstitutetStockholmSE 17177Sweden Chemical Proteomics Core Facility Department of Medical Biochemistry and BiophysicsKarolinska InstitutetStockholmSE 17177Sweden Unit of Chemical Proteomics Science for Life Laboratory(SciLifeLab)StockholmSE 17177Sweden Center for Reproductive Medicine Henan Key Laboratory of Reproduction and GeneticsThe First Affiliated Hospital of Zhengzhou UniversityZhengzhou450003China Department of Chemistry McGill UniversityMontrealH3A2K6Canada Department of Pharmacological&Technological Chemistry I.M.Sechenov First Moscow State Medical UniversityMoscow119146Russia Reproduction and Development Li Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong KongChina School of Biomedical Sciences The Chinese University of Hong KongHong KongChina Chinese University of Hong kong-Sichuan University joint Laboratory in Reproductive Medicine The Chinese University of Hong KongHong KongChina

Endometriosis is a common chronic gynecological disease with endometrial cell implantation outside the *** is a major pathophysiology in *** previous studies have demonstrated that the prodrug of epigallocatechin gallate(ProEGCG)exhibits superior anti-endometriotic and anti-angiogenic effects compared to epigallocatechin gallate(EGCG).However,their direct binding targets and underlying mechanisms for the differential effects remain *** this study,we demonstrated that oral ProEGCG can be effective in preventing and treating ***,1D and 2D Proteome Integral Solubility Alteration assay-based chemical proteomics identified metadherin(MTDH)and PX domain containing serine/threonine kinase-like(PXk)as novel binding targets of EGCG and ProEGCG,*** simulation and BioLayer interferometry were used to confirm their binding *** results showed that MTDH-EGCG inhibited protein kinase B(Akt)-mediated angiogenesis,while PXk-ProEGCG inhibited epidermal growth factor(EGF)-mediated angiogenesis via the EGF/hypoxia-inducible factor(HIF-1a)/vascular endothelial growth factor(VEGF)*** vitro and in vivo knockdown assays and microvascular network imaging further confirmed the involvement of these signaling ***,our study demonstrated that ProEGCG has superior therapeutic effects than EGCG by targeting distinct signal transduction pathways and may act as a novel antiangiogenic therapy for endometriosis.

关键词： Molecular targets ProEGCG EGCG Angiogenesis Treatment Endometriosis

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Investigation of contact behavior on a model of the dual-mobility artificial hip joint for Asians in different inner liner thicknesses

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World journal of Orthopedics 2024年第4期15卷 321-336页

作者： Taufiq Hidayat Muhammad Imam Ammarullah Rifky Ismail Eko Saputra M Danny Pratama Lamura Chethan k N Athanasius Priharyoto Bayuseno j jamari Department of Mechanical Engineering Universitas Muria KudusKudus 59352Central JavaIndonesia Department of Mechanical Engineering Universitas DiponegoroSemarang 50275Central JavaIndonesia Undip Biomechanics Engineering&Research Centre Universitas DiponegoroSemarang 50275Central JavaIndonesia Center for Biomechanics Biomaterials Biomechatronics and Biosignal Processing Universitas DiponegoroSemarang 50275Central JavaIndonesia Department of Mechanical Engineering Politeknik Negeri SemarangSemarang 50275Central JavaIndonesia Department of Aeronautical and Automobile Engineering Manipal Institute of TechnologyManipalManipal Academy of Higher EducationManipal 576104KarnatakaIndia

