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Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael j.Lee Ryota L.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

Dimensionality reduction of hyperspectral images of vegetation and crops based on self-organized maps

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Information Processing in Agriculture 2021年第2期8卷 310-327页

作者： David Ruiz hidalgo Bladimir Bacca Cortés Eduardo Caicedo Bravo Perception and Intelligent Systems Research Group School of Electrical and Electronic EngineeringUniversidad del ValleSantiago de Cali 76001Colombia

Hyperspectral images are multidimensional massive sets of information that have shown a great potential for different kind of applications as urban mapping,environmental management,vegetation and crops supervision and mineral ***,due to its high dimensional nature and the high variability of the spectral information,the dimensionality reduction process is one of the main challenges in processing hyperspectral *** aim of dimensionality reduction is to eliminate redundant information and simplify the subsequent processes of classification and the search of *** this context,several dimensionality reduction methods have been proposed,but most of them are not flexible enough to deal with the particular features of the hyperspectral *** this way,the use of intelligent methods as neural networks and specially an unsupervised approach as self-organized maps,may improve the dimensionality reduction stage and the final classification *** paper proposes an unsupervised method for the dimensionality reduction of hyperspectral images based on Kohonen self-organized maps,which,compared with other traditional methods such as principal component analysis(PCA)and wavelet decomposition,provides better classification *** results provided in this paper use an RBF(radial basis function)*** average,the proposed method provides a 64%dimensionality reduction and an 88.5%classification *** results suggest that the dimensionality reduction algorithm based on self-organized maps is an efficient approach compared with other popular *** is due to the ability of self-organized maps to automatically detect(self-organizing)relationships within the set of input patterns,which provides flexibility to deal with the special features of the hyperspectral images.

关键词： Dimensionality reduction Hyperspectral images Principal component analysis Radial basis function Remote sensing Self-organized maps Wavelet transform

Maximizing biomass utilization: An integrated strategy for coproducing multiple chemicals

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journal of Energy Chemistry 2025年第1期100卷 180-191页

作者： Byeongchan Ahn Sua jo jonggeol Na j.jay Liu Young-ju Kim Wangyun Won Department of Chemical and Biological Engineering Korea University Department of Chemical Engineering (Integrated process) Kyung Hee University Department of Chemical Engineering and Materials Science Ewha Womans University Department of Chemical Engineering Pukyong National University Resources Engineering Plant Research Department Korea Institute of Geoscience and Mineral Resources

Lignocellulosic biomass is one of the viable solutions to alleviate the global warming. However, the limited utilization of biomass majorly focused on cellulose and hemicellulose restricts the economic and environmental feasibilities. To cope with this issue, we proposed an integrated process of co-producing 1,6-hexanediol（1,6-HDO） with tetrahydrofuran and adipic acid from biomass, referred to as Strategy A. To compare the impacts of lignin upgrading and feedstock, Strategy B, which co-produces tetrahydrofuran alone, and Strategy C, which is the traditional route to produce 1,6-HDO from fossil fuels, were used. Heat networks are also designed to reduce operating costs and indirect carbon emissions due to energy consumption, saving 87% and 83% of the heat and cooling requirements, respectively, in Strategy A. The market competitiveness of Strategy A was evaluated by determining the minimum selling price through techno-economic analysis, and sustainability was thoroughly investigated by quantifying the environmental impacts through both midpoint and endpoint life-cycle assessments（LCAs）.Strategy A was found to be the most favorable both economically（USRDSCHARDOLLAR3,402/ton） and environmentally（-26.9 kg CO2eq.）. This indicates that lignin valorization is not only economically but also environmentally preferred. Finally, changes in economic and environmental feasibilities depending on economic, process, and environmental parameters were investigated using sensitivity and uncertainty analyses. The results of these analyses provide valuable insight into bio-based chemical production.

关键词： Biorefinery Carbon mitigation Climate change Global warming Lignin utilization Bioeconomy

AMP-activated kinase in human spermatozoa： identification, intracellular localization, and key function in the reRulation of sperm motility

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Asian journal of Andrology 2017年第6期19卷 707-714页

作者： Violeta Calle-Guisado Ana Hurtado de Llera David Martin-hidalgo jose Mijares Maria C Gil Ignacio S Alvarez Maria j Bragado Luis j Garcia-Marin Research Group of Intracellular Signalling and Technology of Reproduction (SINTREP) School of Veterinary Medicine University of Extremadura Caceres Spain Assisted Reproduction Unit at the-Minimally Invasive surgery Center jesos Uson (CCMIjU) Caceres Spain Norba Clinic Caceres Spain Research Group of Reproduction and Embryo Development (REDES) University of Extremadura Badajoz Spain Extremadura Institute of Assisted Reproduction (IERA) Badajoz Spain.

