检索结果-南通市图书馆

Impaired CTLA-4 responses in COPD are associated with systemic inflammation

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2014年第6期11卷 606-608页

作者： Dino ba Tan Sonia Fernandez PatriciaPrice Martyn A French Philip j Thompson Yuben P Moodley Centre for Asthma Allergy and Respiratory Research Lung Institute of Western Australia Nedlands Australia School of Medicine and Pharmacology Nedlands Australia School of Pathology and Laboratory Medicine University of Western Australia Nedlands Australia Department of Clinical Immunology Perth Australia Department of Respiratory and Sleep Medicine Royal Perth Hospital Perth Australia

Systemic inflammation is a feature of chronic obstructive pulmo- nary disease （COPD）. Defects in T cell-mediated anti-inflamma- tory pathways such as cytotoxic T lymphocyte antigen-4 （CTLA- 4） may promote damaging inflammation. This study provides novel data implicating the impaired induction of an anti-inflam- matory molecule, CTLA-4 in the elevated inflammation observed in COPD patients. Low induction of CTLA-4 in COPD patients paralleled increased markers of systemic inflammation ex vivo and increased T-cell responses to a bacterial superantigen, staphylo- coccal enterotoxin-B （SEB） in vitro. This mechanism may explain the increased inflammation in COPD patients.

关键词： T淋巴细胞肠毒素类肺疾病慢性阻塞性抗原分化炎症胰岛素体外研究

Diamonds and Other Exotic Minerals Recovered from Peridotites of the Dangqiong Ophiolite, Western Yarlung-Zangbo Suture Zone, Tibet

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Geologica Sinica(English Edition) 2016年第2期90卷 425-439页

作者： XIONG Fahui YANG jingsui ROBINSON Paul T. XU Xiangzhen ba Dengzhu LI Yuan ZHANG Zhongming RONG He CARMA State Key Laboratory for Continental Tectonics and Dynamics Institute of Geology Chinese Academy of Geological Sciences

Various combinations of diamond, moissanite, zircon, quartz, corundum, rutile, titanite, almandine garnet, kyanite, and andalusite have been recovered from the Dangqiong peridotites. More than 80 grains of diamond have been recovered, most of which are pale yellow to reddish-orange to colorless. The grains are all 100-200 μm in size and mostly anhedral, but with a range of morphologies including elongated, octahedral and subhedral varieties. Their identification was confirmed by a characteristic shift in the Raman spectra between 1325 cm^-1 and 1333 cm^-1, mostly at 1331.51 cm^-1 or 1326.96 cm^-1. Integration of the mineralogical, petrological and geochemical data for the Dongqiong peridotites suggests a multi-stage formation for this body and similar ophiolites in the Yarlung-Zangbo suture zone. Chromian spinel grains and perhaps small bodies of chromitite crystallized at various depths in the upper mantle, and encapsulated the UHP, highly reduced and crustal minerals. Some oceanic crustal slabs containing the chromian spinel and their inclusion were later trapped in suprasubduction zones（SSZ）, where they were modified by island arc tholeiitic and boninitic magmas, thus changing the chromian spinel compositions and depositing chromitite ores in melt channels.

关键词： diamond Multi-stage formation Dangqiong ophiolite Yarlung-Zangbo suture zone

Alkaline activation of endogenous latent TGFβ1 by an injectable hydrogel directs cell homing for in situ complex tissue regeneration

在线全文

学校读者我要写书评

暂无评论

Bioactive Materials 2022年第9期7卷 316-329页

作者： Sainan Wang Yuting Niu Peipei jia Zheting Liao Weimin Guo Rodrigo Cotrim Chaves Khanh-Hoa Tran-ba Ling He Hanying bai Sam Sia Laura j.Kaufman Xiaoyan Wang Yongsheng Zhou Yanmei Dong jeremy j.Mao Department of Cariology and Endodontology Peking University School and Hospital of StomatologyBeijing100081China Department of Prosthodontics Peking University School and Hospital of StomatologyBeijing100081China Center for Craniofacial Regeneration Columbia UniversityNew YorkNY10032USA Department of Biomedical Engineering Columbia UniversityNew YorkNY10027USA Department of Chemistry Columbia UniversityNew YorkNY10027USA