BACkGROUND The four components that make up the current dual-mobility artificial hip joint design are the femoral head,the inner liner,the outer liner as a metal cover to prevent wear,and the acetabular *** acetabular cup and the outer liner were constructed of 316L stainless *** the same time,the inner liner was made of ultra-high-molecular-weight polyethylene(UHMWPE).As this new dual-mobility artificial hip joint has not been researched extensively,more tribological research is needed to predict *** thickness of the inner liner is a significant component to consider when calculating the contact *** To make use of finite element analysis to gain a better understanding of the contact behavior in various inner liner thicknesses on a new model of a dual-mobility artificial hip joint,with the ultimate objective of determining the inner liner thickness that was most suitable for this particular type of dual-mobility artificial hip *** In this study,the size of the femoral head was compared between two diameters(28 mm and 36 mm)and eight inner liner thicknesses ranging from 5 mm to 12 *** the finite element method,the contact parameters,including the maximum contact pressure and contact area,have been evaluated in light of the Hertzian contact *** simulation was performed statically with dissipated energy and asymmetric *** types of interaction were surface-to-surface contact and normal contact *** The maximum contact pressures in the inner liner(UHMWPE)at a head diameter of 28 mm and 36 mm are between 3.7-13.5 MPa and 2.7-10.4 MPa,*** maximum von Mises of the inner liner,outer liner,and acetabular cup are 2.4–11.4 MPa,15.7–44.3 MPa,and 3.7–12.6 MPa,respectively,for 28 mm *** the maximum von Mises stresses of the 36 mm head are 1.9-8.9 MPa for the inner liner,9.9-32.8 MPa for the outer liner,and 2.6-9.9 MPa for the acetabular cup.A head with a diameter of 28 mm should have an inner line

关键词： Contact behavior Contact pressure Finite element analysis Dual-mobility Artificial hip joint

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Prophylactic treatment of Lacticaseibacillus paracasei k56 ameliorates asthma by regulating short-chain fatty acid production and Treg differentiation

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Food Science and Human Wellness 2024年

作者： jiaqi Cui Yanfei Hong Wei-Hsien Liu Wen Zhao Xinmei Nan Xuekai Shang Yalan Li Haotian Feng Qiuyue jiang Weilian hung Guiying Peng Inner Mongolia Yili Industrial Group Co.， Ltd. Department of Immunology and Microbiology， School of Life Sciences， Beijing University of Chinese Medicine

Many studies have shown that the development of allergic asthma is associated with intestinal microbiota dysbiosis. Based on the gut-lung axis theory， probiotic intervention may be a potential strategy for respiratory diseases. Lacticaseibacillus paracasei k56 was reported to regulate gut microbiota in mice. However， its effect on allergic asthma has not been reported. In this study， we investigated the effect of the k56 on ovalbumin-induced asthma and its possible mechanisms. Our results showed that k56 reduced asthma symptoms and inflammatory cell infiltration in the lung of asthmatic mice. And k56 regulated the differentiation of helper T cells in the lung and intestine. Results from 16S rRNA gene sequencing showed that k56 prophylaxis significantly elevated the richness of Akkermansia and Burkholderia. Meanwhile， k56 abrogated the decrease in the levels of short-chain fatty acids (SCFAs) in the feces. In addition， a rebound in the mRNA expression of the SCFA receptors was observed after k56 prophylaxis. Notably， the regulatory T cell (Treg) frequencies and the FFAR3 levels were positively correlated. These results suggest that k56 could attenuate asthma， possibly by modulating the intestinal microbiota and regulating Treg differentiation through SCFA metabolized. Our study showed that k56 may be used as a probiotic to prevent pulmonary inflammation and dysbiosis of the intestinal microbiota in allergic asthma.

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Impact of welding equipment on power quality

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China Welding 2024年第3期33卷 44-51页

作者： kovács Attila Molnár judit jármai károly Institute of Physics and Electrical Engineering Department of Electrical and Electronic Engineering Institutional DepartmentUniversity of MiskolcMiskolc H3515Hungary Institute of Energy and Chemical Engineering University of MiskolcMiskolc H3515Hungary

