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A New X-Ray Tidal Disruption Event Candidate with Fast Variability

Research in Astronomy and Astrophysics 2022年第5期22卷 28-35页

作者： j.Hampel S.Komossa j.greiner T.H.Reiprich M.Freyberg T.Erben Argelander-Institut für Astronomie Aufdem Hugel 71D-53121 BonnGermany Max-Planck Institut für Radioastronomie Auf dem Hugel 69D-53121 BonnGermany National Astronomical Observatories Chinese Academy of ScienceBeijing 100101China Max-Planck Institute für Extraterrestrische Physik GieBenbachstrasse 1D-85748 GarchingGermany

During a close encounter between a star and a supermassive black hole,the star can get disrupted by the black hole’s tidal forces,resulting in a tidal disruption event(TDE).The accretion of the star’s material onto the black hole produces strong emission in different wavelength *** we report the discovery with the Roentgen Satellite(ROSAT)of an X-ray-selected transient source in an optically non-active *** the location R.A.:13h31m57s.66 and decl.:-32°43’19".7 a sudden rise in X-ray luminosity by a factor of 8 within 8 days has been ***,a very soft X-ray spectrum with a blackbody temperature kT=0.1 keV and a peak luminosity of at least 1×10^(43)erg s^(-1)suggests a TDE interpretation,and the observed properties are very similar to previously identified soft X-ray(ROSAT)*** optical spectrum taken of the galaxy at the position of RXj133157.6324319.7 six years after the X-ray outburst does not show any emission lines as would be expected from a persistent active galactic *** redshift of the galaxy is determined to be 0.051 based on absorption *** is therefore likely a member of the galaxy cluster *** rise in X-ray luminosity happens within 8 days and thus appears to be fast for such an *** X-ray emission was detected 170 days before and 165 days after the event,and none was detected 25 yr later with the Neil Gehrels Swift *** change in X-ray luminosity is at least a factor of 40.

关键词： accretion-black holes-galaxies-tidal disruption-X-ray sources

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Production of Exotic Nuclei in Low-Energy Multi-Nucleon Transfer Reactions

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原子核物理评论 2015年第2期32卷 137-145页

作者： V.I. Zagrebaev Walter greiner Flerov Laboratory of Nuclear Reactions JINR Frankfurt Institute for Advanced Studies J.W. Goethe-Universitt

Multinucleon transfer processes in low-energy heavy ion collisions open a new field of research in nuclear physics, namely, production and studying properties of heavy neutron rich nuclei. This not-yet-explored area of the nuclear map is extremely important for understanding the astrophysical nucleosynthesis and the origin of heavy elements. Beams of very heavy U-like ions are needed to produce new long-living isotopes of transfermium and superheavy elements located very close to the island of stability. The calculated cross sections are high enough to perform the experiments at available *** of medium-mass ions(such as136 Xe,192Os,198Pt) can be used for the production of neutron rich nuclei located along the neutron closed shell N = 126(the last waiting point) having the largest impact on the astrophysical r-process. The Low-energy multinucleon transfer reactions is a very efficient tool also for the production and spectroscopic study of light exotic nuclei. The corresponding cross sections are 2 or 3 orders of magnitude larger as compared with high energy fragmentation reactions.

关键词： exotic nuclei multi-nucleon transfer reaction superheavy

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The use of feed-grade amino acids in lactating sow diets

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journal of Animal Science and Biotechnology 2018年第2期9卷 399-406页

作者： Laura greiner Pairat Srichana james L.Usry Casey Neill Gary L.Allee joseph Connor Kevin j.Touchette Christopher D.Knight Carthage Innovative Sow Solutions LLCCarthageIL 62321USA Department of Animal Science University of Missouri-ColumbiaColumbiaMO 65211USA Charoen Pokphand Group Co. Ltd.14th Floor313 Silom Rd.BangrakBangkok 10500Thailand Ajinomoto Heartland Inc.ChicagoIL 60631USA Micronutrients 1550 Research WayIndianapolisIN 46231USA PIC HendersonvilleTN 37075USA Pipestone USA Novus International Inc.St.CharlesMO 63304USA