Utilization of the body’s regenerative potential for tissue repair is known as in situ tissue ***,the use of exogenous growth factors requires delicate control of the dose and delivery strategies and may be accompanied by safety,efficacy and cost *** this study,we developed,for the first time,a biomaterial-based strategy to activate endogenous transforming growth factor beta 1(TGFβ1)under alkaline conditions for effective in situ tissue *** demonstrated that alkaline-activated TGFβ1 from blood serum,bone marrow fluids and soaking solutions of meniscus and tooth dentin was capable of increasing cell recruitment and early differentiation,implying its broad ***,we engineered an injectable hydrogel(MS-Gel)consisting of gelatin microspheres for loading strong alkaline substances and a modified gelatin matrix for hydrogel click *** vitro models showed that alkaline MS-Gel controllably and sustainably activated endogenous TGFβ1 from tooth dentin for robust bone marrow stem cell *** importantly,infusion of in vivo porcine prepared root canals with alkaline MS-Gel promoted significant pulp-dentin regeneration with neurovascular stroma and mineralized tissue by endogenous proliferative ***,this work offers a new bench-to-beside translation strategy using biomaterial-activated endogenous biomolecules to achieve in situ tissue regeneration without the need for cell or protein delivery.

关键词： Endogenous TGFβ1 Injectable alkaline hydrogel Cell homing Pulp-dentin complex In situ tissue regeneration

US Georgetown University President john DeGioia Leads Delegation to China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Voice of Friendship 2009年第4期 17-18页

作者： ba Cuicui

Invited by the CPAFFC, john j. DeGioia, president of Georgetown University of the U. S.,and his party visited Gansu, jiangxi and Hubei provinces and Beijing from March 4 to 9. Liu Yandong, state councillor; Li Yuancha... 详细信息

关键词： visited jiangxi party Hubei president delegation c

SR8278改善时差所致小鼠泪腺功能紊乱的转录组学分析

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

眼科新进展 2024年第4期44卷 264-269页

作者：黄深振齐迪裴晓婷路顶立司宏丽黄杜鎏睿张文潇巴梦茹轩书婷李志杰郑州大学人民医院河南省人民医院河南大学人民医院河南省立眼科医院河南省眼科研究所河南省郑州市450003

目的探讨核受体亚家族1 D组成员1(NR1D1)合成拮抗剂SR8278在改善时差诱导的小鼠眶外泪腺结构和功能损伤方面的作用及其机制。方法 36只健康的8~10周龄野生型C57BL/6j小鼠在12 h光照/12 h黑暗循环的昼夜节律箱内适应2周后随机分为3组:... 详细信息

目的探讨核受体亚家族1 D组成员1(NR1D1)合成拮抗剂SR8278在改善时差诱导的小鼠眶外泪腺结构和功能损伤方面的作用及其机制。方法 36只健康的8~10周龄野生型C57BL/6j小鼠在12 h光照/12 h黑暗循环的昼夜节律箱内适应2周后随机分为3组:正常组(12 h光照/12 h黑暗循环的昼夜节律箱饲养)、时差组(8 h前移的12 h光照/12 h黑暗循环的昼夜节律箱饲养)及时差+SR8278组(8 h前移的12 h光照/12 h黑暗循环的昼夜节律箱饲养,并给予25 mg·kg^(-1)的SR8278干预),每组12只,共干预5 d。干预结束后,收集各组小鼠的活动度和核心体温,记录小鼠的泪液分泌量,并对泪腺组织进行称重和泪腺细胞大小测量。采用免疫组织化学方法对小鼠眶外泪腺进行组织学评估。提取泪腺RNA进行包含NR1D1的高通量RNA-Seq分析,并对获得的转录组数据进行KEGG和GO功能富集分析。结果与正常组相比,时差组小鼠白天活动度较高,夜间活动度较低,白天核心体温较高,夜间核心体温较低,差异均有统计学意义(均为P<0.05)。与时差组相比,时差+SR8278组小鼠白天活动度较低,夜间活动度较高,白天核心体温较低,夜间核心体温较高,差异均有统计学意义(均为P<0.05)。与正常组相比,时差组小鼠泪腺重量及泪液分泌量降低,泪腺细胞增大,差异均有统计学意义(均为P<0.05);与时差组相比,时差+SR8278组小鼠泪腺重量及泪液分泌量增加,泪腺细胞减小,差异均有统计学意义(均为P<0.05)。与正常组相比,时差组小鼠夜晚泪腺中NR1D1表达量较高;与时差组相比,时差+SR8278组小鼠夜晚泪腺中NR1D1表达量较低,差异均有统计学意义(均为P<0.05)。生物信息学分析显示,时差组和时差+SR8278组共有947个显著性差异基因,其中显著性上调基因43个,显著性下调基因904个,信号通路差异最大的为Notch信号通路。结论 SR8278通过靶向抑制NR1D1,有效增强了时差小鼠的泪液分泌功能,其过程可能是通过Notch信号通路完成的。