In an industrial facility,many electrical consumers can affect the quality of ***,the freedom from interference sources of these devices and equipment can be crucial for quality and uninterrupted electricity *** welding equipment is also a possible source of *** electrical harmonic injections created by welding equipment into the electrical network can affect the op-eration of other consumers connected to the given distribution points and cause unjustified overheating and shutdowns of some network *** aim of the research is to analyse the current harmonic injection of welding equipment of different types and modes of oper-ation connected to the internal distribution network of the industrial *** effectiveness of the active harmonic filter built into the welding equipment was also examined in the *** results showed that the built-in active harmonic filter of the DC045 laser welding equipment was ineffective because the total harmonic distortion(THD)was about three times the 8%allowed by IEEE 519−2022 *** current harmonic injection of MIG 320 and MM403 type welding equipment was more than five times the permissible value of 5%.The current harmonic distortion of the PLAS140 type plasma-jet cutter equipment was below the 5%value allowed in the standard,thus it com-plied with *** on the measurement results,it can be concluded that the use of protection against harmonics is also necessary for weld-ing ***,proposals were made in the paper to reduce the effect of harmonics.

关键词： electrical transients harmonic distortion electrical network disturbances voltage breaks total harmonic distortion(THD)

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Fe_(3)O_(4)对黄铜矿在酸性硫酸铁溶液中铜溶解氧化还原反应的影响

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Transactions of Nonferrous Metals Society of China 2024年第6期34卷 1965-1975页

作者： kolela j NYEMBWE Elvis FOSSO-kANkEU Frans WAANDERS Martin MkANDAWIRE Didier k NYEMBWE Bhekie B MAMBA Water Pollution Monitoring and Remediation Initiatives Research Group School of Chemical and Minerals EngineeringFaculty of EngineeringNorth-West UniversityPotchefstroomSouth Africa Department of Mining Engineering College of Science Engineering and TechnologyUniversity of South AfricaFlorida Science CampusJohannesburgSouth Africa Department of Metallurgy Faculty of Engineering and Built EnvironmentUniversity of JohannesburgDoornfonteinJohannesburgSouth Africa Department of Chemistry School of Science and TechnologyCape Breton UniversityCanada School of Mining Metallurgy and Chemical EngineeringFaculty of Engineering and the Built EnvironmentUniversity of JohannesburgJohannesburgSouth Africa Institute for Nanotechnology and Water Sustainability College of Science Engineering and TechnologyUniversity of South AfricaFlorida Science CampusJohannesburgSouth Africa

由于钝化层的形成,黄铜矿(CuFeS_(2))在氧化条件下浸出通常具有溶解速率缓慢的特点。为了将黄铜矿浸出过程中的钝化效应降至最低并提高铜的回收率,研究了CuFeS_(2)在不同pH值(1.0、1.5和1.8)和温度(25和50℃)条件下浸出时,向Fe_(2)(SO_(... 详细信息

由于钝化层的形成,黄铜矿(CuFeS_(2))在氧化条件下浸出通常具有溶解速率缓慢的特点。为了将黄铜矿浸出过程中的钝化效应降至最低并提高铜的回收率,研究了CuFeS_(2)在不同pH值(1.0、1.5和1.8)和温度(25和50℃)条件下浸出时,向Fe_(2)(SO_(4))_(3)−H_(2)SO_(4)浸出剂中添加磁铁矿(Fe_(3)O_(4))对铜溶解速率的影响。结果表明,溶液pH值、电位和温度在溶解过程中起着关键作用。在pH 1.8、50℃和400 mV的条件下,Fe_(3)O_(4)−CuFeS_(2)混合体系中铜的回收率达到最大值(70%),而未添加Fe_(3)O_(4)时,CuFeS_(2)中铜的回收率较低(48%)。添加Fe_(3)O_(4)有助于维持较高的氧化还原值。添加Fe_(3)O_(4)还使活化能从79.04 kj/mol降低到53.69 kj/mol。这表明,当Fe_(3)O_(4)存在时,由于形成了更易溶解的中间体斑铜矿(Cu_(5)FeS_(4))和辉铜矿(Cu_(2)S),CuFeS_(2)更易被氧化。两种溶解过程都受到矿物表面的化学控制。此外,对浸出残渣的矿物学分析表明,当无Fe_(3)O_(4)存在时,作为表面钝化物的黄钾铁矾浓度较高。因此,添加Fe_(3)O_(4)减少了钝化层的形成,提升了铜的回收率。

