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Cd4^(+)T cells produce IFN-I to license cdC1s for induction of cytotoxic T-cell activity in human tumors

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Cellular & molecular Immunology 2024年第4期21卷 374-392页

作者： Xin lei daniël C.de Groot marij j.P.Welters Tom de Wit Ellen Schrama hans van Eenennaam Saskia j.Santegoets Timo Oosenbrug Annemarthe van der Veen joris l.Vos Charlotte l.Zuur Noel F.C.C.de miranda heinz jacobs Sjoerd h.van der Burg jannie Borst Yanling Xiao department of Immunology Leiden University Medical CenterLeidenThe Netherlands Oncode Institute Leiden University Medical CenterLeidenThe Netherlands department of Tumor Biology and Immunology The Netherlands Cancer InstituteAmsterdamThe Netherlands department of medical Oncology Oncode InstituteLeiden University Medical CenterLeidenThe Netherlands ImmIOS B.V. OssThe Netherlands division of medical Oncology The Netherlands Cancer InstituteAmsterdamThe Netherlands department of Otorhinolaryngology leiden University medical Center LeidenThe Netherlands department of Pathology Leiden University Medical CenterLeidenThe Netherlands

Cd4^(+)T cells can"help"or"license" conventional type 1 dendritic cells(cdC1s)to induce Cd8^(+)cytotoxic T lymphocyte(CTl)anticancer responses,as proven in mouse *** recently identified cdC1s with a transcriptomic imprint of Cd4^(+)T-cell help,specifically in T-cell-infiltrated human cancers,and these cells were associated with a good prognosis and response to Pd-1-targeting ***,we delineate the mechanism of cdC1 licensing by Cd4^(+)T cells in *** Cd4^(+)T cells produce IFNβvia the STING pathway,which promotes mhC-I antigen(cross-)presentation by cdC1s and thereby improves their ability to induce CTl anticancer *** cooperation with Cd40 ligand(l),IFNβalso optimizes the costimulatory and other functions of cdC1s required for CTl response ***-I-producing Cd4^(+)T cells are present in diverse T-cell-infiltrated cancers and likely deliver“help”signals to CTls locally,according to their transcriptomic profile and colocalization with“helped/licensed”cdCs and tumor-reactive Cd8^(+)T *** agreement with this scenario,the presence of IFN-I-producing Cd4^(+)T cells in the TmE is associated with overall survival and the response to Pd-1 checkpoint blockade in cancer patients.

关键词： Cd4^(+)T-cell help cdC1 licensing IFN-I signaling Cd40 costimulation (cross-)presentation CTl priming Tumor control

由超拍电子伏特加速器产生的超高能伽马射线气泡

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Science Bulletin 2024年第4期69卷 449-457页

作者： lhAASO Collaboration Zhen Cao Chuandong Gao Cong li Ruo-Yu liu Ruizhi Yang 不详 Key laboratory of Particle Astrophyics&Experimental Physics division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China TIANFU Cosmic Ray Research Center ChengduChina Institute of Frontier and Interdisciplinary Science Shandong UniversityQingdao 266237China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China University of Science and Technology of China Hefei 230026China

We report the detection of aγ-ray bubble spanning at least 100deg2 in ultra-high energy(UhE)up to a few PeV in the direction of the star-forming region Cygnus X,implying the presence super PeVatron(s)accelerating protons to at least 10 PeV.A log-parabola form with the photon indexΓ(E)=(2.71±0.02)+(0.11±0.02)×log10(E/10 TeV)is found fitting the gamma-ray energy spectrum of the bubble *** sources,“hot spots”correlated with very massive molecular clouds,and a quasi-spherical amorphousγ-ray emitter with a sharp central brightening are observed in the *** the core of~0.5°,spatially associating with a region containing massive OB association(Cygnus OB2)and a microquasar(Cygnus X-3),as well as previously reported multi-TeV sources,an enhanced concentration of UhEγ-rays is observed with 2 photons at energies above 1 *** general feature of the bubble,the morphology,and the energy spectrum,are reasonably reproduced by the assumption of a particle accelerator in the core,continuously injecting protons into the ambient medium.