关键词：时差 SR8278 泪腺功能紊乱小鼠

INFLUENCE OF PULSED MAGNETIC FIELD ON MICROSTRUC-TURES AND MACRO-SEGREGATION IN 2124 Al-ALLOY

在线全文

学校读者我要写书评

暂无评论

Acta Metallurgica Sinica(English Letters) 2002年第4期15卷 380-384页

作者： C.Y.ban,j.Z.Cui,Q.X.ba,G.M.Lu and B.j.ZhangP.O. Box 317, The Key Laboratory of Electromagnetic Processing of Materials, Ministry of Education, Northeastern University, Shenyang 110004, China Manuscript received 10 October 2001 P.O. Box 317 The Key Laboratory of Electromagnetic Processing of Materials Ministry of Education Northeastern University Shenyang 110004 China

The structures and macro-segregation of 2124 Al-alloy were studied when a pulsed magnetic field (PMF) was applied during solidification. It is found through experi-ments that a remarkable change occurs in the solidification structures of 2124 Al-alloy under pulsed magnetic field. The eutectic phase at grain boundaries change from thick continuous eutectic network to thin discontinuous one, and the distribution of solute elements was also homogenized. The typical negative segregation phenomenon of Cu in common solidification condition was restrained, and the segregation of Mg decreased.

关键词： aluminium alloy pulsed magnetic field microstructure segrega-tion

baTiO3 solid solutions co-doped with Gd3+ and Eu3+:Synthesis,structural evolution and dielectric properties

在线全文

学校读者我要写书评

暂无评论

journal of Rare Earths 2024年第10期42卷 1920-1926页

作者： R.Martínez-López M.Pérez-Labra j.A.Romero-Serrano F.R.barrientos-Hernández M.Reyes-Pérez M.I.Valenzuela-Carrillo G.Urbano-Reyes V.E.Reyes-Cruz G.I.Dávila-Pulido Academic Area of Earth Sciences and Materials Autonomous University of Hidalgo State Metallurgy and Materials Department ESIQIE-IPNUPALM Autonomous University of Coahuila Boulevard Adolfo López Mateos S/n

In this paper,the synthesis,structural evolution,and dielectric properties of baTiO3solid solutions codoped with rare earth elements(Gd3+and Eu3+) prepared using the solid-state reaction method are *** pure precursor powders of baCl3,TiO2,Gd2O3,and Eu2O3were mixed in stoichiometric proportions,ground in an agate mortar before being uniaxially pressed at 250 MPa and sintered at 1300℃ in air atmosphere for 6 h to obtain ba1-3xGd2xTi1-3xEu4xO3（x=0,0.0015,0.01 and0.1）.X-ray diffraction（XRD） and Rietveld's refinement results reveal the crystal phase ferroelectric tetragonal baTiO3for the samples with x=0,0.0015 and 0.01, as well as a consistent increment in the lattice parameters caused by the *** solubility limit of Gd3+and Eu3+in the baTiO3structure is reached for the sample with x>0.01,and the orthorhombic Eu2TiO5and monoclinic baTi2O5secondary phases were *** Raman results show the characteristic peaks of ferroelectric tetragonal baTiO3around 716 cm-1（LO of A1 symmetry）,515 cm-1（TO of A1 symmetry）,and 305 cm-1（B1）.The maximum relative permittivity measured at 1 kHz was recorded to be 6151.8 for the sample with x=0.0015,and a decrease in the Curie temperature to 105℃ with respect to the undoped sample was *** punctual microanalysis for the samples with x=0.0015,0.01,and 0.1 reveals grains composed of ba,Ti,O,Gd,and Eu homogeneously distributed in the *** ba/Ti ratios for samples with x=0.0015,0.01 and 0.1 are 2.86,2.91,and 0.68,respectively,indicating substitution at the Ti site for samples with x=0.0015 and 0.01 and a substitution at the ba site for the sample with x=0.1.