Background: The use of feed grade amino acids can reduce the cost of lactation feed. With changing genetics,increasing feed costs, and higher number of pigs weaned with heavier wean weights further evaluation of higher inclusion levels of feed-grade amino acid in lactation diets than previously published is warranted. Two experiments(Exp.) were conducted to determine the optimal inclusion level of L-lysine HCl to be included in swine lactation diets while digestible lysine levels remain constant across dietary treatments and allowing feed grade amino acids to be added to the diet to maintain dietary ratios relative to lysine to maximize litter growth rate and sow reproductive performance. Furthermore, the studies were to evaluate minimal amino acid ratios relative to lysine that allows for optimal litter growth rate and sow reproductive ***: Exp. 1: Increasing L-lysine HCl resulted in similar gilt feed intake, litter, and reproductive *** litter gain from birth to weaning was 2.51, 2.49, 2.59, 2.43, and 2.65 kg/d when gilts were fed 0.00, 0.075,0.150, 0.225, and 0.30% L-lysine HCl, respectively. Exp. 2: The average litter gain from birth to weaning was 2.68,2.73, 2.67, 2.70, and 2.64 kg/d(P < 0.70) when sows were fed 0.1, 0.2, 0.3, 0.4, and 0.4% L-lysine HCl plus valine,respectively. No other differences among dietary treatments were ***: Collectively, these studies demonstrate corn-soybean meal based lactation diets formulated with a constant SID lysine content for all parities containing up to 0.40% L-lysine HCl with only supplemental feed grade threonine and a methionine source have no detrimental effect on litter growth rate and subsequent total born.

关键词： Amino acid ratio Lactation L-lysine Sow

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Neurocognitive Graphs of First-Episode Schizophrenia and Major Depression Based on Cognitive Features

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Neuroscience Bulletin 2018年第2期34卷 312-320页

作者： Sugai Liang Roberto Vega Xiangzhen Kong Wei Deng Qiang Wang Xiaohong Ma Mingli Li Xun Hu Andrew j.Greenshaw Russell greiner Tao Li Mental Health Centre West China Hospital Sichuan University Huaxi Brain Research Centre West China Hospital Sichuan University Department of Computing Science University of Alberta Language and Genetics Department Max Planck Institute for Psycholinguistics Huaxi Biobank West China Hospital Sichuan University Department of Psychiatry University of Alberta

Neurocognitive deficits are frequently observed in patients with schizophrenia and major depressive disorder(MDD). The relations between cognitive features may be represented by neurocognitive graphs based on cognitive features, modeled as Gaussian Markov random fields. However, it is unclear whether it is possible to differentiate between phenotypic patterns associated with the differential diagnosis of schizophrenia and depression using this neurocognitive graph approach. In this study, we enrolled 215 first-episode patients with schizophrenia(FES), 125 with MDD, and 237 demographically-matched healthy controls(HCs). The cognitive performance of all participants was evaluated using a battery of neurocognitive tests. The graphical LASSO model was trained with aone-vs-one scenario to learn the conditional independent structure of neurocognitive features of each group. Participants in the holdout dataset were classified into different groups with the highest likelihood. A partial correlation matrix was transformed from the graphical model to further explore the neurocognitive graph for each group. The classification approach identified the diagnostic class for individuals with an average accuracy of 73.41% for FES vs HC, 67.07% for MDD vs HC, and 59.48% for FES vs MDD. Both of the neurocognitive graphs for FES and MDD had more connections and higher node centrality than those for HC. The neurocognitive graph for FES was less sparse and had more connections than that for ***, neurocognitive graphs based on cognitive features are promising for describing endophenotypes that may discriminate schizophrenia from depression.

关键词： Schizophrenia Major depressive disorder Neurocognition Neurocognitive graph Graphical LASSO

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DEVELOPMENT OF THERMALLY STABLE OHMIC CONTACTS TO GaAs MESFETs

DEVELOPMENT OF THERMALLY STABLE OHMIC CONTACTS TO GaAs MESFE...

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The Second International Conference on Solid State and Integrated Circuit Technology

作者： Masanori Murakami W.H.Price j.H.greiner IBM Thomas j.Watson Research Center Yorktown lleightsNew York 10598

＜正＞Recently,based on analysis of the interfacial microstructure of indium-based ohmic contacts, thermally stable,low resistance NilnW ohmic contacts to n-type GaAs have been developed in our laboratories using a standard evaporation and lift-off technique and annealing by a rapid thermal annealing *** device performance and thermal stability were observed in MESFET（metalsemiconductor field-effect transistor） devices with NilnW ohmic contacts by replacing the conventional AuNiGe ohmic contacts.