关键词：黄铜矿溶解磁铁矿电偶钝化

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Structural,morphological,optical and antibacterial performances of rare earth(Sm)-doped ZnO nanorods

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journal of Rare Earths 2024年第11期42卷 2119-2127页

作者： A.Ravi j.Samuel S.Sahaya jude Dhas S.Usharani Turibius Simon D.Senthil kumar S.k.jasmin Vijitha A.Sivakumar Raju Suresh kumar C.S.Biju Department of Physics University College of Engineering Department of Physics and Research Centre Malankara Catholic College Manonmaniam Sundaranar University Saveetha School of Engineering Saveetha Institute of Medical and Technical SciencesSaveetha University Department of Chemistry S.I.V.E.T College Department of Biotechnology Vivekanandha College of Arts and Science for Woman (Autonomous) Department of Physics Vel Tech Rangarajan Dr.Sagunthala R & D Institute of Science and Technology Department of Physics & Research Centre Muslim Arts College key Laboratory of High-temperature and High-pressure Study of the Earth's Interior Institute of GeochemistryChinese Academy of Sciences Department of Chemistry College of ScienceKing Saud University Department of Physics St. Alphonsa College of Arts and Science

The significant rise of ultra-violet（UV） radiation and pathogenic infectious bacteria poses a serious threat to global *** researchers' interests are attracted by novel materials with strong UVblocking ability,antibacterial activity and low toxicity to other *** this case,a simple wet chemical method with different annealing temperatures（400,500,and 600℃） was employed to create highly effective rare earth（Sm）-doped ZnO ***（101） plane of wurtzite ZnO shifts towards a lower angle with increasing annealing temperature,according to the X-ray diffraction（XRD） study findings,which additionally establishes the consequence of lattice *** of doublet peaks of Sm 3d(Sm 3d5/2and Sm 3d3/2) in the X-ray photoelectron spectroscopy（XPS） spectrum clearly validates the substitution of Sm3+ions in the 500℃-annealed *** 500℃-annealed nanorods exhibit combined performances of the wide band gap,improved UV absorbance,and vivid green luminescent emission（563 nm）.Additio nally,the nanorods have favorable UV-blocking execution of 96% for UVA at 360 nm,92% for UVB at 320 nm,and 57% for UVC at 225 nm,which is greater than the majority of ZnO-related materials that have been reported up to this *** doping is also appropriate for improving bacterial inhibition against the two studied strains（Escherichia coli and Staphylococcus aureus）,in addition to the intriguing features discussed ***,with maximum inhibition zone diameters of 20±0.72 and 18±0.57 mm,respectively,these nanorods exhibit high inhibitory action against *** and *** bacterial *** rare earth-doped material developed during the current experiment,which was annealed at 500℃,could potentially serve as an effective replacement for UV-blocking and antibacterial material,especially for biomedical applications.

关键词： Bacterial inhibition Metal oxide Rare earth doping UV-Shielding Wet chemical method

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Performance and combustion study of a low heat rejection engine running with biogas–diethyl ether–diesel

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Waste Disposal and Sustainable Energy 2024年第1期6卷 151-162页

作者： Sanjaya k.Mishra Premananda Pradhan Shakti P.jena Department of Mechanical Engineering S‘O’A Deemed to be UniversityBhubaneswar751030India