关键词： baTiO3 Doping Europium Gadolinium Rare earths Synthesis

3D Vector Reconstruction of the Typical Cervical Vertebra from Anatomical Sections of Korean Visible Human at the Laboratory of Clinical and Digital Anatomy of Paris Descartes University

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Forensic Medicine and Anatomy Research 2020年第3期8卷 55-63页

作者： Abdoulaye Kanté jean Franç ois Uhl Mariam Daou Vincent Delmas j. S. Park B. S. Chung babou ba Nouhoum Ongoï ba Anatomy Laboratory University of Paris 5 Paris France Anatomy Laboratory University of Sciences Techniques and Technologies of Bamako Bamako Mali Department of Neurology Gabriel Touré University Hospital in Bamako Bamako Mali Department of Anatomy Dongguk University School of Medicine Dongguk Republic of Korea

Aim: To carry out a 3D vector reconstruction of the typical cervical vertebra from anatomical sections of the “Korean Visible Human” for educational purposes. Material and Methods: The anatomical subject was a 33-year-old Korean man who died of leukemia. He was 164 cm tall and weighed 55 kg. This man donated his body to science. Her body was frozen and cut into several anatomical sections after an MRI and CT scan. These anatomical sections were made using a special saw called a 0.2 mm thick cryomacrotome. Thus 8100 cuts were obtained. Only the sections numbered 940 to 1200 were used for our study. A segmentation by manual contouring of the different parts of the typical cervical vertebra was made using the software Winsurf version 3.5 on a laptop PC running Windows 7 equipped with a Ram of 8 gigas. Results: Our 3D vector model of the typical cervical vertebra is easily manipulated using the Acrobat 3DPDF interface. Each part of the vertebra accessible in a menu can be displayed, hidden or made transparent, and 3D labels are available as well as educational menus for learning anatomy. Conclusion: This original work constitutes a remarkable educational tool for the anatomical study of the typical cervical vertebra and can also be used as a 3D atlas for simulation purposes for training in therapeutic gestures.

关键词： Three-Dimensional Anatomy Korean Human Visible Modeling of the Typical Cervical Vertebra Virtual Reality 3D Reconstruction Virtual Dissection Surgical Simulation Surgical Training

Ionization Process of Atoms by Intense Femtosecond Chirped Laser Pulses

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

journal of Modern Physics 2013年第10期4卷 20-26页

作者： Stéphane Laulan jérémie Haché Harouna S. ba Samira barmaki Laboratoire de Physique Computationnelle et Photonique Université de Moncton Campus de Shippagan Shippagan Canada

We numerically investigate the ionization mechanism in a real hydrogen atom under intense fem to second chirped laser pulses. The central carrier frequency of the pulses is chosen to be 6.2 eV (λ = 200 nm), which corresponds to the fourth-harmonic of the Ti:Sapphire laser. Our simulation of the laser-atom interaction consists on numerically solving the three-dimensional time-dependent Schrodinger equation with a spectral method. The unperturbed wave functions and electronic energies of the atomic system were found by using an L2 discretization technique based on the expansion of the wave functions on B-spline functions. The presented results of kinetic energy spectra of the emitted electrons show the sensitivity of the ionization process to the chirp parameter. Particular attention is paid to the important role of the excited bound states involved in the ionization paths.

关键词： Hydrogen Atom Chirped Laser Multiphoton Ionization Population Transfer Nonperturbative Approach