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阿尔卑斯北部前沿地区构造应力的测量与解释

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地震地质译丛 1981年第2期 34-37页

作者： G.greiner j.Lohr 丁健民

阿尔卑斯北部中欧地区被一条活动的裂谷带所切割。主要块段是来因地堑、穿越来因地块的地震活动带、来因河下游支地槽及其邻近的须德海洼地(荷兰)。这些单元形成一条延伸

关键词：地堑波速地块断层槽构造应力磨拉石主应力方向地震波速度地震波速褶皱带地槽带构造带盆地地质构造阿尔卑斯第三纪前沿地区北北西

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环孢霉素与他克莫司治疗后部和中部脉络膜炎的疗效比较

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世界核心医学期刊文摘（眼科学分册） 2005年第9期1卷 28-29页

作者： Murphy C.C. greiner K. Plskova j. A.D. Dick 杨秀梅 Division of Ophthalmology University of Bristol Bristol Eye Hospital Lower Maudlin Street Bristol BS1 2LX United Kingdom Dr.

Objective: To compare the efficacy and tolerability of tacrolimus and cyclosporine therapy for noninfectious posterior segment intraocular inflammation and to evaluate their effect on peripheral blood CD4+T-cell phenotype and activation status. Method: Thirty-seven patients who required secondline immunosuppression for posterior segment intraocular inflammation were enrolled in this prospective randomized trial of tacrolimus vs cyclosporine therapy. The main outcome measures were visual acuity, binocular indirect ophthalmoscopy score, adverse effects, and quality of life. In addition, peripheral blood CD4+T-cell phenotype and activation status were evaluated by flow cytometry before treatment and at 2, 4, and 12 weeks using CD69, chemokine receptor (CCR4, CCR5, and CXCR3), and intracellular cytokine (tumor necrosis factor α, interferon-γ, and interleukin 10) expression. Results: Thirteen patients (68%) taking tacrolimus and 12 patients (67%) taking cyclosporine responded to treatment. Cyclosporine therapy was associated with a higher incidence of reported adverse effects. Mean arterial pressure and serum cholesterol level were significantly higher at 3 months in the cyclosporine group than the tacrolimus group. No significant difference was detected with regard to effect on quality of life or CD4+T-cell phenotype. Conclusion: Tacrolimus and cyclosporine were similar with regard to ef-ficacy for posterior segment intraocular inflammation, but the results suggested a more favorable safety profile for tacrolimus therapy.

关键词：环孢霉素脉络膜炎双眼间接检眼镜随机对照试验眼内炎后段细胞内细胞流式细胞计活化状态趋化因子受体

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A very energetic supernova associated with the γ-ray burst of 29 March 2003

A very energetic supernova associated with the γ-ray burst ...

