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Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage Mark l.Dell’Acqua Brian M.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Constrained fixed-fulcrum reverse shoulder arthroplasty improves functional outcome in epileptic patients with recurrent shoulder instability

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World journal of Orthopedics 2016年第7期7卷 434-441页

作者： Tanujan Thangarajah Deborah Higgs j.i l bayley Simon M lambert the Shoulder and Elbow Service the Royal National Orthopaedic Hospital

AiM: To report the results of fixed-fulcrum fully constrained reverse shoulder arthroplasty for the treatment of recurrent shoulder instability in patients with epilepsy. METHODS: A retrospective review was conducted at a single facility. Cases were identified using a com-puterized database and all clinic notes and operative reports were reviewed. All patients with epilepsy and recurrent shoulder instability were included for study. Between july 2003 and August 2011 five shoulders in five consecutive patients with epilepsy underwent fixed-fulcrum fully constrained reverse shoulder arthroplasty for recurrent anterior shoulder instability. The mean duration of epilepsy in the cohort was 21 years(range, 5-51) and all patients suffered from grand mal seizures. RESUlTS: Mean age at the time of surgery was 47 years(range, 32-64). The cohort consisted of four males and one female. Mean follow-up was 4.7 years(range, 4.3-5 years). There were no further episodes of instability, and no further stabilisation or revision procedures were performed. The mean Oxford shoulder instability score improved from 8 preoperatively(range, 5-15) to 30 postoperatively(range, 16-37)(P = 0.015) and the mean subjective shoulder value improved from 20(range, 0-50) preoperatively to 60(range, 50-70) postoperatively(P = 0.016). Mean active forward elevation improved from 71° preoperatively(range,45°-130°) to 100° postoperatively(range, 80°-90°) and mean active external rotation improved from 15° preoperatively(range, 0°-30°) to 40°(20°-70°) postoperatively. No cases of scapular notching or loosening were noted. CONClUSiON: Fixed-fulcrum fully constrained reverse shoulder arthroplasty should be considered for the treatment of recurrent shoulder instability in patients with epilepsy.

关键词： Arthroplasty Dislocation Epilepsy instability Shoulder

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher j.O’Connell Matthew j.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA james l.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBi)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBis are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

Non-polynomial Zig-Zag and ESl shear deformation theory to study advanced composites

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Chinese journal of Aeronautics 2019年第4期32卷 906-920页

作者： j.l.MANTARi i.A.RAMOS j.C.MONGE Faculty of Mechanical Engineering Instituto de investigación en ingeniería naval(IDIIN)National University of Engineering(UNI)Lima 15333Peru Department of Mechanical Engineering University of New Mexico Faculty of Mechanical Engineering Universidad de Ingeniería y Tecnología(UTEC)

The mechanical behavior of advanced composites can be modeled mathematically through unknown variables and Shear Strain Thickness Functions(SSTFs). Such SSTFs can be of polynomial or non-polynomial nature and some parameters of non-polynomial SSTFs can be optimized to get optimal results. in this paper, these parameters are called ‘‘r" and ‘‘s" and they are the argument of the trigonometric SSTFs introduced within the Carrera Unified Formulation(CUF). The Equivalent Single layer(ESl) governing equations are obtained by employing the Principle of Virtual Displacement(PVD) and are solved using Navier method solution. Furthermore, trigonometric expansion with Murakami theory was implemented in order to reproduce the Zig-Zag effects which are important for multilayer structures. Several combinations of optimization parameters are evaluated and selected by different criteria of average error. Results of the present unified trigonometrical theory with CUF bases confirm that it is possible to improve the stress and displacement results through the thickness distribution of models with reduced unknown variables. Since the idea is to find a theory with reduced numbers of unknowns, the present method appears to be an appropriate technique to select a simple model. However these optimization parameters depend on the plate geometry and the order of expansion or unknown variables. So, the topic deserves further research.

