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Physical activity and amyloid beta in middle-aged and older adults:A systematic review and meta-analysis

journal of Sport and Health Science 2024年第2期13卷 133-144页

作者： María Rodriguez-Ayllon Patricio Solis-Urra Cristina Arroyo-ávila Miriam álvarez-Ortega Pablo Molina-García Cristina Molina-hidalgo Manuel Gómez-Río Belinda Brown Kirk I.Erickson Irene Esteban-Cornejo Department of Epidemiology Erasmus University Medical Center RotterdamRotterdamGD 3015the Netherlands Department of Physical Education and Sports Faculty of Sport SciencesSport and Health University Research Institute(iMUDS)University of GranadaGranada 18071Spain Faculty of Education and Social Sciences Universidad Andres BelloVina del Mar 2531015Chile Department of Nuclear Medicine Virgen de las Nieves University HospitalInstitute of Biosanitary Research of Granada(IBS)Granada 18014Spain Physical Medicine and Rehabilitation Service Virgen de las Nieves University HospitalInstitute of Biosanitary Research of Granada(IBS)Granada 18014Spain Department of Psychology University of PittsburghPittsburghPA 15260USA Centre for Healthy Ageing Health Futures InstituteMurdoch UniversityMurdochWA 6150Australia School of Medical and Health Sciences Edith Cowan UniversityJoondalupWA 6027Australia Advent Health Research Institute Neuroscience Institute OrlandoOrlandoFL 32803USA Physiopathology of Obesity and Nutrition Research Center(CIBERobn) Institute of Health Carlos Ⅲ(ISCⅢ)Madrid 28029Spain

Background:One of the pathological hallmarks distinguishing Alzheimer’s disease from other dementias is the accumulation of amyloid beta(Aβ).Higher physical activity is associated with decreased dementia risk,and one potential path could be through Aβlevels *** aimed to explore the relationship between physical activity and Aβin middle-aged and older ***:A systematic search of PubMed,Web of Science,PsycINFO,Cochrane Central Register of Controlled Trials,and SPORTDiscus was performed from inception to April 28,*** were eligible if they included physical activity and Aβdata in adults aged 45 years or ***-level metaanalyses of intervention and observational studies were performed to examine the role of physical activity in modulating Aβ***:In total,37 articles were included(8 randomized controlled trials,3 non-randomized controlled trials,4 prospective longitudinal studies,and 22 cross-sectional studies).The overall effect size of physical activity interventions on changes in blood Aβwas medium(pooled standardized mean difference=-0.69,95%confidence interval(95%CI):-1.41 to 0.03;I^(2)=74.6%).However,these results were not statistically significant,and there were not enough studies to explore the effects of physical activity on cerebrospinal fluid(CSF)and brain Aβ.Data from observational studies were examined based on measurements of Aβin the brain using positron emission tomography scans,CSF,and *** physical activity was positively associated with Aβonly in the CSF(Estimate r=0.12;95%CI:0.05-0.18;I^(2)=38.00%).Conclusion:Physical activity might moderately reduce blood Aβin middle-aged and older ***,results were only near statistical significance and might be interpreted with caution given the methodological limitations observed in some of the included *** observational studies,higher levels of physical activity were positively associated with Aβonly in ***,further research is needed t

关键词： Aging Cognitive impairment Dementia Exercise PET

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Nature-based bioreactors: Tackling antibiotic resistance in urban wastewater treatment

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Environmental Science and Ecotechnology 2024年第6期22卷 155-167页

作者： Lluís Bertrans-Tubau Sergio Martínez-Campos julio Lopez-Doval Meritxell Abril Sergio Ponsá Victoria Salvadó Manuela hidalgo Anna Pico-Tomàs jose Luis Balcazar Lorenzo Proia BETA Technological Centre-University of Vic-Central University of Catalunya(BETA-UVIC-UCC) Carretera de Roda 7008500VicBarcelonaSpain Chemistry Department University of Girona.Campus Montilivi17005GironaSpain Catalan Institute Water Research(ICRA-CERCA) Emili Grahit 10117003GironaSpain University of Girona 17004GironaSpain