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中国天文学会高能分会2004年学术年会

作者： jens Hjorth jesper Sollerman Palle Mφller johan P.U.Fynbo Stan E.Woosley Chryssa Kouveliotou Nial R.Tanvir jochen greiner Michael I.Andersen Alberto j.Castro-Tirado josé María Castro Cerón Andrew S.Fruchter javier Gorosabel Páll jakobsson Lex Kaper S Astronomical Observatory NBIfAFG University of Copenhagen Juliane Maries VejDK-2100 Copenhagenφ Denmark Stockholm Observatory Department of Astronomy AlbaNova S-10691 StockholmSweden European Southern Observatory Karl-Schwarzschild-Strasse 2 D-85748 Garchingbei München Germany Department of Physics and Astronomy University of Aarhus Ny MunkegadeDK-8000rhus C Denmark Department of Astronomy and Astrophysics University of California Santa CruzCalifornia 95064 USA NSSTC SD-50 320 Sparkman Drive Huntsville Alabama 35805 USA Department of Physical Sciences University of Hertfordshire College LaneHatfield AL10 9AB UK Max-Planck-Institut für extraterrestrische Physik D-85741 Garching Germany Astrophysikalisches Institut D-14482 Potsdam Germany Instituto de Astrofísica de Andalucía （IAA-CSIC） PO Box 03004 E-18080 GranadaSpain Space Telescope Science Institute 3700 San Martin Drive BaltimoreMaryland 21218 USA Space Telescope Science Institute 3700 San Martin Drive BaltimoreMaryland 21218 USA Space Telescope Science Institute 3700 San Martin Drive BaltimoreMaryland 21218 USA Instituto de Astrofísica de Andalucía （IAA-CSIC） PO Box 03004 E-18080 GranadaSpain Astronomical Observatory NBIfAFG University of Copenhagen Juliane Maries VejDK-2100 Copenhagen φ Denmark Astronomical Institute Anton Pannekoek Kruislaan 403 NL-1098 SJ AmsterdamNetherlands Thüringer Landessternwarte Tautenburg D-07778 Tautenburg Germany Istituto di Astrofisica Spaziale e Fisica Cosmica - Sezione di Bologna CNRvia Gobetti 101 I-40129 Bologna Italy Astronomical Observatory NBIfAFG University of Copenhagen Juliane Maries VejDK-2100 Copenhagen φ Denmark Astronomical Observatory NBIfAFG University of Copenhagen Juliane Maries VejDK-2100 Copenhagen φ Denmark INAF Osservatorio Astronomico di Trieste Via G.B. Tiepolo 11 I-34131 TriesteItaly Istituto di Astrofisica Spaziale e Fisica Cosmica - Sezione di Bologna CNRvia Gobetti 101 I-40129 Bologna Italy Space Telescope Science I

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Fungal diversity notes 1–110:taxonomic and phylogenetic contributions to fungal species

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Fungal Diversity 2015年第3期72卷 1-197页

作者： jian Kui Liu Kevin D.Hyde E.B.Gareth jones Hiran A.Ariyawansa Darbhe j.Bhat Saranyaphat Boonmee Sajeewa S.N.Maharachchikumbura Eric H.C.McKenzie Rungtiwa Phookamsak Chayanard Phukhamsakda Belle Damodara Shenoy Mohamed A,Abdel-Wahab Bart Buyck jie Chen K.W.Thilini Chethana Chonticha Singtripop Dong Qin Dai Yu Cheng Dai Dinushani ADaranagama Asha j.Dissanayake Mingkwan Doilom Melvina j.D’souza Xin Lei Fan Ishani DGoonasekara Kazuyuki Hirayama Sinang Hongsanan Subashini C.jayasiri Ruvishika S.jayawardena Samantha C.Karunarathna Wen jing Li Ausana Mapook Chada Norphanphoun Ka Lai Pang Rekhani H.Perera Derek Peršoh Umpava Pinruan Indunil CSenanayake Sayanh Somrithipol Satinee Suetrong Kazuaki Tanaka Kasun M.Thambugala Qing Tian Saowaluck Tibpromma Danushka Udayanga Nalin N.Wijayawardene Dhanuska Wanasinghe Komsit Wisitrassameewong Xiang Yu Zeng Faten AAbdel-Aziz Slavomir Adamčík Ali H.Bahkali Nattawut Boonyuen Timur Bulgakov Philippe Callac Putarak Chomnunti Katrin greiner Akira Hashimoto Valerie Hofstetter ji Chuan Kang David Lewis Xing Hong Li Xing Zhong Liu Zuo Yi Liu Misato Matsumura Peter E.Mortimer Gerhard Rambold Emile Randrianjohany Genki Sato Veera Sri-Indrasutdhi Cheng Ming Tian Annemieke Verbeken Wolfgang von Brackel Yong Wang Ting Chi Wen jian Chu Xu ji Ye Yan Rui Lin Zhao Erio Camporesi Guizhou Key Laboratory of Agricultural Biotechnology Guizhou Academy of Agricultural SciencesGuiyang 550006GuizhouChina Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanChina Institute of Excellence in Fungal Research and School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Department of Botany and Microbiology King Saudi UniversityRiyadhSaudi Arabia Manaaki Whenua Landcare Research Private Bag 92170AucklandNew Zealand Formerly Department of Botany Goa UniversityGoaIndia No.128/1–j Azad Housing SocietyCurcaGoa VelhaIndia Muséum national d’histoire naturelle Dépt.Systématique etévolutionUMR 720575005 ParisFrance Institute of Microbiology&Beijing Key Laboratory for Forest Pest Control Beijing Forestry UniversityPO Box 61Beijing 100083China Institute of Plant and Environment Protection Beijing Academy of Agriculture and Forestry SciencesNo.9 of Shu Guang Hua Yuan Zhong LuHaidian DistrictBeijing 10097China The Key Laboratory for Silviculture and Conservation of Ministry of Education Beijing Forestry UniversityBeijing 100083China Mycology University of BayreuthUniversitätsstraße 3095440 BayreuthGermany The United Graduate School of Agricultural Sciences Iwate University18-8 Ueda 3 chomeMorioka 020-8550Japan Apple Experiment Station Aomori Prefectural Agriculture and Forestry Research Center24 FukutamiBotandairaKuroishiAomori 036-0332Japan Department of Plant Protection Agroscope Changins-Wadenswil Research Station ACWRte de Duiller1260 NyonSwitzerland Department of Botany and Microbiology College of ScienceKing Saud UniversityP.O.Box:2455Riyadh 1145Saudi Arabia Department of Botany Faculty of ScienceSohag UniversitySohagEgypt Institute of Botany Slovak Academy of SciencesDúbravskácesta 984523 BratislavaSlovakia Hirosaki University Bleakwood262 CR 3062NewtonTexas 75966USA Faculty of Agriculture and Life Sciences Hirosaki University3 Bunkyo-choHirosakiAomori