AMP-activated kinase （AMPK）, a protein that regulates energy balance and metabolism, has recently been identified in boar spermatozoa where regulates key functional sperm processes essential for fertilization. This work＇s aims are AMPK identification, intracellular localization, and their role in human spermatozoa function. Semen was obtained from healthy human donors. Sperm AMPK and phospho-Thr172-AMPK were analyzed by Western blotting and indirect immunofluorescence. High- and low-quality sperm populations were separated by a 40%-80% density gradient. Human spermatozoa motility was evaluated by an Integrated Semen Analysis System （ISAS） in the presence or absence of the AMPK inhibitor compound C （CC）. AMPK is localized along the human spermatozoa, at the entire acrosome, midpiece and tail with variable intensity, whereas its active form, phospho-Thr172-AMPK, shows a prominent staining at the acrosome and sperm tail with a weaker staining in the midpiece and the postacrosomal region. Interestingly, spermatozoa bearing an excess residual cytoplasm show strong AMPK staining in this subcellular compartment. Both AMPK and phospho-Thr172-AMPK human spermatozoa contents exhibit important individual variations. Moreover, active AMPK is predominant in the high motility sperm population, where shows a stronger intensity compared with the low motility sperm population. Inhibition of AMPK activity in human spermatozoa by CC treatment leads to a significant reduction in any sperm motility parameter analyzed： percent of motile sperm, sperm velocities, progressivity, and other motility coefficients. This work identifies and points out AMPK as a new molecular mechanism involved in human spermatozoa motility. Further AMPK implications in the clinical efficiency of assisted reproduction and in other reproductive areas need to be studied.

关键词： AMP-activated kinase human spermatozoa immunolocalization sperm motility sperm quality

Implications of denitrification in the ecological status of an urban river using enzymatic activities in sediments as an indicator

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journal of Environmental Sciences 2019年第1期31卷 255-268页

作者： jessica Unda-Calvo Miren Martínez-Santos Estilita Ruiz-Romera juan Luis Lechuga-crespo Department of Chemical and Environmental Engineering University of the Basque Country

A better understanding of the effects of a number of environmental factors on denitrification is vital for analyzing its role as nitrogen sink and providing deeper knowledge about the ecological status of a nitrate-rich ecosystem. Since few studies have addressed the occurrence and implications of denitrification in river sediments, and complexity of interactions among all these environmental factors makes comprehension of the process difficult, the potential of sediments from the Deba River to attenuate nitrate excess through denitrification was investigated. For this purpose, we adapted an in vitro method to measure activities of two enzymes contributing to the entire multiple-step nitrate reduction: Nitrate Reductase and Nitrite Reductase. The environmental features that influence both or single enzymatic activities were identified as oxygen availability,regulated directly by the moisture content or indirectly through the aerobic respiration,organic matter and nitrate content of sediments, and electrical conductivity and exchangeable sodium percentage of water. Additionally, our results showed that Nitrate Reductase catalyzes the principal limiting step of denitrification in sediments. Therefore,taking this enzymatic activity as an indicator, the southern part of the Deba River catchment presented low potential to denitrify but nitrate-limited sediments, whereas the middle and northern parts were characterized by high denitrification potential but nitraterich sediments. In general, this study on denitrifying enzymatic activities in sediments evaluates the suitability of the management of the effluents from wastewater treatment plants and municipal sewages to ensure a good ecological status of the Deba River.