关键词： Analytical solution Composite materials CUF ESl Plate Trigonometric functions Zig-Zag effects

Patterns of trends in niveograph characteristics across the western United States from snow telemetry data

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Frontiers of Earth Science 2020年第2期14卷 315-325页

作者： S.R.FASSNACHT j.i.lÓPEZ-MORENO ESS-Watershed Science Colorado State UniversityFort CollinsCO 80523-1472USA Cooperative institute for Research in the Atmosphere Colorado State UniversityFort CollinsCO 80523-1375USA Natural Resources Ecology laboratory Colorado State UniversityFort CollinsCO 80523-1499USA instituto Pirenaico de Ecología CSICCampus de Aula Dei 50080Spain

The snowpack is changing across the globe,as the climate warms and *** used daily snow water equivalent(SWE)niveograph(time series of SWE)data from 458 snow telemetry(SNOTEl)stations for the period 1982 through *** indices based on amount,timing,time length,and rates were used to describe the annual temporal evolution in SWE accumulation and *** trends in these annual indices were computed over the time period for each station using the Theil-Sen *** trends were then clustered into four groups to determine the spatial pattern of SWE *** and precipitation data were extracted from the PRiSM data set,due to the shorter time period of temperature measurement at the SNOTEl *** show that SNOTEl stations can be clustered in four clusters according to the observed trends in snow *** 1 stations are mostly located in the Eastern-and South-eastern most parts of the study area and they exhibit a generalized decrease in the indices related with peak SWE and snow *** stations recorded a negative trend in precipitation and an increase in *** 4 that is mostly restricted to the North and North-west of the study area shows an almost opposite pattern to cluster 1,due to months with positive trends and a more moderate increase of *** grouped in clusters 2 and 3 appear mixed with clusters 1 and 4,in general they show very little trends in the snow indices.

关键词： snow water equivalent cluster analysis SNOTEl

Synthetic biology in the UK-An outline of plans and progress

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Synthetic and Systems Biotechnology 2016年第4期1卷 243-257页

作者： l.j.Clarke R.i.Kitney UK Synthetic Biology leadership Council UK Department of BioEngineering Imperial CollegeUK Faculty of life Sciences University of ManchesterUK BionerG UK EPSRC National Centre for Synthetic Biology and innovation UK institute of Systems and Synthetic Biology UK BioMedical Systems Engineering Imperial CollegeUK BioMedical Systems EngineeringImperial CollegeUK

Synthetic biology is capable of delivering new solutions to key challenges spanning the bioeconomy,both nationally and *** this significant potential and the associated need to facilitate its translation and commercialisation the UK government commissioned the production of a national Synthetic Biology Roadmap in 2011,and subsequently provided crucial support to assist its *** infrastructural investments have been made,and important strides made towards the development of an effectively connected community of practitioners and interest groups.A number of Synthetic Biology Research Centres,DNA Synthesis Foundries,a Centre for Doctoral Training,and an innovation Knowledge Centre have been established,creating a nationally distributed and integrated network of complementary facilities and *** UK Synthetic Biology leadership Council published a UK Synthetic Biology Strategic Plan in 2016,increasing focus on the processes of translation and *** 50 start-ups,SMEs and larger companies are actively engaged in synthetic biology in the UK,and inward investments are starting to *** these initiatives provide an important foundation for stimulating innovation,actively contributing to international research and development partnerships,and helping deliver useful benefits from synthetic biology in response to local and global needs and challenges.

关键词： Synthetic biology Engineering biology Biodesign Roadmap Responsible Research and innovation(RRi) innovation and Knowledge Centre(iKC) Synthetic Biology leadership Council(SBlC) Bioeconomy

Mechanochemical synthesis of cerium orthophosphate

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journal of Rare Earths 2009年第4期27卷 598-602页

作者： A.Matraszek i.Szczygie l.Macalik j.Hanuza Department of inorganic Chemistry Wroctaw University of Economics ul.Komandorska 118/120 Wroctaw 53-345 Poland institute of low Temperature and Structure Research Polish Academy of Sciences ul.Okólna 2 Wroctaw 50-422 Poland Wroctaw University of Economics Department of Bioorganic Chemistry ul.Komandorska 118/120 Wroctaw 53-345 Poland

A facile, simple and rapid preparation method of cerim orthophosphate was presented. The synthesis of low-crystalline CePO4 occurred upon mixing of cerium （Ⅲ） nitrate and sodium phosphate, and was an exchange-type reaction. The phase composition of the obtained powder was checked by the XRD and FTiR methods, indicating the presence of cerium phosphate. Further investigations on thermal behavior of the synthesized cerium salt had shown that the obtained orthophosphate crystallized at first in rhabdophane-type structure. it converted to monazite （monoclinic symmetry） during heating at the temperatures of above 600℃. Oxidation of Ce3＋ to Ce4＋ was avoided during the syntheses, as confirmed by the XPS experiments.