The overuse and misuse of antibiotics have accelerated the selection of antibiotic-resistant bacteria,significantly impacting human,animal,and environmental *** aquatic environments are vulnerable to antibiotic resistance,suitable management practices should be adopted to tackle this *** we show an effective,nature-based solution for reducing antibiotic resistance from actual *** utilize a bioreactor that relies on benthic(biofilms)and planktonic microbial communities to treat secondary effluent from a small urban wastewater treatment plant(<10,000 population equivalent).This treated effluent is eventually released into the local aquatic *** observe high removal efficiency for genes that provide resistance to commonly used antibiotic families,as well as for mobile genetic elements that could potentially aid in their ***,we notice a buildup of sulfonamide(sul1 and sul2)and tetracycline(tet(C),tet(G),and tetR)resistance genes specifically in *** advancement marks the initial step in considering this bioreactor as a nature-based,cost-effective tertiary treatment option for small UWWTPs facing antibiotic resistance challenges.

关键词： ARGs MGEs UWWTPs NBS Biofilms

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Biquinho pepper(Capsium chinense):Bioactive compounds,in vivo and in vitro antioxidant capacities and anti-cholesterol oxidation kinetics in fish balls during frozen storage

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Food Bioscience 2022年第3期47卷 512-523页

作者： Bárbara jardim Mariano Vanessa Sales de Oliveira Davy William hidalgo Chávez Rosane Nora Castro Cristiano jorge Riger jéssica Sodré Mendes Marcelo da Costa Souza Alexandra Christine Helena Frankland Sawaya Geni Rodrigues Sampaio Elizabeth Aparecida Ferraz da Silva Torres Tatiana Saldanha Department of Food Technology Institute of TechnologyUniversity Federal Rural of Rio de JaneiroRodovia Br 465SeropédicaRJ23890-000Brazil Department of Chemistry Institute of ChemistryUniversity Federal Rural of Rio de JaneiroRodovia Br 465SeropédicaRJ23890-000Brazil Department of Biochemistry Institute of ChemistryUniversity Federal Rural of Rio de JaneiroRodovia Br 465SeropédicaRJ23890-000Brazil Department of Botany Institute of Biological Sciences and HealthUniversity Federal Rural of Rio de JaneiroRodovia Br 465SeropédicaRJ23890-000Brazil Faculty of Pharmaceutical Science University of CampinasUNICAMPCampinasSPBrazil Department of Nutrition School of Public HealthUniversity of São Paulo (USP)Ave.Dr.Arnaldo715São PauloSP01246-904Brazil

The present study reports bioactive constituents from biquinho pepper,such as carotenoids,capsaicinoids,and capsinoids,identified by *** pepper extract showed an antioxidant potential by DPPH(33.17±0.08%),ORAC(32.35±0.02μM TE/g),β-carotene/linoleic acid(55.80±1.30%),and FRAP(315.88±4.23μmol TE/g)***,in vivo antioxidant analyses demonstrated that the pepper extract(170μg/mL)decreased the damage promoted by H_(2)O_(2) in Saccharomyces cerevisiae *** balls were prepared using different concentrations of pepper(0.0%,0.5%,0.75%,1.0%)to investigate its antioxidant effect during frozen *** pepper effectively reduced the formation of cholesterol oxides and preserved essential fatty acids,mainly in samples containing 1.0%of ***,this treatment was more efficient than sodium erythorbate(p0.8).

关键词： Bioactive compounds Capsicum chinense Cholesterol oxides Frozen storage Natural antioxidants Unsaturated lipids

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The nature of the companion of PSR j1719-1438: a white dwarf or an exotic object?

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Research in Astronomy and Astrophysics 2012年第7期12卷 813-816页

作者： j. E. Horvath Instituto de Astronomia Geofísica e Ciências Atmosfricas - Universidade de So Paulo

We raise the possibility that the very dense, compact companion of PSR j1719-1438, which has a jupiter-like mass, is an exotic quark object rather than a light helium or carbon white dwarf. The exotic hypothesis naturally explains some of the observed features, and provides quite strong predictions for this system, to be confirmed or refuted in feasible future studies.