关键词： Cosmic rays γ-rays Interstellar medium Star cluster

Supramolecular Polymerization of hydrogen-Bonded Trimers in Bulk and Aqueous medium

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CCS Chemistry 2024年第6期6卷 1458-1465页

作者： Freek V.de Graaf Stef A.h.jansen Sandra m.C.Schoenmakers Bas van Genabeek marle E.j.Vleugels Bart W.l.van den Bersselaar E.W.meijer Ghislaine Vantomme Institute for Complex molecular Systems Laboratory of Macromolecular and Organic ChemistryEindhoven University of Technology5600 MBEindhoven School of Chemistry and RNA Institute University of New South WalesSydneyNew South Wales 2052

Synthetic molecules that form functional noncovalent assemblies in water have received much attention for their potential applications as *** this work,we introduce a novel water-compatible monomer based on the phthalhydrazide moiety that assembles into hydrogen-bonded trimeric *** bulk,the material exhibits a cylindrical nanostructure in the liquid-crystalline phase at elevated temperatures,morphologically distinct from the crystalline lamellar *** water,these molecules effectively form cylinders in a one-dimensional fashion,yielding fibrous *** formation of these supramolecular polymers follows a cooperative mechanism,as evidenced by denaturation *** trimerized pattern represents a new category of aqueous su pramolecular polymers with future prospects for functional complex molecular systems.

关键词： noncovalent chemistry supramolecular polymers hydrogen bonding cooperativity nanostructure

Finding biomarkers of experience in animals

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journal of Animal Science and Biotechnology 2024年第3期15卷 925-944页

作者： Sarah Babington Alan j.Tilbrook Shane K.maloney jill N.Fernandes Tamsyn m.Crowley luoyang ding Archa h.Fox Song Zhang Elise A.Kho daniel Cozzolino Timothy j.mahony dominique Blache School of Agriculture and Environment The University of Western AustraliaCrawleyWA 6009Australia Centre for Animal Science The Queensland Alliance for Agriculture and Food InnovationThe University of QueenslandSt LuciaQLD 4072Australia School of Veterinary Science The University of QueenslandGattonQLD 4343Australia School of human Sciences The University of Western AustraliaCrawleyWA 6009Australia School of medicine Deakin UniversityGeelongVIC 3217Australia Poultry hub Australia University of New EnglandArmidaleNSW 2350Australia College of Animal Science and Technology Yangzhou UniversityYangzhou 225009China Centre for Nutrition and Food Sciences The Queensland Alliance for Agriculture and Food InnovationThe University of QueenslandSt LuciaQLD 4072Australia

At a time when there is a growing public interest in animal welfare,it is critical to have objective means to assess the way that an animal experiences a *** is critical to ensure appropriate animal welfare *** behavioural,physiological,and neurobiological indicators that are used to assess animal welfare can verify the absence of extremely negative *** welfare is more than an absence of negative outcomes and an appropriate indicator should reflect the full spectrum of experience of an animal,from negative to *** this review,we draw from the knowledge of human biomedical science to propose a list of candidate biological markers(biomarkers)that should reflect the experiential state of non-human *** proposed biomarkers can be classified on their main function as endocrine,oxidative stress,non-coding molecular,and thermobiological *** also discuss practical challenges that must be addressed before any of these biomarkers can become useful to assess the experience of an animal in real-life.

关键词： Animal experience Animal welfare Biomarker Stress Welfare assessment

Causes of Cretaceous subduction termination below South China and Borneo:Was the Proto-South China Sea underlain by an oceanic plateau?

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Geoscience Frontiers 2024年第2期15卷 100-124页

作者： Suzanna h.A.van de lagemaat licheng Cao junaidi Asis Eldert l.Advokaat Paul R.d.mason mark j.dekkers douwe j.j.van hinsbergen department of Earth Sciences Utrecht UniversityUtrechtthe Netherlands College of marine Science and Technology China University of GeosciencesWuhanChina Faculty of Science and Natural Resources Universiti Malaysia SabahKota KinabaluMalaysia