This paper is a compilation of notes on 110 fungal taxa,including one new family,10 new genera,and 76 new species,representing a wide taxonomic and geographic *** new family,Paradictyoarthriniaceae is introduced based on its distinct lineage in Dothideomycetes and its unique *** family is sister to Biatriosporaceae and *** new genera are Allophaeosphaeria(Phaeosphaeriaceae),Amphibambusa(Amphisphaeriaceae),Brunneomycosphaerella(Capnodiales genera incertae cedis),Chaetocapnodium(Capnodiaceae),Flammeascoma(Anteagloniaceae),Multiseptospora(Pleosporales genera incertae cedis),Neogaeumannomyces(Magnaporthaceae),Palmiascoma(Bambusicolaceae),Paralecia(Squamarinaceae)and Sarimanas(Melanommataceae).The newly described species are the Ascomycota Aliquandostipite manochii,Allophaeosphaeria dactylidis,***,Alternaria cesenica,Amphibambusa bambusicola,Amphisphaeria sorbi,Annulohypoxylon thailandicum,Atrotorquata spartii,Brunneomycosphaerella laburni,Byssosphaeria musae,Camarosporium aborescentis,***,***,Chaetocapnodium siamensis,Chaetothyrium agathis,Colletotrichum sedi,Conicomyces pseudotransvaalensis,Cytospora berberidis,***,Diaporthe thunbergiicola,Diatrype palmicola,Dictyosporium aquaticum,***,***,Didymella cirsii,Dinemasporium nelloi,Flammeascoma bambusae,Kalmusia italica,***,Keissleriella sparticola,Lauriomyces synnematicus,Leptosphaeria ebuli,Lophiostoma pseudodictyosporium,***,Lophiotrema eburnoides,Montagnula graminicola,Multiseptospora thailandica,Myrothecium macrosporum,Natantispora unipolaris,Neogaeumannomyces bambusicola,Neosetophoma clematidis,***,Oxydothis atypica,Palmiascoma gregariascomum,Paraconiothyrium nelloi,***,Paradictyoarthrinium tectonicola,Paralecia pratorum,Paraphaeosphaeria spartii,Pestalotiopsis digitalis,***,***,Phaeoisaria pseudoclematidis,Phragmocapnias philippinensis,Pseudocamarosporium cotinae,Pseudocercospora tam

关键词： Ascomycota Basidiomycota Global Taxonomy Initiative Phylogeny Taxonomy

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AGNP精神科治疗药物监测共识指南：2011

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实用药物与临床 2016年第10期19卷 1193-1218页