关键词： binary pulsars -- exotic matter-- pulsars: individual (PSR j1719-1438)

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多功能Las Naves法院大楼

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世界建筑导报 2019年第2期34卷 18-23页

作者： Sebastián crespo arquitectura x Colectivo Arquitectura and Espinoza Carvajal for Hospiplan Cia.Ltda

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Helicity Amplitude Analysis of Z_c(3900)~± in e^+e^- →π^+π^-j/ψ

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Chinese Physics Letters 2016年第6期33卷 9-11页

作者：平荣刚 j.G.Messchendorp 苑长征 Institute of High Energy Physics Chinese Academy of Sciences KVI-CART University of Groningen

It is crucial to determine the spin and parity （jR） of Zc（3900）＋ for understanding its structure. We perform a helicity amplitude analysis on Zc（3900）＋ in the process e＋e- →π＋π-j/φ＊ with the hypotheses jP = 0-, 1＋, 1-, 2＋ and 2-. To estimate the significance of jP = 1＋ over other hypotheses, we perform a Monte Carlo simulation study, and we also discuss the prospect of measuring the spin parity in the future experiment with a large data sample.

关键词： of on is Helicity Amplitude Analysis of Z_c in e for that

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Inflammasome links traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1644-1664页

作者： Gabriela Seplovich Yazan Bouchi juan Pablo de Rivero Vaccari jennifer C.Munoz Pareja Andrew Reisner Laura Blackwell Yehia Mechref Kevin K.Wang j.Adrian Tyndall Binu Tharakan Firas Kobeissy Department of Surgery Morehouse School of MedicineAtlantaGAUSA Department of Neurobiology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA Department of Neurological Surgery and the Miami Project to Cure Paralysis University of Miami Miller School of MedicineMiamiFLUSA Division of Pediatric Critical Care Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA Department of Pediatrics Emory UniversityAtlantaGAUSA Department of Neurosurgery Children’s Healthcare of AtlantaAtlantaGAUSA Department of Chemistry and Biochemistry Texas Tech UniversityLubbockTXUSA Morehouse School of Medicine AtlantaGAUSA

Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease are three distinct neurological disorders that share common pathophysiological mechanisms involving neuroinflammation. One sequela of neuroinflammation includes the pathologic hyperphosphorylation of tau protein, an endogenous microtubule-associated protein that protects the integrity of neuronal cytoskeletons. Tau hyperphosphorylation results in protein misfolding and subsequent accumulation of tau tangles forming neurotoxic aggregates. These misfolded proteins are characteristic of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease and can lead to downstream neuroinflammatory processes, including assembly and activation of the inflammasome complex. Inflammasomes refer to a family of multimeric protein units that, upon activation, release a cascade of signaling molecules resulting in caspase-induced cell death and inflammation mediated by the release of interleukin-1β cytokine. One specific inflammasome, the NOD-like receptor protein 3, has been proposed to be a key regulator of tau phosphorylation where it has been shown that prolonged NOD-like receptor protein 3 activation acts as a causal factor in pathological tau accumulation and spreading. This review begins by describing the epidemiology and pathophysiology of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease. Next, we highlight neuroinflammation as an overriding theme and discuss the role of the NOD-like receptor protein 3 inflammasome in the formation of tau deposits and how such tauopathic entities spread throughout the brain. We then propose a novel framework linking traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease as inflammasomedependent pathologies that exist along a temporal continuum. Finally, we discuss potential therapeutic targets that may intercept this pathway and ultimately minimize long-term neurological decline.

关键词： Alzheimer's disease caspase-1 chronic traumatic encephalopathy inflammasomes neurodegeneration neuroinflammation NLRP1 NLRP3 pyroptosis tauopathy traumatic brain injury

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The supernova remnant CTB 37B and its associated magnetar CXOU j171405.7-381031:evidence for a magnetar-driven remnant

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Research in Astronomy and Astrophysics 2011年第6期11卷 625-630页

作者： j.E.Horvath M.P.Allen Instituto de Astronomia Geofísica e Ciências Atmosféricas-Universidade de So PauloRua do Mato122605508-900 Cidade Universitria So Paulo SPBrazil CEFET So Paulo Rua Pedro Vicente 62501109-010Caninde'So Paulo SPBrazil

We discuss the association between the candidate magnetar CXOU j171405.7-381031 and the supernova remnant CTB *** recent detection of the period derivative of the object allowed an estimation of a young characteristic age of only ～ *** value is too small to be compatible even with the minimum radius of the remnant being ≥ 10 pc,the value corresponding to the lower limit of the estimated distance of 10.2 ± 3.5 kpc,unless the true distance happens to be even smaller than the lower *** argue that a consistent scenario for the remnant＇s origin,in which the latter is powered by the energy injected by a young magnetar,is indeed more accurate to explain the young age,and demonstrates its non-standard（***-driven） nature.