The present research focuses on addressing the faster depletion of fossil fuels and environmental pollution in addition to the energy crisis that hinders the progress of a *** the current research,waste banana leaves were considered as substrates for biogas *** is taken as the primary fuel in dual fuel(DF)operations to maximize possible diesel *** performance and combustion assessment were executed in a low heat rejection(LHR)engine using 5%diethyl ether by volume blended with diesel(5DEE)as pilot *** combustion attributes of the engine reveal that the apex of net heat release rate(NHRR)curve retarded a bit as compared to apex of base *** peak cylinder pressure was noted to be 6.19 MPa in the LHR engine running with 5DEE+biogas at 11.7°crank angle(CA)after top dead center(aTDC)compared to 5.23 MPa for the diesel alone operation at the same *** apex point for NHRR was observed to be 54.51 j(°)^(−1)for 5DEE+biogas in LHR engine positioned at 3.2°*** brake thermal efficiency at full engine load operation decreased by 12.7%and 5.2%for biogas substitutions of 0.8 kg h^(−1)with diesel and 5DEE,respectively,compared to the base *** smoke opacity and nitric oxide emissions were reduced during the DF run accompanied by diethyl ether as a fuel additive.

关键词： Biogas Banana leaves Coating Diesel engine Diethyl ether Exhaust emissions

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Particle elasticity influences polymeric artificial antigen presenting cell effectiveness in vivo via CD8+T cell activation,macrophage uptake,and the protein corona

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Nano Research 2024年第10期17卷 9052-9064页

作者： Savannah E.Est-Witte Sydney R.Shannon Dennis H.Gong kaitlyn G.Calabresi jawaun j.Harris kaitlyn Storm Edwin j.Yoo Ariel Isser Vivek P.jani Natalie k.Livingston Mary O.Omotoso kelly Rhodes Elana Ben-Akiva Randall A.Meyer Zoe T.Hsieh Simone Sidoli Stephany Y.Tzeng jonathan P.Schneck jordan j.Green Translational Tissue Engineering Center Institute for NanobiotechnologyDepartment of Biomedical EngineeringJohns Hopkins School of Medicine400 N BroadwayBaltimoreMD 21231USA Institute for Cell Engineering Department of PathologyJohns Hopkins School of Medicine733 N BroadwayBaltimoreMD 21205USA Department of Biochemistry Albert Einstein College of MedicineThe BronxNew York CityNY 10461USA

Adoptive cell therapy(ACT)is an immunotherapy strategy for cancer that has seen widespread clinical *** ACT,patient-derived lymphocytes are stimulated with the antigen of interest ex vivo,proliferated,then returned to the patient to initiate an antigen-specific antitumor *** effective,this process is resource-intensive and logistically impossible for many *** artificial antigen presenting cells(aAPCs)offer a potential“off-the-shelf”alternative to ex vivo *** particulate aAPCs perform well in vitro,they have had limited success in vivo due to poor bioavailability after *** to bioavailability include rapid clearance,unfavorable biodistribution,and inadequate interactions with CD8+T cells at sites of *** properties such as elasticity have been shown to vastly impact the bioavailability and particle-cell interactions,but this has yet to be investigated in the context of aAPCs for in vivo T-cell *** literature likewise indicates that biomaterial properties,especially elasticity,can modulate T-cell activation in *** the goal of creating a more biomimetic,next-generation particulate aAPC,we developed a poly(ethylene)glycol hydrogel particle platform with tunable elasticity to investigate the impact of elasticity on antigen-specific T cell activation for in vivo adoptive *** this knowledge,we were able to gain more precise control over in vivo T cell activation and investigate possible mechanisms including the effects of aAPC elasticity on T cell binding,macrophage uptake,and the protein corona.