作者： Hiemke C Baumann P Bergemann N Conca A Dietmaier O Egberts K Fric M Gerlach M greiner C Gründer G Haen E Havemann-Reinecke U jaquenoud Sirot E Kirchherr H Laux G Lutz UC Messer T Müller Mj Pfuhlmann B Rambeck B Riederer P Schoppek B Stingl j Uhr M Ulrich S Waschgler R Zernig G 李文标(译) 果伟(译) 阮灿军(译) 贺静(译) 汤宜朗(审校) 王传跃(审校) Department of Psychiatry and Psychotherapy University MedicalCenter of MainzGermany Department of Psychiatry University of LausannePrilly-LausanneSwitzerland Psychiatric Hospital Bad ArolsenGermany Psychiatric Hospital BolzanoItaly Psychiatrc Hospital WeinsbergGermany Department Child and Adolescent Psychiatry University Hospital of WurzburgGermany Kliniken des Bezirks Oberbayern(kbo)Salzach-Inn-Klinikum Was-serburg a.InnGermany Federal Institute for Drugs and Medical Devices(BfArM) BonnGermany Department of Psychiatry and Psychotherapy University of AachenGermany Clinical Pharmacology Department of Psychiatry and Psychoso-maticsUniversity of RegensburgGermany Department of Psychiatry and Psychosomatics University of GotingenGermany Psychiatric Hospital KonigsfeldenBruggAargauSwitzerland Medical Laboratory Bremen Germany Department of Psychiatry and Psychotherapy University of TubingenGermany Psychiatric Hospital PfaffenhofenGermany Psychiatric Hospital Marburg and GieβenGermany Department of Psychiatry Psychotherapy and PsychosomaticsUniversity Hospital of WurzburgGermany Center of Epilepsy BielefeldGermany Psychiatric Hospital HaarGermany Department of Pharmacology of Natural Products and ClinicalPharmacology University of UlmGermany Max Planck Institute of Psychiatry MunichGermany Aristo Pharma GmbH BerlinGermany Psychiatric Hospital FeldkirchAustria Experimental Psychiatry Unit Department of Psychiatry and PsychotherapyMedical University of InnsbruckAustria 首都医科大学附属北京安定医院北京 Emory University School of Medicine AtlantaUSA

治疗药物监测(Therapeutic drug monitoring,TDM),如通过定量测定血清或血浆药物浓度指导用药剂量优化,已经成为对患者进行精神药物治疗的很有价值的工具。在患者用药依从性难以判断、药物耐受性不佳、治疗剂量下无效以及可能存在药代... 详细信息

治疗药物监测(Therapeutic drug monitoring,TDM),如通过定量测定血清或血浆药物浓度指导用药剂量优化,已经成为对患者进行精神药物治疗的很有价值的工具。在患者用药依从性难以判断、药物耐受性不佳、治疗剂量下无效以及可能存在药代动力学药物-药物相互作用等情况下,测定药物浓度是很有用的。在精神科,有可能明显获益于TDM的主要患者群体包括儿童、孕妇、老年患者、智力障碍患者、涉及司法的患者、已知或怀疑携带药代动力学相关基因变异的患者,以及合并躯体疾病影响药代动力学的患者。然而,只有将TDM充分整合到临床治疗过程中去,才能发挥其优化药物治疗的潜在优势。为了促进TDM的合理应用,神经精神药理学与药物精神病学协会(Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie,AGNP)的TDM专家组在2004年发表了精神药物治疗药物监测指南。之后,随着知识不断更新,又有许多可能需要进行TDM的新药上市。因此,本次更新将神经精神药物的种类扩展到了128种,并将其TDM必要性划分为从"强烈推荐"到"可能有用"的四个等级。经过大量细致且全面的文献检索与分门别类的汇总整理,将基于循证医学理念的"治疗参考浓度范围"和"剂量相关参考浓度范围"呈现给大家。本共识指南引入了"实验室警戒浓度"的新概念,即实验室需要马上告知治疗医生的药物浓度上限。本共识指南还给出了诸如药物作为细胞色素P450酶的底物和抑制剂的性质,代谢物与母药浓度比值的常见范围,以及与结果解释相关的内容,还提供了何时将TDM与遗传药理学检测相结合的建议。遵循本指南,有助于改善许多患者精神药物治疗的效果,特别是那些存在药代动力学异常的患者。TDM是一门交叉学科,有时针对看起来不一致的数据,需要多学科坦诚地讨论,只有这样,患者才能从这种合作中获益。

关键词：共识指南药物分析药代动力学精神药物治疗参考浓度范围治疗药物监测治疗窗

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