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基于心脏MR的新型扩张型心肌病个性化风险分层模型：一项前瞻性研究

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国际医学放射学杂志 2024年第4期 504-504页

作者： D.Zhou L.Y.Zhu W.C.Wu B.Y.Zhuang j.he j.Xu 代静文

摘要目的探讨预测扩张型心肌病（DCM）病人中期预后的心脏MR(CMR)指标的个体权重，并开发基于CMR生物标志物的中期预后的风险算法。方法前瞻性纳入接受

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Unable to forget in autism susceptibility genes mutants

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Unable to forget in autism susceptibility genes mutants

第三届“模式生物与人类健康”发育遗传学全国学术研讨会

作者： T.Dong j.he S.Wang L.Wang 钟毅 School of Life Sciences Tsinghua University

To investigate whether common neurobiological mechanisms underlie effects of autism susceptibility genes,we assayed both the immediate memory and reversal memory in mutants of multiple homologous such genes in *** found that although showing mild immediate memory defects,all these mutants displayed a serve defect in reversal *** other words,much pronounced alteration was observed in cognitive flexibility than in learning among all homologous autism

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Particulate organic carbon export fluxes and validation of steady state model of 234Th export in the Chukchi Sea

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Particulate organic carbon export fluxes and validation of s...

福建省海洋学会2014年学术年会暨福建省科协第十四届学术年会

作者： W.Yu j.he Y.Lia W.Lin L.Chen Third Institute of Oceanography State Oceanic Administration Key Laboratory of Global Change and Marine-Atmospheric Chemistry State Oceanic Administration Department of Engineering Physics Tsinghua University

To evaluate the efficiency of biological pump and carbon sequestration content on Arctic shelf, estimations of POC export fluxes derived from 234Th/238 U disequilibrium were made during the 3rd Chinese National Arctic Research Expedition(CHINARE-3) from july 12 to September 22, 2008. The 234 Th analysis was based on small volume Mn O2 co-precipitation and β-counting method. Great deficits of 234 Th to 238 U were observed widely over Chukchi shelf, with an average 234Th/238 U activity ratio of 0.64±0.28, resulting from intense particle scavenging. The average POC export fluxes in the entire study area, shelf and slope area were 24.9±23.3, 29.5±23.0 and 2.1±0.5 mmol C m-2 d-1, respectively, resulting in that 21% of the primary production on average was exported to the benthos. Comparing with steady state model, non-steady-state model was recommended to derive a more accurate particulate 234 Th export flux in a rapidly changing environment in the high latitude areas.

关键词： POC export flux Organic carbon burial rate 234Th/238U disequilibrium Non-steady-state model

研究HIV/HCV和药物滥用相互作用的动物模型

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研究HIV/HCV和药物滥用相互作用的动物模型

第十届全国药物依赖性学术会议暨首届中美药物滥用和HIV/HCV共病专题研讨会

作者： johnny j.he Center for AIDS Research and Department of Microbiology and Immunology Indiana University School of Medicine IndianapolisIN46202

Investigation of many aspects of the in vivo behavior of HIV/HCV as well as testing of the in vi- vo efficacy of novel anti-HIV/HCV therapies and vaccines has been hampered by the restriction of HIV/HCV infection to h... 详细信息

关键词： animal model HIV/HCV drug abuse interaction

Effects of Microalgal Carotenoids on Acute Renal Injury Prophylaxis in Male Wistar Rats

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Effects of Microalgal Carotenoids on Acute Renal Injury Prop...

全国第九届海洋生物技术与创新药物学术会议

作者： j.G.Liu j.he Y.Zhang H.Gao D.Y.Liu T.Pang Institute of Oceanology Chinese Academy of Sciences

Microalgal bioproducts enriched with astaxanthin andβ-carotene were systematically studied to determine their effects on the acute renal injury prophylaxis in male wistar *** rats were pre-fed with different doses of astaxanthin-riched Haematococcus pluvialis powder andβ-carotene extracted from Dunaliella salina via orogastric gavage for 30 ***,acute renal injury was induced by daily intraperitoneal injection of gentamicin(150 mg/kg body weight/day)for 7 *** indexes including serum urea nitrogen(BUN)and ceatinine(CREA),activities of acidic phosphatase(ACP),superoxide dismutase(SOD),protein content,and membrane lipids peroxidized malondialdehyde(MDA)in kidney homogenates were *** samples of renal tissues were microscopically ***,lysosomes,endoplasmic reticula and plasma membrane of the proximal convoluted tubular cells were observed by transmission electron *** results suggested that natural astaxanthin and P-carotene significantly decreased the serum CREA levels in the male rats with acute renal injury,and astaxanthin had greater influence on serum CREA reduction than the same dose ofβ-carotene *** data suggested that astaxanthin increased the ACP activity in lysosomes of the renal ***,those rats with significant increase of ACP activity,also showed a significant decrease in RUN and *** other words,the strongly preventive effects of astaxanthin on acute renal injury in the tested rats are obviously *** andβ-carotene increased SOD activity in the renal tissues of male rats but did not significantly decrease the membrane *** photographs suggested that astaxanthin could prevent the proximal convoluted tubules in the wistar rats from necrosis and prevent glomeruli from atrophia,whereasβ-carotene could not do *** andβ-carotene helped relieve symptoms of the acute renal injury in male rats,such as the rupture of cel