关键词： adoptive cell therapy artificial antigen presenting cells particle drug delivery elasticity protein corona poly(ethylene glycol)

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Burden of routine orthopedic implant removal a single center retrospective study

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World journal of Orthopedics 2024年第2期15卷 139-146页

作者： Ammar k AlOmran Nader Alosaimi Ahmed A Alshaikhi Omar M Bakhurji khalid j Alzahrani Basil Ziyad Salloot Tamim Omar Alabduladhem Ahmed I AlMulhim Arwa Alumran Department of Orthopedic College of MedicineImam Abdulrahman Bin Faisal UniversityDammam 31441Saudi Arabia Health Information Management and Technology Department Imam Abdulrahman Bin Faisal UniversityDammam 31441Saudi Arabia

BACkGROUND Open reduction and internal fixation represent prevalent orthopedic procedures,sparking ongoing discourse over whether to retain or remove asymptomatic *** consensus on this matter is paramount for orthopedic *** study aims to quantify the impact of routine implant removal on patients and healthcare facilities.A retrospective analysis of implant removal cases from 2016 to 2022 at king Fahad Hospital of the University(kFHU)was conducted and subjected to statistical *** these cases,44%necessitated hospitalization exceeding one day,while 56%required only a single *** exhibited a 55%need for extended hospital stays,contrasting with 22.8%among the pediatric *** complication rate was 6%,with all patients experiencing at least one ***,34.1%required sick leave and 4.8%exceeded 14 *** anesthesia was predominant(88%).Routine implant removal introduces unwarranted complications,particularly in adults,potentially prolonging *** procedure strains hospital resources,tying up the operating room that could otherwise accommodate critical *** defined institutional guidelines are imperative to regulate this *** To measure the burden of routine implant removal on the patients and *** This is a retrospective analysis study of 167 routine implant removal cases treated at kFHU,a tertiary hospital in Saudi *** were collected in the orthopedic department at kFHU from February 2016 to August 2022,which includes routine asymptomatic implant removal cases across all age *** indications such as infection,pain,implant failure,malunion,nonunion,restricted range of motion,and prominent hardware were *** who had external fixators removed or joints replaced were also *** Between February 2016 and August 2022,360 implants were retrieved;however,only 167 of those who met the inclusion criteria were included in this

关键词： Implant removal Healed fracture Orthopedic implant Complications Healthcare system

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kinetics of glyphosate and aminomethylphosphonic acid sorption onto montmorillonite clays in soil and their translocation to genetically modified corn

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journal of Environmental Sciences 2024年第1期135卷 669-680页

作者： Meichen Wang kelly j Rivenbark Timothy D Phillips Veterinary Physiology and Pharmacology College of Veterinary Medicine and Biomedical SciencesTexas A&M UniversityTX 77845USA

The co-occurrence of glyphosate(GLP)and aminomethylphosphonic acid(AMPA)in contaminated water,soil,sediment and plants is a cause for concern due to potential threats to the ecosystem and human health.A major route of exposure is through contact with contaminated soil and consumption of crops containing GLP and AMPA ***,clay-based sorption strategies for mixtures of GLP and AMPA in soil,plants and garden produce have been very *** this study,in vitro soil and in vivo genetically modified corn models were used to establish the proof of concept that the inclusion of clay sorbents in contaminated soils will reduce the bioavailability of GLP and AMPA in soils and their adverse effects on plant *** of chemical concentration(1–10 mg/kg),sorbent dose(0.5%-3%in soil and 0.5%-1%in plants)and duration(up to 28 days)on sorption kinetics were *** time course results showed a continuous GLP degradation to *** inclusion of calcium montmorillonite(CM)and acid processed montmorillonite(APM)clays at all doses significantly and consistently reduced the bioavailability of both chemicals from soils to plant roots and leaves in a dose-and time-dependent manner without detectable *** treated with 0.5%and 1%APM inclusion showed the highest growth rate(p≤0.05)and lowest chemical bioavailability with up to 76%reduction in roots and57%reduction in *** indicated that montmorillonite clays could be added as soil supplements to reduce hazardous mixtures of GLP and AMPA in soils and plants.

关键词： Glyphosate AMPA Adsorption Soil remediation Plant Hydroponic system

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