关键词： Urban catchment Sediments Denitrification Enzymatic activity Ecological status

The Tower of Nisida as centre of 17^(th)century fortified naples system

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Frontiers of Architectural Research 2023年第2期12卷 308-318页

作者： Ignacio-javier Gil-crespo Concetta Cusano Claudia Cennamo Research Center“jose´joaquı´n de Mora”/Ca´rdenas Foundation MadridSpain Dipartimento di Architettura e Disegno Industriale Universita`degli Studi della Campania“Luigi Vanvitelli”Aversa(CE)Italy

The paper investigates the territorial layout of the fortified system of Naples that developed during the Spanish Vice Kingdom in the 16th-17th *** existing castles and towers,and constructions built for the purpose,were included in the *** Tower of Nisida is one of the existing ancient towers that became part of the impressive 17th century defense system of *** study focus is on the strategic importance acquired by Nisida and its Tower in those years,when it became a key location in the fortified system,both evidencing its cruciality through the study of the field of vision that widens from the location and dealing the issue with the point of view landscape and territorial defense,recalling the concept that the defense architecture is part of architectural heritage.

关键词： Fortification Architectural heritage Territory and landscape Artillery Military architecture

Simvastatin,atorvastatin,and pravastatin equally improve the hemodynamic status of diabetic rats

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World journal of Diabetes 2015年第10期6卷 1168-1178页

作者： María j crespo josé Quidgley Departments of Physiology and Anesthesiology University of Puerto Rico-School of Medicine Departments of Physiology University of Puerto Rico-School of Medicine

AIM: To investigate if the effect of statins improving cardiovascular(CV) status of diabetics is drug-specific or class-dependent, and the underlying mechanisms *** HOD S : We compared the results of daily administration over a four-week period of a low dose(10 mg/kg per day) of atorvastatin(AV), simvastatin(SV), and pravastatin(PV) on cardiac performance in diabetic rats. Echocardiographic variables were tested, as well as systolic blood pressure(SBP), acetylcholine(ACh)-induced relaxation, plasma cholesterol levels, and perivascular fibrosis. Malondialdehyde(MDA) and 4-hydroxyalkenal(4-HAE), and endothelial nitric oxide synthase(e NOS) and inducible nitric oxide synthase(i NOS) protein levels were also measured in cardiac and aortic homogenates. RESULTS: In untreated diabetic rats, cholesterol levels were higher than in control rats(CT; n = 8, P < 0.05), and the low dose of statins used did not modify these levels. In diabetic rats, SBP was higher than in CT, and was significantly reduced by all three statins(n = 10, P < 0.05). Echocardiographic parameters(EF, SV, and COI) were all lower in untreated diabetic rats than in CT(n = 10, P < 0.05). These CV parameters were equallyimproved by all three statins. The maximal relaxation(EMax) induced by ACh in aortic ring from diabetic rats was also improved. Moreover, this relaxation was abolished by 1 mmol/L NG-nitro-L-arginine methyl ester, suggesting the involvement of a NO-dependent mechanism. CONCLUSION: AV, SV, and PV are equally effective in improving CV performance in diabetic rats. All tree statins decreased media thickness, perivascular fibrosis, and both MDA and 4-HAE in the aortas of diabetic rats, without affecting e NOS and i NOS protein levels. The observed hemodynamic benefits are cholesterolindependent. These benefits appear to be secondary to the improved endothelial function, and to the reduced vascular tone and remodeling that result from decreased oxidative stress.

关键词： Statins Diabetes Oxidative stress Cardiac function

Harnessing artificial intelligence for identifying conflicts of interest in research

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World journal of Methodology 2025年第1期15卷 6-8页

作者： Abdulqadir j Nashwan Department of Nursing&Midwifery Research Hamad Medical CorporationDoha 3050Qatar

This editorial explores the transformative potential of artificial intelligence(AI)in identifying conflicts of interest(COIs)within academic and scientific *** harnessing advanced data analysis,pattern recognition,and natural language processing techniques,AI offers innovative solutions for enhancing transparency and integrity in *** editorial discusses how AI can automatically detect COIs,integrate data from various sources,and streamline reporting processes,thereby maintaining the credibility of scientific findings.

关键词： Artificial intelligence Conflicts of interest Transparency Research integrity Natural language processing

Neuroprotection by resveratrol-glucuronide and quercetin-glucuronide via binding to polyphenol-and glycosaminoglycan-binding sites in the laminin receptor

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Neural Regeneration Research 2025年第3期20卷 819-820页

作者： Rayudu Gopalakrishna jennifer Aguilar Emily Lee William j.Mack Department of Integrative Anatomical Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of Neurological Surgery Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA

The dietary polyphenolic compounds resveratrol and quercetin prevent neurodegenerative diseases in experimental models;however, they reach the brain only in nanomolar concentrations in the glucuronidated and sulfated ... 详细信息

关键词： resveratrol molar dated