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泥膜对软土泥水盾构隧道施工的影响

科技资讯 2007年第4期5卷 84-85页

作者： j.he W.j.VLASBLOM 卓永军 Huisman-Intrec Sciedam Delft技术大学中铁隧道股份有限公司河南新乡453000

泥水盾构施工中有三种机理对泥膜的形成起作用。泥膜阻止隧道掘进流体自由流入剪切区域,造成泥浆粘度增高和含泥浆的土的渗透性降低。不管泥膜的贯入深度大小,覆盖泥浆的饱和土所需的切削力比无泥浆覆盖的饱和土所需的切削力至少高一倍... 详细信息

泥水盾构施工中有三种机理对泥膜的形成起作用。泥膜阻止隧道掘进流体自由流入剪切区域,造成泥浆粘度增高和含泥浆的土的渗透性降低。不管泥膜的贯入深度大小,覆盖泥浆的饱和土所需的切削力比无泥浆覆盖的饱和土所需的切削力至少高一倍。气窝也更容易在覆盖泥浆的饱和土内出现。

关键词：泥膜泥浆

Comparison of Quadrupole,hexapole and Octopole Collision Cell:SlMION Analysis and Experimental Demonstration

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Comparison of Quadrupole,Hexapole and Octopole Collision Cel...

第三十五届国际光谱会议

作者： Q.Yu Y.Gao X.Y.Tian D.Peng j.he W.Hang~* Department of Chemistry and Department of Mechanical and Electrical Engineering Xiamen University Xiamen 361005 China

＜正＞Different multipole collision cells have been widely used in current mass spectrometry for their outstanding performances in transmission and cooling *** them, radio frequency（rf）-only quadrupole,hexapole,and octopole are routinely used in practical *** of their performances has been carried out using an in-house built electrospray time-of-flight mass spectrometry（ESI-TOFMS）,equipped with changable multipole ***-written program has also been developed by SIMION

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An acoustofluidic scanning nanoscope using enhanced image stacking and processing

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Microsystems & Nanoengineering 2022年第4期8卷 191-198页

作者： Geonsoo jin joseph Rich jianping Xia Albert jhe Chenglong Zhao Tony jun Huang Thomas Lord Department of Mechanical Engineering and Material Science Duke UniversityDurhamNC 27708USA Department of Biomedical Engineering Duke UniversityDurhamNC 27708USA Department of Physics University of Dayton300 College ParkDaytonOH 45469USA Department of Electro-Optics and Photonics University of Dayton300 College ParkDaytonOH 45469USA

Nanoscale optical resolution with a large field of view is a critical feature for many research and industry areas,such as semiconductor fabrication,biomedical imaging,and nanoscale material *** scanning microscopes have been developed to resolve the inverse relationship between the resolution and field of view;however,those scanning microscopes still rely upon fluorescence labeling and complex optical *** overcome these limitations,we developed a dual-camera acoustofluidic nanoscope with a seamless image merging algorithm(alphablending process).This design allows us to precisely image both the sample and the microspheres simultaneously and accurately track the particle path and ***,the number of images required to capture the entire field of view(200×200μm)by using our acoustofluidic scanning nanoscope is reduced by 55-fold compared with previous ***,the image quality is also greatly improved by applying an alpha-blending imaging technique,which is critical for accurately depicting and identifying nanoscale objects or *** dual-camera acoustofluidic nanoscope paves the way for enhanced nanoimaging with high resolution and a large field of view.

关键词： image overcome stacking

joint optimization of production,maintenance,and quality control considering the product quality variance of a degraded system

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Frontiers of Engineering Management 2024年第3期11卷 413-429页

作者： Xiaolei LV Liangxing SHI Yingdong he Zhen he Dennis K.j.LIN CollegeofManagementandEconomics TianjinUniversityTianjin 300072China Laboratory of Computation and Analytics of Complex Management Systems(CACMS) Tianjin UniversityTianjin 300072China Department of Statistics Purdue UniversityWest LafayetteIN 47907USA

The joint optimization of production,maintenance,and quality control has shown effectiveness in reducing long-term operational costs in production ***,existing studies often assume that changes in the mean value of product quality characteristics in a deteriorating system follow a specific distribution while keeping variance *** address this limitation,we propose an innovative method based on the continuous ranking probability score(CRPS).This method enables the simultaneous detection of changes in mean and variance in nonconformities,thus removing the assumption of a specific distribution for quality *** approach focuses on developing optimal strategies for production,maintenance,and quality control to minimize cost per unit of ***,we employ a stochastic model to optimize the production time allocated to the inventory buffer,resulting in significant cost *** effectiveness of our proposed joint optimization method is demonstrated through comprehensive numerical experiments,sensitivity analysis,and a comparative *** results show that our method can achieve cost reductions compared to several other related methods,highlighting its practical applicability for manufacturing companies aiming to reduce costs.

关键词： joint optimization degraded system CRPS control chart uncertain buffer stocking time