The South China,Indochina,and Borneo margins surrounding the South China Sea contain long-lived arcs that became inactive at approximately 85 ma,even though an embayment of oceanic crust(the‘Proto-South China Sea’)remained in the intervening *** oceanic crust eventually subducted in the Cenozoic below Borneo and the Cagayan arc,while the modern South China Sea opened in its *** investigate the enigmatic cessation of mesozoic subduction below South China and Borneo,we studied a fragment of oceanic crust and overlying trench-fill sediments that accreted to NW Borneo during the final stages of Paleo-Pacific *** on radiolarian biostratigraphy of cherts overlying the pillow basalts and detrital zircon geochronology of the trench-fill,we constrained the minimum age of the oceanic crust during accretion to 40 *** shows that subduction cessation was not related to ridge *** analysis of pillow basalts revealed an enriched mid-ocean ridge basalt signature comparable to oceanic *** paleomagnetism,we show that this fragment of oceanic crust was not part of the Izanagi Plate but was part of a plate(the‘Pontus’Plate)separated from the Izanagi Plate by a subduction *** on the minimum 40 ma age of the oceanic crust and its geochemistry,we suggest that mesozoic subduction below South China and Borneo stopped when an oceanic plateau entered the trench,while the eastern plate margin with the Izanagi Plate remained *** show how our findings offer opportunities to restore plate configurations of the Panthalassa-Tethys junction region.

关键词： Proto-South China Sea Paleomagnetism Geochemistry Borneo Paleo-Pacific Izanagi Plate

Crystal structure and luminescence dynamics of highly pure lim(PO_(3))_(3):Eu^(3+)(m=Sr,Ca) red phosphors for white light emitting diodes

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journal of Rare Earths 2024年第8期42卷 1470-1478,I0002页

作者： Payal Khajuria m.manhas A.K.Bedyal Ankush Vij h.C.Swart Vinay Kumar department of Physics and Astronomical Sciences Central University of JammuRahy-Suchani.Samba1143J&KIndia department of Physics School of SciencesCluster University of JammuCanal RoadJammu180001India department of Physics University of Petroleum and Energy StudiesDehradunUttarakhand248007India department of Physics University of the Free StateP.O.Box 339BloemfonteinZA 9300South Africa

highly pure red phosphors lim(PO_(3))_(3):Eu^(3+)(m=Sr,Ca) doped with Eu^(3+)(1 mol%) were synthesized via solution combustion method and their crystal structure and luminescence dynamics were studied to explore its suitability in white light emitting *** Rietveld refinement analysis of the powder Xray diffraction patterns reveals that the phosphors belong to the pure triclinic phase of liSr(PO_(3))_(3) and liCa(PO_(3)) with space group P-1(2).The scanning electron microscopy images showed the agglomerated *** photoluminescence emission spectra under 393 nm show an orange band at 594 nm and a red band at 613 nm ascribed to ^(5)d_(0)→^(7)F_(1).^(5)d_(0)→^(7)F_(2) transitions of Eu^(3+)ion in both the ***,the spectroscopic properties such as luminescence behaviour,and Stark splitting were used to examine the symmetry of Eu^(3+)ions in lim(PO_(3))_(3):Es^(3+)(m=Sr,Ca) phosphors in terms of distortion induced upon *** Stark splitting shows that the actual site symmetry for Eu^(3+)ion was estimated to be d_(2) type for both *** photometric properties of liCa(PO_(3))_(3):Eu^(3+)such as Commission International de l'Eclairage coordinates(x=0.64,y=0.36) near to the standard one(red),high color purity(95%) and higher brightness reveal that the phosphor has the capability of acting as a red component in n-UV white light emitting diodes.

关键词： Photoluminescence Phosphate WlEds Stark splitting Rare earths

Phanerozoic co-evolution of O2-CO2 and ocean habitability

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National Science Review 2024年第6期11卷 18-21页

作者： Zunli lu Rosalind E.m.Rickaby jonathan l.Payne Ashley N.Prow department of Earth & Environmental Sciences Syracuse University department of Earth Sciences University of Oxford department of Earth and Planetary Sciences Stanford University

Atmospheric carbon dioxide and oxygen concentrations are partially linked via the geological cycle of organic carbon （Fig. 1A–C; e.g. CO2+h2O■Ch2O+O2）. The history of these two biologically active components, controls on their concentrations, and implications for the complexity of the biosphere and habitability of Earth have been hotly debated, but are generally considered independently.