关键词： stars:supernova — stars:neutron

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Safe mining practices under wide spans in underground non-caving mines——Case studies

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International journal of Mining Science and Technology 2019年第4期29卷 535-540页

作者： j.j.Ran Kinross Gold Corporation

Mining under wide span is of concern as it increases the probability of back caving causing personnel injury and equipment damage in underground mines in open stoping and underhand drift-and-fill *** restricting personnel access to well supported lateral development is commonly practiced,it is not always possible to implement this requirement due to various factors such as ore loss control,drilling equipment limitations,availability of remote operating capacity and consideration of *** with rules implemented to limit personnel entry into openings with wide spans,the hazards of equipment damage and back caving still *** the years,different practices have been reported and adopted to minimize risks associated with exposure to large spans in various underground *** from these practices are beneficial to current and future mines with challenges of safe extraction of thick deposits in a non-caving *** paper briefly summarizes practices in mining wide orebodies using the open stoping method without personnel access and underhand mining using the drift-andfill method with personnel exposure in the industry and presents cases from Kinross mines where the hanging pillar design was tested,and stope backs were naturally and artificially supported for extraction under wide spans using the open stoping method.

关键词： Mine safety Wide span Back stability Underhand mining Hanging pillar

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Seroprevalence of viral and bacterial pathogens among malaria patients in an endemic area of southern Venezuela

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Infectious Diseases of Poverty 2023年第2期12卷 130-131页

作者： David A.Forero-Peña Fhabián S.Carrión-Nessi Mary Lopez-Perez Marisol Sandoval-de Mora Iván D.Amaya Ángel F.Gamardo Melynar Chavero Luisamy Figuera María V.Marcano Natasha A.Camejo-Ávila Mariana hidalgo Cariagne j.Arenas Myriam Arévalo-Herrera Sócrates Herrera Biomedical Research and Therapeutic Vaccines Institute Ciudad Bolivar Venezuela Internal Medicine Department “Ruiz y Páez” University Hospital Complex Ciudad Bolivar Venezuela “Dr. Francisco Battistini Casalta” Health Sciences School University of Oriente – Bolivar Nucleus Ciudad Bolivar Venezuela Department of Immunology and Microbiology Faculty of Health and Medical Sciences Centre for Medical Parasitology University of Copenhagen Copenhagen Denmark Immunoparasitology Laboratory Microbiology and Cell Biology Centre Venezuelan Institute for Scientific Research Miranda Venezuela Caucaseco Scientific Research Centre Cali Colombia

Background Malaria remains a leading public health problem ***-infections with other pathogens complicate its diagnosis and may modify the disease’s clinical course and *** in malaria clinical presentation with other infections and overlapping endemicity result in underdiagnosis of co-infections and increased ***,the aim of this study was to determine the seroprevalence of viral and bacterial pathogens among diagnosed malaria patients in malaria-endemic areas in *** A cross-sectional study was conducted on malaria patients attending three reference medical centres in Ciudad Bolivar,*** evaluation and laboratory tests for dengue virus(DENV),chikungunya virus(CHIKV),viral hepatitis[hepatitis A virus(HAV),hepatitis B virus(HBV),and hepatitis C virus(HCV)],and leptospirosis(LEP)were performed by enzyme-linked immunosorbent *** exposure to these pathogens was defined by the presence of specific immunoglobulin(Ig)G,and co-infection or recent exposure(CoRE)was determined by the presence of specific IgM alone or IgM+*** analysis considered descriptive *** distribution was statistically evaluated using Kolmogorov–Smirnov test and the necessary comparison *** ratio(OR)for complications was determined according to CoRE presence with a 95%confidence interval(CI).Results A total of 161 malaria patients were studied,66%infected with Plasmodium vivax,27%with ***,and 7.5%harboured ***/*** mixed *** exposure to DENV(60%)and CHIKV(25%)was *** was confirmed in 55 of the 161 malaria patients(34%)and were more frequent in ***(49%)than in ***(29%)and mixed malaria patients(25%)(OR=2.43,95%CI:1.39–4.25,P=0.018).The most frequent CoRE was DENV(15%),followed by HAV(12%),HBV(6.2%),CHIKV(5.5%),and LEP(3.7%);HCV CoRE was *** malaria was significantly more frequent in patients with CoRE(56%)than those without CoR

关键词： Malaria Seroprevalence Co-infection Chikungunya Dengue Hepatitis Venezuela

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