关键词： cerium phosphate synthesis phase purity characteristics rare earths

Hydrogen production by catalytic decomposition of methane using a Fe-based catalyst in a fluidized bed reactor

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journal of Natural Gas Chemistry 2012年第4期21卷 367-373页

作者： D.Torres S.dellobet j.l.Pinilla M.j.lzaro i.Suelves R.Moliner instituto de Carboquímica CSICMiguel Luesma Castn 450018 ZaragozaSpain

Catalytic decomposition of methane using a Fe-based catalyst for hydrogen production has been studied in this work. A Fe/Al2O3 catalyst previously developed by our research group has been tested in a fluidized bed reactor （FBR）. A parametric study ot the effects of some process variables, including reaction temperature and space velocity, is undertaken. The operating conditions strongly affect the catalyst performance. Methane conversion was increased by increasing the temperature and lowering the space velocity. Using temperatures between 700 and 900℃ and space velocities between 3 and 6 lN/（gcat·h）, a methane conversion in the range of 25%-40% for the gas exiting the reactor could be obtained during a 6 h run. in addition, carbon was deposited in the form of nanofilaments （chain like nanofibers and multiwall nanotubes） with similar properties to those obtained in a fixed bed reactor.

关键词： hydrogen production fluidized bed reactor metal catalysts

Rietveld refinement and optical properties of SrWO_4:Eu^(3+) powders prepared by the non-hydrolytic sol-gel method

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journal of Rare Earths 2015年第2期33卷 113-128页

作者： P.F.S.Pereira i.C.Nogueira E.longo E.j.Nassar i.l.V.Rosa l.S.Cavalcante Chemistry institute University of the State of Sao Paulo Julio de Mesquita Filho-UNESP Francisco DegniAraraquara-SP 14800-900 Brazil liEC-Chemistry Department Federal University of Sao Carlos Via Washington Luis Km 235Sao Carlos-SP 13565-905 Brazil University of Franca-UNiFRAN Via Dr.Armando Sales de OliveiraNo.201 Franca-SP 14404-600 Brazil CCN-DQ-GERATEC University of the State of Piauí Joao Cabral 2231 P.O.Box 391Terezina PI 64002-150 Brazil

We investigated the effect of annealing time on the structure and optical properties of Sr WO4：Eu^3＋ powders prepared by the non-hydrolytic sol-gel method and heat treated at 800 ℃ for 2,4,8 and 16 *** and differential thermal analyses revealed that Sr WO4：Eu^3＋ powders were obtained at about 800 ℃.X-ray diffraction patterns and Rietveld refinement data confirmed that all powders had a scheelite-type tetragonal ***-Raman and Fourier transform infrared spectra indicated structural order at short range and anti-symmetric stretching vibrations of O-W-O bonds associated with tetrahedral[WO4]*** properties were investigated by ultraviolet-visible（UV-vis）diffuse reflectance,and photoluminescence（Pl）data which provided the evolution of quantum efficiency（η）and lifetime（τ）.UV-vis spectroscopy evidenced intermediate energy levels within the band gap of Sr WO4：Eu^3＋ *** properties validated that the Eu^3＋ electric-dipole（^5D0→^7F2）transition in Pl emission spectra was dominant which proved that Eu^3＋ ions were positioned in a site without an inversion center.[（^5D0→^7F2）/（^5D0→^7F1）]band ratios showed that Eu^3＋ ions were located in a low symmetry *** Pl emission,ηandτproved the dependence on the annealing time in the behavior of Sr WO4：Eu3＋powders with a higher relative emission Pl intensity as well as higherηandτvalues related to other samples when heat treated at 800℃ for 8 h.

关键词： SrWO4 Rietveld refinement optical band gap Eu^(3+) +-rare earth luminescence