关键词： CO2-CONCENTRATING mEChANISm OXYGEN EVOlUTION ANOXIA

CO oxidation under lean and stoichiometric conditions over ceriazirconia with very low metal contents(Cu,Co,Ag and Pt)

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journal of Rare Earths 2024年第9期42卷 1669-1681,I0002页

作者： j.C.martínez-munuera m.P.Yeste A.García-García mCmA Group Department of Inorganic Chemistry and Institute of MaterialsUniversity of AlicanteCarretera de San Vicente del Raspeig s/n03690San Vicente del RaspeigAlicanteSpain Solid Chemistry and Catalysis Group Department of Materials ScienceMetallurgic Engineering and Inorganic ChemistryInstitute of Electronic Microscopy and Materials ResearchUniversity of CádizAp.40E-11510Puerto RealCádizSpain

In this work,several ceria-zirconia based catalysts with very lo w(and equimolar) metal contents were prepared,characterised and tested for the CO oxidatio n reaction(under lean and stoichiometric conditions),trying to emulate those conditions found in a diesel oxidation catalyst(dOC) system from a diesel engine and those encountered under gasoline exhaust(λ=1).The metals chosen are Cu,Co,Ag and Pt(as a reliable benchmark).The results reveal enormous differences among reducibility and catalytic activity despite quite similar structural and textural properties of the catalysts,showing differences among dispersion(Ag-catalyst seems to present a low level of dispersion).This catalyst seems to be characterised,as well,by a strong electronic interaction between Ce and Ag centres which is suggested to yield an improved reducibility under h_(2)-TPR ***,the order in catalytic activity(Cu>Ag>Co≈Pt>>support) seems not to follow the order found in reducibility and the Cu-catalyst seems to be the most active independently on the reaction conditions,yielding nearly overlapped CO oxidation catalytic *** restingly,a stro ng correlation between the catalytic activity under the two conditions tested and the OSC values of the Ce_(0.8)Zr_(0.2)O_(2)-supported metal catalysts is ***,OSC parameter measured at 150℃ can be used as a relevant descriptor to evaluate the CO oxidation activity at low and medium conversions for the investigated catalysts,much better than the h_(2)-TPR measurements.

关键词： CO oxidation low metal content Ceria-zirconia Copper species OSC parameter Rare earths

Enabling Technologies for Autonomous Robotic Systems in manufacturing

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Transactions of Nanjing University of Aeronautics and Astronautics 2024年第4期41卷 403-431页

作者： ERdŐS Gábor ABAI Kristóf BEREGI Richárd CSEmPESZ jános CSERTEG Tamás GOdÓGábor hAjÓS mátyás hÁY Borbála hORVÁTh dániel hORVÁTh Gergely jUNIKIÁdám KEmÉNY Zsolt KOVÁCS András NACSA jános PANITI Imre PEdONE Gianfranco TAKÁCS Emma TIPARY Bence ZAhORÁN lászló VÁNCZA józsef Institute for Computer Science and Control Hungarian Research Network(HUN-REN SZTAKI)BudapestHungary department of manufacturing Science and Technology Budapest University of Technology and Economics(BME)BudapestHungary EPIC Innolabs Nonprofit ltd. BudapestHungary Eötvös loránd University(ElTE) BudapestHungary

Research of autonomous manufacturing systems is motivated both by the new technical possibilities of cyber-physical systems and by the practical needs of the *** operation in semi-structured industrial environments can now be supported by advanced sensor technologies,digital twins,artificial intelligence and novel communication *** enable real-time monitoring of production processes,situation recognition and prediction,automated and adaptive(re)planning,teamwork and performance improvement by *** paper summarizes the main requirements towards autonomous industrial robotics and suggests a generic workflow for realizing such *** case studies will be presented from recent practice at hUN-REN SZTAKI in a broad range of domains such as assembly,welding,grinding,picking and placing,and *** various solutions have in common that they use a generic digital twin concept as their *** making general recommendations for realizing autonomous robotic solutions in the industry,open issues for future research will be discussed.

关键词： industrial robotics autonomy digital twin enabling technology